Faculty

Institution

Unit

Venue

Kyle Emmitte

Chair and Professor Pharmaceutical Sciences

University of North Texas Health Science Center

Affiliations

College of Biomedical and Translational Sciences

Pharmaceutical Sciences

College of Pharmacy

Pharmaceutical Sciences

UNT System College of Pharmacy ; Pharmaceutical Sciences

Kyle Emmitte is currently serving as a College Of Biomedical And Translational Sciences Chair and Professor Pharmaceutical Sciences at University of North Texas Health Science Center.

Honors

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Experiences

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Education

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Kyle Emmitte

University of North Texas Health Science Center

Chair and Professor Pharmaceutical Sciences

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pharmacology drug discovery medicinal chemistry neuroscience neuropharmacology receptors medicine molecular biology enzyme inhibition pharmaceutical chemistry clinical chemistry molecular pharmacology bioorganic chemistry neuropsychopharmacology neurochemistry metabotropic glutamate receptor pharmacological research negative allosteric modulators therapeutic targets medicinal research protein science pharmaceutical sciences slack potassium channels receptor (biochemistry) bioactive compounds lead identification drug development pharmacokinetics mechanisms of action neurotransmission functional selectivity pharmacotherapy clinical neuroscience functional regulation functional modification g protein-coupled receptor molecular neurobiology therapeutic efficacy cns exposure structure-activity relationship studies drug analysis affective neuroscience drug targeting psychopharmacology cellular neurobiology synthetic chemistry experimental pharmacology patent review novel series chemical sciences biological psychiatry nucleic acids laboratory investigation peptides nanoparticle research peptide science pharmaceutical research brain function inhibitory activity molecular basis peptide engineering bioactive materials clinical pharmacology peptide therapeutics translational pharmacology molecular evidence host response allosteric modulation metabotropic glutamate receptors practical strategies small-molecule probes biological understanding therapeutics discovery fear extinction medial prefrontal cortex long-term depression protein binding central nervous system parkinson disease structure-activity relationship psychotropic drugs high-throughput screening assays neurology molecular probes metabolism toxicology allosteric site allosteric regulation g-protein-coupled receptors muscarinic receptors

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Review of Recent Efforts Directed Toward the Discovery of Small Molecule Modulators of Kcnt1 Channels. Future Medicinal Chemistry (2026)

future medicinal chemistrymedicinal chemistrysmall moleculesbiochemistrymolecular physiologysmall molecule librarypharmacologymolecular pharmacologydrug discoverypharmacological researchmolecular communicationmechanisms of action

An Updated Patent Review of Small Molecule Kcnt1 Inhibitors (2022–2024). Expert Opinion on Therapeutic Patents (2025)

drug developmentdrug targetsbiochemistrysmall moleculesrational drug designupdated patent reviewpharmacologytherapeutic targetsdrug discoverypharmacotherapypharmacological researchenzyme inhibition

Developing Inhibitors of the Guanosine Triphosphate Hydrolysis Accelerating Activity of Regulator of G Protein Signaling-14. Journal of Biological Chemistry (2025)

molecular and cellular biologyprotein sciencecell signalingprotein functionbiochemistryguanosine triphosphate hydrolysischemical biologymolecular pathwaysmolecular biologybiological chemistrybiochemical interactiong protein-coupled receptorsignal transductionenzyme inhibitioncellular biochemistry

Efficient Regioselective Synthesis of Benzimidazoles and Azabenzimidazoles to Enable the Rapid Development of Structure–Activity Relationships for Activation of Slack Potassium Channels. Synlett (2025)

organic chemistry frontiersynthetic chemistryslack potassium channelsstructure-activity relationshipsbiochemistrymedicinal chemistrychemical synthesisorganic process researchchemistryorganic chemistryefficient regioselective synthesisorganic synthesiscombinatorial chemistry

I-Gat: Interpretable Graph Attention Networks for Ligand Optimization. ACS Omega (2025)

neural computationgraph theorycomputational biologyligand optimizationneural network (machine learning)graph neural networkscomputational intelligencedata scienceknowledge graphs

PHENETHYLAMINYLATION: Preliminary in Vitro Evidence for the Covalent Transamidation of Psychedelic Phenethylamines to Glial Proteins Using 3,5-Dimethoxy-4-(2-Propynyloxy)-Phenethylamine as a Model Compound. bioRxiv (Cold Spring Harbor Laboratory) (2025)

neurochemistrypharmaceutical chemistryneuropharmacologycheminformaticscovalent transamidationneuropsychopharmacologybiochemistryexperimental pharmacologychemical biologyvitro evidencepsychedelic phenethylaminespharmacologymolecular pharmacologyneurotransmitterspharmacological researchmolecular psychiatry

Author Response: Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Sst- and Pv-Expressing Cortical Gabaergic Neurons. (2024)

neurogeneticsneural circuitsphysiologycellular neurobiologyneuronsneuropsychopharmacologyneurosciencemolecular neurobiologymolecular physiologyneurophysiologymolecular neuroscienceheterozygous expressionneurotransmissionkcnt1 gain-of-function variantmolecular psychiatryneuromodulation (medicine)author response

Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Somatostatin- and Parvalbumin-Expressing Cortical Gabaergic Neurons. eLife (2024)

neural circuitsphysiologydifferential effectsneuronsneuropsychopharmacologyneurosciencemolecular neurobiologyneurophysiologymolecular neuroscienceheterozygous expressionneurotransmissionkcnt1 gain-of-function variantneurotransmittersneuromodulation (medicine)

Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(Pyrimidin-5-Yl)Acetamide Inhibitors of Slack Potassium Channels. Molecules (2024)

Nigam M. MishraBrittany D. SpitznagelYu DuYasmeen K. MohamedYing QinC. David WeaverKyle A. Emmitte

biophysicsstructure-activity relationship studiesslack potassium channelsmolecular sciencemedicinal chemistrybiochemistrymolecular chemistrychemistrychemical structuremolecular structureenzyme inhibition

Structure–Activity Relationship Studies in a Series of Xanthine Inhibitors of Slack Potassium Channels. Molecules (2024)

Alshaima’a M. QuniesBrittany D. SpitznagelYu DuPaul K. PeprahYasmeen K. MohamedC. David WeaverKyle A. Emmitte

biophysicsstructure-activity relationship studiesneuropharmacologyslack potassium channelsxanthine inhibitorsmedicinal chemistrymolecular biologypharmacologymolecular pharmacologydrug discovery

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Kyle Emmitte

Chair and Professor Pharmaceutical Sciences

University of North Texas Health Science Center

Affiliations

College of Biomedical and Translational Sciences

Pharmaceutical Sciences

College of Pharmacy

Pharmaceutical Sciences

UNT System College of Pharmacy ; Pharmaceutical Sciences

Kyle Emmitte is currently serving as a College Of Biomedical And Translational Sciences Chair and Professor Pharmaceutical Sciences at University of North Texas Health Science Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kyle Emmitte

University of North Texas Health Science Center

Chair and Professor Pharmaceutical Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Review of Recent Efforts Directed Toward the Discovery of Small Molecule Modulators of Kcnt1 Channels. Future Medicinal Chemistry (2026)

An Updated Patent Review of Small Molecule Kcnt1 Inhibitors (2022–2024). Expert Opinion on Therapeutic Patents (2025)

drug developmentdrug targetsbiochemistrysmall moleculesrational drug designupdated patent reviewpharmacologytherapeutic targetsdrug discoverypharmacotherapypharmacological researchenzyme inhibition

Developing Inhibitors of the Guanosine Triphosphate Hydrolysis Accelerating Activity of Regulator of G Protein Signaling-14. Journal of Biological Chemistry (2025)

I-Gat: Interpretable Graph Attention Networks for Ligand Optimization. ACS Omega (2025)

neural computationgraph theorycomputational biologyligand optimizationneural network (machine learning)graph neural networkscomputational intelligencedata scienceknowledge graphs

Author Response: Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Sst- and Pv-Expressing Cortical Gabaergic Neurons. (2024)

Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Somatostatin- and Parvalbumin-Expressing Cortical Gabaergic Neurons. eLife (2024)

Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(Pyrimidin-5-Yl)Acetamide Inhibitors of Slack Potassium Channels. Molecules (2024)

Nigam M. MishraBrittany D. SpitznagelYu DuYasmeen K. MohamedYing QinC. David WeaverKyle A. Emmitte

Structure–Activity Relationship Studies in a Series of Xanthine Inhibitors of Slack Potassium Channels. Molecules (2024)

Alshaima’a M. QuniesBrittany D. SpitznagelYu DuPaul K. PeprahYasmeen K. MohamedC. David WeaverKyle A. Emmitte

biophysicsstructure-activity relationship studiesneuropharmacologyslack potassium channelsxanthine inhibitorsmedicinal chemistrymolecular biologypharmacologymolecular pharmacologydrug discovery

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5
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10 / page