Faculty

Institution

Unit

Venue

Kevin Thomas VanBortle

assistant professor Assistant Professor of Cell & Developmental Biology

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Cell and Developmental Biology

School of Molecular & Cellular Biology

Department of Cell & Developmental Biology

Kevin Thomas Vanbortle is currently serving as a College Of Liberal Arts & Sciences assistant professor Assistant Professor of Cell & Developmental Biology at Uiuc.

Honors

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Education

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Kevin Thomas VanBortle

UIUC

assistant professor Assistant Professor of Cell & Developmental Biology

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molecular cell biology cell biology gene expression transcription (biology) genetics chromatin molecular biology transcription factors cancer cells transcription regulation nucleic acids molecular cancer developmental biology genome biology gene regulation oncogenes epigenetics insect molecular biology chromatin remodeling cancer biology molecular and cellular biology nuclear organization developmental cell stem cells transcriptome stem cell research genomic mechanisms cancer genomics non-coding rna pol iii molecular regulation cancer genetics rna processing embryonic stem cells gene function rna biology cancer growth cancer immunosurveillance insulator function protein science biomolecular structure structural molecular biology cellular biochemistry cardiovascular research cellular structure tissue development induced pluripotent stem cells cell specialization transcriptomics technology gene structure stem cell toxicology breast oncology cell lines other insulator proteins chromatin organization chromatin insulators developmental system cellular physiology protein function protein assembly cell regulation bone morphogenic protein signaling pathways cell fate determination stem-cell therapy lineage plasticity architectural protein robust insulator function ap-1-bound activation hubs dynamic dna loops macrophage development open chromatin genome-wide temporal profiling other drosophila insulator insulator activity gene activation translational bioinformatics computational biology bioinformatics database biomedical informatics genome organization molecular informatics systems biology drug discovery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract B063: The Cholesterol Efflux Protein, Abca1, Plays a Critical Role in Modulating Anti-Tumor Myeloid Immune Cell Functions. Cancer Immunology Research (2025)

Shruti V BendreNatalia KrawczynskaRajendra K CYu WangShaunak BhogaleErin WeisserBasel HajyousifSimon HanAvni SinghClaire P. SchaneAdam T. NelczykDhanya PradeepAnasuya Das GuptaLara KockayaHashni Epa Vidana GamageKevin Van BortleEmad TajkorshidSaurabh SinhaWendy A. WoodwardWonhwa ChoErik R Nelson

tumor biologycancer immunotherapyimmunologycell biologycholesterol effluximmunotherapymolecular cancercholesterol efflux proteincancer immunosurveillancetumor microenvironmentcancer cellscholesterol homeostasisimmune checkpoint inhibitorsoncologycancer biology

An Rna Polymerase III Tissue and Tumor Atlas Uncovers Context-Specific Activities Linked to 3D Epigenome Regulatory Mechanisms. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Simon LizarazoSihang ZhouRuiying ChengRajendra K CYawei ShenQing LiuKevin Van Bortle

oncogenesgene expression profilingnon-coding rnarna polymerase iiipol iiiepigeneticscell biologyfunctional genomicsmolecular cancermolecular cell biologytranscription (biology)cancer genomicsgene accessibilitycancer cellsgene expressiontranscriptomics technologytranscriptomegenetics

Cholesterol Efflux Protein, Abca1, Supports Anti-Cancer Functions of Myeloid Immune Cells. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Shruti V. BendreYu WangBasel HajyousifK C RajendraShounak G. BhogaleDhanya PradeepNatalia KrawczynskaClaire P. SchaneErin WeisserAvni SinghSimon HanHannah KimLara KockayaAnasuya Das GuptaAdam T. NelczykHashni Epa Vidana GamageYifan FeiXingyu GuoRyan J. DeatonMaria SverdlovPeter H. GannSaurabh SinhaKun WangKevin Van BortleEmad TajkorshidWendy A. WoodwardWonhwa ChoErik R. Nelson

metastasisradiation oncologytumor biologyimmunologycholesterol homeostasismolecular cancercholesterol efflux proteincancer growthcancer immunosurveillancecancer cellsabca1 activitytumor microenvironmentcancer biology

Abstract 174: Cholesterol Efflux Protein Abca1 Skews Macrophages Towards an Anti-Tumor Phenotype and Consequently Impacts Breast Cancer Progression. Cancer Research (2024)

Shruti V. BendreNatalia KrawczynskaShaunak BhogaleErin WeisserSimon HanBasel HajyousifAvni SinghRajendra K CYu WangClaire P. SchaneAdam T. NelczykAnasuya DasGuptaHashni E. GamageKevin T. VanBortleEmad TajkhorshidSaurabh SinhaWohnwa ChoErik R. Nelson

breast oncologyradiation oncologytumor biologyoncologycancer biologyimmunologyplasma cholesterolmolecular cancercancer immunosurveillancecancer cellscholesterol homeostasistumor microenvironmentbreast cancer

Abstract A048: The Loss of Cholesterol Efflux Pump Abca1 Skews Macrophages Towards a Pro-Tumor Phenotype and Facilitates Breast Cancer Progression. Cancer Immunology Research (2024)

Shruti BendreNatalia KrawczynskaShaunak BhogaleErin WeisserSimon HanBasel HajyousifAvni SinghRajendra KCYu WangClaire P SchaneAdam T NelczykDhanya PradeepLara KockayaHashni Epa Vidana GamageKevin VanBortleEmad TajkorshidSaurabh SinhaWendy A WoodwardWonhwa ChoErik R Nelson

breast oncologypathologyradiation oncologytumor biologycancer biologycancer immunotherapycell biologybreast cancer progressionmolecular cancercancer growthbreast cancer recurrencetumor microenvironmentcancer cellsoncologybreast cancer

Cancer-Associated Snar-a Noncoding Rna Interacts With Core Splicing Machinery and Disrupts Processing of Mrna Subpopulations. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Sihang ZhouSimon LizarazoLeela MouliSandip ChorghadeRuiying ChengK C RajendraAuinash KalsotraKevin Van Bortle

oncogenespathologynon-coding rnatumor biologyrna processingpol iiicell biologysplicing variantmolecular cancermrna splicing factorscarcinogenesiscancer researchmolecular cell biologytranscription (biology)mrna subpopulationscancer cellsgene expressioncancer genomics

Evidence of Rna Polymerase III Recruitment and Transcription at Protein-Coding Gene Promoters. Molecular Cell (2024)

Rajendra K CRuiying ChengSihang ZhouSimon LizarazoDuncan J SmithKevin Van Bortle

protein-coding gene promotersrna processingnucleic acidstranscription factorsgene regulationmolecular cell biologytranscription (biology)molecular biologytranscription regulationsystems biologygene expressiongenetics

Mancr Lncrna Modulates Cell-Cycle Progression and Metastasis by Cis-Regulation of Nuclear Rho-Gef. Molecular and Cellular Biology (2024)

Deepak K. SinghZhengmin CongYou Jin SongMinxue LiuRitu ChaudharyDazhen LiuYu WangRishabh PrasanthRajendra K CSimon LizarazoMiriam AkhnoukhOmid GholamalamdariAnurupa MoitraLisa M. JenkinsRohit BhargavaErik R. NelsonKevin Van BortleSupriya G. PrasanthKannanganattu V. Prasanth

oncogenesmetastasisradiation oncologynon-coding rnatumor biologylong non-coding rnacancer biologycell migrationdna repaircell biologymolecular cell biologycancer cellscancer geneticscancer genomicsbreast cancer

A Combinatorial Regulatory Platform Determines Expression of Rna Polymerase III Subunit Rpc7α (Polr3G) in Cancer. Cancers (2023)

Ruiying ChengSihang ZhouRajendra K CSimon LizarazoLeela MouliAnshita JayanthQing LiuKevin Van Bortle

oncogenestumor biologytranscription factorscell biologymolecular cancercancer researchmolecular cell biologytranscription (biology)transcription regulationtumor growthsubunit rpc7αsystems biologycancer cellsgene expressioncancer geneticscancer genomicscancer biologychromatin architecture

Rna Polymerase III Transcription and Cancer: A Tale of Two Rpc7 Subunits. Frontiers in Molecular Biosciences (2023)

Ruiying ChengKevin Van Bortle

oncogenestumor biologypol iiicell biologymolecular cancercarcinogenesismolecular cell biologytranscription (biology)molecular biologyrpc7 subunitscancer cellsgene expressioncancer geneticscancer genomicscancer biologypol iii identity

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Kevin Thomas VanBortle

assistant professor Assistant Professor of Cell & Developmental Biology

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Cell and Developmental Biology

School of Molecular & Cellular Biology

Department of Cell & Developmental Biology

Kevin Thomas Vanbortle is currently serving as a College Of Liberal Arts & Sciences assistant professor Assistant Professor of Cell & Developmental Biology at Uiuc.

Honors