Faculty

Institution

Unit

Venue

Litong Nie

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Experimental Radiation Oncology

Litong Nie is a Senior Professor at The University of Texas MD Anderson Cancer Center. Her research integrates cell and molecular biology, genetics, and genome biology to investigate DNA repair mechanisms, tumor biology, and cancer cell behavior. Recent work includes in vivo CRISPR activation screens identifying drivers of bone metastasis, the role of CHK1 in DNA replication, and the function of USP37 in protecting damaged replication forks in BRCA1-deficient cells, contributing to PARP inhibitor resistance. Her laboratory also explores protein modification systems as cancer biomarkers and therapeutic targets, as well as the mechanisms of ferroptosis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Litong Nie

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

cell biology molecular biology dna repair molecular cell biology tumor biology cancer cells oncogenes systems biology cell death cell signaling molecular cancer nucleic acids cancer biology genetics genome biology medicinal research crispr genome editing proteomics molecular medicine cell research cancer discovery genome instability cell cycle tumor microenvironment cellular biochemistry mutagenesis cancer treatment tumor targeting drug targeting signal transduction cancer imaging tumor suppressors molecular pathways cancer genomics gene editing cellular biology molecular research inter-strand crosslink repair cellular physiology vascular biology cell metabolism molecular metabolism intracellular trafficking cell motility protein misfolding cell physiology redox signaling metabolic regulation metabolic remodeling protein genetics oncogenic agent signaling pathways biomolecular interactions pancreatic cancer sclerostin cancer genetics cancer growth breast oncology cell control cancer management actin cytoskeleton vulnerability stress mediates disulfidptosis mtorc1 couples cyst gpx4 protein synthesis non-canonical function tumor radioresistance genome-wide crispr screens pathway activation genetic vulnerabilities proteomic analysis ferroptosis pathways dna damage glioma novel gene proteomics analysis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Chk1 is an Integral Regulator of Dna Replication in Human Cells. Cell Death and Disease (2026)

molecular and cellular biologyoncogenesplo biologycell deathcell signalingnucleic acidscell biologytranscription factorscell divisiondna replicationmolecular cell biologymolecular physiologymolecular biologychromatinsystems biologycell researchdna repair

Protein Modification Systems as Cancer Biomarkers and Therapeutic Targets. Precision Clinical Medicine (2026)

tumor biologyprotein designmolecular cancercancer discoverymolecular biologytherapeutic targetsbiomolecular engineering

Cell Cycle Progression of Under-Replicated Cells. Nucleic Acids Research (2025)

cell cyclecell researchcell biologycell cycle progressioncell divisioncell control

In Vivo Crispr Activation Screen Identifies Acyl-Coa–Binding Protein as a Driver of Bone Metastasis. Science Translational Medicine (2025)

oncogenesmetastasisgenome editingtumor biologycrisprcell biologysclerostinmolecular cell biologymolecular biologycancer cellsacyl-coa–binding proteinbone metastasis

Usp37 Counteracts Hltf to Protect Damaged Replication Forks and Promote Survival of Brca1-Deficient Cells and Parp Inhibitor Resistance. Nucleic Acids Research (2025)

molecular and cellular biologyoncogenesplo biologymutagenesis (molecular biology technique)cell deathmolecular medicinecell biologynucleic acidscancer lettermolecular cancerdna replicationmolecular cell biologymolecular biologychromatinsystems biologydna repaircell and molecular biology

Author Response: Deparylation is Critical for S Phase Progression and Cell Survival. (2024)

cell cyclecell deathcellular senescencecell biologys phase progressioncell divisionmolecular biologycancer cellscell survivalauthor responsecell and molecular biology

Deparylation is Critical for S Phase Progression and Cell Survival. eLife (2024)

cell cyclecell deathcell biologys phase progressioncell divisionbiochemistrymolecular cell biologycellular biologydna repaircellular biochemistry

In Vivo Crispr Screens Identify Mga as an Immunotherapy Target in Triple-Negative Breast Cancer. Proceedings of the National Academy of Sciences (2024)

breast oncologygene editinggenome editingvivo crispr screenscancer immunotherapycrisprimmunologycell biologycancer discoverytriple-negative breast cancerimmunotherapy targetcancer lettertumor microenvironmentbreast cancer

Proteomic Analysis of Ferroptosis Pathways Reveals a Role of Cept1 in Suppressing Ferroptosis. Protein & Cell (2024)

Xiaoguang LiuZhen ChenYuelong YanFereshteh ZandkarimiLitong NieQidong LiAmber HorbathKellen OlszewskiLavanya KondiparthiChao MaoHyemin LeeLi ZhuangMasha PoyurovskyBrent R StockwellJunjie ChenBoyi Gan

proteomic analysisproteomicsprotein sciencecell biologyferroptosis pathways

Systematic Investigation of Brca1-a, -B, and -C Complexes and Their Functions in Dna Damage Response and Dna Repair. Oncogene (2024)

genome instabilitynucleic acidscell biologygenome biologydna damage responsemolecular geneticsmolecular cell biologymolecular biologysystematic investigationdna repairmolecular researchgenetics

1
2
3
4
10 / page

Litong Nie

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Experimental Radiation Oncology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Litong Nie

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Chk1 is an Integral Regulator of Dna Replication in Human Cells. Cell Death and Disease (2026)

Protein Modification Systems as Cancer Biomarkers and Therapeutic Targets. Precision Clinical Medicine (2026)

tumor biologyprotein designmolecular cancercancer discoverymolecular biologytherapeutic targetsbiomolecular engineering

Cell Cycle Progression of Under-Replicated Cells. Nucleic Acids Research (2025)

cell cyclecell researchcell biologycell cycle progressioncell divisioncell control

In Vivo Crispr Activation Screen Identifies Acyl-Coa–Binding Protein as a Driver of Bone Metastasis. Science Translational Medicine (2025)

oncogenesmetastasisgenome editingtumor biologycrisprcell biologysclerostinmolecular cell biologymolecular biologycancer cellsacyl-coa–binding proteinbone metastasis

Usp37 Counteracts Hltf to Protect Damaged Replication Forks and Promote Survival of Brca1-Deficient Cells and Parp Inhibitor Resistance. Nucleic Acids Research (2025)

Author Response: Deparylation is Critical for S Phase Progression and Cell Survival. (2024)

cell cyclecell deathcellular senescencecell biologys phase progressioncell divisionmolecular biologycancer cellscell survivalauthor responsecell and molecular biology

Deparylation is Critical for S Phase Progression and Cell Survival. eLife (2024)

cell cyclecell deathcell biologys phase progressioncell divisionbiochemistrymolecular cell biologycellular biologydna repaircellular biochemistry

In Vivo Crispr Screens Identify Mga as an Immunotherapy Target in Triple-Negative Breast Cancer. Proceedings of the National Academy of Sciences (2024)

Proteomic Analysis of Ferroptosis Pathways Reveals a Role of Cept1 in Suppressing Ferroptosis. Protein & Cell (2024)

Xiaoguang LiuZhen ChenYuelong YanFereshteh ZandkarimiLitong NieQidong LiAmber HorbathKellen OlszewskiLavanya KondiparthiChao MaoHyemin LeeLi ZhuangMasha PoyurovskyBrent R StockwellJunjie ChenBoyi Gan

proteomic analysisproteomicsprotein sciencecell biologyferroptosis pathways

Systematic Investigation of Brca1-a, -B, and -C Complexes and Their Functions in Dna Damage Response and Dna Repair. Oncogene (2024)

genome instabilitynucleic acidscell biologygenome biologydna damage responsemolecular geneticsmolecular cell biologymolecular biologysystematic investigationdna repairmolecular researchgenetics

1
2
3
4
10 / page