Faculty

Institution

Unit

Venue

Lucia Carbone

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Botanical Dietary Supplements Research Center (Benfra)

Center For Developmental Health (Formerly Heart Research Center)

Department Of Cell, Developmental And Cancer Biology

Department Of Chemical Physiology And Biochemistry

Department Of Family Medicine

Department Of Medicine

Department Of Molecular And Medical Genetics

Department of Medicine

Division of Infectious Diseases

Division Of Informatics, Clinical Epidemiology

Department Of Medicine

Division of Informatics, Clinical Epidemiology and Translational Data Science (DICE)

Oregon Health & Science University

Oregon National Primate Research Center

Department Of Family Medicine

School Of Medicine

Department Of Cell, Developmental And Cancer Biology

School Of Medicine

Department Of Chemical Physiology And Biochemistry

School Of Medicine

Department Of Molecular And Medical Genetics

School Of Medicine

Division of Infectious Diseases

School Of Medicine

Lucia Carbone is a Senior Professor at Oregon Health & Science University. Her research integrates genetics, epigenetics, and evolutionary genomics to investigate mammalian genome architecture and neurobiology. She has led landmark efforts, including the haplotype-resolved sequencing of six ape genomes and the non-human primate developmental GTEx projects, both published in Nature. Her recent work also explores the epigenetic regulation of spermatogenesis, centromeric transposable elements in gibbon karyotypic variation, and the transcriptomic basis of vocal evolution in frogs. Carbone’s laboratory further examines astrocyte-mediated effects on neuronal development and alcohol dependence, reflecting a broad interest in the molecular underpinnings of neural and reproductive biology.

Honors

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Experiences

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Education

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Lucia Carbone

Oregon Health & Science University

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genetics genomics evolutionary biology genome biology molecular biology epigenetics molecular evolution mammalian biology biology gene expression cytogenetics reproductive biology epigenetic changes population genetics avian biology heredity embryonic development chromatin molecular genetics reproductive science chromosome biology genome analysis primate systematics human evolution developmental system oncogenes epigenomics evolutionary anthropology medicinal research biological evolution developmental genetics gametogenesis genome sequencing cancer genomics implantation (embryology) next-generation sequencing gibbon genome molecular ecology molecular cell biology developmental cell animal biotechnology nucleic acids genome studies germ cell fate primatology evolutionary genetics transcriptomics technology genome structure medical genetics human embryonic development animal genetics chromosomal rearrangements chromatin remodeling epigenetic maintenance topological domains insect molecular biology plant breeding breeding behavior reference genome nucleic acid amplification gene characterization viral genetics viral evolution small apes large-scale variation great ape genomes recurrent sites syntenic clusters evolutionary movement chromosome elimination single-cell sequencing primate preimplantation embryos comparative analyses ape genomes complete sequencing complete sequence

Notable Scholarly Works

Notable Federal Grants

Collaborators

Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala. bioRxiv (Cold Spring Harbor Laboratory) (2026)

psychiatrybiological psychiatryalcohol (drug)brain scienceneurosciencealcohol dependenceneurophysiologyaddiction biology

Transcriptomic Profiling Reveals Neurophysiological Gene Candidates Underlying Vocal Evolution in African Clawed Frogs. bioRxiv (Cold Spring Harbor Laboratory) (2026)

molecular evolutionvocal evolutionanimal behaviormorphogenesismorphology (biology)developmental systembiologyevolutionary biologyzoologycomparative physiologybioacoustics

695 Investigating the Effects of Azacytidine on T Cell Exhaustion in Aml. Regular and Young Investigator Award Abstracts (2025)

hematologymedicinet cell exhaustionleukemiapharmacologyclinical researchpharmacotherapy

Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens. Neurobiology of Disease (2025)

psychoneuroimmunologyalcohol (drug)neuroscienceneuroimmunologyaddictionaddictive behaviorsalcohol dependencenucleus accumbensaddiction biology

Astrocyte Extracellular Matrix Modulates Neuronal Dendritic Development. Glia (2025)

developmental biologydevelopmental neurobiologycellular neurobiologymolecular neuroscienceneuronsependymaneurosciencespinal cordcellular physiology

Centromeric Transposable Elements and Epigenetic Status Drive Karyotypic Variation in the Eastern Hoolock Gibbon. Cell Genomics (2025)

molecular evolutionevolutionary geneticsgeneticshuman evolutionprimate systematicsevolutionary developmental biologyeastern hoolock gibbonheredityevolutionary biologymammalian biologycentromeric transposable elementsgenetic variation

Complete Sequencing of Ape Genomes. Nature (2025)

DongAhn YooArang RhiePrajna HebbarFrancesca AntonacciGlennis A LogsdonSteven J SolarDmitry AntipovBrandon D PickettYana SafonovaFrancesco MontinaroYanting LuoJoanna MalukiewiczJessica M StorerJiadong LinAbigail N SequeiraRiley J ManganGlenn HickeyGraciela Monfort AnezParithi BalachandranAnton BankevichChristine R BeckArjun BiddandaMatthew BorchersGerard G BouffardEmry BrannanShelise Y BrooksLucia CarboneLaura CarrelAgnes P ChanJuyun CrawfordMark DiekhansEric EngelbrechtCedric FeschotteGiulio FormentiGage H GarciaLuciana de GennaroDavid GilbertRichard E GreenAndrea GuarracinoIshaan GuptaDiana HaddadJunmin HanRobert S HarrisGabrielle A HartleyWilliam T HarveyMichael HillerKendra HoekzemaMarlys L HouckHyeonsoo JeongKaivan KamaliManolis KellisBryce KilleChul LeeYoungho LeeWilliam LeesAlexandra P LewisQiuhui LiMark LoftusYong Hwee Eddie LohHailey LoucksJian MaYafei MaoJuan F I MartinezPatrick MastersonRajiv C McCoyBarbara McGrathSean McKinneyBritta S MeyerKaren H MigaSaswat K MohantyKatherine M MunsonKarol PalMatt PennellPavel A PevznerDavid PorubskyTamara PotapovaFrancisca R RingelingJoana L RochaOliver A RyderSamuel SaccoSwati SahaTakayo SasakiMichael C SchatzNicholas J SchorkCole ShanksLinnéa SmedsDongmin R SonCynthia SteinerAlexander P SweetenMichael G TassiaFrançoise Thibaud-NissenEdmundo Torres-GonzálezMihir TrivediWenjie WeiJulie WertzMuyu YangPanpan ZhangShilong ZhangYang ZhangZhenmiao Zhang

molecular evolutiongeneticshuman evolutiongenome sequencingape genomesevolutionary anthropologyprimate systematicscomplete sequencingreference genomegenomicsevolutionary biologygenome analysisgenome biologycomparative analyses

Deletion of an Evolutionarily Conserved Tad Boundary Impacts Spermatogenesis in Mice. Biology of Reproduction (2025)

Ana C LimaMariam OkhovatAlexandra M StendahlRan YangJake VanCampenKimberly A NevonenJarod HerreraWeiyu LiLana HarshmanLev M FedorovKatinka A Vigh-ConradNadav AhituvDonald F ConradLucia Carbone

developmental biologyreproductive sciencegametogenesisanimal reproductionreproductive physiologyreproduction responseboundary impacts spermatogenesisbiologyevolutionary biologygerm cell fatereproductive biology

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Alzheimer’s Disease Appnl-G-F Knock-in Mouse Model. Scientific Reports (2025)

epigeneticsbrain pathologytranscriptomic alterationsdegenerative pathologyneuroscience of agingalzheimer's diseaseneurodegenerative diseasescell biologyneurosciencemolecular neurodegeneration

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease App Nl-G-F Knock in Mouse Model. bioRxiv (Cold Spring Harbor Laboratory) (2025)

brain pathologycognitive impairmentdegenerative pathologyneuroscience of agingmolecular neurosciencealzheimer's diseaseneurodegenerative diseaseshuntington's diseaseneurochemical biomarkersalzheimer ’neurosciencemolecular neurodegenerationneurologymouse model

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Lucia Carbone

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Botanical Dietary Supplements Research Center (Benfra)

Center For Developmental Health (Formerly Heart Research Center)

Department Of Cell, Developmental And Cancer Biology

Department Of Chemical Physiology And Biochemistry

Department Of Family Medicine

Department Of Medicine

Department Of Molecular And Medical Genetics

Department of Medicine

Division of Infectious Diseases

Division Of Informatics, Clinical Epidemiology

Department Of Medicine

Division of Informatics, Clinical Epidemiology and Translational Data Science (DICE)

Oregon Health & Science University

Oregon National Primate Research Center

Department Of Family Medicine

School Of Medicine

Department Of Cell, Developmental And Cancer Biology

School Of Medicine

Department Of Chemical Physiology And Biochemistry

School Of Medicine

Department Of Molecular And Medical Genetics

School Of Medicine

Division of Infectious Diseases

School Of Medicine

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Lucia Carbone

Oregon Health & Science University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Astrocyte Reactivity by Alcohol Dependence in the Central Amygdala. bioRxiv (Cold Spring Harbor Laboratory) (2026)

psychiatrybiological psychiatryalcohol (drug)brain scienceneurosciencealcohol dependenceneurophysiologyaddiction biology

Transcriptomic Profiling Reveals Neurophysiological Gene Candidates Underlying Vocal Evolution in African Clawed Frogs. bioRxiv (Cold Spring Harbor Laboratory) (2026)

molecular evolutionvocal evolutionanimal behaviormorphogenesismorphology (biology)developmental systembiologyevolutionary biologyzoologycomparative physiologybioacoustics

695 Investigating the Effects of Azacytidine on T Cell Exhaustion in Aml. Regular and Young Investigator Award Abstracts (2025)

hematologymedicinet cell exhaustionleukemiapharmacologyclinical researchpharmacotherapy

Alcohol Dependence-Induced Astrocyte Immune Activation in the Nucleus Accumbens. Neurobiology of Disease (2025)

psychoneuroimmunologyalcohol (drug)neuroscienceneuroimmunologyaddictionaddictive behaviorsalcohol dependencenucleus accumbensaddiction biology

Astrocyte Extracellular Matrix Modulates Neuronal Dendritic Development. Glia (2025)

developmental biologydevelopmental neurobiologycellular neurobiologymolecular neuroscienceneuronsependymaneurosciencespinal cordcellular physiology

Centromeric Transposable Elements and Epigenetic Status Drive Karyotypic Variation in the Eastern Hoolock Gibbon. Cell Genomics (2025)

Complete Sequencing of Ape Genomes. Nature (2025)

Deletion of an Evolutionarily Conserved Tad Boundary Impacts Spermatogenesis in Mice. Biology of Reproduction (2025)

Ana C LimaMariam OkhovatAlexandra M StendahlRan YangJake VanCampenKimberly A NevonenJarod HerreraWeiyu LiLana HarshmanLev M FedorovKatinka A Vigh-ConradNadav AhituvDonald F ConradLucia Carbone

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Alzheimer’s Disease Appnl-G-F Knock-in Mouse Model. Scientific Reports (2025)

epigeneticsbrain pathologytranscriptomic alterationsdegenerative pathologyneuroscience of agingalzheimer's diseaseneurodegenerative diseasescell biologyneurosciencemolecular neurodegeneration

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer’s Disease App Nl-G-F Knock in Mouse Model. bioRxiv (Cold Spring Harbor Laboratory) (2025)

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