Faculty

Institution

Unit

Venue

John R Horton

Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

John R. Horton is an Associate Professor at The University of Texas MD Anderson Cancer Center. His research integrates molecular biology, biochemistry, and structural biology to elucidate gene expression and epigenetic regulation. He specializes in the structural mechanisms of enzymes and nucleic acid-binding proteins, with recent work focusing on the autoinhibited state of the lymphoid-specific helicase HELLS, the multimeric DNA-binding architecture of transcription factor BCL11A, and the unique non-B DNA recognition by the ICF syndrome protein CDCA7. His publications appear in Nature Communications, Science Advances, and Nucleic Acids Research.

Honors

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John R Horton

The University of Texas MD Anderson Cancer Center

Associate Professor

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molecular biology structural biology biochemistry genetics protein science structural molecular biology protein structure epigenetics biomolecular structure enzymes gene expression nucleic acids molecular genetics structural basis biophysics molecular structure chromatin genome biology enzyme inhibition biological chemistry genomics mammalian biology molecular cell biology epigenetic changes molecular regulation rna biology nucleic acid chemistry gene regulation molecular basis respiratory medicine epigenomics transcription regulation molecular substrates medicinal research enzymatic modification protein genetics rational drug design key site gene function structural bioinformatics structure-function enzyme kinetics dna methylation biomolecules molecular science genome structure dna analysis chromatin remodeling gene structure enzyme specificity enzyme catalysis dna helix structural characterization atrial fibrillation cell research vascular biology signal recognition structural genomics cancer biology gene recognition protein chemistry yeast gene regulatory networks molecular design protein synthesis signaling pathways dna shape histone lysine methyltransferases long-term outcomes circular permutation sudden cardiac death single-photon emission metal ions methyl-lysine binding dna substrate adenosine analogs sra domain

Notable Scholarly Works

Notable Federal Grants

Collaborators

Regulation of Bcl11A Dna Binding and Expression in Human Erythrocyte Precursor Hudep-2 Cells. bioRxiv (Cold Spring Harbor Laboratory) (2026)

molecular and cellular biologybcl11a dna bindingcell signalingcell biologytranscription factorsblood cellsgene regulationmolecular cell biologycell regulationmolecular biologygene expressionleukemiamolecular regulation

Structure of Human Lymphoid-Specific Helicase Hells in Its Autoinhibited State. Nucleic Acids Research (2026)

protein structurepathologyautoinhibited statehistopathologymolecular biologyprotein foldingstructural biology

Multimeric Transcription Factor Bcl11A Utilizes Two Zinc-Finger Tandem Arrays to Bind Clustered Short Sequence Motifs. Nature Communications (2025)

John R HortonMeigen YuJujun ZhouMelody TranRithvi R AnakalYue LuRobert M BlumenthalXiaotian ZhangYun HuangXing ZhangXiaodong Cheng

zinc-finger tandemsequence assemblylong non-coding rnaprotein sciencetranscription factorsfunctional genomicstranscription (biology)molecular biologysequence alignmentsequence motifsystems biologygene sequence annotationgene expressionstructural molecular biologybioinformaticsgenetics

Nuclear Poly(a)-Binding Protein and Nucleolin Utilize Their Rna Recognition Motifs to Read Par Chains. Nucleic Acids Research (2025)

par chainsnucleic acidstranscription factorsrna recognition motifstranscription (biology)molecular biologychromatinnucleic acid chemistrysystems biologystructural molecular biologyrna biologynuclear poly

Structural Basis for the Substrate Specificity of Helix Pomatia Amp Deaminase and a Chimeric Adgf Adenosine Deaminase. Journal of Biological Chemistry (2025)

enzymesprotein sciencebiomolecular structurebiochemistrymolecular basismolecular biologystructure-function enzyme kineticsprotein structurestructural basisstructural molecular biologystructural biologysubstrate specificitymolecular substrates

Quinoline-Based Compounds Can Inhibit Diverse Enzymes That Act on Dna. Cell chemical biology (2024)

Jujun ZhouQin ChenRen RenJie YangBigang LiuJohn R HortonCaleb ChangChuxuan LiLeora MaksoudYifei YangDante RotiliAbhinav K JainXing ZhangRobert M BlumenthalTaiping ChenYang GaoSergio ValenteAntonello MaiXiaodong Cheng

enzymesdiverse enzymesbiochemistryquinoline-based compoundsmolecular biologyenzyme inhibitiongenetics

The Icf Syndrome Protein Cdca7 Harbors a Unique Dna Binding Domain That Recognizes a Cpg Dyad in the Context of a Non-B Dna. Science Advances (2024)

Swanand HardikarRen RenZhengzhou YingJujun ZhouJohn R. HortonMatthew D. BrambleBin LiuYue LuBigang LiuLuis Della ColettaJianjun ShenJiameng DanXing ZhangXiaodong ChengTaiping Chen

non-b dnaimmune dysregulationmolecular biologyscience advancegene expressiongeneticscpg dyad

Toward Understanding Pharmacological Modulation of Dna Methylation. (2024)

environmental epigeneticsnucleic acidsepigeneticsepigenetic changesepigenomicspharmacologygene expressiondna repairdna methylationpharmacological research

Allosteric Autoregulation of Dna Binding via a Dna-Mimicking Protein Domain: A Biophysical Study of Znf410–Dna Interaction Using Small Angle X-Ray Scattering. Nucleic Acids Research (2023)

Gundeep KaurRen RenMichal HammelJohn R HortonJie YangYu CaoChenxi HeFei LanXianjiang LanGerd A BlobelRobert M BlumenthalXing ZhangXiaodong Cheng

biophysicsallosteric autoregulationbiophysical studymolecular biophysicsmolecular biologydna-mimicking protein domainstructural biologygenetics

Author Correction: Hic2 Controls Developmental Hemoglobin Switching by Repressing Bcl11A Transcription. Nature Genetics (2023)

Peng HuangScott A. PeslakRen RenEugene KhandrosKunhua QinCheryl A. KellerBelinda GiardineHenry W. BellXianjiang LanMalini SharmaJohn R. HortonOsheiza AbdulmalikStella T. ChouJunwei ShiMerlin CrossleyRoss C. HardisonXiaodong ChengGerd A. Blobel

hematologydevelopmental biologymolecular geneticsgene regulationtranscription regulationmolecular biologyauthor correctiongene expressiondevelopmental geneticsgenetics

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John R Horton

Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John R Horton

The University of Texas MD Anderson Cancer Center

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Regulation of Bcl11A Dna Binding and Expression in Human Erythrocyte Precursor Hudep-2 Cells. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Structure of Human Lymphoid-Specific Helicase Hells in Its Autoinhibited State. Nucleic Acids Research (2026)

protein structurepathologyautoinhibited statehistopathologymolecular biologyprotein foldingstructural biology

Multimeric Transcription Factor Bcl11A Utilizes Two Zinc-Finger Tandem Arrays to Bind Clustered Short Sequence Motifs. Nature Communications (2025)

John R HortonMeigen YuJujun ZhouMelody TranRithvi R AnakalYue LuRobert M BlumenthalXiaotian ZhangYun HuangXing ZhangXiaodong Cheng

Nuclear Poly(a)-Binding Protein and Nucleolin Utilize Their Rna Recognition Motifs to Read Par Chains. Nucleic Acids Research (2025)

Structural Basis for the Substrate Specificity of Helix Pomatia Amp Deaminase and a Chimeric Adgf Adenosine Deaminase. Journal of Biological Chemistry (2025)

Quinoline-Based Compounds Can Inhibit Diverse Enzymes That Act on Dna. Cell chemical biology (2024)

enzymesdiverse enzymesbiochemistryquinoline-based compoundsmolecular biologyenzyme inhibitiongenetics

The Icf Syndrome Protein Cdca7 Harbors a Unique Dna Binding Domain That Recognizes a Cpg Dyad in the Context of a Non-B Dna. Science Advances (2024)

Swanand HardikarRen RenZhengzhou YingJujun ZhouJohn R. HortonMatthew D. BrambleBin LiuYue LuBigang LiuLuis Della ColettaJianjun ShenJiameng DanXing ZhangXiaodong ChengTaiping Chen

non-b dnaimmune dysregulationmolecular biologyscience advancegene expressiongeneticscpg dyad

Toward Understanding Pharmacological Modulation of Dna Methylation. (2024)

environmental epigeneticsnucleic acidsepigeneticsepigenetic changesepigenomicspharmacologygene expressiondna repairdna methylationpharmacological research

Allosteric Autoregulation of Dna Binding via a Dna-Mimicking Protein Domain: A Biophysical Study of Znf410–Dna Interaction Using Small Angle X-Ray Scattering. Nucleic Acids Research (2023)

Gundeep KaurRen RenMichal HammelJohn R HortonJie YangYu CaoChenxi HeFei LanXianjiang LanGerd A BlobelRobert M BlumenthalXing ZhangXiaodong Cheng

biophysicsallosteric autoregulationbiophysical studymolecular biophysicsmolecular biologydna-mimicking protein domainstructural biologygenetics

Author Correction: Hic2 Controls Developmental Hemoglobin Switching by Repressing Bcl11A Transcription. Nature Genetics (2023)

hematologydevelopmental biologymolecular geneticsgene regulationtranscription regulationmolecular biologyauthor correctiongene expressiondevelopmental geneticsgenetics

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5
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10 / page