Faculty

Institution

Unit

Venue

Kyle Emmitte

University of North Texas Health Science Center

Affiliations

College of Nursing

Undergraduate Studies

University of North Texas Health Science Center

Texas Center for Health Disparities

Texas College of Osteopathic Medicine

UNT System College of Pharmacy

NoneKyle Emmitte is currently serving as a College Of Nursing faculty at University of North Texas Health Science Center.

Honors

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Experiences

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Education

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Kyle Emmitte

University of North Texas Health Science Center

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pharmacology drug discovery medicinal chemistry neuroscience neuropharmacology receptors medicine molecular biology enzyme inhibition pharmaceutical chemistry clinical chemistry molecular pharmacology bioorganic chemistry neuropsychopharmacology neurochemistry metabotropic glutamate receptor pharmacological research negative allosteric modulators therapeutic targets medicinal research protein science pharmaceutical sciences slack potassium channels receptor (biochemistry) bioactive compounds lead identification pharmacokinetics drug development mechanisms of action neurotransmission functional selectivity pharmacotherapy clinical neuroscience functional regulation functional modification g protein-coupled receptor molecular neurobiology therapeutic efficacy cns exposure structure-activity relationship studies drug analysis affective neuroscience drug targeting psychopharmacology cellular neurobiology synthetic chemistry experimental pharmacology patent review novel series chemical sciences biological psychiatry nucleic acids laboratory investigation peptide science peptides nanoparticle research pharmaceutical research brain function inhibitory activity molecular basis bioactive materials peptide engineering clinical pharmacology translational pharmacology peptide therapeutics molecular evidence host response allosteric modulation metabotropic glutamate receptors practical strategies therapeutics discovery biological understanding small-molecule probes medial prefrontal cortex fear extinction long-term depression

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Review of Recent Efforts Directed Toward the Discovery of Small Molecule Modulators of Kcnt1 Channels. Future Medicinal Chemistry (2026)

medicinal chemistrypharmacologysmall moleculesmechanisms of actionfuture medicinal chemistrymolecular pharmacologydrug discoverysmall molecule librarymolecular communicationmolecular physiologypharmacological researchbiochemistry

An Updated Patent Review of Small Molecule Kcnt1 Inhibitors (2022–2024). Expert Opinion on Therapeutic Patents (2025)

drug targetsenzyme inhibitionpharmacologysmall moleculesrational drug designupdated patent reviewpharmacotherapytherapeutic targetsdrug discoverydrug developmentpharmacological researchbiochemistry

Developing Inhibitors of the Guanosine Triphosphate Hydrolysis Accelerating Activity of Regulator of G Protein Signaling-14. Journal of Biological Chemistry (2025)

g protein-coupled receptorbiochemical interactionenzyme inhibitionprotein functioncell signalingmolecular and cellular biologychemical biologyguanosine triphosphate hydrolysismolecular biologybiological chemistrymolecular pathwayssignal transductionprotein sciencecellular biochemistrybiochemistry

Efficient Regioselective Synthesis of Benzimidazoles and Azabenzimidazoles to Enable the Rapid Development of Structure–Activity Relationships for Activation of Slack Potassium Channels. Synlett (2025)

medicinal chemistryorganic chemistryslack potassium channelscombinatorial chemistryorganic synthesissynthetic chemistryefficient regioselective synthesischemistrystructure-activity relationshipsorganic process researchorganic chemistry frontierchemical synthesisbiochemistry

I-Gat: Interpretable Graph Attention Networks for Ligand Optimization. ACS Omega (2025)

knowledge graphsligand optimizationgraph theorygraph neural networksneural computationdata sciencecomputational intelligencecomputational biologyneural network (machine learning)

PHENETHYLAMINYLATION: Preliminary in Vitro Evidence for the Covalent Transamidation of Psychedelic Phenethylamines to Glial Proteins Using 3,5-Dimethoxy-4-(2-Propynyloxy)-Phenethylamine as a Model Compound. bioRxiv (Cold Spring Harbor Laboratory) (2025)

vitro evidenceneuropsychopharmacologypharmaceutical chemistrypharmacologypsychedelic phenethylaminescovalent transamidationneurochemistrymolecular pharmacologyneuropharmacologychemical biologyexperimental pharmacologyneurotransmittersmolecular psychiatrycheminformaticspharmacological researchbiochemistry

Author Response: Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Sst- and Pv-Expressing Cortical Gabaergic Neurons. (2024)

physiologyauthor responseneuropsychopharmacologyheterozygous expressionneural circuitsneurogeneticsmolecular neuroscienceneurotransmissionmolecular neurobiologyneuromodulation (medicine)molecular psychiatrymolecular physiologycellular neurobiologyneuroscienceneurophysiologyneuronskcnt1 gain-of-function variant

Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Somatostatin- and Parvalbumin-Expressing Cortical Gabaergic Neurons. eLife (2024)

physiologyneuropsychopharmacologyneural circuitsdifferential effectsmolecular neuroscienceneurotransmissionmolecular neurobiologyneuromodulation (medicine)neurotransmittersheterozygous expressionneuroscienceneurophysiologyneuronskcnt1 gain-of-function variant

Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(Pyrimidin-5-Yl)Acetamide Inhibitors of Slack Potassium Channels. Molecules (2024)

Nigam M. MishraBrittany D. SpitznagelYu DuYasmeen K. MohamedYing QinC. David WeaverKyle A. Emmitte

medicinal chemistrybiophysicsenzyme inhibitionstructure-activity relationship studiesslack potassium channelsmolecular sciencemolecular structurechemistrymolecular chemistrychemical structurebiochemistry

Structure–Activity Relationship Studies in a Series of Xanthine Inhibitors of Slack Potassium Channels. Molecules (2024)

Alshaima’a M. QuniesBrittany D. SpitznagelYu DuPaul K. PeprahYasmeen K. MohamedC. David WeaverKyle A. Emmitte

medicinal chemistrybiophysicspharmacologyslack potassium channelsneuropharmacologymolecular pharmacologyxanthine inhibitorsdrug discoverymolecular biologystructure-activity relationship studies

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Kyle Emmitte

University of North Texas Health Science Center

Affiliations

College of Nursing

Undergraduate Studies

University of North Texas Health Science Center

Texas Center for Health Disparities

Texas College of Osteopathic Medicine

UNT System College of Pharmacy

NoneKyle Emmitte is currently serving as a College Of Nursing faculty at University of North Texas Health Science Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Kyle Emmitte

University of North Texas Health Science Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Review of Recent Efforts Directed Toward the Discovery of Small Molecule Modulators of Kcnt1 Channels. Future Medicinal Chemistry (2026)

An Updated Patent Review of Small Molecule Kcnt1 Inhibitors (2022–2024). Expert Opinion on Therapeutic Patents (2025)

drug targetsenzyme inhibitionpharmacologysmall moleculesrational drug designupdated patent reviewpharmacotherapytherapeutic targetsdrug discoverydrug developmentpharmacological researchbiochemistry

Developing Inhibitors of the Guanosine Triphosphate Hydrolysis Accelerating Activity of Regulator of G Protein Signaling-14. Journal of Biological Chemistry (2025)

I-Gat: Interpretable Graph Attention Networks for Ligand Optimization. ACS Omega (2025)

knowledge graphsligand optimizationgraph theorygraph neural networksneural computationdata sciencecomputational intelligencecomputational biologyneural network (machine learning)

Author Response: Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Sst- and Pv-Expressing Cortical Gabaergic Neurons. (2024)

Heterozygous Expression of a Kcnt1 Gain-Of-Function Variant Has Differential Effects on Somatostatin- and Parvalbumin-Expressing Cortical Gabaergic Neurons. eLife (2024)

Structure–Activity Relationship Studies in a Series of 2-Aryloxy-N-(Pyrimidin-5-Yl)Acetamide Inhibitors of Slack Potassium Channels. Molecules (2024)

Nigam M. MishraBrittany D. SpitznagelYu DuYasmeen K. MohamedYing QinC. David WeaverKyle A. Emmitte

Structure–Activity Relationship Studies in a Series of Xanthine Inhibitors of Slack Potassium Channels. Molecules (2024)

Alshaima’a M. QuniesBrittany D. SpitznagelYu DuPaul K. PeprahYasmeen K. MohamedC. David WeaverKyle A. Emmitte

medicinal chemistrybiophysicspharmacologyslack potassium channelsneuropharmacologymolecular pharmacologyxanthine inhibitorsdrug discoverymolecular biologystructure-activity relationship studies

1
2
3
4
5
10
10 / page