John O’Reilly

Southeastern Louisiana University

Affiliations

The College of Science and Technology

Department Of Biological Sciences

Laboratory Of Crother/White Molecular Phylogenetics

School Of Graduate

Southeastern Louisiana University

NoneJohn O’reilly is currently serving as a Biological Sciences faculty at Southeastern Louisiana University.

Honors

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Experiences

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Education

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John O’Reilly

Southeastern Louisiana University

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slow inactivation physiology electrophysiology signal transduction cardiac muscle biophysics cardiology cardiovascular research circulatory physiology cellular physiology molecular physiology hyperpolarization (biology) membrane biology gene expression applied physiology enzyme inhibition molecular cell biology cardiovascular physiology neuroscience cell biology neurophysiology muscular dystrophies cardiovascular fitness animal physiology cellular therapy liver physiology molecular science structural molecular biology cellular biochemistry nucleic acids general virology virus research skeletal muscle muscle function human physiology comparative physiology cell physiology translational physiology tissue physiology cellular biology physiological research biochemical interaction molecular communication structure-function enzyme kinetics molecular pathways molecular regulation molecular research molecular virology viral genetics rna biology viral replication human heart rat skeletal muscle relative resistance glutamine substitution cardiac na+ channel domain 2-segment 6 state-dependent effects methanethiosulfonate ethylammonium exposure differ structural interactions cysteine substitutions voltage-gated na channels scam technique molecular determinants investigate reconfiguration

Notable Scholarly Works

Notable Federal Grants

Collaborators

In Search of a Molecular Mechanism for Slow Inactivation in Voltage-Gated Na Channels Using the Scam Technique in D2-S6 of Hnav1.4. Biophysical Journal (2019)

gene therapyslow inactivationneuronsscam techniquehyperpolarization (biology)molecular biologyvoltage-gated na channels

Substituted Cysteine Scanning in D1-S6 of the Sodium Channel Hnav1.4 Alters Kinetics and Structural Interactions of Slow Inactivation. Biochimica et Biophysica Acta (BBA) - Biomembranes (2019)

biophysicsstructural interactionsstructural molecular biologyenzymesmolecular communicationslow inactivationmolecular sciencebiochemistrymolecular biophysicsenzyme inhibitionmolecular biologystructure-function enzyme kineticsprotein structurebiochemical interactionbiophysical chemistrystructural biology

Using Scam to Investigate Reconfiguration of Molecular Determinants in D1-S6 During Slow Inactivation of Hnav1.4. Biophysical Journal (2019)

general virologyinvestigate reconfigurationviral geneticsmutagenesis (molecular biology technique)virologyviral replicationslow inactivationnucleic acidsmolecular determinantsmolecular cell biologymolecular biologymolecular virologysystems biologygene expressiondna repairrna biologyvirus research

Effects of Cysteine Substitutions in D1-S6 on Fast and Slow Inactivation in Nav1.4. Biophysical Journal (2017)

slow inactivationmolecular researchbiochemistryenzyme inhibitionmolecular physiologymolecular cell biologymolecular pathwaysmolecular regulationmolecular biologycysteine substitutionsmolecular pharmacologysignal transductionbiophysical chemistrycellular biochemistry

Time- and State-Dependent Effects of Methanethiosulfonate Ethylammonium (Mtsea) Exposure Differ Between Heart and Skeletal Muscle Voltage-Gated Na+ Channels. Biochimica et Biophysica Acta (BBA) - Biomembranes (2011)

cardiovascular researchphysiological researchcardiologymethanethiosulfonate ethylammoniumcirculatory physiologyphysiologystate-dependent effectselectrophysiologycardiac musclehyperpolarization (biology)exposure differpharmacologymuscular dystrophiescardiovascular physiologycardiovascular fitness

Relative Resistance to Slow Inactivation of Human Cardiac Na + Channel Hna V 1.5 is Reversed by Lysine or Glutamine Substitution at V930 in D2-S6. American Journal of Physiology-Cell Physiology (2007)

Jessica Hotard ChanceyPenny E. ShockettJohn P. O'Reilly

liver physiologyglutamine substitutiontissue physiologycellular biologygeneticscell physiologyphysiologycell biologyrelative resistanceapplied physiologygene expressioncardiac musclecardiologycellular physiologycellular therapytranslational physiologyelectrophysiologymolecular physiologymembrane biologysignal transduction

Slow-Inactivation Induced Conformational Change in Domain 2-Segment 6 of Cardiac Na+ Channel. Biochemical and Biophysical Research Communications (2006)

biophysicscardiovascular researchcirculatory physiologyphysiologydomain 2-segment 6cardiac na+ channelelectrophysiologycellular physiologycardiac musclehyperpolarization (biology)molecular physiologysignal transductioncardiovascular physiology

Residue-Specific Effects on Slow Inactivation at V787 in D2-S6 of Nav1.4 Sodium Channels. Biophysical Journal (2001)

A Point Mutation in Domain 4-Segment 6 of the Skeletal Muscle Sodium Channel Produces an Atypical Inactivation State. Biophysical Journal (2000)

Comparison of Slow Inactivation in Human Heart and Rat Skeletal Muscle Na + Channel Chimaeras. The Journal of Physiology (1999)

John P. O'ReillySho‐Ya WangRoland G. KallenGing Kuo Wang

muscle functionneurosciencehuman heartneurophysiologyanimal physiologycirculatory physiologyphysiologyapplied physiologyhuman physiologycardiac musclecardiologycomparative physiologycellular physiologyskeletal musclebiophysicscardiovascular researchrat skeletal muscleslow inactivationelectrophysiologymembrane biologysignal transduction