Faculty

Institution

Unit

Venue

Konstantin Khrapko

Professor

Northeastern University

Affiliations

College of Science

Biology

Bouve College of Health Sciences

School of Pharmacy and Pharmaceutical Sciences

Konstantin Khrapko is currently serving as a Biology Professor at Northeastern University.

Honors

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Experiences

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Education

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Konstantin Khrapko

Northeastern University

Professor

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genetics molecular biology genomics human genetics genome biology molecular genetics population genetics evolutionary biology biology ageing biogerontology mitochondrial function mammalian biology bioinformatics cancer genetics membrane biology epigenetics redox biology capillary electrophoresis mutagenesis cytogenetics mitochondrial dna deletions mitochondrial dna mutations mitochondrial dna animal physiology evolutionary genetics mtdna mutations aging cell aging process molecular diagnostics avian biology respiratory medicine rna biology mammalian physiology medical genetics genetic analysis gene evolution skeletal muscle mtdna deletions somatic mtdna mutations mitochondrial genomes heredity reproductive biology nucleic acids cancer biology human tissues epigenomics mitochondrial dynamics dna sequencing genome analysis human mitochondrial dna individual cells clonal expansion transgenic mice serum response factor mutational spectrum mtdna mutator mouse single-molecule pcr mutational spectrometry neuroscience of aging experimental gerontology stem cell research cell transplantation clinical transplantation geriatric neurology plant genetics molecular neurobiology genome studies animal genetics cancer genomics stem cell transplantation in vivo systems human sciences cardiomyopathy biomolecular analysis choroid plexus

Notable Scholarly Works

Notable Federal Grants

Collaborators

Evolutionary Mismatch Between Nuclear and Mitochondrial Genomes Does Not Promote Reversion Mutations in Mtdna.. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Melissa FrancoKonstantin PopadinDori WoodsKonstantin Khrapko

evolutionary geneticsevolutionary mismatchreversion mutationsevolutionary biologymitochondrial genomes

Mitochondrial Direct Repeat Reduction as a Strategy for Enhancing Human Longevity: The Case of the Common Repeat. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Victor ShamanskiyKonstantin GunbinEvgenii O. TretiakovIlya MazuninViktoria SkripskayaAlina A. MikhailovaAlina G. MikhailovaNatalia ReeValeriia TimoninaDmitry KnorreWolfram S. KunzYukinori OkadaNathan FiorellAlexandre ReymondGeorgii A. BazykinJacques FellayMasashi TanakaKonstantin KhrapkoKonstantin Popadin

mitochondrial functiongeneticslongevityhuman longevitycommon repeat

Somatic Mitochondrial Dna Mutations Are a Source of Heterogeneity Among Primary Leukemic Cells. medRxiv (2024)

Kelly McCastlainCatherine WelshYonghui NiLiang DingMelissa FrancoRobert AutryBesian SejdiuTi-Cheng ChangWenan ChenHuiyun WuQingfei PanVeronica Gonzalez-PenaPatrick SchreinerSasi ArunachalamJoung JooBenshang LiShuhong ShenSamuel BradyJinghui ZhangCharles GawadWilliam EvansM. Madan BabuKonstantin KhrapkoGang WuJiyang YuStanley PoundsMondira Kundu

microbiologyepigeneticsgeneticsmitochondrial functiongene expressionleukemiaprimary leukemic cellsmitochondrial biogenesissomatic variantgenetic variationmolecular biologysomatic cell geneticstumor heterogeneity

A Novel, Wave-Shaped Profile of Germline Selection of Pathogenic Mtdna Mutations is Discovered by Bypassing a Classical Statistical Bias. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Auden Cote-LHeureuxZoe FleischmannMelissa FrancoZhibin ChenMark KhrapkoBenjamin VyshedskiyMaxim BravermanKonstantin PopadinSarah PickettDori C. WoodsJon TillyDoug TurnbullKonstantin Khrapko

geneticsclassical statistical biaspopulation geneticsgermline selectionbiostatisticsgenomicspathogenic mtdna mutationsmolecular biology

Are Some Mutations More Equal Than Others?. eLife (2023)

Auden Cote-L’HeureuxYogesh NK MaithaniaMelissa FrancoKonstantin Khrapko

geneticshuman variationhuman geneticspopulation geneticsmutagenesisgenetic variationmolecular biology

Interpreting Sequence-Levenshtein Distance for Determining Error Type and Frequency Between Two Embedded Sequences of Equal Length.. PubMed (2023)

Robert LoganAmy Wangsness WeheDori C WoodsJon TillyKonstantin Khrapko

sequence-levenshtein distancegeneticserror typeequal lengthbioinformatics

Mitochondrial Mutation Spectrum in Chordates: Damage Versus Replication Signatures, Causes, and Dynamics. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Dmitrii IliushchenkoBogdan EfimenkoAlina G. MikhailovaVictor ShamanskiyMurat K. SaparbaevIlya MazuninDmitrii KnorreWolfram S. KunzPhilipp KapranovStepan DenisovJacques FellayKonstantin KhrapkoKonstantin GunbinKonstantin Popadin

geneticspopulation geneticsevolutionary biologymolecular biologymitochondrial mutation spectrum

Reanalysis of Mtdna Mutations of Human Primordial Germ Cells (Pgcs) Reveals Numt Contamination and Suggests That Selection in Pgcs May Be Positive. Mitochondrion (2023)

Zoë FleischmannAuden Cote-L'HeureuxMelissa FrancoSergey OreshkovSofia AnnisMark KhrapkoDylan AidlenKonstantin PopadinDori C. WoodsJonathan L. TillyKonstantin Khrapko

epigeneticsgeneticshuman geneticspopulation geneticscell biologycytogeneticsmtdna mutationsgenomicspopulation genomicsnumt contaminationgerm cell fategenome biologymolecular biologygerm cells

Secondary Structure of the Human Mitochondrial Genome Affects Formation of Deletions. BMC Biology (2023)

Victor ShamanskiyAlina A MikhailovaEvgenii O TretiakovKristina UshakovaAlina G MikhailovaSergei OreshkovDmitry A KnorreNatalia ReeJonathan B OverdevestSamuel W LukowskiIrina GostimskayaValerian YurovChia-Wei LiouTsu-Kung LinWolfram S KunzAlexandre ReymondIlya MazuninGeorgii A BazykinJacques FellayMasashi TanakaKonstantin KhrapkoKonstantin GunbinKonstantin Popadin

secondary structuregeneticshuman geneticsgenome biologymolecular biology

The ‘Stem’ and the ‘Workers’ of the Mtdna Population of the Cell. Evidence From Mutational Analysis. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Auden Cote-L’HeureuMelissa FrancoYogesh N. K. MaithaniaKonstantin PopadinDori WoodsJonathan TillyKonstantin Khrapko

geneticsstem cellscell biologymtdna populationgenomicsmutational analysisgenome biologymolecular biology

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Konstantin Khrapko

Professor

Northeastern University

Affiliations

College of Science

Biology

Bouve College of Health Sciences

School of Pharmacy and Pharmaceutical Sciences

Konstantin Khrapko is currently serving as a Biology Professor at Northeastern University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Konstantin Khrapko

Northeastern University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Evolutionary Mismatch Between Nuclear and Mitochondrial Genomes Does Not Promote Reversion Mutations in Mtdna.. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Melissa FrancoKonstantin PopadinDori WoodsKonstantin Khrapko

evolutionary geneticsevolutionary mismatchreversion mutationsevolutionary biologymitochondrial genomes

Mitochondrial Direct Repeat Reduction as a Strategy for Enhancing Human Longevity: The Case of the Common Repeat. bioRxiv (Cold Spring Harbor Laboratory) (2024)

mitochondrial functiongeneticslongevityhuman longevitycommon repeat

Somatic Mitochondrial Dna Mutations Are a Source of Heterogeneity Among Primary Leukemic Cells. medRxiv (2024)

A Novel, Wave-Shaped Profile of Germline Selection of Pathogenic Mtdna Mutations is Discovered by Bypassing a Classical Statistical Bias. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Auden Cote-LHeureuxZoe FleischmannMelissa FrancoZhibin ChenMark KhrapkoBenjamin VyshedskiyMaxim BravermanKonstantin PopadinSarah PickettDori C. WoodsJon TillyDoug TurnbullKonstantin Khrapko

geneticsclassical statistical biaspopulation geneticsgermline selectionbiostatisticsgenomicspathogenic mtdna mutationsmolecular biology

Are Some Mutations More Equal Than Others?. eLife (2023)

Auden Cote-L’HeureuxYogesh NK MaithaniaMelissa FrancoKonstantin Khrapko

geneticshuman variationhuman geneticspopulation geneticsmutagenesisgenetic variationmolecular biology

Interpreting Sequence-Levenshtein Distance for Determining Error Type and Frequency Between Two Embedded Sequences of Equal Length.. PubMed (2023)

Robert LoganAmy Wangsness WeheDori C WoodsJon TillyKonstantin Khrapko

sequence-levenshtein distancegeneticserror typeequal lengthbioinformatics

Mitochondrial Mutation Spectrum in Chordates: Damage Versus Replication Signatures, Causes, and Dynamics. bioRxiv (Cold Spring Harbor Laboratory) (2023)

geneticspopulation geneticsevolutionary biologymolecular biologymitochondrial mutation spectrum

Reanalysis of Mtdna Mutations of Human Primordial Germ Cells (Pgcs) Reveals Numt Contamination and Suggests That Selection in Pgcs May Be Positive. Mitochondrion (2023)

Zoë FleischmannAuden Cote-L'HeureuxMelissa FrancoSergey OreshkovSofia AnnisMark KhrapkoDylan AidlenKonstantin PopadinDori C. WoodsJonathan L. TillyKonstantin Khrapko

epigeneticsgeneticshuman geneticspopulation geneticscell biologycytogeneticsmtdna mutationsgenomicspopulation genomicsnumt contaminationgerm cell fategenome biologymolecular biologygerm cells

Secondary Structure of the Human Mitochondrial Genome Affects Formation of Deletions. BMC Biology (2023)

secondary structuregeneticshuman geneticsgenome biologymolecular biology

The ‘Stem’ and the ‘Workers’ of the Mtdna Population of the Cell. Evidence From Mutational Analysis. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Auden Cote-L’HeureuMelissa FrancoYogesh N. K. MaithaniaKonstantin PopadinDori WoodsJonathan TillyKonstantin Khrapko

geneticsstem cellscell biologymtdna populationgenomicsmutational analysisgenome biologymolecular biology

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University of California, San Diego

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growth hormone

Susan Bailey

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