Jiajie Yan

Rush University

Affiliations

Department Of Molecular Biophysics And Physiology

Rush University

NoneJiajie Yan is currently serving as a Molecular Biophysics And Physiology faculty at Rush University.

Honors

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Education

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Jiajie Yan

Rush University

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cardiology cardiovascular research physiology neuroscience pharmacology cell signaling circulatory physiology vascular biology electrophysiology cardiovascular disease cardiovascular physiology stress (biology) molecular biology cardiac pathologies alcohol (drug) membrane biology molecular and cellular biology respiratory medicine cellular physiology molecular physiology alcohol misuse cardiac muscle addiction biology applied physiology enzyme inhibition aging cell alcohol dependence substance use cardiovascular imaging biomedical imaging neuroscience of aging signaling pathways alcohol abuse disease progression late binding aging-associated diseases structural remodeling stress kinase jnk atrial fibrillation aged heart nuclear cardiology echocardiography stress biomarkers cardiovascular function tissue imaging human tissues physiological research cardiac care andrology clinical physiology clinical medicine protein phosphorylation cellular regulatory mechanism cell regulation molecular regulation functional regulation enzyme specificity mitochondrial function protein function human physiology behavioral health behavioral addictions experimental analysis scientific visualization obesity-mediated atrial fibrillation ion channel atrial arrhythmogenesis atrial arrhythmias pro-arrhythmic camkiid expression aged atrium transcriptional regulation disc composition atrioventricular node conduction novel methods gap junction distribution automated quantification

Notable Scholarly Works

Notable Federal Grants

Collaborators

Trpm7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn 2+ Homeostasis. Circulation (2026)

cell deathcell signalingtranslational medicineclinical proteomicscell biologyvascular biologychronic inflammationdisease pathophysiologycardiomyopathyinflammationcellular physiologycardiovascular translational researchmolecular physiologyimmunologyphysiologymyocardial infarctioncardiovascular researchsignal transductionexperimental medicinemolecular medicinecardiovascular disease

Abstract Fri145: Emotional Stress Activated Jnk2 Kinase Drives Atrial Fibrillation Risk With Abnormal Behaviors via Heart-Brain Crosstalk. Circulation Research (2025)

physiologycardiologycardiovascular physiologyelectrophysiologycardiovascular researchcell signalingheart-brain crosstalkcardiomyopathycardiac muscleabnormal behaviorsmolecular psychiatrysignal transductionabstract fri145neurosciencestress (biology)

Abstract Fri155: Cardiac Stress-Activated Kinase Jnk2 Mediates a Heart-Platelet Crosstalk in Driving Platelet Hyperreactivity and Thrombogenesis in Aging. Circulation Research (2025)

physiologydriving platelet hyperreactivityblood plateletpharmacologythrombosisaging cellvascular biologycardiovascular researchvascular agingheart-platelet crosstalkabstract fri155cell biologysignal transductioncirculatory physiologycardiovascular disease

Abstract Wed038: A Novel Role for Akap1 in Jnk2 Trafficking to Endoplasmic Reticulum and Ca 2+ Triggered Arrhythmic Activities. Circulation Research (2025)

cell deathcellular physiologyjnk2 traffickingabstract wed038cell signalingintracellular traffickingmolecular and cellular biologymolecular cell biologymolecular biologymolecular pathwaysnovel rolesignal transductioncellular biochemistrybiochemistrycell biology

Po-05-096 Social Isolation Stress and Alcohol-Evoked Af Risk via a Cardiac Jnk2-Mediated Heart-Brain Crosstalk. Heart Rhythm (2025)

biological psychiatryalcohol (drug)neuropsychologyalcohol misusepsychologymolecular psychiatrystress (biology)neurosciencealcohol dependence

Abstract Mo065: An Anti-Arrhythmic Action and Novel Molecular Mechanisms of Alda-1 in Holiday Heart Syndrome. Circulation Research (2024)

Saugat KhanalJiajie YanYuanyuan CaoNikola RicchiutiAlma NaniWayne ChenMichael FillDan BareXun Ai

mechanobiologycerebral blood flownovel molecular mechanismsbiochemistryheart failurevascular biologycardiomyopathyhealth sciencesmolecular evidencecardiologyholiday heart syndromeanti-arrhythmic actionatherosclerosismetabolic syndromecardiovascular diseaseimmunologycardiovascular researchcongenital heart defectsmedicinal researchcardiac pathologiescardiovascular pharmacology

Abstract Or117: Jnk2-Mediated Gut-Heart Crosstalk in Aging-Associated Af Pathogenesis.. Circulation Research (2024)

Elena CarrilloSaugat KhanalAbigail RichardsonNikola RicchiutiJiajie YanXun Ai

cerebral blood flowneuroscience of agingdisease progressionageingaging-associated diseasesimmune responsesaging-associated af pathogenesisinflammationgut-organ axisoxidative stressaging cellmolecular neurodegenerationphysiologycardiovascular researchgeneticsvascular agingcardiac pathologiesneurosciencecardiovascular disease

Abstract Tu040: A Novel Anti-Thrombotic and Anti-Af Drug Without an Adverse Bleeding Problem. Circulation Research (2024)

Nikola RicchiutiMaxwell NiebrzydowskiAbigail RichardsonJiajie YanXun Ai

pharmacologycardiovascular researchtherapeutic targetsanti-af drugadverse bleeding problem

Abstract Tu074: A Potential Link Between Stress Kinase Jnk2 and Akap-1 in Catecholamine-Induced Acute Heart Failure. Circulation Research (2024)

Aaryan KohliJiajie YanYuanyuan CaoDan BareXun Ai

cardiologyheart failurecardiovascular researchstress (biology)biochemistry

Alda-1 Attenuation of Binge Alcohol-Caused Atrial Arrhythmias Through a Novel Mechanism of Suppressed C-Jun N-Terminal Kinase-2 Activity. Journal of Molecular and Cellular Cardiology (2024)

Jiajie YanSaugat KhanalYuanyuan CaoNikola RicchiutiAlma NaniS.R. Wayne ChenMichael FillDan J. BareXun Ai

physiologycardiologyalcohol (drug)cardiovascular physiologycardiac pathologiesmechanisms of actioncardiovascular researchnovel mechanismmolecular and cellular biologyalcohol misuseaddiction biologymolecular biologymechanobiologysubstance use disorderscirculatory physiologycardiac musclebiochemistry