Faculty

Institution

Unit

Venue

Klaus Früh

Oregon Health & Science University

Affiliations

Biostatistics Shared Resources

Institute Of Knight Cancer

OHSU School of Medicine

Cancer Early Detection Advanced Research Center (Cedar)

Department Of Cell, Developmental And Cancer Biology

Department Of Molecular Microbiology And Immunology

Division Of Oncological Sciences

Center Of Cancer Early Detection Advanced Research (Cedar)

Institute Of Knight Cancer

Center Of Knight Cancer

Department of Medicine

Division Of Hematology/Medical Oncology

Division Of Pathobiology And Immunology

Flow Cytometry Shared Resource

Institute Of Knight Cancer

Cancer Early Detection Advanced Research Center (Cedar)

Institute Of Knight Cancer

Division Of Oncological Sciences

Institute Of Knight Cancer

Department Of Cell, Developmental And Cancer Biology

Institute Of Knight Cancer

Division Of Hematology/Medical Oncology

Institute Of Knight Cancer Insitute

Institute Of University Knight Cancer

OHSU Knight Cancer Institute

Klaus Früh is a Senior Professor at Oregon Health & Science University, where his research focuses on viral immunology, particularly cytomegalovirus (CMV) pathogenesis and immune evasion. His recent work has elucidated the role of the pentameric complex in congenital CMV transmission using rhesus macaque models, and he has pioneered MHC-E–restricted CD8+ T cell responses as a novel vaccine strategy against SIV. His 2025 publications in *Science Translational Medicine* and *Nature Reviews Immunology* highlight breakthroughs in vertical transmission mechanisms and MHC-E-targeted immunotherapeutics. Früh’s contributions span vaccine development, infectious disease epidemiology, and malaria antigen discovery, with ongoing international collaborations advancing translational virology.

Honors

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Experiences

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Education

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Klaus Früh

Oregon Health & Science University

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immunology virology virus research medical virology infectious diseases immune responses cell biology molecular biology general virology viral pathogenesis pathogenesis virus-host interactions immunity (medicine) antiviral research molecular virology antiviral responses vaccines vaccination viral genetics adaptive immune system cellular immune responses cell research hiv molecular cell biology viral oncology vascular biology vaccine development pathogens cellular therapy antigen processing protein science vaccine research viral replication viral persistence clinical microbiology cancer cells infection control host response viral evolution histocompatibility immunological memory endothelial cells oncogenes virus structure innate immune system hla typing rhesus cytomegalovirus sarcoma-associated herpesvirus human cytomegalovirus medicinal research communicable diseases molecular cancer host-microbe interactions protein function molecular immunology t-regulatory cell cancer biology cancer genomics vaccine design virus transmission therapeutic vaccines viral diagnostics cytomegalovirus vectors immune evasion protein expression cytokines quantitative membrane proteomics interferon response proteomic analysis ubiquitin ligase cowpox virus viral virulence cynomolgus macaques btrcp-dependent mechanism human ubiquitin ligases cytomegalovirus-based vaccine

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Cytoplasmic Motif in Hla-E That Drives Clathrin-Mediated Endocytosis and Vcp-Associated Postendocytic Trafficking. Proceedings of the National Academy of Sciences (2025)

endocytic pathwayclathrin-mediated endocytosiscell traffickingcellular physiologycell signalingintracellular traffickingvcp-associated postendocytic traffickingmolecular cell biologymolecular biologymembrane proteinssignal transductioncytoplasmic motifmembrane biologycell biology

A Rhesus Macaque Model of Congenital Cytomegalovirus Infection Reveals a Spectrum of Vertical Transmission Outcomes. Communications Biology (2025)

immunologyvirus researchpathogenesisviral persistencevirus-host interactionsmedical virologyvertical transmission outcomescongenital cytomegalovirus infectionviral pathogenesisviral geneticsviral dynamicsvirologyrhesus macaque modelinfectious diseasesinfectious diseases (medical specialty)

Glycoprotein L–Deleted Single-Cycle Rhesus Cytomegalovirus Vectors Elicit Mhc-E–Restricted Cd8+ T Cells That Protect Against Siv. The Journal of Immunology (2025)

immunologyvaccinesvirus researchantiviral researchmedical virologygeneral virologyvirologyantiviral responsesimmune responsesinfectious diseasesviral replicationcell biology

Identification of Cross-Stage, Cross-Species Malaria Cd8+ T Cell Antigens. Research Square (2025)

immunologytropical medicinevector-parasite relationshipantigen processingimmune responsesinfectious diseasesneglected tropical diseasesmalaria

Mapping of Species-Specific Determinants Enabling the Induction of Mhc-E and Mhc-II-Restricted Cd8+ T Cells by Cytomegalovirus 4406. The Journal of Immunology (2025)

immunologyvirus researchpathogenesiscytomegalovirus 4406medical virologycellular immune responsesspecies-specific determinantsgeneral virologyadaptive immune systemvirologyantigen processingimmune responsesinfectious diseasesimmunity (medicine)

Nonhuman Primate Model Mirroring Human Congenital Cytomegalovirus Infection Reveals a Spectrum of Vertical Transmission Outcomes. Research Square (2025)

immunologyvirus researchpathogenesisviral persistencevirus-host interactionsmedical virologyvertical transmission outcomesepidemiologyviral pathogenesisviral geneticsvirologyinfectious diseasesimmunity (medicine)infectious diseases (medical specialty)

Targeting Mhc-E as a New Strategy for Vaccines and Immunotherapeutics. Nature reviews. Immunology (2025)

immunologyvaccinesantiviral researchcancer immunotherapyimmune responsesimmunomodulationinfectious diseasesnew strategycellular therapytherapeutic vaccinesimmunotherapy

The Pentameric Complex is Not Required for Congenital CMV Transmission in Seronegative Rhesus Macaques. Science Translational Medicine (2025)

Hsuan-Yuan WangHusam TaherCraig N. KreklywichKimberli A. SchmidtElizabeth A. ScheefRichard BarfieldClaire E. OteroSarah M. ValenciaKe ZhangClaire CallahanFrancesco MonticoloYueqing QiaoRoxanne M. GilbrideChelsea M. CrooksAnne MirzaKelsey KnightMatilda J. MoströmTabitha D. ManuelLesli SpreheSavannah KendallNathan Vande BurgtTimothy F. KowalikPeter A. BarryScott G. HansenJian ShuAlice F. TarantalCliburn ChanDaniel N. StreblowLouis J. PickerAmitinder KaurKlaus FrühSallie R. PermarDaniel Malouli

medicineseronegative rhesus macaquestranslational researchcongenital cmv transmissiontranslational medicine

Cd8 + T Cell Targeting of Tumor Antigens Presented by Hla-E. Science Advances (2024)

Ravi F. IyerMarieke C. VerweijSujit S. NairDavid MorrowMandana MansouriDimple ChakravartyTeresa BeechwoodChristine MeyerLuke UebelhoerElvin J. LauronAndrea SelsethNessy JohnTin Htwe ThinSiarhei DzedzikColin Havenar-DaughtonMichael K. AxthelmJanet DouglasAlan KormanNina BhardwajAshutosh K. TewariScott HansenDaniel MalouliLouis J. PickerKlaus Früh

immunologytumor targetinghla typingcellular immune responsescancer immunosurveillancecancer immunotherapyscience advanceimmune responsest-regulatory celltumor microenvironmentimmunity (medicine)tumor antigensimmunotherapy

Cytomegalovirus Vaccine Vector-Induced Effector Memory Cd4 + T Cells Protect Cynomolgus Macaques From Lethal Aerosolized Heterologous Avian Influenza Challenge. Nature Communications (2024)

Daniel MalouliMeenakshi TiwaryRoxanne M GilbrideDavid W MorrowColette M HughesAndrea SelsethToni PenneyPriscila CastanhaMegan WallaceYulia YeungMorgan MidgettConnor WilliamsJason ReedYun YuLina GaoGabin YunLuke TreasterAmanda LaughlinJeneveve LundyJennifer Tisoncik-GoLeanne S WhitmorePyone P AyeFaith SchiroJason P DufourCourtney R PapenHusam TaherLouis J PickerKlaus FrühMichael GaleNicholas J ManessScott G HansenSimon Barratt-BoyesDouglas S ReedJonah B Sacha

immunologyvirus researchavian biologyvaccine developmentepidemiologyavian medicineadaptive immune systemimmune responsesvaccinationinfluenzacynomolgus macaquesvaccine research

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Klaus Früh

Oregon Health & Science University

Affiliations

Biostatistics Shared Resources

Institute Of Knight Cancer

OHSU School of Medicine

Cancer Early Detection Advanced Research Center (Cedar)

Department Of Cell, Developmental And Cancer Biology

Department Of Molecular Microbiology And Immunology

Division Of Oncological Sciences

Center Of Cancer Early Detection Advanced Research (Cedar)

Institute Of Knight Cancer

Center Of Knight Cancer

Department of Medicine

Division Of Hematology/Medical Oncology

Division Of Pathobiology And Immunology

Flow Cytometry Shared Resource

Institute Of Knight Cancer

Cancer Early Detection Advanced Research Center (Cedar)

Institute Of Knight Cancer

Division Of Oncological Sciences

Institute Of Knight Cancer

Department Of Cell, Developmental And Cancer Biology

Institute Of Knight Cancer

Division Of Hematology/Medical Oncology

Institute Of Knight Cancer Insitute

Institute Of University Knight Cancer

OHSU Knight Cancer Institute

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Klaus Früh

Oregon Health & Science University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Cytoplasmic Motif in Hla-E That Drives Clathrin-Mediated Endocytosis and Vcp-Associated Postendocytic Trafficking. Proceedings of the National Academy of Sciences (2025)

A Rhesus Macaque Model of Congenital Cytomegalovirus Infection Reveals a Spectrum of Vertical Transmission Outcomes. Communications Biology (2025)

Glycoprotein L–Deleted Single-Cycle Rhesus Cytomegalovirus Vectors Elicit Mhc-E–Restricted Cd8+ T Cells That Protect Against Siv. The Journal of Immunology (2025)

immunologyvaccinesvirus researchantiviral researchmedical virologygeneral virologyvirologyantiviral responsesimmune responsesinfectious diseasesviral replicationcell biology

Identification of Cross-Stage, Cross-Species Malaria Cd8+ T Cell Antigens. Research Square (2025)

immunologytropical medicinevector-parasite relationshipantigen processingimmune responsesinfectious diseasesneglected tropical diseasesmalaria

Mapping of Species-Specific Determinants Enabling the Induction of Mhc-E and Mhc-II-Restricted Cd8+ T Cells by Cytomegalovirus 4406. The Journal of Immunology (2025)

Nonhuman Primate Model Mirroring Human Congenital Cytomegalovirus Infection Reveals a Spectrum of Vertical Transmission Outcomes. Research Square (2025)

Targeting Mhc-E as a New Strategy for Vaccines and Immunotherapeutics. Nature reviews. Immunology (2025)

immunologyvaccinesantiviral researchcancer immunotherapyimmune responsesimmunomodulationinfectious diseasesnew strategycellular therapytherapeutic vaccinesimmunotherapy

The Pentameric Complex is Not Required for Congenital CMV Transmission in Seronegative Rhesus Macaques. Science Translational Medicine (2025)

medicineseronegative rhesus macaquestranslational researchcongenital cmv transmissiontranslational medicine

Cd8 + T Cell Targeting of Tumor Antigens Presented by Hla-E. Science Advances (2024)

Cytomegalovirus Vaccine Vector-Induced Effector Memory Cd4 + T Cells Protect Cynomolgus Macaques From Lethal Aerosolized Heterologous Avian Influenza Challenge. Nature Communications (2024)

immunologyvirus researchavian biologyvaccine developmentepidemiologyavian medicineadaptive immune systemimmune responsesvaccinationinfluenzacynomolgus macaquesvaccine research

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