Faculty

Institution

Unit

Venue

Jie Chen

Professor Professor of Cell & Developmental Biology

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Cell & Developmental Biology

Jie Chen is currently serving as a College Of Liberal Arts & Sciences Professor Professor of Cell & Developmental Biology at University of Illinois Urbana-Champaign.

Honors

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Experiences

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Education

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Jie Chen

University of Illinois Urbana-Champaign

Professor Professor of Cell & Developmental Biology

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cell biology cell signaling signal transduction molecular physiology molecular cell biology cellular physiology cell metabolism signaling pathways cellular biochemistry molecular and cellular biology skeletal muscle developmental biology molecular regulation cellular differentiation gene expression protein phosphorylation cell regulation molecular biology biological chemistry molecular metabolism systems biology regeneration (biology) developmental cell muscle function metabolic regulation metabolic pathways metabolism protein function insulin signaling mammalian target protein science diabetes research stem cell research molecular pathways tissue development mtor signaling skeletal muscle regeneration cytokines protein synthesis metabolic syndrome musculoskeletal disorders metabolic remodeling muscle regeneration aging cell oncogenes muscle injury cell autophagy receptor tyrosine kinases cell death biomolecular interactions microrna detection rapamycin complex 1 biogerontology non-coding rna small rna cell proliferation single-molecule detection tumor suppressors mtor kinase activity amino acids insulin resistance rapamycin complex 2 gef activity protein assembly single molecule biophysics apoptosis inflammatory diseases mechanisms of action cell migration protein transport mtor pathway skeletal muscle development skeletal muscle differentiation phosphatidic acid nuclear export mtor downstream effectors protein structure

Notable Scholarly Works

Notable Federal Grants

Collaborators

Arhgef3 Coordinates Adipocyte Hypertrophy and Differentiation Through Dual Yap-Rhoa and Pparγ Activation. Journal of Advanced Research (2025)

Sana Abdul KhaliqShi-Young ParkSyeda MahamYoonil ChoMiseon LeeSeungyoon NamJe Kyung SeongJie ChenCheol Soo ChoiMee-Sup Yoon

gene expressionsignal transductionpparγ activationdual yap-rhoacell metabolismmolecular physiologybiochemistrymolecular metabolismmetabolic regulationadipocyte hypertrophycell signalingmetabolic remodelingmetabolismphysiology

Nanodisc Single-Molecule Pulldown to Study Lipid-Protein Interactions. Journal of Lipid Research (2025)

Adriana Reyes-OrdoñezShweta ShreeNilmani SinghStephen G SligarJie Chen

lipid chemistrymembrane biologylipid nanodiscsbiophysicsproteinlipid interactionnanodiscsingle-molecule detectionbiochemistrylipidsmembrane proteinsbiological macromoleculesmembrane sciencenanodisc single-molecule pulldownlipid movementfluorescencecellular biochemistrylipid-protein interactionsmolecular biophysics

Regulation of Rho Guanine Nucleotide Exchange Factor 3 (Arhgef3) by Phosphorylation in the Ph Domain. iScience (2025)

Jesus F MorenoJae-Sung YouCarlos C RodriguezShashank PantAdriana Reyes-OrdoñezReean AbdullahNilmani SinghMaxine J van der DonkEmad TajkhorshidJie Chen

molecular pathwaysmolecular cell biologysignal transductionbiological chemistryrhogef regulationmolecular physiologygef activitymolecular biologycellular physiologycell signalingprotein phosphorylationsignaling pathwaysvitro gefcell biologymolecular and cellular biologymolecular regulationcellular biochemistry

Beyond Protein Synthesis: Non-Translational Functions of Threonyl-Trna Synthetases. Biochemical Society Transactions (2024)

Pallob BaraiJie Chen

molecular cell biologyprotein biosynthesisgene expressionsignal transductioncell metabolismmolecular biologythreonyl-trna synthetasescell signalingcell biologyprotein synthesismolecular regulationbeyond protein synthesismitochondrial biogenesis

Cytokine Expression and Cytokine‐Mediated Cell–Cell Communication During Skeletal Muscle Regeneration Revealed by Integrative Analysis of Single‐Cell Rna Sequencing Data. Journal of Cell Communication and Signaling (2024)

Pallob BaraiJie Chen

cytokinesmolecular cell biologyskeletal musclesingle-cell analysiscytokine expressionintegrative analysiscellular differentiationdevelopmental biologyregenerative medicinecellular therapycell researchcellular physiologystem cell researchtranscriptomecell biologysingle cell sequencingregeneration (biology)skeletal muscle regeneration

Leucyl-Trna Synthetase Contributes to Muscle Weakness Through Mammalian Target of Rapamycin Complex 1 Activation and Autophagy Suppression in a Mouse Model of Duchenne Muscular Dystrophy. American Journal Of Pathology (2024)

Jae-Sung YouKate KaramanAdriana Reyes-OrdoñezSoohyun LeeYongdeok KimRashid BashirJie Chen

molecular cell biologyskeletal muscleprotein synthesisduchenne muscular dystrophymuscular dystrophiesautophagycell autophagyrapamycin complex 1cell metabolismmolecular neurodegenerationmolecular metabolismmolecular biologydegenerative diseasecell biologymolecular and cellular biologyautophagy suppression

Muscle Cell‐Derived Ccl8 is a Negative Regulator of Skeletal Muscle Regeneration. The FASEB Journal (2024)

A. Boss‐KennedyD. KimP. BaraiC. MaldonadoA. Reyes‐OrdoñezJ. Chen

cytokinesskeletal musclemuscle stem cellsimmune responsesinflammationcellular differentiationdevelopmental biologyregenerative medicinecellular physiologycell signalingimmunologystem cell researchcellular therapycell biologymuscle regenerationregeneration (biology)stem cellsskeletal muscle regeneration

Arginyl-Trna Synthetase in Inflammation. Nature Cell Biology (2023)

Jie Chen

arginyl-trna synthetasegene expressioninflammationbiological chemistryanti-inflammatorymolecular metabolismenzyme inhibitionimmunologyinflammatory diseasesprotein synthesistranscription (biology)

Rhoa/Rock Signalling Activated by Arhgef3 Promotes Muscle Weakness via Autophagy in Dystrophic MDX Mice. Journal of Cachexia Sarcopenia and Muscle (2023)

Jae‐Sung YouYongdeok KimSoohyun LeeRashid BashirJie Chen

skeletal musclecellular physiologycytoskeletoncell biologydmd muscle functiondmd pathologycell autophagymolecular physiologymolecular neurodegenerationcellular biochemistrymuscle functionmuscular dystrophiesautophagysignaling pathwaysgef activity‐signal transductioncell signalingmusculoskeletal disordersphysiology

Sex Differences in Skeletal Muscle Size, Function, and Myosin Heavy Chain Isoform Expression During Post‐Injury Regeneration in Mice. Physiological Reports (2023)

Jae‐Sung YouPallob BaraiJie Chen

musculoskeletal disordersanimal physiologyskeletal muscleapplied physiologyskeletal muscle sizemolecular physiologydevelopmental biologycellular physiologymuscle injuryregeneration (biology)sex hormonesregenerative medicinemuscle functionphysiology

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Jie Chen

Professor Professor of Cell & Developmental Biology

University of Illinois Urbana-Champaign

Affiliations

College of Liberal Arts & Sciences

School of Molecular & Cellular Biology

Department of Cell & Developmental Biology

Jie Chen is currently serving as a College Of Liberal Arts & Sciences Professor Professor of Cell & Developmental Biology at University of Illinois Urbana-Champaign.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jie Chen

University of Illinois Urbana-Champaign

Professor Professor of Cell & Developmental Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Arhgef3 Coordinates Adipocyte Hypertrophy and Differentiation Through Dual Yap-Rhoa and Pparγ Activation. Journal of Advanced Research (2025)

Sana Abdul KhaliqShi-Young ParkSyeda MahamYoonil ChoMiseon LeeSeungyoon NamJe Kyung SeongJie ChenCheol Soo ChoiMee-Sup Yoon

Nanodisc Single-Molecule Pulldown to Study Lipid-Protein Interactions. Journal of Lipid Research (2025)

Adriana Reyes-OrdoñezShweta ShreeNilmani SinghStephen G SligarJie Chen

Regulation of Rho Guanine Nucleotide Exchange Factor 3 (Arhgef3) by Phosphorylation in the Ph Domain. iScience (2025)

Jesus F MorenoJae-Sung YouCarlos C RodriguezShashank PantAdriana Reyes-OrdoñezReean AbdullahNilmani SinghMaxine J van der DonkEmad TajkhorshidJie Chen

Beyond Protein Synthesis: Non-Translational Functions of Threonyl-Trna Synthetases. Biochemical Society Transactions (2024)

Pallob BaraiJie Chen

Jae-Sung YouKate KaramanAdriana Reyes-OrdoñezSoohyun LeeYongdeok KimRashid BashirJie Chen

Muscle Cell‐Derived Ccl8 is a Negative Regulator of Skeletal Muscle Regeneration. The FASEB Journal (2024)

A. Boss‐KennedyD. KimP. BaraiC. MaldonadoA. Reyes‐OrdoñezJ. Chen

Arginyl-Trna Synthetase in Inflammation. Nature Cell Biology (2023)

Jie Chen

arginyl-trna synthetasegene expressioninflammationbiological chemistryanti-inflammatorymolecular metabolismenzyme inhibitionimmunologyinflammatory diseasesprotein synthesistranscription (biology)

Rhoa/Rock Signalling Activated by Arhgef3 Promotes Muscle Weakness via Autophagy in Dystrophic MDX Mice. Journal of Cachexia Sarcopenia and Muscle (2023)

Jae‐Sung YouYongdeok KimSoohyun LeeRashid BashirJie Chen

Sex Differences in Skeletal Muscle Size, Function, and Myosin Heavy Chain Isoform Expression During Post‐Injury Regeneration in Mice. Physiological Reports (2023)

Jae‐Sung YouPallob BaraiJie Chen

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cell signaling

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biochemistry

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diabetes mellitus

type 1

Richard A. Cerione

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pharmacological research