Faculty

Institution

Unit

Venue

Luigi Perelli

Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Department Of Biology And Biochemistry

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Luigi Perelli is an Assistant Professor at The University of Texas MD Anderson Cancer Center. His research focuses on tumor biology, cancer genetics, and molecular pathology, with a particular emphasis on pancreatic cancer and SMARCB1-deficient renal medullary carcinoma. His recent work investigates single-cell transcriptomic dynamics driving chemotherapy resistance, targeting mitochondrial complex I to overcome adaptive responses in advanced pancreatic cancer, and KRAS allelic imbalance in NSCLC tumor evolution. He has also explored the epigenetic role of DPY30 in linking replication stress to immunoediting in pancreatic cancer. His publications appear in leading journals, including Cancer Research, Clinical Cancer Research, and the Journal of Clinical Oncology, reflecting his contributions to translational oncology and precision cancer therapeutics.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Luigi Perelli

The University of Texas MD Anderson Cancer Center

Assistant Professor

You can click a keyword to filter the displayed items

tumor biology pathology cancer research cell biology cancer biology cancer cells oncogenes molecular cancer genetics oncology carcinogenesis pancreatic cancer cancer genetics immunology cancer genomics renal medullary carcinoma medicinal research mammalian biology genitourinary cancers cancer treatment sickle cell trait cell signaling cancer immunotherapy genomics cell research cancer care pharmacotherapy extracellular microvesicles tumor suppressors pancreatic ductal adenocarcinoma membrane biology cellular therapy cancer imaging vascular biology cancer growth pancreatic surgery power ultrasound marine genomics host factors treatment effects colorectal cancer extracellular vesicles evolutionary fingerprints kras inhibitors proteotoxic stress sensitizes pancreatic tumors improved dna repair high-intensity exercise chromosomal instability liver physiology brain tumor research leukemia cell death biomedical analysis hematological malignancies hepatocellular carcinoma liver cancer cell detection tissue development cell lineage cancer risk human sciences host genetics mammalian physiology coral reefs biological oceanography functional modification clinical therapeutics clinical medicine clinical translation cancer management immune hallmarks kidney cancer metastasis experimental animal studies clinical observations metastatic evolution gynecologic oncology epidemiology forensic genetics gliomas functional genomics developmental biology cancer discovery thoracic oncology medical history human genetics bioinformatics individualized medicine translational research surgical pathology lung cancer jama oncology omics radiation oncology biomedical informatics molecular informatics molecular diagnostics systems biology genetic epidemiology cancer letter personalized medicine tumor microenvironment genome biology statistical genetics biostatistics metastasis molecular medicine histopathology medicine heredity experimental medicine mesothelioma neuro-oncology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1468: Germline Whole Exome Sequencing Implicates Homologous Recombination Repair Pathway Genes as Risk Factors in Smarcb1 Deficient Renal Medullary Phenotypes Without Sickle Hemoglobinopathies.. Cancer Research (2026)

pathologygenetic disordersabstract 1468risk factorsgenome biologydisease gene identificationmolecular geneticsmolecular diagnosticsheredityhuman geneticsmedical geneticsgermline whole exomegenetics

Abstract 2807: Immune Cell-Dependent Resistance to Lag3 Blockade in Smarcb1-Deficient Renal Medullary Carcinoma. Cancer Research (2026)

oncogeneskidney cancerimmune cell-dependent resistanceabstract 2807immunologycell biologyimmunotherapycancer immunosurveillancecancer cellsimmune checkpoint inhibitorslag3 blockade

Abstract 3451: Single-Cell Transcriptomic Insights Into Tumor and Immune Dynamics Driving Resistance to Ixazomib Combined With Gemcitabine and Doxorubicin in Smarcb1-Deficient Renal Medullary Carcinoma. Cancer Research (2026)

single-cell transcriptomic insightstumor biologykidney cancerimmune dynamicsabstract 3451immunologycell biologymolecular cancercancer cellsimmune checkpoint inhibitorstumor microenvironmentcancer biology

Abstract 3540: Kras Allelic Imbalance Reshapes Tumor Evolution Through Selective Clonal Outgrowth and Chromosomal Instability in Nsclc. Cancer Research (2026)

oncogenespathologytumor biologycancer biologyabstract 3540chromosomal instabilitycarcinogenesisselective clonal outgrowthmolecular diagnosticscancer discoveryoncogenic agentcancer geneticscancer genomicstumor microenvironmentgeneticstumor heterogeneity

Abstract 6803: Targeting Mitochondrial Complex I Overcomes Adaptive Response to Chemotherapy in Advanced Pancreatic Cancer. Cancer Research (2026)

oncogenesmitochondrial complexadvanced pancreatic cancercell biologycell metabolismcancer researchpancreatic cancermolecular biologytherapeutic targetsmitochondrial functioncancer cellsabstract 6803

Dpy30 is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. Cancer Research (2026)

oncogenespathologyepigenetic decouplertumor biologyimmunologycell biologyepigeneticsmolecular cancerreplication stresscancer researchpancreatic cancercancer cellscancer biology

Future Directions and Research Opportunities. Current clinical pathology (2026)

pathologysurgical pathologyhuman pathologyhistopathologygeneral pathologyanatomical pathology

Integrative Genomic Landscape of Germline Exome Alterations in Renal Cell Carcinoma, Unclassified With Medullary Phenotype.. Journal of Clinical Oncology (2026)

renal cell carcinomakidney cancerintegrative genomic landscapegenome biologymolecular diagnosticsgermline exome alterationshuman geneticsurologycancer geneticscancer genomicsgenetics

Phase II Trial of Ixazomib Combined With Gemcitabine and Doxorubicin in Patients With Smarcb1-Deficient Renal Medullary Carcinoma. Clinical Cancer Research (2026)

pathologykidney cancermetronomic chemotherapyixazomib combinedcancer treatmentjama oncologytherapeutic targetsphase ii trialurologypharmacotherapyoncology

Abstract 3824: Investigating the Role of Allelic Imbalance in Pancreatic Cancer Aggressiveness, Survival, and Therapeutic Resistance. Cancer Research (2025)

oncogenespathologytumor biologypancreatic cancer aggressivenesscell biologyallelic imbalancemolecular cancermolecular diagnosticspancreatic cancerabstract 3824cancer cellscancer geneticsoncologycancer biology

1
2
3
4
5
6
10 / page

Luigi Perelli

Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Department Of Biology And Biochemistry

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Luigi Perelli

The University of Texas MD Anderson Cancer Center

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

pathologygenetic disordersabstract 1468risk factorsgenome biologydisease gene identificationmolecular geneticsmolecular diagnosticsheredityhuman geneticsmedical geneticsgermline whole exomegenetics

Abstract 2807: Immune Cell-Dependent Resistance to Lag3 Blockade in Smarcb1-Deficient Renal Medullary Carcinoma. Cancer Research (2026)

oncogeneskidney cancerimmune cell-dependent resistanceabstract 2807immunologycell biologyimmunotherapycancer immunosurveillancecancer cellsimmune checkpoint inhibitorslag3 blockade

Abstract 3540: Kras Allelic Imbalance Reshapes Tumor Evolution Through Selective Clonal Outgrowth and Chromosomal Instability in Nsclc. Cancer Research (2026)

Abstract 6803: Targeting Mitochondrial Complex I Overcomes Adaptive Response to Chemotherapy in Advanced Pancreatic Cancer. Cancer Research (2026)

oncogenesmitochondrial complexadvanced pancreatic cancercell biologycell metabolismcancer researchpancreatic cancermolecular biologytherapeutic targetsmitochondrial functioncancer cellsabstract 6803

Dpy30 is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. Cancer Research (2026)

oncogenespathologyepigenetic decouplertumor biologyimmunologycell biologyepigeneticsmolecular cancerreplication stresscancer researchpancreatic cancercancer cellscancer biology

Future Directions and Research Opportunities. Current clinical pathology (2026)

pathologysurgical pathologyhuman pathologyhistopathologygeneral pathologyanatomical pathology

Integrative Genomic Landscape of Germline Exome Alterations in Renal Cell Carcinoma, Unclassified With Medullary Phenotype.. Journal of Clinical Oncology (2026)

renal cell carcinomakidney cancerintegrative genomic landscapegenome biologymolecular diagnosticsgermline exome alterationshuman geneticsurologycancer geneticscancer genomicsgenetics

Phase II Trial of Ixazomib Combined With Gemcitabine and Doxorubicin in Patients With Smarcb1-Deficient Renal Medullary Carcinoma. Clinical Cancer Research (2026)

pathologykidney cancermetronomic chemotherapyixazomib combinedcancer treatmentjama oncologytherapeutic targetsphase ii trialurologypharmacotherapyoncology

Abstract 3824: Investigating the Role of Allelic Imbalance in Pancreatic Cancer Aggressiveness, Survival, and Therapeutic Resistance. Cancer Research (2025)

1
2
3
4
5
6
10 / page