Faculty

Institution

Unit

Venue

Lin-Feng Chen

Professor of Biochemistry Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Lin-feng Chen is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry Professor at Uiuc.

Honors

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Experiences

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Education

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Lin-Feng Chen

UIUC

Professor of Biochemistry Professor

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cell biology molecular cell biology cell signaling immunology transcription factors immune responses gene expression inflammation signal transduction molecular biology cancer cells oncogenes cell death transcription regulation molecular and cellular biology biological chemistry molecular regulation transcription (biology) signaling pathways cell regulation molecular gastroenterology molecular physiology digestive diseases gene regulation pathology cancer biology molecular cancer chronic inflammation chromatin remodeling nucleic acids tumor suppressors innate immune system antiviral research general virology cytokines cellular biochemistry bone research inflammatory diseases h. pylori human retrovirus antiviral responses viral oncology cellular regulatory mechanism mucosal immunology gastrointestinal oncology cancer growth bone homeostasis gastric cancer protein science medical virology cellular immune responses apoptosis virulence factors protein function anti-inflammatory sclerostin bone metabolism lysine 310 rela subunit gene function protein expression bone morphogenic protein protein phosphorylation molecular pathways nf-κb activation inflammatory response lysine methylation paused pol ii nlrc4 inflammasome activation ubiquitin-proteasome system ikappabalpha gene expression nuclear nf-κb action nuclear action discrete sites distinct nuclear functions alzheimer disease metabolic regulation innate immune response systems biology metabolic remodeling chromatin

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brd4 Regulates Pai-1 Expression in Tumor-Associated Macrophages to Drive Chemoresistance in Colorectal Cancer. Oncogene (2025)

Dun PanJinfeng HuGuo LiXuming GaoJie WangLeisi JiangHong LinYulin ChenYanheng ChenYiran ZhengJunjin LinMin ZhengHui ChenLin-Feng ChenXiangming Hu

oncogenescolorectal cancerradiation oncologytumor biologyoncologycell biologycancer researchpai-1 expressioncancer cellscancer geneticstumor microenvironmentcancer biologytumor-associated macrophages

Brd4 Modulates Metabolic Endotoxemia-Induced Inflammation by Regulating Colonic Macrophage Infiltration in High-Fat Diet-Fed Mice. Communications Biology (2024)

Jinfeng HuGuo LiXiaoxin HeXuming GaoDun PanXingchen DongWentao HuangFunan QiuLin-Feng ChenXiangming Hu

metabolic syndromeinflammationchronic inflammationimmunologycell biologycolonic macrophage infiltrationdigestive diseasesgut barriermacrophage migrationgut microbesimmune responsesmucosal immunologymacrophage infiltrationmicrobiomeobesity medicine

The Histone Methyltransferase Ash1L Protects Against Bone Loss by Inhibiting Osteoclastogenesis. Cell Death and Differentiation (2024)

Xiaoli ZhaoShuai LinHangjiang RenShenghui SunLiyun ZhengLin-Feng ChenZhen Wang

bone repairosteoporosiscell biologyepigeneticsorthopaedic surgerycell metabolismbone metabolismhistone methyltransferase ash1lmolecular cell biologybone homeostasisbone losschromatinmusculoskeletal disordersbone researchregeneration (biology)

Wsb1/2 Target Chromatin-Bound Lysine-Methylated Rela for Proteasomal Degradation and Nf-κB Termination. Nucleic Acids Research (2024)

Jie ZhangYuanyuan YuXiuqun ZouYaning DuQiankun LiangMengyao GongYurong HeJunqi LuoDandan WuXiaoli JiangMatt SinclairEmad TajkhorshidHong-Zhuan ChenZhaoyuan HouYuejuan ZhengLin-Feng ChenXiao-Dong Yang

molecular and cellular biologychromatin remodelingmethylated relacell signalingepigeneticscell biologytranscription factorswdr domaingene regulationmolecular cell biologytranscription regulationmolecular biologychromatinbiological chemistrynf-κb terminationgene expressionproteome research

Brd4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H Pylori Infection. Cellular and Molecular Gastroenterology and Hepatology (2023)

Nikita ModiYanheng ChenXingchen DongXiangming HuGee W LauKeith T WilsonRichard M PeekLin-Feng Chen

glycolysis-dependent nos2 expressionpathogenesisimmunologyhost-microbe interactionscell metabolismmicrobiologymolecular cell biologyimmune responsesmolecular pathwaysphagocytesmacrophages upon hinnate immune systemmicrobial pathogenesis

Brd4 Regulates Metabolic Reprogramming of Macrophages Upon H. Pylori Infection.. The Journal of Immunology (2023)

Nikita ModiYanheng ChenLin-feng Chen

molecular metabolismmetabolic regulationimmunologycell biologymetabolic pathwaysm1 polarizationcell metabolismh. pyloriinfectionimmune responsesautophagyphagocytesbrd4-mediated glycolysisinnate immune system

Data From Myeloid Stat3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance Into Tumor-Promoting Inflammation. (2023)

Jingjiao ZhouZhaoxia QuFan SunLei HanLiwen LiShapei YanLaura P. StabileLin-Feng ChenJill M. SiegfriedGutian Xiao

oncogenesinflammationtumor biologytumor-promoting inflammationimmunologycell biologytranscription factor stat3lung cancermyeloid stat3immune responsescancer immunosurveillancecancer cellsimmunologic mechanismsimmunoeditingtumor microenvironment

Runx3 Meets the Ubiquitin-Proteasome System in Cancer. Cells (2023)

Albano ToskaNikita ModiLin-Feng Chen

oncogenesradiation oncologytumor biologycell deathcell signalingcell biologyubiquitin–proteasome systemcarcinogenesismolecular cell biologytumor suppressorscancer growthoncogenic agentcancer cellscell regulationubiquitin-proteasome systemcancer biology

Brd4 Modulates Diet-Induced Obesity via Pparγ-Dependent Gdf3 Expression in Adipose Tissue Macrophages. JCI Insight (2021)

Xiangming HuXingchen DongGuo LiYanheng ChenJinjing ChenXiaoxin HeHao SunDong-Hyun KimJongsook Kim KemperLin-Feng Chen

lipidsinflammationmetabolic syndromeassociated lipolysisadipose tissue macrophagescell signalingimmunologycell biologymetabolic regulationchronic inflammationcell metabolismmolecular physiologyimmune responsesadipose tissueinsulin signalingmetabolic healthobesityobesity medicine

Brd4 Regulates Nlrc4 Inflammasome Activation by Facilitating Irf8-Mediated Transcription of Naips. The Journal of Cell Biology (2021)

Xingchen DongXiangming HuYan BaoGuo LiXiao-dong YangJames M. SlauchLin-Feng Chen

inflammationil-1β maturationcell deathcell signalingpathogenesisimmunologycell biologysubsequent maturationmolecular cell biologyimmune responsescell researchinnate immune systemnlrc4 inflammasome activationcytokines

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Lin-Feng Chen

Professor of Biochemistry Professor

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Lin-feng Chen is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry Professor at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Lin-Feng Chen

UIUC

Professor of Biochemistry Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Brd4 Regulates Pai-1 Expression in Tumor-Associated Macrophages to Drive Chemoresistance in Colorectal Cancer. Oncogene (2025)

Dun PanJinfeng HuGuo LiXuming GaoJie WangLeisi JiangHong LinYulin ChenYanheng ChenYiran ZhengJunjin LinMin ZhengHui ChenLin-Feng ChenXiangming Hu

oncogenescolorectal cancerradiation oncologytumor biologyoncologycell biologycancer researchpai-1 expressioncancer cellscancer geneticstumor microenvironmentcancer biologytumor-associated macrophages

Brd4 Modulates Metabolic Endotoxemia-Induced Inflammation by Regulating Colonic Macrophage Infiltration in High-Fat Diet-Fed Mice. Communications Biology (2024)

Jinfeng HuGuo LiXiaoxin HeXuming GaoDun PanXingchen DongWentao HuangFunan QiuLin-Feng ChenXiangming Hu

The Histone Methyltransferase Ash1L Protects Against Bone Loss by Inhibiting Osteoclastogenesis. Cell Death and Differentiation (2024)

Xiaoli ZhaoShuai LinHangjiang RenShenghui SunLiyun ZhengLin-Feng ChenZhen Wang

Wsb1/2 Target Chromatin-Bound Lysine-Methylated Rela for Proteasomal Degradation and Nf-κB Termination. Nucleic Acids Research (2024)

Jie ZhangYuanyuan YuXiuqun ZouYaning DuQiankun LiangMengyao GongYurong HeJunqi LuoDandan WuXiaoli JiangMatt SinclairEmad TajkhorshidHong-Zhuan ChenZhaoyuan HouYuejuan ZhengLin-Feng ChenXiao-Dong Yang

Brd4 Regulates Glycolysis-Dependent Nos2 Expression in Macrophages Upon H Pylori Infection. Cellular and Molecular Gastroenterology and Hepatology (2023)

Nikita ModiYanheng ChenXingchen DongXiangming HuGee W LauKeith T WilsonRichard M PeekLin-Feng Chen

Brd4 Regulates Metabolic Reprogramming of Macrophages Upon H. Pylori Infection.. The Journal of Immunology (2023)

Nikita ModiYanheng ChenLin-feng Chen

Data From Myeloid Stat3 Promotes Lung Tumorigenesis by Transforming Tumor Immunosurveillance Into Tumor-Promoting Inflammation. (2023)

Jingjiao ZhouZhaoxia QuFan SunLei HanLiwen LiShapei YanLaura P. StabileLin-Feng ChenJill M. SiegfriedGutian Xiao

Runx3 Meets the Ubiquitin-Proteasome System in Cancer. Cells (2023)

Albano ToskaNikita ModiLin-Feng Chen

Brd4 Modulates Diet-Induced Obesity via Pparγ-Dependent Gdf3 Expression in Adipose Tissue Macrophages. JCI Insight (2021)

Xiangming HuXingchen DongGuo LiYanheng ChenJinjing ChenXiaoxin HeHao SunDong-Hyun KimJongsook Kim KemperLin-Feng Chen

Brd4 Regulates Nlrc4 Inflammasome Activation by Facilitating Irf8-Mediated Transcription of Naips. The Journal of Cell Biology (2021)

Xingchen DongXiangming HuYan BaoGuo LiXiao-dong YangJames M. SlauchLin-Feng Chen

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