Faculty

Institution

Unit

Venue

Larry David

Professor of Chemical Physiology and Biochemistry Director Proteomics Shared Resource OHSU Knight Cancer Institute School of Medicine Cancer Biology Graduate Program School of Medicine Graduate Program in Biomedical Sciences School of Medicine

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Bob And Charlee Moore Institute For Nutrition And Wellness

Center Of The Amyloidosis

Division Of Cardiology

Department Of Physiology And Pharmacology

Oregon Health & Science University

Bob And Charlee Moore Institute For Nutrition And Wellness

School Of Medicine

Division Of Cardiology

School Of Medicine

Larry David is a Professor of Chemical Physiology and Biochemistry and Director of the Proteomics Shared Resource at the Oregon Health & Science University Knight Cancer Institute. His research integrates proteomics, protein biochemistry, and cell biology to investigate protein structure, post-translational modifications, and disease mechanisms. Recent breakthroughs include a high-throughput protease-activated nanosensor assay for early pancreatic cancer detection (*Science Translational Medicine*, 2025) and the identification of glutathionylation-induced disulfide bonding in γS-crystallin. His work also spans lens proteomics, mitochondrial regulation by lamins, and tear proteomics for orbital inflammatory disorders.

Honors

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Experiences

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Education

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Larry David

Oregon Health & Science University

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molecular biology biochemistry ophthalmology proteomics protein science cell biology structural biology protein structure proteome research molecular and cellular biology molecular cell biology gene expression visual science mammalian biology biological chemistry experimental ophthalmology membrane biology clinical proteomics molecular physiology cellular physiology mass spectrometry ocular disease ophthalmology retina structural molecular biology biomolecular structure vascular biology protein mass spectrometry ocular tissues genomics ocular surface cellular biochemistry protein function vision research retina oral biology proteomic technologies molecular regulation hemostasis blood platelet proteomic analysis protein genetics cell physiology gene function rna biology cancer biology protein x-ray crystallography translational proteomics ocular pathology protein biosynthesis ocular surface physiology mitochondrial function protein transport proteomic profiling vestibular system cellular structure sequence analysis key site protein expression membrane transport gene regulation cataracts protein phosphorylation age-related changes human lens crystallins lens proteomics tandem mass spectrometry rat lens chemical genetics hemodynamic load quantitative mass spectrometry solvent accessibility guinea pig human lens extended multiplexing tandem mass tags two-dimensional electrophoresis drug metabolism medicine drug analysis experimental medicine pharmacology free radical biology analytical toxicology molecular pharmacology biomedical analysis nutritional biochemistry bioanalysis medical optical imaging biomarkers metabolic pathways confocal microscopy metabolism oxidative stress systems biology cell metabolism drug discovery clinical biochemistry biochemical sciences translational medicine optogenetics clinical chemistry in vitro toxicology neuro-ophthalmology glaucoma redox biology physiology vision rehabilitation molecular medicine molecular metabolism pharmacological research applied pharmacology translational research metabolomics enzyme inhibition clinical research health sciences pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analysis of Mouse Lens Morphological and Proteomic Abnormalities Following Deletion of the βB3-Crystallin Promoter. Experimental Eye Research (2025)

ocular diseasemolecular cell biologygene functiongene expressionβb3-crystallin promoterocular tissuesophthalmologytranscription factorsproteome researchdevelopmental biologydevelopmental cellproteomic abnormalitiescell biologymolecular and cellular biology

Bps2025 - Pursuit of the Elusive Disulfide Crosslink in Oxidized γS-Crystallin From the Eye Lens. Biophysical Journal (2025)

structural biologycrystal structuresstructural chemistryprotein structureelusive disulfide crosslinkbiochemistrybiological macromoleculeseye lensoxidized γs-crystallincrystal structure designchemistry

Early Detection of Pancreatic Cancer by a High-Throughput Protease-Activated Nanosensor Assay. Science Translational Medicine (2025)

Jose L. Montoya MiraArnaud QuentelRanish K. PatelDove KeithMegan SousaJessica MinnierBenjamin R. KingstonLarry DavidSadik C. EsenerRosalie C. SearsCharles D. LopezBrett C. SheppardUtkan DemirciMelissa H. WongJared M. Fischer

nanoparticle researchnanomedicinemedicinetranslational researchcancer researchhigh-throughput protease-activated nanosensorbiosensorscancer discoverybioassay-guided isolationtranslational medicinenanosensorsmolecular diagnosticspancreatic cancer

Isomerized and Racemized Aspartyl and Deamidated Asparagine Residues Identified in ɣS‐Crystallin. ChemBioChem (2025)

protein x-ray crystallographybiomolecular structureorganic chemistrystructural biologycrystal structuresstructural chemistryprotein structurebiochemistrymolecular biologystructural molecular biologybiological macromoleculescrystallographyprotein sciencechemical biologyorganic chemistry frontier

Proteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Post-Translational Modifications. Investigative Ophthalmology & Visual Science (2025)

ocular diseasemolecular cell biologyocular tissuesproteomicsophthalmologyproteome researchhuman lensprotein solubilitymolecular biologyproteomic characterizationneuro-ophthalmologyprotein science

Smap3-Id for Identification of Endogenous Protein–Protein Interactions Reveals Regulation of Mitochondrial Activity by Lamins. JACS Au (2025)

molecular cell biologymitochondrial functionautophagyproteomicsproteome researchcell metabolismmitochondrial activitybiochemistrymolecular biologycell signalingcytoskeletonmitophagycell biologymolecular and cellular biologyprotein sciencecellular biochemistry

The Eye Lens Protein, γS Crystallin, Undergoes Glutathionylation-Induced Disulfide Bonding Between Cysteines 22 and 26. Biomolecules (2025)

ocular surface physiologyocular tissuesexperimental ophthalmologyophthalmologyprotein foldingprotein structurebiochemistrymolecular biologyophthalmology retinaγs crystallineye lens proteinocular surfaceprotein sciencechemical biology

The Potential of Tear Proteomics for Diagnosis and Management of Orbital Inflammatory Disorders. (2025)

inflammationproteomicsophthalmologyclinical proteomicsorbital disorderinflammatory diseases

A High Throughput Blood-Based Assay for the Early Detection of Pancreatic Cancer. medRxiv (2024)

Jose L Montoya MiraArnaud QuentelRanish K PatelDove KeithJessica MinnierLarry DavidSadik C EsenerRosalie C SearsCharles D LopezBrett C SheppardUtkan DemirciMelissa H WongJared M Fischer

health sciencesmedicineoncologylaboratory medicinemolecular diagnosticspancreatic cancer

Characterization of Different-Sized Human αA-Crystallin Homomers and Implications to Asp151 Isomerization. PLoS ONE (2024)

biomolecular structurestructural biologybiological chemistryprotein foldingasp151 isomerizationprotein structureprotein assemblybiochemistrymolecular biologystructural molecular biologyprotein functionbiological macromoleculesprotein sciencemolecular basisprotein chemistry

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Larry David

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Bob And Charlee Moore Institute For Nutrition And Wellness

Center Of The Amyloidosis

Division Of Cardiology

Department Of Physiology And Pharmacology

Oregon Health & Science University

Bob And Charlee Moore Institute For Nutrition And Wellness

School Of Medicine

Division Of Cardiology

School Of Medicine

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Larry David

Oregon Health & Science University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Analysis of Mouse Lens Morphological and Proteomic Abnormalities Following Deletion of the βB3-Crystallin Promoter. Experimental Eye Research (2025)

Bps2025 - Pursuit of the Elusive Disulfide Crosslink in Oxidized γS-Crystallin From the Eye Lens. Biophysical Journal (2025)

Early Detection of Pancreatic Cancer by a High-Throughput Protease-Activated Nanosensor Assay. Science Translational Medicine (2025)

Isomerized and Racemized Aspartyl and Deamidated Asparagine Residues Identified in ɣS‐Crystallin. ChemBioChem (2025)

ocular diseasemolecular cell biologyocular tissuesproteomicsophthalmologyproteome researchhuman lensprotein solubilitymolecular biologyproteomic characterizationneuro-ophthalmologyprotein science

Smap3-Id for Identification of Endogenous Protein–Protein Interactions Reveals Regulation of Mitochondrial Activity by Lamins. JACS Au (2025)

The Eye Lens Protein, γS Crystallin, Undergoes Glutathionylation-Induced Disulfide Bonding Between Cysteines 22 and 26. Biomolecules (2025)

The Potential of Tear Proteomics for Diagnosis and Management of Orbital Inflammatory Disorders. (2025)

inflammationproteomicsophthalmologyclinical proteomicsorbital disorderinflammatory diseases

A High Throughput Blood-Based Assay for the Early Detection of Pancreatic Cancer. medRxiv (2024)

Jose L Montoya MiraArnaud QuentelRanish K PatelDove KeithJessica MinnierLarry DavidSadik C EsenerRosalie C SearsCharles D LopezBrett C SheppardUtkan DemirciMelissa H WongJared M Fischer

health sciencesmedicineoncologylaboratory medicinemolecular diagnosticspancreatic cancer

Characterization of Different-Sized Human αA-Crystallin Homomers and Implications to Asp151 Isomerization. PLoS ONE (2024)

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