Faculty

Institution

Unit

Venue

Li Shen

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

The University of Texas MD Anderson Cancer Center

Li Shen is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on cancer biology, tumor biology, and oncology, with particular emphasis on oncogenes, radiation oncology, and cell biology. His recent work has identified that KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS-mutant non-small cell lung cancer, and that human papillomavirus integration induces oncogenic host gene fusions in oropharyngeal cancers. He has also investigated Polo-like kinase 1 inactivation in NOTCH1-mutant head and neck squamous cell carcinoma, Aurora-A inhibition in HPV-driven cancers, and mutant p53 oncogenic gain-of-function via chromosomal instability-induced cytosolic DNA response. His research integrates pharmacology and medicinal research to advance cancer treatment strategies.

Honors

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Experiences

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Education

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Li Shen

The University of Texas MD Anderson Cancer Center

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cancer research tumor biology cancer biology oncology oncogenes medicinal research cell biology pharmacology cancer treatment molecular cancer molecular biology cancer cells lung cancer cancer genomics immunology therapeutic targets cancer genetics cancer care enzyme inhibition cell death cancer immunotherapy thoracic oncology cellular therapy anti-cancer agents cell signaling tumor targeting gene expression cancer management apoptosis tumor suppressors viral oncology cancer risk novel therapies cell regulation molecular diagnostics virus research receptor tyrosine kinases genome biology immune checkpoint inhibitors lung cancer models vascular biology stem cell research protein science pharmacotherapy prostatic disease cancer-associated virus oral cancer viral pathogenesis disease progression immunologic mechanisms tumor heterogeneity biomarker target phosphoprotein levels adenocarcinoma cell lines atr inhibition cancer genome atlas glioblastoma subtypes drug targets hematological malignancies therapy resistance brain-immune interaction neuroregeneration neuroinflammation mesenchymal stem cells brain function cellular immune responses egfr inhibitor resistance novel therapeutic targets proteomic profiling identifies immune heterogeneity increased expression cross-species identification preneoplastic intermediates genomic drivers blood-brain barrier integrity traumatic brain injury

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3094: Aurora-a Inhibition Sensitizes Hpv-Driven Cancers to Anti-Ctla-4 Immunotherapy by Modulating the Tumor Immune Microenvironment. Cancer Research (2025)

immunologyhpv-driven cancersmedical virologyabstract 3094immune checkpoint inhibitorscancer immunosurveillanceaurora-a inhibitioncancer immunotherapyimmune responsescancer cellstumor microenvironmentoncogenescellular therapyviral oncologyimmunotherapycell biology

Abstract 363: Exploiting Rb-Deficiency: Dual Inhibition of Trip13 and Aurora a as a Path to Mitotic Catastrophe. Cancer Research (2025)

cell cycleaurora adual inhibitionmolecular and cellular biologycell divisionmolecular cell biologymitotic catastrophemolecular biologybiological chemistrycell regulationcell biology

Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers. Cancer Discovery (2025)

carcinogenesispathogenesismedical virologyneck oncologymolecular canceroropharyngeal cancersoral pathologyvirologyoral cancercancer-associated virusoncogenespathologytumor biologycell biology

Keap1 and Stk11/Lkb1 Alterations Enhance Vulnerability to Atr Inhibition in Kras Mutant Non-Small Cell Lung Cancer. Cancer Cell (2025)

cancer geneticsstk11/lkb1 alterationscancer biologythoracic oncologycell signalingatr inhibitionmolecular cell biologymolecular biologyoncogenescancer cellslung cancertumor biologycell biology

Polo-Like Kinase 1 Inactivation Enhances Pi3K Inhibition-Mediated Apoptosis of Notch1-Mutant Head and Neck Squamous Cell Carcinoma. Cancer Letters (2025)

carcinogenesiscell deathcell regulationcancer researchcell signalingmolecular cancertherapeutic targetsmolecular cell biologynotch1-mutant headapoptosisoncogenescancer cellspolo-like kinase 1cancer biologypathologytumor biologycell biology

Supplementary Figures From Sustained Aurora Kinase B Expression Confers Resistance to Pi3K Inhibition in Head and Neck Squamous Cell Carcinoma. (2025)

cell deathcell regulationradiation oncologycell signalingcancer researchreceptor tyrosine kinasestherapeutic targetsoncogenescancer cellspi3k inhibitioncancer biologytumor biologysupplementary figurescell biology

Abstract 6392: Activity of Her2-and Trop2- Antibody Drug Conjugates (Adcs) in Small Cell Lung Cancer (Sclc) Models With Slfn11 as a Predictive Biomarker. Cancer Research (2024)

Bingnan ZhangAli IbrahimC.Allison StewartLixia DiaoQi WangLi ShenYuann xiAlejandra SerranoLuisa M. SolisWei-Lien WangKavya RamkumarRobert J. CardnellRunsheng WangAlberto DuarteJing WangLauren A. ByersCarl Gay

immunologytumor targetingbiomarker targetcancer biologycancer researchcancer discoverycancer immunotherapytherapeutic targetsmolecular biologyoncologycancer cellscancer treatmentpredictive biomarkerlung cancer

Abstract 6799: The Impact of Targeting Traf2 and Nck-Interacting Protein Kinase on Anti-Tumor Effect and Tumor Immune Environment in Cmyc-High Small Cell Lung Cancer. Cancer Research (2024)

Azusa TanimotoKavya RamkumarAllison StewartBingnan ZhangRobert CardnellShen LiQi WangJing WangCarl GayLauren Averett Byers

tumor immune environmentanti-cancer agentsanti-tumor effecttumor microenvironmentcancer biologycancer researchimmune checkpoint inhibitorstumor suppressorscancer immunotherapynck-interacting protein kinasecancer treatmentlung cancersystems biologycancer discoverybiomolecular engineeringmolecular biologyoncologyoncogenescancer cells

Mutant P53 Gains Oncogenic Functions Through a Chromosomal Instability-Induced Cytosolic Dna Response. Nature Communications (2024)

Mei ZhaoTianxiao WangFrederico O. Gleber-NettoZhen ChenDaniel J. McGrailJavier A. GomezWutong JuMayur A. GadhikarWencai MaLi ShenQi WangXiming TangSen PathakMaria Gabriela RasoJared K. BurksShiaw-Yih LinJing WangAsha S. MultaniCurtis R. PickeringJunjie ChenJeffrey N. MyersGe Zhou

immunologycarcinogenesisvirus researchcancer geneticscancer researchmolecular cancergeneticscancer genomicstumor suppressorsmutagenesis (molecular biology technique)molecular biologycytogeneticsoncogenesepigeneticscancer biologytumor biology

Yap1 Status Defines Two Intrinsic Subtypes of Lcnec With Distinct Molecular Features and Therapeutic Vulnerabilities. Clinical Cancer Research (2024)

C. Allison StewartLixia DiaoYuanxin XiRunsheng WangKavya RamkumarAlejandra G. SerranoAzusa TanimotoB. Leticia RodriguezBenjamin B. MorrisLi ShenBingnan ZhangYan YangSamera H. HamadRobert J. CardnellAlberto DuarteMoushumi SahuVeronica Y. NovegilBernard E. WeissmanMichael FrumovitzNeda KalhorLuisa Solis SotoPedro da RochaNatalie VokesDon L. GibbonsJing WangJohn V. HeymachBonnie GlissonLauren Averett ByersCarl M. Gay

pharmacologymorphological evidenceprotein sciencemolecular cancermammalian biologycancer immunotherapytherapeutic targetscancer genomicsmolecular biologyoncologybreast cancermedicinal researchoncogenespathologytumor biologyintrinsic subtypestherapeutic vulnerabilities

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Li Shen

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

The University of Texas MD Anderson Cancer Center

Honors

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Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Li Shen

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3094: Aurora-a Inhibition Sensitizes Hpv-Driven Cancers to Anti-Ctla-4 Immunotherapy by Modulating the Tumor Immune Microenvironment. Cancer Research (2025)

Abstract 363: Exploiting Rb-Deficiency: Dual Inhibition of Trip13 and Aurora a as a Path to Mitotic Catastrophe. Cancer Research (2025)

cell cycleaurora adual inhibitionmolecular and cellular biologycell divisionmolecular cell biologymitotic catastrophemolecular biologybiological chemistrycell regulationcell biology

Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers. Cancer Discovery (2025)

carcinogenesispathogenesismedical virologyneck oncologymolecular canceroropharyngeal cancersoral pathologyvirologyoral cancercancer-associated virusoncogenespathologytumor biologycell biology

Keap1 and Stk11/Lkb1 Alterations Enhance Vulnerability to Atr Inhibition in Kras Mutant Non-Small Cell Lung Cancer. Cancer Cell (2025)

cancer geneticsstk11/lkb1 alterationscancer biologythoracic oncologycell signalingatr inhibitionmolecular cell biologymolecular biologyoncogenescancer cellslung cancertumor biologycell biology

Polo-Like Kinase 1 Inactivation Enhances Pi3K Inhibition-Mediated Apoptosis of Notch1-Mutant Head and Neck Squamous Cell Carcinoma. Cancer Letters (2025)

Supplementary Figures From Sustained Aurora Kinase B Expression Confers Resistance to Pi3K Inhibition in Head and Neck Squamous Cell Carcinoma. (2025)

Abstract 6392: Activity of Her2-and Trop2- Antibody Drug Conjugates (Adcs) in Small Cell Lung Cancer (Sclc) Models With Slfn11 as a Predictive Biomarker. Cancer Research (2024)

Abstract 6799: The Impact of Targeting Traf2 and Nck-Interacting Protein Kinase on Anti-Tumor Effect and Tumor Immune Environment in Cmyc-High Small Cell Lung Cancer. Cancer Research (2024)

Azusa TanimotoKavya RamkumarAllison StewartBingnan ZhangRobert CardnellShen LiQi WangJing WangCarl GayLauren Averett Byers

Mutant P53 Gains Oncogenic Functions Through a Chromosomal Instability-Induced Cytosolic Dna Response. Nature Communications (2024)

Yap1 Status Defines Two Intrinsic Subtypes of Lcnec With Distinct Molecular Features and Therapeutic Vulnerabilities. Clinical Cancer Research (2024)

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