Faculty

Institution

Unit

Venue

Katharina Schlacher

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

NoneKatharina Schlacher is currently serving as a Center For Rna Interference And Non-Coding Rna faculty at The University of Texas Md Anderson Cancer Center.

Honors

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Experiences

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Education

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Katharina Schlacher

The University of Texas MD Anderson Cancer Center

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molecular biology dna replication dna repair cell biology molecular cell biology genome instability genetics nucleic acids molecular cancer cancer research molecular genetics oncogenes cancer genetics genome biology cancer cells cancer biology oncology biochemistry replication dna analysis cancer genomics mitochondrial function tumor biology epigenetic changes genomics protein science medicinal research cancer care cancer treatment nucleic acid chemistry cell cycle mutagenesis replication fork stability thoracic oncology structural molecular biology molecular metabolism anti-cancer agents cellular senescence immune checkpoint inhibitors pancreatic cancer innate immune system mitochondrial dynamics mitochondrial biogenesis replication fork protection polθ pathways genome stability mre11-dependent instability cell research vascular biology cellular therapy leukemia genitourinary cancers hematological malignancies chemoprevention strategies cell regulation clinical radiation oncology cytogenetics chromosome biology molecular research gene regulation molecular biological method genetic disorders mendelian disorder disease gene identification tumor suppressors renal medullary carcinoma immune hallmarks mutagenic rad52 domain-independent chromosomal instability pancreatic cancer metastasis limits replication stress atr-dependent replication restart cgas immune dna replication roles cancer patient mutations replication stress response

Notable Scholarly Works

Notable Federal Grants

Collaborators

Characteristics and Clinical Outcomes of Brca Germline Mutation Carriers With Advanced Breast Cancer Treated With Parp (Poly Adp-Ribose Polymerase) Inhibitors: A Single-Institution Experience. Cancers (2026)

breast oncologypathologyradiation oncologysingle-institution experiencepoly adp-ribose polymerasemolecular cancertherapeutic targetsclinical outcomescancer geneticscancer careoncologybreast cancer

Dpy30 is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. Cancer Research (2026)

oncogenespathologyepigenetic decouplertumor biologyimmunologycell biologyepigeneticsmolecular cancerreplication stresscancer researchpancreatic cancercancer cellscancer biology

Eepd1 Evolved a Unique Dna Clamping Dimer Protecting Reversed Replication Forks. Nucleic Acids Research (2026)

mutagenesis (molecular biology technique)genome instabilityreplication forksnucleic acidsgenomic mechanismsgenome biologydna replicationmolecular geneticsmolecular cell biologymolecular biologynucleic acid chemistrydna analysisunique dnadna repairgenetics

Rf-Sirf Reveals a Replication Stress-Specific Epigenetic Code by Spatio-Temporal Mapping of Reversed Forks. Nature Communications (2026)

chromatin remodelingepigenetic changesepigeneticsfunctional genomicsgenome biologyrf-sirf revealsdna replicationmolecular cell biologyepigenomicsreversed forksmolecular biologychromatinspatio-temporal mappinggenetics

A Multiverse of Brca Vulnerabilities. Nature Cancer (2025)

computer sciencedata securitycomputer securityinformation securityhardware securitysecurity managementbrca vulnerabilities

Brca2 C-Terminal Clamp Restructures Rad51 Dimers to Bind B-Dna for Replication Fork Stability. Molecular Cell (2025)

biophysicsstructural molecular biologygenome instabilityreplication fork stabilitynucleic acidsbrca2 c-terminal clampdna replicationmolecular biologychromatinnucleic acid chemistrydna repairrad51 dimers

Keap1 and Stk11/Lkb1 Alterations Enhance Vulnerability to Atr Inhibition in Kras Mutant Non-Small Cell Lung Cancer. Cancer Cell (2025)

oncogenestumor biologyatr inhibitioncell signalingcell biologylung cancermolecular cell biologymolecular biologythoracic oncologycancer cellscancer geneticsstk11/lkb1 alterationscancer biology

Rf-Sirf Defining Reversed Dna Replication Forks With Single-Cell and Spatio-Temporal Resolution Reveals a Replication Stress Specific Epigenetic Code. bioRxiv (Cold Spring Harbor Laboratory) (2025)

dna replication forksrf-sirf definingspatio-temporal resolutionnucleic acidsepigeneticsgenome biologyepigenetic changesgenomic mechanismsdna replicationmolecular cell biologyepigenomicsmolecular biologychromatindna repairgenetics

Abstract 6404: Grb2 Stabilizes Rad51 at Reversed Replication Forks Restricting Genomic Instability and Associated Innate Immune Response. Cancer Research (2024)

Zamal AhmedZu YeShengfeng XuYin ShiXueqian ChengYuan ZhangSunetra RoySarita NamjoshiMichael A. LongoTodd LinkKatharina SchlacherGuang PengDihua YuBin WangJohn Tainer

genome instabilitygenomic instabilitycancer researchmolecular biologyinnate immune system

Abstract A018: Grb2 Acts at Reversed Forks in the Brca2-Rad51-Mre11 Axis: A Therapeutic Target and Enabling Predictive Biomarker for Parp Inhibitor-Immunotherapy Combination. Cancer Research (2024)

cancer immunotherapycell signalingimmunologycell biologynovel therapiesmolecular cancergrb2 actsabstract a018reversed forkscancer discoverymolecular biologytherapeutic targetscancer geneticsimmune checkpoint inhibitors

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Katharina Schlacher

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

NoneKatharina Schlacher is currently serving as a Center For Rna Interference And Non-Coding Rna faculty at The University of Texas Md Anderson Cancer Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Katharina Schlacher

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

breast oncologypathologyradiation oncologysingle-institution experiencepoly adp-ribose polymerasemolecular cancertherapeutic targetsclinical outcomescancer geneticscancer careoncologybreast cancer

Dpy30 is an Epigenetic Decoupler Linking Replication Stress to Immunoediting in Pancreatic Cancer. Cancer Research (2026)

oncogenespathologyepigenetic decouplertumor biologyimmunologycell biologyepigeneticsmolecular cancerreplication stresscancer researchpancreatic cancercancer cellscancer biology

Eepd1 Evolved a Unique Dna Clamping Dimer Protecting Reversed Replication Forks. Nucleic Acids Research (2026)

Rf-Sirf Reveals a Replication Stress-Specific Epigenetic Code by Spatio-Temporal Mapping of Reversed Forks. Nature Communications (2026)

A Multiverse of Brca Vulnerabilities. Nature Cancer (2025)

computer sciencedata securitycomputer securityinformation securityhardware securitysecurity managementbrca vulnerabilities

Brca2 C-Terminal Clamp Restructures Rad51 Dimers to Bind B-Dna for Replication Fork Stability. Molecular Cell (2025)

Keap1 and Stk11/Lkb1 Alterations Enhance Vulnerability to Atr Inhibition in Kras Mutant Non-Small Cell Lung Cancer. Cancer Cell (2025)

oncogenestumor biologyatr inhibitioncell signalingcell biologylung cancermolecular cell biologymolecular biologythoracic oncologycancer cellscancer geneticsstk11/lkb1 alterationscancer biology

Rf-Sirf Defining Reversed Dna Replication Forks With Single-Cell and Spatio-Temporal Resolution Reveals a Replication Stress Specific Epigenetic Code. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Abstract 6404: Grb2 Stabilizes Rad51 at Reversed Replication Forks Restricting Genomic Instability and Associated Innate Immune Response. Cancer Research (2024)

Zamal AhmedZu YeShengfeng XuYin ShiXueqian ChengYuan ZhangSunetra RoySarita NamjoshiMichael A. LongoTodd LinkKatharina SchlacherGuang PengDihua YuBin WangJohn Tainer

genome instabilitygenomic instabilitycancer researchmolecular biologyinnate immune system

Abstract A018: Grb2 Acts at Reversed Forks in the Brca2-Rad51-Mre11 Axis: A Therapeutic Target and Enabling Predictive Biomarker for Parp Inhibitor-Immunotherapy Combination. Cancer Research (2024)

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10 / page