Faculty

Institution

Unit

Venue

Jonathan Sachs

Professor Department of Biomedical Engineering

University of Minnesota

Affiliations

College of Science & Engineering

Department of Biomedical Engineering

Jonathan Sachs is currently serving as a College Of Science & Engineering Professor Department of Biomedical Engineering at University of Minnesota.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jonathan Sachs

University of Minnesota

Professor Department of Biomedical Engineering

You can click a keyword to filter the displayed items

biophysics membrane biology molecular biology biophysical modeling structural biology pharmacology biochemistry membrane science protein science membranes biophysical chemistry lipids biophysical review computational biophysics biomolecular structure molecular dynamics simulations vascular biology membrane proteins neurodegenerative diseases receptors molecular neurodegeneration experimental biophysics medicinal research theoretical biology structural molecular biology molecular structure cell death membrane structure proteinlipid interaction molecular science neurochemistry lipid movement high-throughput screening apoptosis lipid bilayers biological chemistry enzyme inhibition protein function single molecule biophysics molecular neurobiology signaling pathways biophysical aspect cancer cells biomolecular interactions membrane characterization pancreatic cancer cancer treatment cell regulation cancer biology lipid bilayer structure pancreatic cancer cells clinical biochemistry neutron scattering lipid chemistry lipid science remedial action anti-cancer agents brain science innovative diagnostics pharmaceutical research molecular substrates amphiphilic system bioconjugation integrative biology x-ray scattering data simultaneous analysis methionine-aromatic motif atomistic simulations lipid bilayer simulations fluctuation spectra x-ray scattering hofmeister effect chaotropic anions monovalent salts water order phosphatidylcholine headgroup tilt inflammatory diseases protein modeling molecular informatics protein engineering protein bioinformatics protein structure systems biology drug discovery

Notable Scholarly Works

Notable Federal Grants

Collaborators

Fluorescence Lifetime-Based Fret Biosensors for Monitoring N-Terminal Domain Interactions of Tdp-43 in Living Cells: A Novel Resource for Als and Ftd Drug Discovery. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Noah Nathan KochenMarguerite MurrayNagamani VunnamElly E. LiaoLihsia ChenAnthony R. BraunJonathan N. Sachs

biosensorsbiophysicsliving cellsftd drug discoveryn-terminal domain interactionsfluorescencedrug discoverymolecular biology

Post‐Translational Modification Sites Are Present in Hydrophilic Cavities of Alpha‐Synuclein, Tau, Fus, and Tdp ‐43 Fibrils: A Molecular Dynamics Study. Proteins Structure Function and Bioinformatics (2024)

Noah Nathan KochenDarren SeaneyVivek VasandaniMarguerite MurrayAnthony R. BraunJonathan N. Sachs

protein structuremolecular dynamics studyhydrophilic cavitiesbiochemistrymolecular scienceprotein transportbiomolecular structureprotein modelingprotein sciencemembrane biologyprotein foldingmolecular biophysicsprotein assemblyprotein chemistrymolecular and cellular biologystructural bioinformaticsmolecular neurodegenerationpost-translational modification sitesbiophysicsmolecular biologystructural molecular biology

Advancements in a Fret Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein. ASN NEURO (2023)

Anthony R. BraunNoah Nathan KochenSamantha L. YuenElly E. LiaoRazvan L. CorneaDavid D. ThomasJonathan N. Sachs

neurologybiosensorshigh-throughput screeningneuroimagingneurogeneticsgeneticsneuroinformaticsfluorescencemolecular diagnosticsinnovative diagnosticsfret biosensorneuroscienceneurodegenerative diseases

Discovery of a Non-Competitive Tnfr1 Antagonist Affibody With Picomolar Monovalent Potency That Does Not Affect Tnfr2 Function. Molecular Pharmaceutics (2023)

Nagamani VunnamMaryJane BeenEvan HuberCarolyn PaulsonSophia SzymonskiBenjamin J. HackelJonathan N. Sachs

pharmacologypicomolar monovalent potencypharmaceutical researchmolecular pharmacologydrug discovery

Indirubin Inhibits Trail-Induced Activation of Death Receptor 5 in Jurkat Cells. Natural Product Communications (2023)

Malaney C. YoungNagamani VunnamRobyn T. RebbeckSamantha L. YuenDavid D. ThomasJonathan N. Sachs

immunologynatural productsreceptorsenzyme inhibitionpharmacologyjurkat cellscell signalinginhibitory activityapoptosisnatural product communicationremedial actionnatural product researchcell biology

Nimesulide, a Cox-2 Inhibitor, Sensitizes Pancreatic Cancer Cells to Trail-Induced Apoptosis by Promoting Dr5 Clustering †. Cancer Biology & Therapy (2023)

Nagamani VunnamMalaney C. YoungElly E. LiaoChih Hung LoEvan HuberMaryJane BeenDavid D. ThomasJonathan N. Sachs

pancreatic cancercell biologymedicinecancer carecancer managementanti-cancer agentstrail-induced apoptosiscancer researchcancer immunotherapytherapeutic targetscancer treatmenttumor biologyenzyme inhibitionpharmacologybiological therapiesoncologypancreatic cancer cellscancer cellsmedicinal researchcellular therapy

Ph Effects Can Dominate Chemical Shift Perturbations in 1 H, 15 N-Hsqc Nmr Spectroscopy for Studies of Small Molecule/α-Synuclein Interactions. ACS Chemical Neuroscience (2023)

Anil K. PandeyCaroline R. BuchholzNoah Nathan KochenWilliam C. K. PomerantzAnthony R. BraunJonathan N. Sachs

biophysicssmall moleculesneurochemistryph effectsnuclear magnetic resonance spectroscopychemical shift perturbationsneuroscience

Proteasomal Stimulation by Mk886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology. Molecular Neurobiology (2023)

Elly E. LiaoMu YangNoah Nathan KochenNagamani VunnamAnthony R. BraunDavid M. FergusonJonathan N. Sachs

neurologytau-induced neurite pathologymolecular neurosciencemolecular neurobiologyproteasomal stimulationneuroscience

Zafirlukast is a Promising Scaffold for Selectively Inhibiting Tnfr1 Signaling. ACS Bio & Med Chem Au (2023)

Nagamani VunnamMu YangChih Hung LoCarolyn PaulsonWilliam D. FiersEvan HuberMaryJane BeenDavid M. FergusonJonathan N. Sachs

immunologymedicinal chemistrydermatologyenzyme inhibitionpharmacologysignaling pathwayscell regulationcell signalingcancer immunotherapycellular therapyanti-cancer agentspromising scaffolddrug targetingmedicinal researchcatalyst activationsignal transductiontumor biology

Broad Tricyclic Ring Inhibitors Block Sars-Cov-2 Spike Function Required for Viral Entry. ACS Infectious Diseases (2022)

Sneha RatnapriyaAnthony R. BraunHéctor Cervera BenetDanielle CarlsonShilei DingCarolyn N. PaulsonNeeraj MishraJonathan N. SachsCourtney C. AldrichAndrés FinziAlon Herschhorn

medicinepharmacologysars-cov-2virus-host interactionsvirologyinfectious diseasesviral entry

1
2
3
4
5
11
10 / page

Jonathan Sachs

Professor Department of Biomedical Engineering

University of Minnesota

Affiliations

College of Science & Engineering

Department of Biomedical Engineering

Jonathan Sachs is currently serving as a College Of Science & Engineering Professor Department of Biomedical Engineering at University of Minnesota.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jonathan Sachs

University of Minnesota

Professor Department of Biomedical Engineering

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Noah Nathan KochenMarguerite MurrayNagamani VunnamElly E. LiaoLihsia ChenAnthony R. BraunJonathan N. Sachs

biosensorsbiophysicsliving cellsftd drug discoveryn-terminal domain interactionsfluorescencedrug discoverymolecular biology

Noah Nathan KochenDarren SeaneyVivek VasandaniMarguerite MurrayAnthony R. BraunJonathan N. Sachs

Advancements in a Fret Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein. ASN NEURO (2023)

Anthony R. BraunNoah Nathan KochenSamantha L. YuenElly E. LiaoRazvan L. CorneaDavid D. ThomasJonathan N. Sachs

Discovery of a Non-Competitive Tnfr1 Antagonist Affibody With Picomolar Monovalent Potency That Does Not Affect Tnfr2 Function. Molecular Pharmaceutics (2023)

Nagamani VunnamMaryJane BeenEvan HuberCarolyn PaulsonSophia SzymonskiBenjamin J. HackelJonathan N. Sachs

pharmacologypicomolar monovalent potencypharmaceutical researchmolecular pharmacologydrug discovery

Indirubin Inhibits Trail-Induced Activation of Death Receptor 5 in Jurkat Cells. Natural Product Communications (2023)

Malaney C. YoungNagamani VunnamRobyn T. RebbeckSamantha L. YuenDavid D. ThomasJonathan N. Sachs

immunologynatural productsreceptorsenzyme inhibitionpharmacologyjurkat cellscell signalinginhibitory activityapoptosisnatural product communicationremedial actionnatural product researchcell biology

Nimesulide, a Cox-2 Inhibitor, Sensitizes Pancreatic Cancer Cells to Trail-Induced Apoptosis by Promoting Dr5 Clustering †. Cancer Biology & Therapy (2023)

Nagamani VunnamMalaney C. YoungElly E. LiaoChih Hung LoEvan HuberMaryJane BeenDavid D. ThomasJonathan N. Sachs

Ph Effects Can Dominate Chemical Shift Perturbations in 1 H, 15 N-Hsqc Nmr Spectroscopy for Studies of Small Molecule/α-Synuclein Interactions. ACS Chemical Neuroscience (2023)

Anil K. PandeyCaroline R. BuchholzNoah Nathan KochenWilliam C. K. PomerantzAnthony R. BraunJonathan N. Sachs

biophysicssmall moleculesneurochemistryph effectsnuclear magnetic resonance spectroscopychemical shift perturbationsneuroscience

Proteasomal Stimulation by Mk886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology. Molecular Neurobiology (2023)

Elly E. LiaoMu YangNoah Nathan KochenNagamani VunnamAnthony R. BraunDavid M. FergusonJonathan N. Sachs

neurologytau-induced neurite pathologymolecular neurosciencemolecular neurobiologyproteasomal stimulationneuroscience

Zafirlukast is a Promising Scaffold for Selectively Inhibiting Tnfr1 Signaling. ACS Bio & Med Chem Au (2023)

Nagamani VunnamMu YangChih Hung LoCarolyn PaulsonWilliam D. FiersEvan HuberMaryJane BeenDavid M. FergusonJonathan N. Sachs

Broad Tricyclic Ring Inhibitors Block Sars-Cov-2 Spike Function Required for Viral Entry. ACS Infectious Diseases (2022)

Sneha RatnapriyaAnthony R. BraunHéctor Cervera BenetDanielle CarlsonShilei DingCarolyn N. PaulsonNeeraj MishraJonathan N. SachsCourtney C. AldrichAndrés FinziAlon Herschhorn

medicinepharmacologysars-cov-2virus-host interactionsvirologyinfectious diseasesviral entry

1
2
3
4
5
11
10 / page

Similar Faculty Members

George Khelashvili

Institution

Weill Cornell Medicine

biophysics

membrane biology

David Eliezer

Institution

Weill Cornell Medicine

molecular biology

protein science

Olaf Andersen

Institution

Weill Cornell Medicine

membrane computing

biophysical modeling

Kalina Hristova

Institution

Johns Hopkins University

biophysics

membrane biology

Diwakar Shukla

Institution

University of Illinois Urbana-Champaign

molecular design

molecular science

Feng Ding

Institution

Clemson University

biophysics

molecular biology

Wonpil Im

Institution

Lehigh University

biophysics

structural biology

Deborah Leckband

Institution

University of Illinois Urbana-Champaign

biophysics

cell biology

Robert Stroud

Institution

University of California, San Francisco

structural basis

biomolecular structure

Ivet Bahar

Institution

University of Pittsburgh

computational biology

molecular informatics

Similar Faculty Members

George Khelashvili

Institution

Weill Cornell Medicine

biophysics

membrane biology

David Eliezer

Institution

Weill Cornell Medicine

molecular biology

protein science

Olaf Andersen

Institution

Weill Cornell Medicine

membrane computing

biophysical modeling

Kalina Hristova

Institution

Johns Hopkins University

biophysics

membrane biology

Diwakar Shukla

Institution

University of Illinois Urbana-Champaign

molecular design

molecular science

Feng Ding

Institution

Clemson University

biophysics

molecular biology

Wonpil Im

Institution

Lehigh University

biophysics

structural biology

Deborah Leckband

Institution

University of Illinois Urbana-Champaign

biophysics

cell biology

Robert Stroud

Institution

University of California, San Francisco

structural basis

biomolecular structure

Ivet Bahar

Institution

University of Pittsburgh

computational biology

molecular informatics