Faculty

Institution

Unit

Venue

John Ash

E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research

University of Pittsburgh

Affiliations

Medicine

Ophthalmology

John Ash is currently serving as a Medicine E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research at University of Pittsburgh.

Honors

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Experiences

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Education

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John Ash

University of Pittsburgh

E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research

You can click a keyword to filter the displayed items

ophthalmology neuroscience retina visual science genetics gene expression vision research membrane biology immunology signal transduction mammalian biology receptors cell signaling vascular biology neuroprotection medicinal research photoreceptor cells experimental ophthalmology protein science neuro-ophthalmology experimental medicine experimental biology molecular regulation leukemia inhibitory factor molecular physiology leukemia gene regulation tumor biology redox biology gene function cell regulation angiogenesis virology neuroradiology enzyme inhibition cellular neurobiology retinal pigment epithelium light damage transcription regulation biological chemistry oncogenes photomedicine receptor (biochemistry) ocular disease host specificity light regulation transgenic mice cellular physiology animal biotechnology molecular neurobiology clinical neuroscience brain science mitochondrial function functional regulation biological function experimental pharmacology metabolic regulation receptor tyrosine kinases neuroinflammation retinal photoreceptors protein expression angiology pathway analysis tissue development retinal degenerations age-related macular degeneration cre recombinase preconditioning-induced protection retinal muller cells retinal degenerative diseases neurochemistry vertebrate retinal regeneration knowledge gaps current landscape mitochondrial oxidative stress metabolic dysfunction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acyl-Coa Synthetase 6 Controls Rod Photoreceptor Function and Survival by Shaping the Phospholipid Composition of Retinal Membranes. Communications Biology (2024)

Yixiao WangSilke BeckerStella FinkelsteinFrank M. DykaHaitao LiuMark EminhizerYing HaoRichard S. BrushWilliam J. SpencerVadim Y. ArshavskyJohn D. AshJianhai DuMartin-Paul AgbagaFrans VinbergJessica M. EllisEkaterina S. Lobanova

photoreceptor cellsphospholipid compositionbiologymolecular biologyretinal membranesmembrane biologybiochemistry

Overexpression of Nfe2L1 Increases Proteasome Activity and Delays Vision Loss in a Preclinical Model of Human Blindness. Science Advances (2023)

Yixiao WangAaron SnellFrank M. DykaElizabeth R. ColvinCristhian IldefonsoJohn D. AshEkaterina S. Lobanova

proteomicspreclinical modelophthalmologyhuman blindnessscience advance

Tsc2 Knockout Counteracts Ubiquitin-Proteasome System Insufficiency and Delays Photoreceptor Loss in Retinitis Pigmentosa. Proceedings of the National Academy of Sciences (2022)

Yixiao WangClaudio PunzoJohn D. AshEkaterina S. Lobanova

retinitis pigmentosapeptidesmolecular regulationinhibitory activityubiquitin-proteasome system insufficiencycell biologyproteomicsphotoreceptor cellsprotein sciencemolecular evidencemolecular and cellular biologyreceptorsgene expressionpharmacologyenzyme inhibitionredox biologyhost specificityphotomedicinemolecular biologysignal transduction

MITOCHONDRIA: The Retina’s Achilles’ Heel in Amd. Advances in experimental medicine and biology (2021)

Deborah A. FerringtonM. Cristina KenneyShari R. AtilanoJames B. HurleyEmily E. BrownJohn D. Ash

physiologybiophysicsophthalmologymathematical biologyretinamedical biophysicsstructural biologyexperimental surgeryexperimental medicineexperimental biology

Amp-Activated-Protein Kinase (Ampk) is an Essential Sensor and Metabolic Regulator of Retinal Neurons and Their Integrated Metabolism With Rpe. bioRxiv (Cold Spring Harbor Laboratory) (2020)

Lei XuEmily E. BrownCasey J. KeuthanHimani GubbiElodie-Kim GrellierJerome RogerAnand SwaroopJianhai DuJohn D. Ash

ophthalmologyintegrated metabolismneuro-ophthalmologymolecular regulationessential sensorbioenergeticselectrophysiologyretinametabolic regulationretinal neuronsamp-activated-protein kinasemembrane biologycell metabolismcellular physiologyredox signalingsystems neurosciencemetabolic regulatormolecular physiologycellular neurobiologyphysiologyredox biologysignal transductionneuroscience

Correction to: Retinal Degenerative Diseases. Advances in experimental medicine and biology (2020)

Catherine Bowes RickmanChristian GrimmRobert E. AndersonJohn D. AshMatthew M. LaVailJoe G. Hollyfield

dermatologymedicineophthalmologyretinamammalian biologyerror correctionretinal degenerative diseasesexperimental ophthalmologyexperimental medicineexperimental biology

Gene Regulatory Networks Controlling Vertebrate Retinal Regeneration. Science (2020)

Thanh HoangJie WangPatrick BoydFang WangClayton SantiagoLizhi JiangSooyeon YooManuela LahneLevi J. ToddMeng JiaCristian SaezCasey KeuthanIsabella PalazzoNatalie SquiresWarren A. CampbellFatemeh RajaiiTrisha ParayilVickie TrinhDong Won KimGuohua WangLeah J. CampbellJohn AshAndy J. FischerDavid R. HydeJiang QianSeth Blackshaw

ophthalmologygeneticsmembrane biologyneurosciencegene regulationvertebrate retinal regeneration

Retinal Homeostasis and Metformin-Induced Protection Are Not Affected by Retina-Specific Pparδ Knockout. Redox Biology (2020)

Lei XuEmily E. BrownClayton P. SantiagoCasey J. KeuthanEkaterina LobanovaJohn D. Ash

receptorspharmacologyophthalmologyredox biologymetformin-induced protectionretina-specific ppard knockoutretinal homeostasis

Universal Responses to Stress in Inherited Retinal Degeneration. (2020)

John D AshJerome E RogerElodie-Kim GrellierAnand SwaroopKatya LobanovaCasey Keuthan

ophthalmologygeneticsuniversal responsesmolecular biologystress (biology)inherited retinal degeneration

Ampk May Play an Important Role in the Retinal Metabolic Ecosystem. Advances in experimental medicine and biology (2019)

Emily E. BrownAlfred S. LewinJohn D. Ash

experimental gerontologyophthalmologyneuro-ophthalmologyretinal metabolic ecosystembioenergeticscell biologyelectrophysiologyretinametabolic regulationendocrinologyvascular biologyexperimental ophthalmologymembrane biologyexperimental biologyregenerative medicinephysiologymitochondrial functionmedicinal researchexperimental medicine

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John Ash

E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research

University of Pittsburgh

Affiliations

Medicine

Ophthalmology

John Ash is currently serving as a Medicine E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

John Ash

University of Pittsburgh

E Ronald Salvitti Professor of Ophthalmology Research Vice-Chair of Ophthalmology and Director of Research

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Acyl-Coa Synthetase 6 Controls Rod Photoreceptor Function and Survival by Shaping the Phospholipid Composition of Retinal Membranes. Communications Biology (2024)

photoreceptor cellsphospholipid compositionbiologymolecular biologyretinal membranesmembrane biologybiochemistry

Overexpression of Nfe2L1 Increases Proteasome Activity and Delays Vision Loss in a Preclinical Model of Human Blindness. Science Advances (2023)

Yixiao WangAaron SnellFrank M. DykaElizabeth R. ColvinCristhian IldefonsoJohn D. AshEkaterina S. Lobanova

proteomicspreclinical modelophthalmologyhuman blindnessscience advance

Tsc2 Knockout Counteracts Ubiquitin-Proteasome System Insufficiency and Delays Photoreceptor Loss in Retinitis Pigmentosa. Proceedings of the National Academy of Sciences (2022)

Yixiao WangClaudio PunzoJohn D. AshEkaterina S. Lobanova

MITOCHONDRIA: The Retina’s Achilles’ Heel in Amd. Advances in experimental medicine and biology (2021)

Deborah A. FerringtonM. Cristina KenneyShari R. AtilanoJames B. HurleyEmily E. BrownJohn D. Ash

physiologybiophysicsophthalmologymathematical biologyretinamedical biophysicsstructural biologyexperimental surgeryexperimental medicineexperimental biology

Amp-Activated-Protein Kinase (Ampk) is an Essential Sensor and Metabolic Regulator of Retinal Neurons and Their Integrated Metabolism With Rpe. bioRxiv (Cold Spring Harbor Laboratory) (2020)

Lei XuEmily E. BrownCasey J. KeuthanHimani GubbiElodie-Kim GrellierJerome RogerAnand SwaroopJianhai DuJohn D. Ash

Correction to: Retinal Degenerative Diseases. Advances in experimental medicine and biology (2020)

Catherine Bowes RickmanChristian GrimmRobert E. AndersonJohn D. AshMatthew M. LaVailJoe G. Hollyfield

dermatologymedicineophthalmologyretinamammalian biologyerror correctionretinal degenerative diseasesexperimental ophthalmologyexperimental medicineexperimental biology

Gene Regulatory Networks Controlling Vertebrate Retinal Regeneration. Science (2020)

ophthalmologygeneticsmembrane biologyneurosciencegene regulationvertebrate retinal regeneration

Retinal Homeostasis and Metformin-Induced Protection Are Not Affected by Retina-Specific Pparδ Knockout. Redox Biology (2020)

Lei XuEmily E. BrownClayton P. SantiagoCasey J. KeuthanEkaterina LobanovaJohn D. Ash

receptorspharmacologyophthalmologyredox biologymetformin-induced protectionretina-specific ppard knockoutretinal homeostasis

Universal Responses to Stress in Inherited Retinal Degeneration. (2020)

John D AshJerome E RogerElodie-Kim GrellierAnand SwaroopKatya LobanovaCasey Keuthan

ophthalmologygeneticsuniversal responsesmolecular biologystress (biology)inherited retinal degeneration

Ampk May Play an Important Role in the Retinal Metabolic Ecosystem. Advances in experimental medicine and biology (2019)

Emily E. BrownAlfred S. LewinJohn D. Ash

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