Faculty

Institution

Unit

Venue

Joan Steffan

Associate Professor Psychiatry & Human Behavior

University of California, Irvine

Affiliations

School of Medicine

Joan Steffan is currently serving as a School Of Medicine Associate Professor Psychiatry & Human Behavior at University of California, Irvine.

Honors

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Experiences

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Education

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Joan Steffan

University of California, Irvine

Associate Professor Psychiatry & Human Behavior

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neuroscience genetics molecular biology huntington's disease neurology gene expression protein science molecular genetics neurodegenerative diseases mammalian biology enzymes molecular cell biology molecular neurodegeneration genome biology autophagy yeast structural biology membrane biology neuropharmacology biochemical sciences biological chemistry biochemical genetics molecular neurobiology insect molecular biology gene regulation gene function protein expression cell death cellular biochemistry structural molecular biology genetic disorders rna biology transcription regulation knockout mice clinical neuroscience mutant huntingtin saccharomyces cerevisiae rdna transcription aging cell molecular physiology stem cell research degenerative pathology protein chemistry medical genetics animal genetics protein genetics developmental genetics epigenomics stem cell transplantation molecular regulation protein biosynthesis experimental neuropathology degenerative disease cell regulation histone deacetylase inhibitors malate dehydrogenase mitochondrial malate dehydrogenase aberrant splicing sumo modification animal science motor disorders brain science signaling pathways cell autophagy mitophagy protein evolution protein function protein phosphorylation polyglutamine-dependent neurodegeneration creb-binding protein motor deficits histone deacetylase inhibitor suberoylanilide hydroxamic acid mouse model ikk activation inflammatory kinase ikk neuroscience of aging alzheimer's disease

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted Tdp-43 Activity and Altered M6A Rna Modification. Nature Neuroscience (2025)

Thai B. NguyenRicardo MiramontesCarlos Chillon-MarinasRoy MaimonSonia Vazquez-SanchezAlice L. LauNicolette R. McClureZhuoxing WuKeona Q. WangWhitney E. EnglandMonika SinghaJennifer T. StocksdaleMarie HeathKi-Hong JangSunhee JungKaren LingPaymann Jafar-nejadJharrayne I. McKnightLeanne N. HoOsama Al DalahmahRichard L. M. FaullJoan S. SteffanJack C. ReidlingCholsoon JangGina LeeDon W. ClevelandClotilde Lagier-TourenneRobert C. SpitaleLeslie M. Thompson

rna processingneurosciencehuntington's diseasetranscription factorsneurodegenerative diseasestranscription (biology)molecular biologytranscription regulationgene expressionmolecular neurodegenerationsystems biologyvirus researchaberrant splicingnon-coding rnagenetic disordersdisease accompanieslong non-coding rnabrain tumor researchmolecular cell biology

Dysregulation of Protein Sumoylation Networks in Huntington’s Disease R6/2 Mouse Striatum. Brain (2024)

Marketta KachemovVineet VaibhavCharlene SmithNiveda SundararamanMarie HeathDevon F PendleburyAndrea MatlockAlice LauEva MorozkoRyan G LimJack ReidlingJoan S SteffanJennifer E Van EykLeslie M Thompson

huntington's diseaseexperimental neuropathologymolecular neurodegenerationprotein scienceprotein misfoldingmolecular neurobiologyneuroscienceneurodegenerative diseasesbrain organizationmolecular biologynervous systemprotein structuresystems biologyprotein sumoylation networkscentral nervous systembrain circuitry

Huntingtin Contains an Ubiquitin-Binding Domain and Regulates Lysosomal Targeting of Mitochondrial and Rna-Binding Proteins. Proceedings of the National Academy of Sciences (2024)

Gianna M. FoteVinay V. EapenRyan G. LimClinton YuLisa SalazarNicolette R. McClureJharrayne McKnightThai B. NguyenMarie C. HeathAlice L. LauMark A. VillamilRicardo MiramontesIan H. KratterSteven FinkbeinerJack C. ReidlingJoao A. PauloPeter KaiserLan HuangDavid E. HousmanLeslie M. ThompsonJoan S. Steffan

molecular and cellular biologybiochemistrymolecular biologylysosomal targetingubiquitin-binding domaingene regulatory networksrna-binding proteins

Sumo Modification in Huntington's Disease: Unraveling Complex Mechanisms for Therapeutic Insights. Elsevier eBooks (2024)

Charlene SmithJoan S. SteffanLeslie M. Thompson

huntington's diseaseneurologysumo modificationtherapeutic insightsneuroscienceunraveling complex mechanismspharmacology

Aberrant Splicing in Huntington’s Disease via Disrupted Tdp-43 Activity Accompanied by Altered M6A Rna Modification. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Thai B. NguyenRicardo MiramontesCarlos Chillon-MarinasRoy MaimonSonia Vazquez-SanchezAlice L. LauNicolette R. McClureWhitney E. EnglandMonika SinghaJennifer T. StocksdaleKi-Hong JangSunhee JungJharrayne I. McKnightLeanne N. HoRichard L.M. FaullJoan S. SteffanJack C. ReidlingCholsoon JangGina LeeDon W. ClevelandClotilde Lagier-TourenneRobert C. SpitaleLeslie M. Thompson

huntington's diseaseaberrant splicingbiologymolecular biologygene expressionrna biologygenetics

Author Correction: Gene Expression and Functional Deficits Underlie Trem2-Knockout Microglia Responses in Human Models of Alzheimer’s Disease. Nature Communications (2023)

Amanda McQuadeYou Jung KangJonathan HasselmannAmit JairamanAlexandra SoteloMorgan CoburnSepideh Kiani ShabestariJean Paul ChadarevianGianna FoteChristina H. TuEmma DanhashJorge SilvaEric MartinezCarl CotmanG. Aleph PrietoLeslie M. ThompsonJoan S. SteffanIan SmithHayk DavtyanMichael CahalanHansang ChoMathew Blurton-Jones

alzheimer's diseasesystems neuroscienceneuropharmacologyimmunologyhuman modelscognitive neuroscienceneurosciencemolecular neurobiologyneuroinflammationauthor correctionexperimental medicineclinical neurosciencegenetics

Apoe4 Dysregulates Autophagy in Cultured Cells. Autophagy Reports (2022)

Gianna M. FoteJoan S. Steffan

cell biologyautophagygene expressioncell regulationcultured cellsgenetics

Contributors. Elsevier eBooks (2022)

Ron AltermanJeffrey E. ArleKerry BradleySergio CanaveroSteven M. FalowskiChad W. FarleyYakov GologorskyJianwen Wendy GuH. Louis JournéeJohn KastOlga KhazenJoachim K. KraussVignessh KumarMark LentRobert M. LevyAndres M. LozanoCharles MackelGeorge T. MandyburBryan L. McLaughlinDaniel R. MerrillAlon Y. MogilnerGabi MolnarGuillermo A. MonsalveRichard B. NorthYunseo Linda ParkJohn ParkerShrey PatelJulie G. PilitsisFrancisco A. PonceJason E. PopeAdolfo Ramirez-ZamoraLouis J. RasoJoshua M. RosenowJay L. ShilsPeter SingleKonstantin V. SlavinMichael D. StaudtMark M. SteckerHuy Q. Truong

Diminished Lc3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes. Journal of Huntington s Disease (2022)

Nicole M. WakidaAlice L. LauJessica NguyenGladys Mae S. CruzGianna M. FoteJoan S. SteffanLeslie M. ThompsonMichael W. Berns

huntington's diseaseneurologyliver diseasecell deathimmunologyneuroscience

Isoform-Dependent Lysosomal Degradation and Internalization of Apolipoprotein E Requires Autophagy Proteins. Journal of Cell Science (2022)

Gianna M. FoteNicolette R. GellerNikolaos E. EfstathiouNathan HendricksDemetrios G. VavvasJack C. ReidlingLeslie M. ThompsonJoan S. Steffan

autophagy proteinsphysiologycell biologymembrane biologyisoform-dependent lysosomal degradationautophagymolecular biology

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Joan Steffan

Associate Professor Psychiatry & Human Behavior

University of California, Irvine

Affiliations

School of Medicine

Joan Steffan is currently serving as a School Of Medicine Associate Professor Psychiatry & Human Behavior at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Joan Steffan

University of California, Irvine

Associate Professor Psychiatry & Human Behavior

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aberrant Splicing in Huntington’s Disease Accompanies Disrupted Tdp-43 Activity and Altered M6A Rna Modification. Nature Neuroscience (2025)

Dysregulation of Protein Sumoylation Networks in Huntington’s Disease R6/2 Mouse Striatum. Brain (2024)

Marketta KachemovVineet VaibhavCharlene SmithNiveda SundararamanMarie HeathDevon F PendleburyAndrea MatlockAlice LauEva MorozkoRyan G LimJack ReidlingJoan S SteffanJennifer E Van EykLeslie M Thompson

Huntingtin Contains an Ubiquitin-Binding Domain and Regulates Lysosomal Targeting of Mitochondrial and Rna-Binding Proteins. Proceedings of the National Academy of Sciences (2024)

molecular and cellular biologybiochemistrymolecular biologylysosomal targetingubiquitin-binding domaingene regulatory networksrna-binding proteins

Sumo Modification in Huntington's Disease: Unraveling Complex Mechanisms for Therapeutic Insights. Elsevier eBooks (2024)

Charlene SmithJoan S. SteffanLeslie M. Thompson

huntington's diseaseneurologysumo modificationtherapeutic insightsneuroscienceunraveling complex mechanismspharmacology

Aberrant Splicing in Huntington’s Disease via Disrupted Tdp-43 Activity Accompanied by Altered M6A Rna Modification. bioRxiv (Cold Spring Harbor Laboratory) (2023)

huntington's diseaseaberrant splicingbiologymolecular biologygene expressionrna biologygenetics

Author Correction: Gene Expression and Functional Deficits Underlie Trem2-Knockout Microglia Responses in Human Models of Alzheimer’s Disease. Nature Communications (2023)

Apoe4 Dysregulates Autophagy in Cultured Cells. Autophagy Reports (2022)

Gianna M. FoteJoan S. Steffan

cell biologyautophagygene expressioncell regulationcultured cellsgenetics

Contributors. Elsevier eBooks (2022)

Diminished Lc3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes. Journal of Huntington s Disease (2022)

Nicole M. WakidaAlice L. LauJessica NguyenGladys Mae S. CruzGianna M. FoteJoan S. SteffanLeslie M. ThompsonMichael W. Berns

huntington's diseaseneurologyliver diseasecell deathimmunologyneuroscience

Isoform-Dependent Lysosomal Degradation and Internalization of Apolipoprotein E Requires Autophagy Proteins. Journal of Cell Science (2022)

Gianna M. FoteNicolette R. GellerNikolaos E. EfstathiouNathan HendricksDemetrios G. VavvasJack C. ReidlingLeslie M. ThompsonJoan S. Steffan

autophagy proteinsphysiologycell biologymembrane biologyisoform-dependent lysosomal degradationautophagymolecular biology

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Thomas A. Neubert

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translational research

neuroscience

Ta Yuan Chang

Institution

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autophagy

obesity

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University of California, San Diego

apoptosis

signal transduction pathways

Haining Zhu

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molecular biology

protein science

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clinical translation

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neuroscience

huntington's disease

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drug targeting

anti-cancer agent

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cell biology

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biomedical informatics

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