Faculty

Institution

Unit

Venue

Leslie LaConte

Virginia Tech

Affiliations

Virginia Tech Carilion School of Medicine

Basic Science Education

NoneLeslie Laconte is currently serving as a Basic Science Education faculty at Virginia Tech.

Honors

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Experiences

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Education

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Leslie LaConte

Virginia Tech

You can click a keyword to filter the displayed items

genetics molecular biology genetic disorders medical genetics virology human genetics virus research genomics cell biology biochemistry molecular genetics neurodegenerative diseases molecular virology viral genetics medical education gene expression molecular neurodegeneration molecular cell biology cellular biology disease gene identification molecular and cellular biology higher education molecular science medicinal research free radical biology redox biology antioxidants biochemical sciences neurodevelopmental disorders intellectual disability visual science molecular cancer biological chemistry protein science neurochemistry neurological function neurotransmission brain function contrast agents anti-inflammatory reactive oxygen species magnetic resonance imaging redox signaling separation techniques phase separation protein misfolding viral evolution intellectual impairments molecular neurobiology gene function ocular pathology optic nerve genomic medicine developmental genetics adolescence virus-host interactions path dependence protein phosphorylation epigenetic changes oncogenic agent residency program directors medical school neuronal activity-dependent manner cask-neurexin interaction bilateral retinal dystrophy optic nerve atrophy liquid-liquid phase separation functional divergences cask evolution structural constraints glycerol-induced correction intergenotypic sequence variation post-transcriptional changes cellular metabolic pathways optic nerve hypoplasia male patient

Notable Scholarly Works

Notable Federal Grants

Collaborators

Genetic Evidence for Splicing-Dependent Structural and Functional Plasticity in Cask Protein. Journal of Medical Genetics (2024)

Paras A PatelLeslie E W LaConteChen LiangThomas CecereDeepa RajanSarika SrivastavaKonark Mukherjee

genomicsdermatologystructural plasticityprotein structuregeneticsprotein geneticsfunctional plasticitycask proteinmedical geneticsmolecular geneticsstructural molecular biologystructural biologyhuman geneticsneurosciencegenetic evidence

Flexibility of the Rotavirus Nsp2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation. Journal of Virology (2023)

Sarah L. NicholsEmil M. NilssonHeather Brown-HardingLeslie E. W. LaConteJulia AckerAlexander BorodavkaSarah McDonald Esstman

liquid-liquid phase separationvirologyphase separationmicrobiologyseparation techniques

Residency Program Directors’ Views on Research Conducted During Medical School: A National Survey. Academic Medicine (2023)

Rachel K. WolfsonPaige C. FairchildIngrid BahnerDwayne M. BaxaDeborah R. BirnbaumSarwat I. ChaudhryKatherine C. ChretienDonald B. DeFrancoAmber Z. DeptolaLeslie E.W. LaConteJenny J. LinLeslie Petch LeeMaureen A. PowersIra J. RopsonSaumya M. SankaranKara E. SawarynskiStephen M. Sozio

higher educationmedical educationresidency program directorsmedical school

Complete Loss of the X-Linked Gene Cask Causes Severe Cerebellar Degeneration. Journal of Medical Genetics (2022)

Paras A PatelJulia V HegertIngrid CristianAlicia KerrLeslie E W LaConteMichael A FoxSarika SrivastavaKonark Mukherjee

geneticsdisease gene identificationsevere cerebellar degenerationmedical geneticsgenetic disordersneurodegenerative diseases

Phosphorylation of Guanosine Monophosphate Reductase Triggers a Gtp-Dependent Switch From Pro- to Anti-Oncogenic Function of Epha4. Cell chemical biology (2022)

David W. WolffZhiyong DengAnna Bianchi-SmiragliaColleen E. FoleyZhannan HanXingyou WangShichen ShenMasha M. RosenbergSudha MoparthyDong Hyun YunJialin ChenBrian K. BakerMatthew V. RollAndrew J. MagieraJun LiEdward HurleyMaria Laura FeltriAnderson O. CoxJingyun LeeCristina M. FurduiLiang LiuWiam BsharaLeslie E.W. LaConteEugene S. KandelElena B. PasqualeJun QuLizbeth HedstromMikhail A. Nikiforov

cell signalingepigenetic changesbiological chemistryoncogenic agentenzyme catalysisanti-oncogenic functionbiochemistrycell biologymolecular cancermolecular cell biologyenzymesprotein sciencecellular biologyprotein phosphorylationtumor biologygene expressionenzyme inhibitionguanosine monophosphate reductasemolecular biologygtp-dependent switchepigenetics

The Non-Linear Path From Gene Dysfunction to Genetic Disease: Lessons From the Micpch Mouse Model. Cells (2022)

Konark MukherjeeLeslie E. W. LaConteSarika Srivastava

non-linear pathpathogenesissystems biologygene dysfunctiongeneticsbiologygenetic diseasepath dependencemicpch mouse modelgenetic disorders

Complete Loss of Cask Causes Severe Ataxia Through Cerebellar Degeneration. Research Square (Research Square) (2021)

Paras PatelJulia HegertIngrid CristianAlicia KerrLeslie LaConteMichael FoxSarika SrivastKonark Mukherjee

physiologyneurologybrain injuryneurodegenerative diseasesneurological disordersneurorehabilitationcomplete losscerebellar degenerationcask causesneuroscienceneuroanatomy

Complete Loss of Cask Causes Severe Ataxia Through Cerebellar Degeneration in Human and Mouse. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Paras A PatelJulia HegertIngrid CristianAlicia KerrLeslie EW LaConteMichael A FoxSarika SrivastavaKonark Mukherjee

neurologybrain injuryneurological disordersneuropathologyneurorehabilitationbiologycerebellar degenerationcask causesmolecular neurodegenerationdegenerative diseasecentral nervous systemneuroanatomyneuroscienceneurodegenerative diseases

Reverse Genetic Engineering of Simian Rotaviruses With Temperature-Sensitive Lesions in Vp1, Vp2, and Vp6. Virus Research (2021)

Emil M NilssonOwen M SullivanMackenzie L AndersonHannah M ArgobrightTaylor M ShueFrancis R FedowitzLeslie E W LaConteSarah McDonald Esstman

virus researchtemperature-sensitive lesionsgeneticsviral geneticsvirologysimian rotavirusesreverse genetic engineering

Haploinsufficiency of X-Linked Intellectual Disability Gene Cask Induces Post-Transcriptional Changes in Synaptic and Cellular Metabolic Pathways. Experimental Neurology (2020)

P.A. PatelC. LiangA. AroraS. VijayanS. AhujaP.K. WagleyR. SettlageL.E.W. LaConteH.P. GoodkinI. LazarS. SrivastavaK. Mukherjee

gene expressiongenetic disordersintellectual disabilityneurogeneticscellular metabolic pathwaysmolecular neurosciencegeneticstranscription factorsmolecular cell biologygene functionintellectual impairmentsdisease gene identificationmolecular neurodegenerationneurodevelopmental disorderspost-transcriptional changesmolecular neurobiologycell biology

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Leslie LaConte

Virginia Tech

Affiliations

Virginia Tech Carilion School of Medicine

Basic Science Education

NoneLeslie Laconte is currently serving as a Basic Science Education faculty at Virginia Tech.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Leslie LaConte

Virginia Tech

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Genetic Evidence for Splicing-Dependent Structural and Functional Plasticity in Cask Protein. Journal of Medical Genetics (2024)

Paras A PatelLeslie E W LaConteChen LiangThomas CecereDeepa RajanSarika SrivastavaKonark Mukherjee

Flexibility of the Rotavirus Nsp2 C-Terminal Region Supports Factory Formation via Liquid-Liquid Phase Separation. Journal of Virology (2023)

Sarah L. NicholsEmil M. NilssonHeather Brown-HardingLeslie E. W. LaConteJulia AckerAlexander BorodavkaSarah McDonald Esstman

liquid-liquid phase separationvirologyphase separationmicrobiologyseparation techniques

Residency Program Directors’ Views on Research Conducted During Medical School: A National Survey. Academic Medicine (2023)

higher educationmedical educationresidency program directorsmedical school

Complete Loss of the X-Linked Gene Cask Causes Severe Cerebellar Degeneration. Journal of Medical Genetics (2022)

Paras A PatelJulia V HegertIngrid CristianAlicia KerrLeslie E W LaConteMichael A FoxSarika SrivastavaKonark Mukherjee

geneticsdisease gene identificationsevere cerebellar degenerationmedical geneticsgenetic disordersneurodegenerative diseases

Phosphorylation of Guanosine Monophosphate Reductase Triggers a Gtp-Dependent Switch From Pro- to Anti-Oncogenic Function of Epha4. Cell chemical biology (2022)

The Non-Linear Path From Gene Dysfunction to Genetic Disease: Lessons From the Micpch Mouse Model. Cells (2022)

Konark MukherjeeLeslie E. W. LaConteSarika Srivastava

non-linear pathpathogenesissystems biologygene dysfunctiongeneticsbiologygenetic diseasepath dependencemicpch mouse modelgenetic disorders

Complete Loss of Cask Causes Severe Ataxia Through Cerebellar Degeneration. Research Square (Research Square) (2021)

Paras PatelJulia HegertIngrid CristianAlicia KerrLeslie LaConteMichael FoxSarika SrivastKonark Mukherjee

physiologyneurologybrain injuryneurodegenerative diseasesneurological disordersneurorehabilitationcomplete losscerebellar degenerationcask causesneuroscienceneuroanatomy

Complete Loss of Cask Causes Severe Ataxia Through Cerebellar Degeneration in Human and Mouse. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Paras A PatelJulia HegertIngrid CristianAlicia KerrLeslie EW LaConteMichael A FoxSarika SrivastavaKonark Mukherjee

Reverse Genetic Engineering of Simian Rotaviruses With Temperature-Sensitive Lesions in Vp1, Vp2, and Vp6. Virus Research (2021)

Emil M NilssonOwen M SullivanMackenzie L AndersonHannah M ArgobrightTaylor M ShueFrancis R FedowitzLeslie E W LaConteSarah McDonald Esstman

virus researchtemperature-sensitive lesionsgeneticsviral geneticsvirologysimian rotavirusesreverse genetic engineering

Haploinsufficiency of X-Linked Intellectual Disability Gene Cask Induces Post-Transcriptional Changes in Synaptic and Cellular Metabolic Pathways. Experimental Neurology (2020)

P.A. PatelC. LiangA. AroraS. VijayanS. AhujaP.K. WagleyR. SettlageL.E.W. LaConteH.P. GoodkinI. LazarS. SrivastavaK. Mukherjee

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