Faculty

Institution

Unit

Venue

Jason Yi

Assistant Professor of Neuroscience

Washington University in St. Louis

Affiliations

School of Medicine

Department of Neuroscience

Jason Yi is currently serving as a Neuroscience Assistant Professor of Neuroscience at Washington University In St. Louis.

Honors

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Experiences

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Education

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Jason Yi

Washington University in St. Louis

Assistant Professor of Neuroscience

You can click a keyword to filter the displayed items

neuroscience molecular biology cell biology cell signaling genetics human genetics signal transduction developmental neurobiology gene expression autism membrane biology protein science neurodevelopmental disorders protein function signaling pathways neurophysiology molecular neurodegeneration developmental cognitive neuroscience developmental system cell motility disease gene identification developmental genetics cell regulation specific src-effector complexes neurorehabilitation neuropsychopharmacology molecular physiology plo biology biological chemistry enzyme inhibition molecular cell biology intellectual disability developmental cell spinal cord protein phosphorylation intracellular trafficking brain circuitry protein chemistry sensory science psychiatric genetics catalyst activation molecular regulation cancer genetics cancer genomics biological inorganic chemistry genetic disorders syndromic autism neurochemistry molecular neurobiology cerebral organoids cell manipulation pathway engineering cellular neurobiology brain development synapse function protein turnover monosynaptic tracing olfactory bulb microcircuits activity-induced remodeling living cells endogenous kinase activity photoswitchable inhibitory peptides pd-specific neurodegeneration human striatal glia disease-linked hyperactivating mutations behavioral phenotypes cell-based method functional assessment nervous system development psychiatry autism spectrum disorders synthetic biology molecular psychiatry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Autism and Intellectual Disability Due to a Novel Gain-Of-Function Mutation in Ube3a. Journal of Human Genetics (2025)

novel gain-of-function mutationintellectual disabilityneurogeneticsgeneticssyndromic autismdisease gene identificationmutagenesis (molecular biology technique)molecular geneticsneurodevelopmental disordersdevelopmental biologyhuman geneticsgenetic disordersautism

The Gain-Of-Function Ube3Aq588E Variant Causes Angelman-Like Neurodevelopmental Phenotypes in Mice. Scientific Reports (2025)

developmental systemneurogeneticsgain-of-function ube3aq588emolecular neurosciencemolecular neurobiologydevelopmental geneticscerebral organoidsdevelopmental neurobiologyneurodevelopmental disordersdevelopmental biologyneurosciencedevelopmental cognitive neuroscience

Autism-Linked Ube3A Gain-Of-Function Mutation Causes Interneuron and Behavioral Phenotypes When Inherited Maternally or Paternally in Mice. Cell Reports (2023)

Lei XingJeremy M. SimonTravis S. PtacekJason J. YiLipin LooHanqian MaoJustin M. WolterEric S. McCoySmita R. ParanjapeBonnie Taylor-BlakeMark J. Zylka

behavioral phenotypesdevelopmental geneticsdevelopmental biologybehavioral sciencesautismcell biology

Human Striatal Glia Differentially Contribute to Ad- and Pd-Specific Neurodegeneration. Nature Aging (2023)

Jinbin XuHuifangjie L. FarsadYiran HouKia BarclayBen Anthony LopezShinnosuke YamadaIbrahim Olabayode SaliuYiming ShiWilliam C. KnightRandall J. BatemanTammie L. S. BenzingerJason J. YiQingyun LiTing WangJoel S. PerlmutterJohn C. MorrisGuoyan Zhao

neurologypd-specific neurodegenerationmolecular neurodegenerationneuroscienceneurodegenerative diseaseshuman striatal glia

A Scalable, Cell-Based Method for the Functional Assessment of Em Ube3A /Em Variants. Journal of Visualized Experiments (2022)

Jalin A. StelzerJason J. Yi

cell-based methodfunctional assessmentfunctional genomicscell biology

Ube3A Hyperactivity as a Driver of Neurodevelopmental Disease. The FASEB Journal (2022)

Kellan WestonXiaoyi GaoJinghan ZhaoKwang‐Soo KimJoseph S. HarrisonKuen‐Phon WuJason Yi

developmental neurobiologyneuroscienceneurodevelopmental disordersneurodevelopmental disease

Identification of Disease-Linked Hyperactivating Mutations in Ube3A Through Large-Scale Functional Variant Analysis. Nature Communications (2021)

Kellan P. WestonXiaoyi GaoJinghan ZhaoKwang-Soo KimSusan E. MaloneyJill GotoffSumit ParikhYen-Chen LeuKuen-Phon WuMarwan ShinawiJoshua P. SteimelJoseph S. HarrisonJason J. Yi

genomicscancer geneticsgeneticscancer genomicsdisease gene identificationmolecular biologydisease-linked hyperactivating mutationshuman genetics

The Autism-Linked Ube3A T485A Mutant E3 Ubiquitin Ligase Activates the Wnt/β-Catenin Pathway by Inhibiting the Proteasome. Journal of Biological Chemistry (2017)

Jason J. YiSmita R. ParanjapeMatthew P. WalkerRajarshi ChoudhuryJustin M. WolterGiulia FragolaMichael J. EmanueleMichael B. MajorMark J. Zylka

gene expressionenzyme inhibitionprotein functioncell signalinggeneticsenzymesmolecular biologybiological chemistrypsychiatric geneticsprotein sciencehuman geneticsneuroscienceautism

An Autism-Linked Mutation Disables Phosphorylation Control of Ube3a. Cell (2015)

JY JasonJ BerriosJM NewbernWD SniderBD PhilpotKM Hahn...

human geneticsmolecular biologygeneticscell biology

Dissecting Motility Signaling Through Activation of Specific Src-Effector Complexes. Nature Chemical Biology (2014)

Andrei V KarginovDenis TsygankovMatthew BerginskiPei-Hsuan ChuEvan D TrudeauJason J YiShawn GomezTimothy C ElstonKlaus M Hahn

signaling pathwaysgene expressionprotein functioncell motilitycell signalingmolecular regulationchemical biologymolecular biologyspecific src-effector complexesmembrane biologycatalyst activationsignal transductionneurosciencecell biology

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Jason Yi

Assistant Professor of Neuroscience

Washington University in St. Louis

Affiliations

School of Medicine

Department of Neuroscience

Jason Yi is currently serving as a Neuroscience Assistant Professor of Neuroscience at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jason Yi

Washington University in St. Louis

Assistant Professor of Neuroscience

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Autism and Intellectual Disability Due to a Novel Gain-Of-Function Mutation in Ube3a. Journal of Human Genetics (2025)

The Gain-Of-Function Ube3Aq588E Variant Causes Angelman-Like Neurodevelopmental Phenotypes in Mice. Scientific Reports (2025)

Autism-Linked Ube3A Gain-Of-Function Mutation Causes Interneuron and Behavioral Phenotypes When Inherited Maternally or Paternally in Mice. Cell Reports (2023)

Lei XingJeremy M. SimonTravis S. PtacekJason J. YiLipin LooHanqian MaoJustin M. WolterEric S. McCoySmita R. ParanjapeBonnie Taylor-BlakeMark J. Zylka

behavioral phenotypesdevelopmental geneticsdevelopmental biologybehavioral sciencesautismcell biology

Human Striatal Glia Differentially Contribute to Ad- and Pd-Specific Neurodegeneration. Nature Aging (2023)

neurologypd-specific neurodegenerationmolecular neurodegenerationneuroscienceneurodegenerative diseaseshuman striatal glia

A Scalable, Cell-Based Method for the Functional Assessment of Em Ube3A /Em Variants. Journal of Visualized Experiments (2022)

Jalin A. StelzerJason J. Yi

cell-based methodfunctional assessmentfunctional genomicscell biology

Ube3A Hyperactivity as a Driver of Neurodevelopmental Disease. The FASEB Journal (2022)

Kellan WestonXiaoyi GaoJinghan ZhaoKwang‐Soo KimJoseph S. HarrisonKuen‐Phon WuJason Yi

developmental neurobiologyneuroscienceneurodevelopmental disordersneurodevelopmental disease

Identification of Disease-Linked Hyperactivating Mutations in Ube3A Through Large-Scale Functional Variant Analysis. Nature Communications (2021)

Kellan P. WestonXiaoyi GaoJinghan ZhaoKwang-Soo KimSusan E. MaloneyJill GotoffSumit ParikhYen-Chen LeuKuen-Phon WuMarwan ShinawiJoshua P. SteimelJoseph S. HarrisonJason J. Yi

genomicscancer geneticsgeneticscancer genomicsdisease gene identificationmolecular biologydisease-linked hyperactivating mutationshuman genetics

The Autism-Linked Ube3A T485A Mutant E3 Ubiquitin Ligase Activates the Wnt/β-Catenin Pathway by Inhibiting the Proteasome. Journal of Biological Chemistry (2017)

Jason J. YiSmita R. ParanjapeMatthew P. WalkerRajarshi ChoudhuryJustin M. WolterGiulia FragolaMichael J. EmanueleMichael B. MajorMark J. Zylka

gene expressionenzyme inhibitionprotein functioncell signalinggeneticsenzymesmolecular biologybiological chemistrypsychiatric geneticsprotein sciencehuman geneticsneuroscienceautism

An Autism-Linked Mutation Disables Phosphorylation Control of Ube3a. Cell (2015)

JY JasonJ BerriosJM NewbernWD SniderBD PhilpotKM Hahn...

human geneticsmolecular biologygeneticscell biology

Dissecting Motility Signaling Through Activation of Specific Src-Effector Complexes. Nature Chemical Biology (2014)

Andrei V KarginovDenis TsygankovMatthew BerginskiPei-Hsuan ChuEvan D TrudeauJason J YiShawn GomezTimothy C ElstonKlaus M Hahn

1
2
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Case Western Reserve University

biomedical informatics

translational data science

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Institution

University of California, Davis

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