Faculty

Institution

Unit

Venue

Jiusheng Yan

Assistant Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Pain Medicine

Jiusheng Yan is currently serving as a Pain Medicine Assistant Professor Associate Professor at The University of Texas Md Anderson Cancer Center.

Honors

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Experiences

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Education

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Jiusheng Yan

The University of Texas MD Anderson Cancer Center

Assistant Professor Associate Professor

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molecular physiology signal transduction biochemistry cellular physiology molecular biology hyperpolarization (biology) neuroscience cell signaling neurons cell biology receptors membrane biology electrophysiology membrane proteins neurotransmission membrane transport protein science cell physiology molecular cell biology receptor (biochemistry) bk channels pharmacological research bk channel modulation structural biology biochemical sciences molecular neurobiology protein transport enzyme inhibition biological chemistry redox biology cellular biochemistry protein phosphorylation mechanisms of action cytochrome b6f complex auxiliary γ subunits pain research protein chemistry intracellular trafficking cellular regulatory mechanism cellular pharmacology pain mechanism bk channel activation naadp receptor liver physiology molecular science genome biology photosynthesis membrane science protein function metalloproteins sensory science cellular neurobiology channel characterization intercellular communication heme signaling signaling pathways molecular communication molecular basis inhibitory activity drug targets biochemical interaction pharmaceutical chemistry science studies lipid chemistry electron paramagnetic resonance pharmacokinetics leucine-rich repeat-containing proteins gamma subunits auxiliary beta bk channel function bkca channel acidic organelles calcium mobilization auxiliary î³ subunits time-independent structure bk channel

Notable Scholarly Works

Notable Federal Grants

Collaborators

Lrrc55 Modulates Bk Channels to Support Purkinje Cell Plasticity and Motor Coordination. bioRxiv (Cold Spring Harbor Laboratory) (2026)

motor coordinationneuronsmotor controlcell biologyneurosciencebk channelsmotor systemspurkinje cell plasticityneurophysiologyneural circuitscellular physiologymolecular physiology

Naadp Elicits Two-Pore Channel Currents by Lifting Lsm12-Mediated Inhibition of Pi(3,5)P 2 Activation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

receptorstwo-pore channel currentsneuronscell biologycell signalingneurosciencephysiologysignal transductionneurotransmissionlsm12-mediated inhibitioncellular physiologymolecular physiologyhyperpolarization (biology)

Concatenated Modular Bk Channel Constructs Reveal Divergent Stoichiometry in Gating Control by Lrrc26 (γ1), Pore, and Selectivity Filter. (2025)

selectivity filterchemistrychemical engineering

Spinal α2δ-1 Induces Glua3 Degradation to Regulate Assembly of Calcium-Permeable Ampa Receptors and Pain Hypersensitivity. Journal of Clinical Investigation (2025)

receptorsmolecular neuroscienceneuronscalcium-permeable ampa receptorsneurosciencepain mechanismspinal cordphysiologyneurotransmissionpain hypersensitivitypain researchcellular physiology

Naadp-Evoked Sodium Currents of Two-Pore Channels Mediated by Lsm12 and Pi(3,5)P2. Biophysical Journal (2024)

neuronselectrophysiologyneurosciencephysiologyneurotransmissionnaadp-evoked sodium currentsneurophysiologytwo-pore channelsneuropsychopharmacologyhyperpolarization (biology)

Transmembrane Determinants of Voltage-Gating Differences Between Bk (Slo1) and Slo3 Channels. Biophysical Journal (2024)

membrane transporttransmembrane determinantselectrophysiologyslo3 channelsvoltage-gating differencesmembranesmembrane biologyelectrical engineeringhyperpolarization (biology)

Bk Channel Modulation by Positively Charged Peptides and Auxiliary γ Subunits Mediated by the Ca2+-Bowl Site. The Journal of General Physiology (2023)

receptorsmembrane transportmembrane proteinsauxiliary γ subunitsbk channel modulationpeptide sciencemolecular physiologycell physiologyelectrophysiologymembrane biologypeptidesbiochemistryneurotransmissionbiophysical chemistryhyperpolarization (biology)biophysicsca2+-bowl sitesignal transductionmolecular biologycellular physiology

Diversity of Two-Pore Channels and the Accessory Naadp Receptors in Intracellular Ca2+ Signaling. Cell Calcium (2022)

receptorsreceptor (biochemistry)neuronscell physiologycell biologycell signalingaccessory naadp receptorsneurosciencephysiologysignal transductionneurotransmissiontwo-pore channelsintracellular ca2+ signalingcellular physiologymolecular physiology

Lsm12, an Naadp Receptor, is Also a Pi(3,5)P2-Competitive Antagonist of Human Two Pore Channels. Biophysical Journal (2022)

receptorsreceptor (biochemistry)naadp receptorpharmacological researchmechanisms of actionpore channelsg protein-coupled receptorp2-competitive antagonistpharmacologyphysiologysignal transductionneurotransmissionneuropsychopharmacologymolecular physiology

Novel Concatenated Tandem Constructs Reveal 3 Distinct Types of Subunit Stoichiometry in Bk Channel Modulation. Biophysical Journal (2022)

bk channel modulationtandem constructssignal recognitionprotein sciencemolecular cell biologystructural molecular biologyprotein structurebiomolecular structurebiochemistrydistinct typesmolecular biologystructural biologymolecular physiologyhyperpolarization (biology)

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Jiusheng Yan

Assistant Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Pain Medicine

Jiusheng Yan is currently serving as a Pain Medicine Assistant Professor Associate Professor at The University of Texas Md Anderson Cancer Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jiusheng Yan

The University of Texas MD Anderson Cancer Center

Assistant Professor Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Lrrc55 Modulates Bk Channels to Support Purkinje Cell Plasticity and Motor Coordination. bioRxiv (Cold Spring Harbor Laboratory) (2026)

motor coordinationneuronsmotor controlcell biologyneurosciencebk channelsmotor systemspurkinje cell plasticityneurophysiologyneural circuitscellular physiologymolecular physiology

Naadp Elicits Two-Pore Channel Currents by Lifting Lsm12-Mediated Inhibition of Pi(3,5)P 2 Activation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Concatenated Modular Bk Channel Constructs Reveal Divergent Stoichiometry in Gating Control by Lrrc26 (γ1), Pore, and Selectivity Filter. (2025)

selectivity filterchemistrychemical engineering

Spinal α2δ-1 Induces Glua3 Degradation to Regulate Assembly of Calcium-Permeable Ampa Receptors and Pain Hypersensitivity. Journal of Clinical Investigation (2025)

receptorsmolecular neuroscienceneuronscalcium-permeable ampa receptorsneurosciencepain mechanismspinal cordphysiologyneurotransmissionpain hypersensitivitypain researchcellular physiology

Naadp-Evoked Sodium Currents of Two-Pore Channels Mediated by Lsm12 and Pi(3,5)P2. Biophysical Journal (2024)

neuronselectrophysiologyneurosciencephysiologyneurotransmissionnaadp-evoked sodium currentsneurophysiologytwo-pore channelsneuropsychopharmacologyhyperpolarization (biology)

Transmembrane Determinants of Voltage-Gating Differences Between Bk (Slo1) and Slo3 Channels. Biophysical Journal (2024)

membrane transporttransmembrane determinantselectrophysiologyslo3 channelsvoltage-gating differencesmembranesmembrane biologyelectrical engineeringhyperpolarization (biology)

Bk Channel Modulation by Positively Charged Peptides and Auxiliary γ Subunits Mediated by the Ca2+-Bowl Site. The Journal of General Physiology (2023)

Diversity of Two-Pore Channels and the Accessory Naadp Receptors in Intracellular Ca2+ Signaling. Cell Calcium (2022)

Lsm12, an Naadp Receptor, is Also a Pi(3,5)P2-Competitive Antagonist of Human Two Pore Channels. Biophysical Journal (2022)

Novel Concatenated Tandem Constructs Reveal 3 Distinct Types of Subunit Stoichiometry in Bk Channel Modulation. Biophysical Journal (2022)

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5
10 / page