Faculty

Institution

Unit

Venue

Jian Gu

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epidemiology

Jian Gu is a Professor at The University of Texas MD Anderson Cancer Center, where his research integrates cancer genetics, genomics, and tumor biology. His work focuses on the genetic susceptibility and molecular mechanisms underlying urological and epithelial malignancies, particularly renal cell carcinoma and breast cancer. Recent investigations have identified genetic variations in the MDM2 gene associated with renal cell carcinoma susceptibility, explored the role of long noncoding RNA MNX1-AS1 in breast tumorigenesis, and utilized spatial transcriptomics to characterize the lung premalignancy-to-adenocarcinoma continuum. His research also addresses resistance mechanisms to PD-(L)1 inhibitors and somatic copy number variations in whole-genome bisulfite sequencing.

Honors

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Jian Gu

The University of Texas MD Anderson Cancer Center

Professor

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cancer research oncology cancer genetics genetics oncogenes pathology tumor biology cancer biology urology molecular cancer cancer risk cancer genomics carcinogenesis cell biology lung cancer cancer cells molecular diagnostics thoracic oncology cancer care human genetics bladder cancer medicinal research genomics cancer treatment cancer discovery genome biology genitourinary cancers esophageal cancer medical genetics gynecologic oncology surgical oncology genome-wide association studies cancer management colorectal cancer microrna detection genetic variants epidemiology of cancer peripheral blood leukocytes respiratory medicine gastrointestinal oncology human polymorphisms cancer prevention prognostic biomarkers epigenomics bladder cancer risk clinical outcomes cell death cellular therapy cancer letter prostatic disease epigenetic changes renal cell carcinoma esophageal adenocarcinoma vascular biology tumor suppressors apoptosis bronchial neoplasm radiation therapy esophagus prognosis lung cancer risk clinical evidence malignant disease radiation biology rna biology platinum-based chemotherapy gastric cancer anti-cancer agents lung cancer patients prognostic significance clinical radiation oncology genetic susceptibility mutagen sensitivity soft tissue sarcoma rare variants mendelian randomization study

Notable Scholarly Works

Notable Federal Grants

Collaborators

454P Global Physician and Patient-Reported Symptom Concordance in Association With Quality of Life in Her2-Negative Advanced Gastric, Gastroesophageal or Esophageal Adenocarcinoma. Annals of Oncology (2025)

global physiciancancer careesophageal adenocarcinomaesophagusclinical gastroenterologygastroenterologysymptom managementquality of lifeclinical epidemiologyoutcomes researchesophageal cancermedicineinternal medicinepatient-reported symptom concordancehealth sciencesoncology

Abstract 5050: Comparative Analysis of Somatic Copy Number Variations and Allelic Imbalance in Whole-Genome Bisulfite Sequencing: Challenges and Insights. Cancer Research (2025)

next-generation sequencingwhole-genome bisulfite sequencingnucleic acidsgenome sequencinggenomicsgenome biologymicrobiologyhigh throughput sequencinggeneticscomparative analysisabstract 5050bioinformaticsgenetic variation

Abstract 759: Spatial Transcriptomics Identifies Unique Tumor and Microenvironment Pathomic Programs That Are Associated With the Lung Premalignancy and Adenocarcinoma Continuum. Cancer Research (2025)

Yibo DaiFuduan PengAnsam SinjabSujuan YangMinyue ChenWarapen TreekitkarnmongkolLorena I. Gomez BolanosTieling ZhouAlejandra G. SerranoJianlong LiaoGuangsheng PeiYunhe LiuYang LiuJiahui JiangKyung Serk ChoYanshuo ChuKai YuRuiping WangJiping FengZahraa RahalGuangchun HanNaoe JimboTakuo HayashiSatsuki KishikawaKazuya TakamochiAkshay BasiAvrum SpiraSteven DubinettTomokazu ItohTakashi YaoKenji SuzukiLuisa M. SolisStephen SwisherMingyao LiJunya FujimotoIgnacio I. WistubaJared BurksKadir AkdemirHind RefaiKaty RezvaniJeffrey MyersHumam KadaraLinghua Wang

microenvironment pathomic programsadenocarcinoma continuumcancer researchlung premalignancytumor microenvironmenttranscriptome

Author Correction: Ctla4 Blockade Abrogates Keap1/Stk11-Related Resistance to Pd-(L)1 Inhibitors. Nature (2025)

Ferdinandos SkoulidisHaniel A. AraujoMinh Truong DoYu QianXin SunAna Galan CoboJohn T. LeMeagan MontesionRachael PalmerNadine JahchanJoseph M. JuanChengyin MinYi YuXuewen PanKathryn C. ArbourNatalie VokesStephanie T. SchmidtDavid MolkentineDwight H. OwenRegan MemmottPradnya D. PatilMelina E. MarmarelisMark M. AwadJoseph C. MurrayJessica A. HellyerJustin F. GainorAnastasios DimouChristine M. BestvinaCatherine A. ShuJonathan W. RiessCollin M. BlakelyChad V. PecotLaura MezquitaFabrizio TabbóMatthias SchefflerSubba DigumarthyMeghan J. MooradianAdrian G. SacherSally C. M. LauAndreas N. SaltosJulia RotowRocio Perez JohnsonCorinne LiuTyler StewartSarah B. GoldbergJonathan KillamZenta WaltherKurt SchalperKurtis D. DaviesMark G. WoodcockValsamo AnagnostouKristen A. MarronePatrick M. FordeBiagio RicciutiDeepti VenkatramanEliezer M. Van AllenAmy L. CummingsJonathan W. GoldmanHiram ShaishMelanie KierSharyn KatzCharu AggarwalYing NiJoseph T. AzokJeremy SegalLauren RitterhouseJoel W. NealLudovic LacroixYasir Y. ElaminMarcelo V. NegraoXiuning LeVincent K. LamWhitney E. LewisHaley N. KempBrett CarterJack A. RothStephen SwisherRichard LeeTeng ZhouAlissa PoteeteYifan KongTomohiro TakeharaAlvaro Guimaraes PaulaEdwin R. Parra CuentasCarmen BehrensIgnacio I. WistubaJianjun ZhangGeorge R. BlumenscheinCarl GayLauren A. ByersDon L. GibbonsAnne TsaoJ. Jack LeeTrever G. BivonaD. Ross CamidgeJhannelle E. GrayNatasha B. LeighlBenjamin LevyJulie R. BrahmerMarina C. Garassino

pharmacologyvascular biologycancer immunotherapynovel therapiesreceptorsradiation oncologymedicinal researchmedicinal chemistrycellular therapytranslational pharmacologysystems biologyfuture medicinal chemistrykey sitedrug resistance analysisnon-pharmacological interventionsauthor correctionmolecular pharmacologyenzyme inhibitiononcology

Genetic Variations in Mdm2 Gene Contribute to Renal Cell Carcinoma Susceptibility: A Genotype–Phenotype Correlation Study. Cancers (2025)

oncogenespathologycancer cellstumor biologykidney cancermdm2 gene contributegenetic variationsmolecular cancergenitourinary cancerscarcinogenesiscancer discoverygenotype–phenotype correlation studyurologycancer genetics

Integrating Multi‐Ancestry Genomic and Proteomic Data to Identify Blood Risk Biomarkers and Target Proteins for Breast Cancer Genetic Risk Loci. International Journal of Cancer (2025)

biomarker discoveryblood risk biomarkersproteome researchmulti‐ancestry genomicproteomic datagenomicsgenome biologycancer discoverygenome-wide association studiesbiomarkerssystems biologyhuman geneticsgenetic epidemiologymultiomicsgenetics

Linkage Disequilibrium Score Regression Identifies Genetic Correlations Between Hepatocellular Carcinoma and Clinically Relevant Traits. International Journal of Cancer (2025)

biostatisticsliver cancergenotype-phenotype associationhepatocellular carcinomahepatologylinkage disequilibriumcancer researchcancer discoverymolecular diagnosticshuman geneticsgenetic epidemiologystatistical geneticsgeneticsrelevant traits

Long Noncoding Rna Mnx1‐As1 Promotes Tumorigenesis of Breast Cancer by Binding Igf2Bp1 to Activate C‐Met. Molecular Carcinogenesis (2025)

oncogenesradiation oncologynon-coding rnatumor biologycancer biologylong non-coding rnacell biologymolecular cancercarcinogenesiscancer researchactivate c‐metcancer cellsbreast cancer

Multi-Ancestry Transcriptome-Wide Association Studies Uncover New Insights Into Breast Cancer Genetics and Biology. medRxiv (2025)

genomicsgenome biologymolecular cancercancer discoverymolecular diagnosticsgenome-wide association studiesgeneticssystems biologyhuman geneticsbreast cancer geneticscancer genomicstranscriptomebreast cancermultiomics

A West African Ancestry‐Associated Snp on 8Q24 Predicts a Positive Biopsy in African American Men With Suspected Prostate Cancer Following Psa Screening. The Prostate (2024)

Jian GuLisly CheryGraciela M. Nogueras GonzálezChad HuffSara StromJeffrey A. JonesDonald P. GriffithSteven E. CanfieldXuemei WangXuelin HuangPamela RobersonQing H. MengPatricia TroncosoMichael IttmannMichael CovinskyMichael ScheurerMargarita Irizarry RamirezCurtis A. Pettaway

early diagnosiscancer screeningsuspected prostate cancerprostate cancerafrican american studiesafrican american menurologypositive biopsy

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Jian Gu

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epidemiology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jian Gu

The University of Texas MD Anderson Cancer Center

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 5050: Comparative Analysis of Somatic Copy Number Variations and Allelic Imbalance in Whole-Genome Bisulfite Sequencing: Challenges and Insights. Cancer Research (2025)

microenvironment pathomic programsadenocarcinoma continuumcancer researchlung premalignancytumor microenvironmenttranscriptome

Author Correction: Ctla4 Blockade Abrogates Keap1/Stk11-Related Resistance to Pd-(L)1 Inhibitors. Nature (2025)

Genetic Variations in Mdm2 Gene Contribute to Renal Cell Carcinoma Susceptibility: A Genotype–Phenotype Correlation Study. Cancers (2025)

Integrating Multi‐Ancestry Genomic and Proteomic Data to Identify Blood Risk Biomarkers and Target Proteins for Breast Cancer Genetic Risk Loci. International Journal of Cancer (2025)

Linkage Disequilibrium Score Regression Identifies Genetic Correlations Between Hepatocellular Carcinoma and Clinically Relevant Traits. International Journal of Cancer (2025)

Long Noncoding Rna Mnx1‐As1 Promotes Tumorigenesis of Breast Cancer by Binding Igf2Bp1 to Activate C‐Met. Molecular Carcinogenesis (2025)

oncogenesradiation oncologynon-coding rnatumor biologycancer biologylong non-coding rnacell biologymolecular cancercarcinogenesiscancer researchactivate c‐metcancer cellsbreast cancer

Multi-Ancestry Transcriptome-Wide Association Studies Uncover New Insights Into Breast Cancer Genetics and Biology. medRxiv (2025)

A West African Ancestry‐Associated Snp on 8Q24 Predicts a Positive Biopsy in African American Men With Suspected Prostate Cancer Following Psa Screening. The Prostate (2024)

early diagnosiscancer screeningsuspected prostate cancerprostate cancerafrican american studiesafrican american menurologypositive biopsy

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