Faculty

Institution

Unit

Venue

Johannes Melms

Postdoctoral Residency Fellow in the Department of Medicine

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Residency Program

P&S

P&S Clinical

Johannes Melms is a Postdoctoral Residency Fellow in the Department of Medicine at Columbia University. His research integrates oncology, immunology, and cancer biology, with a specific focus on tumor immunology, cancer immunotherapy, and the tumor microenvironment. His recent work has mapped human natural killer cell development in tonsillar tissue and characterized the single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases. He has also investigated neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis and the role of hepatic stellate cells in liver zonation via R-spondin 3. His publications appear in leading journals including Nature, Nature Medicine, Nature Cancer, and Cell, and he has contributed to scalable functional classification of genetic variants in inborn errors of immunity.

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Johannes Melms

Columbia University

Postdoctoral Residency Fellow in the Department of Medicine

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oncology immunology cancer research tumor biology cancer biology cancer immunotherapy medicinal research cancer treatment genetics cell biology single-cell analysis immunotherapy cancer cells cancer care molecular cancer cellular therapy molecular biology cancer genomics cancer genetics hepatology thoracic oncology enzyme inhibition anti-cancer agents genome biology melanoma brain tumor research cancer management virology covid-19 vascular biology molecular cell biology liver physiology pharmacotherapy liver disease single cell sequencing tumor suppressors immunosuppression immune checkpoint inhibitors liver cancer immunosuppressive myeloid cells anti-tumor hallmarks medical virology respiratory medicine medical mycology cell regulation hepatocellular carcinoma genome analysis genome sequencing viral oncology clinical evidence cancer immune evasion whole-genome sequencing covid-19 pandemic viral diagnostics molecular virology biomedical modeling clinical neuroscience adaptive immune system immunogenetics novel therapies hematological malignancies biliary tract hepatotoxicity microarray data analysis covid-19 tissue atlases single-cell landscape perturb-cite-seq screens patient models treatment-naive ecosystem synovial sarcoma anti-tumor immunity frozen clinical specimens multimodal single-cell spatial genomic landscape histone acetylation neuronal activity-dependent mechanisms

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mapping Human Natural Killer Cell Development in Tonsil. bioRxiv (Cold Spring Harbor Laboratory) (2026)

host responsecell researchimmune responsesinfectious diseases

Single-Cell and Spatial Profiling in Cancer Biology and Clinical Oncology. Nature Cancer (2026)

single-cell analysiscancer cellstumor biologyspatial omicscell biology

A Single-Nucleus and Spatial Transcriptomic Atlas of the Covid-19 Liver Reveals Topological, Functional, and Regenerative Organ Disruption in Patients. Genome biology (2025)

Yered Pita-JuarezDimitra KaragkouniNikolaos KalavrosJohannes C. MelmsSebastian NiezenToni M. DeloreyAdam L. EsseneOlga R. BrookDeepti PantDisha Skelton-BadlaniPourya NaderiPinzhu HuangLiuliu PanTyler HetherTallulah S. AndrewsCarly G. K. ZieglerJason ReevesAndriy MyloserdnyyRachel ChenAndy NamStefan PhelanYan LiangMark GregoryShanshan HeMichael PatrickTushar RaneAster WardhaniAmit Dipak AminJana BiermannHanina HibshooshMolly VereggeZachary KramerChristopher JacobsYusuf YalcinDevan PhillipsMichal SlyperAyshwarya SubramanianOrr AshenbergZohar Bloom-AckermannVictoria M. TranJames GomezAlexander SturmShuting ZhangStephen J. FlemingSarah WarrenJoseph BeechemDeborah HungMehrtash BabadiRobert F. PaderaSonya A. MacParlandGary D. BaderNasser ImadIsaac H. SolomonEric MillerStefan RiedelCaroline B. M. PorterAlexandra-Chloé VillaniLinus T.-Y. TsaiWinston HideGyongyi SzaboJonathan HechtOrit Rozenblatt-RosenAlex K. ShalekBenjamin IzarAviv RegevYury V. PopovZ. Gordon JiangIoannis S. Vlachos

immunologysars-cov-2inflammationcell signalingliver diseasecell researchspatial transcriptomic atlasmolecular cell biologyhepatitishepatologyimmune responseshepatocellular carcinomapathologyspatial transcriptomic profilingliver physiologycell biology

Hepatic Stellate Cells Control Liver Zonation, Size and Functions via R-Spondin 3. Nature (2025)

Atsushi SugimotoYoshinobu SaitoGuanxiong WangQiuyan SunChuan YinKi Hong LeeYana GengPresha RajbhandariCeline HernandezMarcella SteffaniJingran QieThomas SavageDhruv M. GoyalKevin C. RayTaruna V. NeelakantanDeqi YinJohannes MelmsBrandon M. LehrichTyler M. YasakaSilvia LiuMichael OertelTian LanAdrien GuillotMoritz PeiselerAveline FilliolHiroaki KanzakiNaoto FujiwaraSamhita RaviBenjamin IzarMario BroschJochen HampeHelen RemottiJosepmaria ArgemiZhaoli SunTimothy J. KendallYujin HoshidaFrank TackeJonathan A. FallowfieldStorm K. Blockley-PowellRebecca A. HaeuslerJonathan B. SteinmanUtpal B. PajvaniSatdarshan P. MongaRamon BatallerMojgan MasoodiNicholas ArpaiaYoungmin A. LeeBrent R. StockwellHellmut G. AugustinRobert F. Schwabe

immunologyliver transplantationhematologyliver cancervascular biologybiliary tractliver diseasemolecular cell biologybiomolecular engineeringhepatotoxicitymolecular biologystructural molecular biologyhepatologymedicinal researchhepatocellular carcinomamembrane biologyextracellular matrixinflammation

Micronuclai Enables Automated Quantification of Micronuclei for Assessment of Chromosomal Instability. Communications Biology (2025)

genome biologyforensic geneticsgenetic recombinationsystems biologyplo biologygeneticscell divisionmolecular cell biologydna repairmolecular diagnosticsmolecular geneticsbiomedical analysismolecular biologyepigeneticsdna replicationchromatinnucleic acids

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Pathogenesis. Nature (2025)

carcinogenesisbronchial neoplasmcellular physiologycancer biologythoracic oncologyneuronal activity-dependent mechanismscancer cellslung cancertumor biologyneurosciencecell biology

Scalable Generation and Functional Classification of Genetic Variants in Inborn Errors of Immunity to Accelerate Clinical Diagnosis and Treatment. Cell (2025)

immunologygeneticsmolecular diagnosticsinborn errors of immunityimmunity (medicine)

Single-Cell and Spatial Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases. Nature Medicine (2025)

Somnath TagoreLindsay CaprioAmit Dipak AminKresimir BestakKaran LuthriaEdridge D'SouzaIrving BarreraJohannes C MelmsSharon WuSinan AbuzaidYiping WangViktoria JakubikovaPeter KochD Zack BrodtmanBanpreet BawaSachin K DeshmukhLeon EbelMiguel A Ibarra-ArellanoAbhinav JaiswalCarino GurjaoJana BiermannNeha ShaikhPriyanka RamaradjYohanna GeorgisGalina G LagosMatthew I EhrlichPatricia HoZachary H WalshMeri RogavaMichelle Garlin PolitisDevanik BiswasAzzurra CottarelliNikhil RizviCatherine A ShuBenjamin HerzbergNiroshana AnandasabapathyGeorge SledgeEmmanuel ZornPeter CanollJeffrey N BruceNaiyer A RizviAlison M TaylorAnjali SaqiHanina HibshooshGary K SchwartzBrian S HenickFei ChenDenis SchapiroParin ShahBenjamin Izar

gene therapylong-read sequencingmetastasispathologystem cell researchvascular biologymolecular cancerimaging genomicsleukemiaspatial genomic landscapesingle-cell analysismicroarray data analysisimmunologycarcinogenesisgene expressiongliomasthoracic oncologygeneticssingle cell sequencing

Abstract 15: Massively Parallel Base-Editing Screens to Map Variant Effects on Anti-Tumor Hallmarks of Primary Human T Cells and Improve Cell-Based Cancer Immunotherapies. Cancer Research (2024)

Zachary Hudson WalshParin ShahNeeha KothapalliGergo NikolenyiShivem ShahGiuseppe LeuzziNeil VasanMohammed AlQuarishiAlberto CicciaJohannes MelmsBenjamin Izar

immunologytumor targetingcancer researchsingle-cell analysisvariant effectscancer genomicscancer immunotherapycellular therapyoncologycell-based cancer immunotherapiesmedicinal researchcancer treatmentcancer biologytumor biologyanti-tumor hallmarksimmunotherapy

Abstract 5360: Relief of Chromosomal Instability-Induced Cgas-Sting Signaling Sensitizes Stk11 -Mutant Non-Small Cell Lung Cancer to Immune Checkpoint Blockade. Cancer Research (2024)

Lindsay A. CaprioChristy HongAmit D. AminSomnath TagoreMercedes DuranMeri RogavaLuke CaiLeon EbelJohannes MelmsHanina HibshooshSamuel BakhoumBenjamin Izar

tumor targetingcheckpoint blockadecancer carecancer managementmolecular cancercancer immunosurveillanceanti-cancer agentscancer researchchromosomal instability-induced cgas-stingtumor biologycancer preventionimmunotherapyimmunologycarcinogenesisthoracic oncologyradiation oncologygeneticsoncologycancer cellsmedicinal research

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Johannes Melms

Postdoctoral Residency Fellow in the Department of Medicine

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Residency Program

P&S

P&S Clinical

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Johannes Melms

Columbia University

Postdoctoral Residency Fellow in the Department of Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mapping Human Natural Killer Cell Development in Tonsil. bioRxiv (Cold Spring Harbor Laboratory) (2026)

host responsecell researchimmune responsesinfectious diseases

Single-Cell and Spatial Profiling in Cancer Biology and Clinical Oncology. Nature Cancer (2026)

single-cell analysiscancer cellstumor biologyspatial omicscell biology

A Single-Nucleus and Spatial Transcriptomic Atlas of the Covid-19 Liver Reveals Topological, Functional, and Regenerative Organ Disruption in Patients. Genome biology (2025)

Hepatic Stellate Cells Control Liver Zonation, Size and Functions via R-Spondin 3. Nature (2025)

Micronuclai Enables Automated Quantification of Micronuclei for Assessment of Chromosomal Instability. Communications Biology (2025)

Neuronal Activity-Dependent Mechanisms of Small Cell Lung Cancer Pathogenesis. Nature (2025)

carcinogenesisbronchial neoplasmcellular physiologycancer biologythoracic oncologyneuronal activity-dependent mechanismscancer cellslung cancertumor biologyneurosciencecell biology

Scalable Generation and Functional Classification of Genetic Variants in Inborn Errors of Immunity to Accelerate Clinical Diagnosis and Treatment. Cell (2025)

immunologygeneticsmolecular diagnosticsinborn errors of immunityimmunity (medicine)

Single-Cell and Spatial Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases. Nature Medicine (2025)

Abstract 15: Massively Parallel Base-Editing Screens to Map Variant Effects on Anti-Tumor Hallmarks of Primary Human T Cells and Improve Cell-Based Cancer Immunotherapies. Cancer Research (2024)

Zachary Hudson WalshParin ShahNeeha KothapalliGergo NikolenyiShivem ShahGiuseppe LeuzziNeil VasanMohammed AlQuarishiAlberto CicciaJohannes MelmsBenjamin Izar

Abstract 5360: Relief of Chromosomal Instability-Induced Cgas-Sting Signaling Sensitizes Stk11 -Mutant Non-Small Cell Lung Cancer to Immune Checkpoint Blockade. Cancer Research (2024)

Lindsay A. CaprioChristy HongAmit D. AminSomnath TagoreMercedes DuranMeri RogavaLuke CaiLeon EbelJohannes MelmsHanina HibshooshSamuel BakhoumBenjamin Izar

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