Jonah B. Sacha

Jonah B. Sacha is a Professor at Oregon Health & Science University, where his research focuses on immunology, virology, and antiviral immunity, with an emphasis on HIV pathogenesis and viral immune evasion. His recent work includes gene therapy–mediated CCR5 blockade for long-term virus suppression in SHIV-infected macaques, characterization of the urinary DNA virome in transplant recipients, and studies on leronlimab for multidrug-resistant HIV-1. He has also explored HBV susceptibility in transgenic macaques, neutralizing monoclonal antibodies against yellow fever, and MHC-E/MHC-II-restricted CD8+ T-cell induction by cytomegalovirus. His contributions span high-impact venues including *Science Translational Medicine*, *PNAS*, and *The Journal of Immunology*.