Jay P. Reddy is an Assistant Professor at The University of Texas MD Anderson Cancer Center. His research focuses on clinical radiation oncology, with specific interests in proton versus photon radiotherapy for oropharyngeal cancer, reirradiation strategies for recurrent head and neck cancer, and the impact of breast radiotherapy on the tumor genome and immune ecosystem. He has recently published a multicentre, randomised phase 3 trial in *The Lancet* comparing proton and photon therapy, alongside work on treatment techniques such as VMAT and 3D-CRT for regional nodal irradiation. His investigations also explore the interplay between radiation and immune checkpoint blockade, contributing to cost-effectiveness analyses of intensity-modulated proton therapy.