Faculty

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Jingyun Yang

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

Rush University

Jingyun Yang is a High Senior Professor at Rush University. His research integrates human genetics, genomics, and genetic epidemiology to investigate the molecular mechanisms of Alzheimer’s disease and other neurodegenerative conditions. His recent work has identified brain 5-hydroxymethylcytosine alterations linked to Alzheimer’s neuropathology, characterized the APP regulator RHBDL4 as a protective factor in mouse models, and explored associations between pulse rate complexity and cognitive decline. Additional studies examine amyloid beta binding partners, cortical gray matter proteins in cerebral amyloid angiopathy, and causal links between immune-related genes and mouth ulcers. His interdisciplinary collaborations span genome biology, neuroscience of aging, and neurology, advancing translational insights into age-related brain disorders.

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Jingyun Yang

Rush University

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genetics neuroscience human genetics neurology alzheimer's disease genetic epidemiology genomics neuroscience of aging neurodegenerative diseases genetic variants genome-wide association studies molecular neurodegeneration cognitive impairment genome biology medical genetics epidemiology aging-associated diseases heredity molecular diagnostics experimental gerontology disease gene identification neurogenetics geriatrics geriatric neurology brain pathology american indians medicinal research alzheimer ’ ophthalmology retina genetic disorders degenerative pathology imaging genomics older adults oncogenes movement disorders developmental cognitive neuroscience later adulthood genetic analysis genotype-phenotype association retina ocular disease gene-based analysis mendelian randomization analysis scientific data experimental medicine oral health dental disease oral microbiology vascular dementia psychiatric genetics neurochemical biomarkers epigenetic changes experimental ophthalmology motor disorders cognitive decline diabetic retinopathy dna methylation genetic architecture neurorehabilitation metabolic syndrome clinical neurology clinical neuroscience mitochondrial function variant interpretation memory loss brain science brain health oral hygiene sleep disorders somatic variant subcortical brain structures blood metabolome older persons gene ontology alzheimer disease community-dwelling older adults

Notable Scholarly Works

Notable Federal Grants

Collaborators

Amyloid Beta Binding Partners in the Brain Tissue of Older Adults. Alzheimer s & Dementia (2025)

neurologyneuroscience of agingalzheimer's diseasedegenerative pathologymolecular neurodegenerationbrain tissueageingneuroscienceneurodegenerative diseasesbrain pathologycognitive impairmentaging-associated diseasesneurochemical biomarkersamyloid betamolecular neuroscienceolder adults

Brain 5-Hydroxymethylcytosine Alterations Are Associated With Alzheimer’s Disease Neuropathology. Nature Communications (2025)

neurologyalzheimer's diseasemolecular neurodegenerationbrain 5-hydroxymethylcytosine alterationsbrain pathologyneuroscienceneurodegenerative diseasesneuropathology

Causal Association of Immune-Related Genes With Mouth Ulcers: Findings From Summary-Based Mendelian Randomization and Transcriptome-Wide Association Analysis. Immunological Medicine (2025)

epidemiologycausal associationmouth ulcerspathogenesisimmunologydigestive diseasestranscriptome-wide association analysisimmune responsesmolecular diagnosticsmolecular gastroenterologymolecular epidemiologydisease susceptibilityimmune-related gene polymorphismgenetic epidemiologyimmunogenetics

Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults. Neurology (2025)

neurologyneuroscience of agingalzheimer's diseasemolecular neurodegenerationbrain pathologyneuroscienceneurodegenerative diseasescognitive impairmentneuropathologyneuroradiologyvascular cognitive disorderdementiacerebral amyloid angiopathycommunity-dwelling older adults

Genomics of Diffusion-Imaging Integrating Gwas, Exome Data and Single-Cell Sequencing Unravels Lifespan Determinants of Cerebral Small Vessel Disease. Research Square (2025)

Stephanie DebetteYasaman SabaHideaki SuzukiPauline MaillardRick TankardMichelle LucianoIlana CaroNeda JahanshadMarco DueringFrauke BeyerWenjia BaiMartina GlavanQuentin Le GrandAlexander TeumerHervé LemaitreMuralidharan SargurupremrajMarie-Gabrielle DuperronHieab AdamsHugo AparicioKonstantinos ArfanakisNicola J. ArmstrongNick BryanMark BastinAlexa BeiserDavid BennettRavi BhattGuillaume BourqueHenry BrodatySven CichonAmelie CollingIan DearyChristian EnzingerLars ForsbergPiyush GampawarRebecca GottesmanVal borg GudmundsdottirMohamad HabesTsuyoshi HachiyaEdith HoferJustine HsuMohammad IkramM. ImtiazTasfiya IslamJiyang JiangTakahisa KawaguchiKengo KinoshitaMaria KnolAlexandra KochYou KojimaMark LathropSue LeurgansFumihiko MatsudaNaoko MoriThomas MosleyIkuko MotoikeShunji MugikuraIlya NasrallahTalia NirYash PatelJames PrendergastJose RomeroPerminder SachdevClaudia SatizabalMarkus ScholzKevin ShethJean ShinSigurdur SigurdssonAnbupalam ThalamuthuJulian TrollorAmi TsuchidaArno VillringerJoanna WardlawWei WenJingyun YangQiong YangMenglei ZhangAlyssa ZhuThomas MühleisenKaren MatherRon DoZdenka PausovaPhilip De JagerFabrice CrivelloSvenja CaspersVeronica WitteChristophe TzourioHagen TilgnerNenad SestanGennady RoshchupkinTomasi PausSudha SeshadriMyriam FornageCharles DeCarliLenore LaunerHelena SchmidtVilmundur GudnasonPaul MatthewsMonique BretelerAniket Mishra

vascular biologynext-generation sequencinggenomicsmolecular imagingneurodegenerative diseasesfunctional genomicscerebral blood flowmolecular biologyexome datacerebrovascular diseasegene expressionimaging genomicssingle-cell sequencing unravelsdiffusion-imaging integrating gwas

Loss of the App Regulator Rhbdl4 Preserves Memory in an Alzheimer’s Disease Mouse Model. Cell Death and Disease (2025)

neuroscience of agingalzheimer's diseasedegenerative pathologymolecular neurodegenerationmemory losscell biologyneuroscienceneurodegenerative diseasesalzheimer ’cognitive impairmentdisease mouse modelapp regulator rhbdl4

Morphometric Characteristics of Tibial Nerve and Their Relationship With Age. Brain Communications (2025)

gross anatomyanatomyorthopaedic surgeryorthopedic surgeryneuroscienceneuromuscular medicinemorphology (biology)tibial nerveperipheral nerve injuriesperipheral nervebiomechanics

Reduced Complexity of Pulse Rate is Associated With Faster Cognitive Decline in Older Adults. Journal of the American Heart Association (2025)

neuroscience of aginghealthy agingageingneurosciencefaster cognitive declinecognitive impairmentexperimental gerontologyapplied cognitive psychologygeriatricscognitive sciencereduced complexityolder adultsneuropsychologyaging process

0022 Daily Rhythms of Fractal Motor Activity Regulation in Older Adults: Relevance to Prediction of Alzheimer’s Dementia. SLEEP (2024)

neurologycognitive sciencealzheimer's diseaseneuroscience of aginggeriatric neurologyneuroscienceneurodegenerative diseasesalzheimer ’cognitive impairmentexperimental gerontologyaging-associated diseasesdaily rhythmsdementiaolder adults

Altered Motor Activity Patterns Within 10-Minute Timescale Predict Incident Clinical Alzheimer’s Disease. Journal of Alzheimer s Disease (2024)

neurologyalzheimer's diseasegeriatric neurologyneuroscienceneurodegenerative diseasesmotor controlmovement disordersaging-associated diseasesdementianeurorehabilitation

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Jingyun Yang

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

Rush University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jingyun Yang

Rush University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Amyloid Beta Binding Partners in the Brain Tissue of Older Adults. Alzheimer s & Dementia (2025)

Brain 5-Hydroxymethylcytosine Alterations Are Associated With Alzheimer’s Disease Neuropathology. Nature Communications (2025)

neurologyalzheimer's diseasemolecular neurodegenerationbrain 5-hydroxymethylcytosine alterationsbrain pathologyneuroscienceneurodegenerative diseasesneuropathology

Causal Association of Immune-Related Genes With Mouth Ulcers: Findings From Summary-Based Mendelian Randomization and Transcriptome-Wide Association Analysis. Immunological Medicine (2025)

Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults. Neurology (2025)

Genomics of Diffusion-Imaging Integrating Gwas, Exome Data and Single-Cell Sequencing Unravels Lifespan Determinants of Cerebral Small Vessel Disease. Research Square (2025)

Loss of the App Regulator Rhbdl4 Preserves Memory in an Alzheimer’s Disease Mouse Model. Cell Death and Disease (2025)

Morphometric Characteristics of Tibial Nerve and Their Relationship With Age. Brain Communications (2025)

gross anatomyanatomyorthopaedic surgeryorthopedic surgeryneuroscienceneuromuscular medicinemorphology (biology)tibial nerveperipheral nerve injuriesperipheral nervebiomechanics

Reduced Complexity of Pulse Rate is Associated With Faster Cognitive Decline in Older Adults. Journal of the American Heart Association (2025)

0022 Daily Rhythms of Fractal Motor Activity Regulation in Older Adults: Relevance to Prediction of Alzheimer’s Dementia. SLEEP (2024)

Altered Motor Activity Patterns Within 10-Minute Timescale Predict Incident Clinical Alzheimer’s Disease. Journal of Alzheimer s Disease (2024)

neurologyalzheimer's diseasegeriatric neurologyneuroscienceneurodegenerative diseasesmotor controlmovement disordersaging-associated diseasesdementianeurorehabilitation

1
2
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4
5
13
10 / page