Faculty

Institution

Unit

Venue

John J. Lemasters MD, PhD

Professor

Medical University of South Carolina

Affiliations

College of Pharmacy

John J. Lemasters Md, Phd is currently serving as a College Of Pharmacy Professor at Medical University of South Carolina.

Honors

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Experiences

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Education

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John J. Lemasters MD, PhD

Medical University of South Carolina

Professor

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liver physiology cell biology biochemistry hepatology physiology oxidative stress mitochondrial function cell metabolism hepatotoxicity metabolism liver transplantation cell death free radical biology cellular physiology vascular biology inflammation redox biology drug-induced liver injury membrane biology molecular biology molecular metabolism clinical transplantation liver disease mitochondrial dynamics reperfusion injury toxicology molecular physiology apoptosis mitochondrial permeability transition reactive oxygen species organ preservation autophagy cell transplantation transplantation medicine alcohol-related liver disease antioxidants tumor biology graft survival mitophagy hematology medicinal research mitochondrial biogenesis redox signaling hypoxia (medicine) transplant surgery graft rejection endothelial dysfunction cell physiology cell autophagy kupffer cells cardiovascular physiology organelle dynamics cardiac muscle membrane transport rat hepatocytes toxicological mechanism mammalian biology lipid peroxidation perfused rat liver cancer biology solid organ transplantation renal function chemical hypoxia mitochondrial dysfunction mitochondrial depolarization fatty livers rat liver mitochondria secondary metabolism orthotopic liver transplantation rat livers hypoxic injury endothelial cells biochemical interaction carolina rinse solution acidotic ph lethal injury confocal microscopy

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. Cancer Research (2025)

tumor biologymetabolismmolecular metabolismcell autophagymediate tumor suppressioncell biologycell signalingmitophagyautophagymetabolic remodelingpharmacologymetabolic regulationcell metabolismdrives mitophagy

Lp340, a Novel Histone Deacetylase Inhibitor, Decreases Liver Injury and Fibrosis in Mice: Role of Oxidative Stress and Microrna-23a. Frontiers in Pharmacology (2024)

Devadoss J. SamuvelJohn J. LemastersC. James ChouZhi Zhong

fibrosisdrug-induced liver injuryoxidative stresspharmacologyliver injury

Mitotracker Red for Isolation of Zone-Specific Hepatocytes and Characterization of Hepatic Sublobular Metabolism. Biochemical and Biophysical Research Communications (2024)

Matthew SavocaKenji TakemotoJiangting HuLi LiB Jacob KendrickZhi ZhongJohn J Lemasters

biophysicshepatologybiochemical scienceszone-specific hepatocytesmetabolismliver physiologymolecular metabolismhepatic sublobular metabolismsystems biologybiochemistrymembrane biologyvascular biologylipidsliver diseasehepatotoxicitycell metabolismhost specificity

Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity. Livers (2024)

Jiangting HuAnna-Liisa NieminenZhi ZhongJohn J. Lemasters

mitochondrial functiondrug metabolismpharmacologylipid peroxidationsecondary metabolismmetabolismoxidative stresssystems biologyhepatologymitochondrial iron uptakeredox biologybiochemistryvascular biologyacetaminophen hepatotoxicityantioxidantsredox signalingmedicinal researchclinical lipidologyinflammationmitochondrial dynamics

Stellate Cell-Specific Adhesion Molecule Protocadherin 7 Regulates Sinusoidal Contraction. Hepatology (2024)

James K. CarterMing-Chao TsaiNicholas VenturiniJiangting HuJohn J. LemastersMiguel Torres MartinDaniela SiaShuang WangYoungmin A. LeeScott L. Friedman

hepatologycell adhesionadhesioncell biology

Lp342, a Novel Histone Deacetylase Inhibitor, Decreases Nitro-Oxidative Stress, Mitochondrial Dysfunction and Hepatic Ischaemia/Reperfusion Injury in Mice. RPS Pharmacy and Pharmacology Reports (2023)

Devadoss J SamuvelYasodha KrishnasamyLi LiJohn J LemastersC James ChouZhi Zhong

mitochondrial dysfunctionoxidative stresspharmacologynitro-oxidative stressreperfusion injury

The Mitochondrial Calcium Uniporter Mediates Mitochondrial Fe2+ Uptake and Hepatotoxicity After Acetaminophen. Toxicology and Applied Pharmacology (2023)

Jiangting HuAnna-Liisa NieminenJames L. WeemhoffHartmut JaeschkeLaura G. MurphyJudith A. DentJohn J. Lemasters

mitochondrial functionmitochondrial calcium uniporterapplied pharmacologypharmacologyhepatotoxicitytoxicology

A New Fluorescent Sensor Mitoferrofluor Indicates the Presence of Chelatable Iron in Polarized and Depolarized Mitochondria. Journal of Biological Chemistry (2022)

Andaleb KholmukhamedovLi LiChristopher C LindseyJiangting HuAnna-Liisa NieminenKenji TakemotoGyda C BeesonChad M BenekerCampbell McInnesCraig C BeesonJohn J Lemasters

biophysicsmitochondrial functioncell biologyfluorescenceredox biologybiological chemistrymembrane biologychelatable irondepolarized mitochondriamolecular biologybiosensors

Minocycline-Induced Disruption of the Intestinal Fxr/Fgf15 Axis Impairs Osteogenesis in Mice. JCI Insight (2022)

Matthew D. CarsonAmy J. WarnerJessica D. Hathaway-SchraderVincenza L. GeiserJoseph KimJoy E. GerascoWilliam D. HillJohn J. LemastersAlexander V. AlekseyenkoYongren WuHai YaoJ. Ignacio AguirreCaroline WestwaterChad M. Novince

hematologyminocycline-induced disruptionliver physiologyinflammationbone researchbone metabolismremedial actiondermatologynutrient physiologymechanobiologyregenerative medicineimmunologypharmacologyanimal physiologymammalian biologytissue (biology)bone diseasebone homeostasis

Mitochondrial Depolarization After Acute Ethanol Treatment Drives Mitophagy in Living Mice. Autophagy (2022)

Devadoss J. SamuvelLi LiYasodha KrishnasamyMonika GoozKenji TakemotoPatrick M. WosterJohn J. LemastersZhi Zhong

living micemitophagyautophagymitochondrial depolarizationphysiology

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John J. Lemasters MD, PhD

Professor

Medical University of South Carolina

Affiliations

College of Pharmacy

John J. Lemasters Md, Phd is currently serving as a College Of Pharmacy Professor at Medical University of South Carolina.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John J. Lemasters MD, PhD

Medical University of South Carolina

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Ceramide-Induced Metabolic Stress Depletes Fumarate and Drives Mitophagy to Mediate Tumor Suppression. Cancer Research (2025)

Lp340, a Novel Histone Deacetylase Inhibitor, Decreases Liver Injury and Fibrosis in Mice: Role of Oxidative Stress and Microrna-23a. Frontiers in Pharmacology (2024)

Devadoss J. SamuvelJohn J. LemastersC. James ChouZhi Zhong

fibrosisdrug-induced liver injuryoxidative stresspharmacologyliver injury

Mitotracker Red for Isolation of Zone-Specific Hepatocytes and Characterization of Hepatic Sublobular Metabolism. Biochemical and Biophysical Research Communications (2024)

Matthew SavocaKenji TakemotoJiangting HuLi LiB Jacob KendrickZhi ZhongJohn J Lemasters

Role of Mitochondrial Iron Uptake in Acetaminophen Hepatotoxicity. Livers (2024)

Jiangting HuAnna-Liisa NieminenZhi ZhongJohn J. Lemasters

Stellate Cell-Specific Adhesion Molecule Protocadherin 7 Regulates Sinusoidal Contraction. Hepatology (2024)

James K. CarterMing-Chao TsaiNicholas VenturiniJiangting HuJohn J. LemastersMiguel Torres MartinDaniela SiaShuang WangYoungmin A. LeeScott L. Friedman

hepatologycell adhesionadhesioncell biology

Devadoss J SamuvelYasodha KrishnasamyLi LiJohn J LemastersC James ChouZhi Zhong

mitochondrial dysfunctionoxidative stresspharmacologynitro-oxidative stressreperfusion injury

The Mitochondrial Calcium Uniporter Mediates Mitochondrial Fe2+ Uptake and Hepatotoxicity After Acetaminophen. Toxicology and Applied Pharmacology (2023)

Jiangting HuAnna-Liisa NieminenJames L. WeemhoffHartmut JaeschkeLaura G. MurphyJudith A. DentJohn J. Lemasters

mitochondrial functionmitochondrial calcium uniporterapplied pharmacologypharmacologyhepatotoxicitytoxicology

A New Fluorescent Sensor Mitoferrofluor Indicates the Presence of Chelatable Iron in Polarized and Depolarized Mitochondria. Journal of Biological Chemistry (2022)

Andaleb KholmukhamedovLi LiChristopher C LindseyJiangting HuAnna-Liisa NieminenKenji TakemotoGyda C BeesonChad M BenekerCampbell McInnesCraig C BeesonJohn J Lemasters

biophysicsmitochondrial functioncell biologyfluorescenceredox biologybiological chemistrymembrane biologychelatable irondepolarized mitochondriamolecular biologybiosensors

Minocycline-Induced Disruption of the Intestinal Fxr/Fgf15 Axis Impairs Osteogenesis in Mice. JCI Insight (2022)

Mitochondrial Depolarization After Acute Ethanol Treatment Drives Mitophagy in Living Mice. Autophagy (2022)

Devadoss J. SamuvelLi LiYasodha KrishnasamyMonika GoozKenji TakemotoPatrick M. WosterJohn J. LemastersZhi Zhong

living micemitophagyautophagymitochondrial depolarizationphysiology

1
2
3
4
5
86
10 / page

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Similar Faculty Members

Mark L Entman, M.D.

Institution

Baylor College of Medicine

disease pathophysiology

cardiac muscle

Donna Stolz

Institution

University of Pittsburgh

tissue (biology)

developmental biology

Hilda L. Chan

Institution

Baylor College of Medicine

breast cancer

mitochondrial function

Neil Kaplowitz, MD

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toxicological aspect

Clifford Steer

Institution

University of Minnesota

gene editing

stem cell

Yigang Wang

Institution

University of Cincinnati

stem cell research

medicine

Balaraman Kalyanaraman

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Medical College of Wisconsin

toxicology

cell death

Daria Mochly-Rosen

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Stanford University

pharmacology

cardiology

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University of California, San Diego

gastrointestinal peptide hormone

gpcr expression

Bruce J. Aronow

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cancer genetics

systems biology