Faculty

Institution

Unit

Venue

Luke Szweda

Professor Medicine Professor

University of Arizona

Luke Szweda is currently serving as a Professor Medicine Professor at University of Arizona.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Luke Szweda

University of Arizona

Professor Medicine Professor

You can click a keyword to filter the displayed items

biochemistry oxidative stress redox biology physiology free radical biology mitochondrial function cell metabolism metabolism molecular biology cell biology enzymes molecular metabolism cardiology cardiovascular research enzyme inhibition membrane biology redox signaling reactive oxygen species molecular physiology vascular biology liver physiology protein science biological chemistry cellular physiology lipid peroxidation inflammation endocrinology chemical biology mitochondrial dynamics aging cell cardiac muscle reperfusion injury enzyme catalysis mammalian biology cardiovascular physiology metabolic regulation enzymatic modification energy metabolism proteome research structural molecular biology inhibitory activity mitochondrial biogenesis pyruvate dehydrogenase alzheimer disease protein chemistry biocatalysis secondary metabolism structure-function enzyme kinetics vascular aging a-ketoglutarate dehydrogenase immunochemical detection cardiac reperfusion cardiac ischemia renal function protein function neurochemistry experimental neuropathology lipoic acid manganese superoxide dismutase free radicals redox regulation redox chemistry enzyme immobilization hypoxia (medicine) enzyme specificity renal pathophysiology vascular disease oxidative modification hydrogen peroxide selective separation cellular senescence cellular biology multicatalytic protease proteasome activity selective inactivation mitochondrial metabolism cardiovascular function circulatory physiology nutritional biochemistry cardiac metabolism health science

Notable Scholarly Works

Notable Federal Grants

Collaborators

Myocardial Pyruvate Dehydrogenase Kinase 4 Drives Sex-Specific Cardiac Responses to Endotoxemia. JCI Insight (2025)

physiologycardiologycardiac pathologiescardiovascular physiologymyocardial pyruvate dehydrogenasecardiovascular researchsystems biologymetabolismcirculatory physiologycardiac muscle

Paracrine Igfbp3 Spatially Coordinates Igf Signaling to Induce Myocardial Regeneration in Mice. Journal of Molecular and Cellular Cardiology (2025)

fibroblast growth factorsmyocardial regenerationcellular physiologycardiovascular researchcell signalingparacrine igfbp3matrix biologyregeneration (biology)developmental biologytissue developmentmolecular physiologycardiac musclecell biology

Afterload-Induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Hande C. PiristineHerman I. MayNan JiangDaniel DaouFrancisco Olivares-SilvaAbdallah ElnwasanyPamela SzwedaLuke SzwedaCaroline KinterMichael KinterGaurav SharmaXiaodong WenCraig R. MalloyMichael E. JessenThomas G. GilletteJoseph A. Hill

glucose utilizationfatty acid oxidationmetabolic remodelinglipidsmetabolismbiochemistrycell metabolism

In Vivo Investigation of Recuperation Dynamics of Altered Myocardial Pdh Activity Induced by a Ketogenic Diet. Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024)

Jun ChenZohreh ErfaniAbdallah ElnwasanySarah Al NemriMai HuynhMaheen ZaidiCrystal HarrisonXiaodong WenPamela SzwedaLuke SzwedaJae Mo Park

magnetic resonance imagingmedicinemagnetic resonancemedical imagingrecuperation dynamicsketogenic diet

Reciprocal Regulation of Cardiac B-Oxidation and Pyruvate Dehydrogenase by Insulin. J. Biol. Chem. (2024)

physiologyinsulin signalingmetabolic remodelingmetabolic regulationreciprocal regulationmolecular metabolismmetabolismmetabolic pathwaysoxidative stressbiochemistrycell metabolism

Reciprocal Regulation of Cardiac β-Oxidation and Pyruvate Dehydrogenase by Insulin. Journal of Biological Chemistry (2024)

Abdallah ElnwasanyHeba A EwidaIvan Menendez-MontesMonika MizerskaXiaorong FuChai-Wan KimJay D HortonShawn C BurgessBeverly A RothermelPamela A SzwedaLuke I Szweda

biological chemistrymetabolic controlmetabolismcardiac b-oxidationbiochemistrymetabolic regulationendocrinologyenzymesfunctional regulationcell metabolisminsulin signalingmolecular metabolismcardiac muscleenzyme inhibitionsystems biologyredox biologyreciprocal regulationmolecular biologysignal transductionoxidative stresspyruvate dehydrogenase

Thioredoxin-1 and Its Mimetic Peptide Improve Systolic Cardiac Functions and Remodeling in Myocardial Infarction. Free Radical Biology and Medicine (2024)

Tania MedaliDominique CouchieNathalie MougenotMaria MihocOlaf BergmannWouter DerksLuke SzwedaBertrand FriguetMustapha Rouis

peptidesmedicinecardiologypeptide scienceacute myocardial infarctionreactive oxygen speciesbioactive compoundssystolic cardiac functionscardiovascular translational researchsynthetic biologymyocardial infarctionpeptide engineeringfree radical biologycardiovascular researchbiomolecular engineeringmolecular biologymedicinal researchoxidative stressmimetic peptidecardiovascular disease

255-Lb: Liver Pyruvate Carboxylase Deletion in Mice Prevents Fibrosis From a Nash Diet. Diabetes (2023)

MELISSA MAE R. IÑIGO-VOLLMERBLANKA KUCEJOVAMONIKA N. MIZERSKASHAHANSHAH KHANPAMELA A. SZWEDAHASAN ZAKILUKE I. SZWEDAXIAORONG FUSHAWN C. BURGESS

fibrosisdiabetesnash dietdiabetes researchmetabolic syndromechronic diseasesobesitybiomolecular engineeringmolecular metabolismmice prevents fibrosismolecular biologymetabolismcell metabolismliver physiologybiochemistryinflammation

Abstract P3201: Fatty Acid Oxidation Decreases Independently of Up-Regulated Glucose Utilization in the Setting of Elevated Afterload. Circulation Research (2023)

Hande C PiristineHerman I MayNan JiangFrancisco Olivares-SilvaAbdallah ElnwasanyPamela SzwedaLuke I SzwedaCaroline KinterMichael T KinterGaurav SharmaXiaodong WenCraig MalloyMichael E JessenThomas G GilletteJoseph A Hill

physiologyfatty acid oxidationcardiovascular researchlipidsvascular biologyup-regulated glucose utilization

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy. Antioxidants (2023)

Abdallah ElnwasanyHeba A. EwidaPamela A. SzwedaLuke I. Szweda

cardiologyenzyme inhibitiondiabetesdiabetic cardiomyopathypyruvate dehydrogenasesecondary metabolismantioxidantsmetabolic syndromereactive oxygen speciesinitiating eventdiabetic medicinecardiomyopathyoxidative stressdiabetes researchbiochemistrycardiovascular disease

1
2
3
4
5
29
10 / page

Luke Szweda

Professor Medicine Professor

University of Arizona

Luke Szweda is currently serving as a Professor Medicine Professor at University of Arizona.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Luke Szweda

University of Arizona

Professor Medicine Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Myocardial Pyruvate Dehydrogenase Kinase 4 Drives Sex-Specific Cardiac Responses to Endotoxemia. JCI Insight (2025)

physiologycardiologycardiac pathologiescardiovascular physiologymyocardial pyruvate dehydrogenasecardiovascular researchsystems biologymetabolismcirculatory physiologycardiac muscle

Paracrine Igfbp3 Spatially Coordinates Igf Signaling to Induce Myocardial Regeneration in Mice. Journal of Molecular and Cellular Cardiology (2025)

Afterload-Induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization. bioRxiv (Cold Spring Harbor Laboratory) (2024)

glucose utilizationfatty acid oxidationmetabolic remodelinglipidsmetabolismbiochemistrycell metabolism

Jun ChenZohreh ErfaniAbdallah ElnwasanySarah Al NemriMai HuynhMaheen ZaidiCrystal HarrisonXiaodong WenPamela SzwedaLuke SzwedaJae Mo Park

magnetic resonance imagingmedicinemagnetic resonancemedical imagingrecuperation dynamicsketogenic diet

Reciprocal Regulation of Cardiac B-Oxidation and Pyruvate Dehydrogenase by Insulin. J. Biol. Chem. (2024)

physiologyinsulin signalingmetabolic remodelingmetabolic regulationreciprocal regulationmolecular metabolismmetabolismmetabolic pathwaysoxidative stressbiochemistrycell metabolism

Reciprocal Regulation of Cardiac β-Oxidation and Pyruvate Dehydrogenase by Insulin. Journal of Biological Chemistry (2024)

Abdallah ElnwasanyHeba A EwidaIvan Menendez-MontesMonika MizerskaXiaorong FuChai-Wan KimJay D HortonShawn C BurgessBeverly A RothermelPamela A SzwedaLuke I Szweda

Thioredoxin-1 and Its Mimetic Peptide Improve Systolic Cardiac Functions and Remodeling in Myocardial Infarction. Free Radical Biology and Medicine (2024)

Tania MedaliDominique CouchieNathalie MougenotMaria MihocOlaf BergmannWouter DerksLuke SzwedaBertrand FriguetMustapha Rouis

255-Lb: Liver Pyruvate Carboxylase Deletion in Mice Prevents Fibrosis From a Nash Diet. Diabetes (2023)

MELISSA MAE R. IÑIGO-VOLLMERBLANKA KUCEJOVAMONIKA N. MIZERSKASHAHANSHAH KHANPAMELA A. SZWEDAHASAN ZAKILUKE I. SZWEDAXIAORONG FUSHAWN C. BURGESS

Abstract P3201: Fatty Acid Oxidation Decreases Independently of Up-Regulated Glucose Utilization in the Setting of Elevated Afterload. Circulation Research (2023)

physiologyfatty acid oxidationcardiovascular researchlipidsvascular biologyup-regulated glucose utilization

Inhibition of Pyruvate Dehydrogenase in the Heart as an Initiating Event in the Development of Diabetic Cardiomyopathy. Antioxidants (2023)

Abdallah ElnwasanyHeba A. EwidaPamela A. SzwedaLuke I. Szweda

1
2
3
4
5
29
10 / page

Similar Faculty Members

Henry Jay Forman

Institution

University of Southern California

immune mediator

allergy

Sushil Mahata

Institution

University of California, San Diego

metabolic disorder

hormone secretion

Shahid Baba

Institution

University of Louisville

pharmacology

physiology

Lawrence J Mandarino

Institution

University of Arizona

endocrinology

metabolism

Suresh C. Tyagi

Institution

University of Louisville

health science

cardiovascular translational research

Ta Yuan Chang

Institution

Dartmouth College

autophagy

obesity

Jianjie Ma

Institution

University of Virginia

cell biology

cellular physiology

Daria Mochly-Rosen

Institution

Stanford University

pharmacology

cardiology

Birgit Schilling

Institution

University of Southern California

molecular metabolism

clinical proteomics

Enrique Cadenas

Institution

University of Southern California

free radical biology

brain metabolism

Similar Faculty Members

Henry Jay Forman

Institution

University of Southern California

immune mediator

allergy

Sushil Mahata

Institution

University of California, San Diego

metabolic disorder

hormone secretion

Shahid Baba

Institution

University of Louisville

pharmacology

physiology

Lawrence J Mandarino

Institution

University of Arizona

endocrinology

metabolism

Suresh C. Tyagi

Institution

University of Louisville

health science

cardiovascular translational research

Ta Yuan Chang

Institution

Dartmouth College

autophagy

obesity

Jianjie Ma

Institution

University of Virginia

cell biology

cellular physiology

Daria Mochly-Rosen

Institution

Stanford University

pharmacology

cardiology

Birgit Schilling

Institution

University of Southern California

molecular metabolism

clinical proteomics

Enrique Cadenas

Institution

University of Southern California

free radical biology

brain metabolism