Faculty

Institution

Unit

Venue

Jason T Huse, M.D., Ph.D.

Professor with Tenure

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Breast Pathology

Department Of Pathology And Genomic Medicine

Department Of Pathology And Translational Molecular Pathology

Department Of Surgical Pathology

The University of Texas MD Anderson Cancer Center

Jason T. Huse, M.D., Ph.D., is a Professor with Tenure at The University of Texas MD Anderson Cancer Center. He integrates cancer genomics, tumor biology, and neuro-oncology to investigate the multilayered transcriptional architecture and longitudinal trajectories of diffuse gliomas, utilizing integrative single-cell and spatial multi-omics to map glioma plasticity and proliferation. His recent 2026 publications extend this work to brain metastasis, exploring CSF microRNA diagnostics, immune dysfunction in renal cell carcinoma brain metastasis, and prognostically significant cellular immunity programs in the microenvironment. A leader in brain tumor research, his work on glioblastoma ecosystems in *Nature Genetics* provides foundational insights into cancer evolution.

Honors

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Experiences

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Education

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Jason T Huse, M.D., Ph.D.

The University of Texas MD Anderson Cancer Center

Professor with Tenure

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brain tumor research neuro-oncology oncology gliomas cancer research tumor biology neurology cancer biology neuroscience cancer genomics molecular biology cancer genetics genetics medicinal research molecular cancer cancer cells cancer treatment oncogenes vascular biology tumor microenvironment cancer care cancer discovery genome biology tumor heterogeneity genomics tumor targeting cancer imaging surgical oncology neuropathology brain pathology cellular therapy molecular neurodegeneration molecular diagnostics tumor suppressors tumoral pathology stem cell research leukemia cancer growth single-cell analysis malignant disease cancer management brain-immune interaction brain metastases cancer immunosurveillance radiation therapy novel therapies disease progression immune checkpoint inhibitors therapeutic efficacy diffuse gliomas cell regulation in vivo systems genitourinary cancers microrna detection oncologic imaging transcription regulation signaling pathways diffuse glioma melanoma brain metastases breast oncology receptor tyrosine kinases magnetic resonance imaging stereotactic radiosurgery liver cancer hepatocellular carcinoma brain cancer recurrent glioblastoma atrx-deficient malignant glioma cancer genome atlas high-grade glioma window-of-opportunity clinical trial integrative genomic analysis molecular classification molecular landscape immune landscape whole exome

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1296: Integrated Single Cell Spatial Multi-Omics Landscape of Who Grades 2-4 Diffuse Gliomas Identifies Locoregional Metabolomic Correlates of Glioma Plasticity and Proliferation.. Cancer Research (2026)

omicsomics integrationgliomasbrain tumor researchsingle-cell analysiscancer genomicsabstract 1296neuro-oncologycancer cellstumor heterogeneitypathologytumor biologyglioma plasticitycell biology

Exploring Csf Microrna Signatures as Diagnostic Biomarkers in Adult-Type Diffuse Gliomas. Non-coding RNA Research (2026)

csf microrna signaturesneurologybiomarkersmicrorna detectiongliomasnon-coding rnabrain tumor researchneuroimmunologymolecular cancermolecular diagnosticsadult-type diffuse gliomasbiomedical analysisneuro-oncologydiagnostic biomarkerspathologycell biology

HYPATIA: Comparative Isoform Profiling Across Cell Populations From Long-Read Single-Cell Transcriptomes. bioRxiv (Cold Spring Harbor Laboratory) (2026)

genomicstranscriptomegenome biologygene expressionomicslong-read sequencingfunctional genomicssingle-cell analysisgeneticscell researchmolecular cell biologymolecular biologysingle cell sequencinglong-read single-cell transcriptomes

Ionizing Radiation Enhances Prognostically Significant Cellular Immunity Programs in the Brain Metastasis Microenvironment. Clinical Cancer Research (2026)

immunologyradiation effectsmetastasisbrain metastasis microenvironmentradiation oncologybrain tumor researchradiation biologycancer immunotherapycancer cellstumor microenvironmentradiationradiation therapycellular therapybrain-immune interaction

Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance. bioRxiv (Cold Spring Harbor Laboratory) (2026)

immunologymetastasisbrain tumor researchcancer immunosurveillancesingle-cell analysiskidney cancercell biology

Advancing Intraoperative Diagnostics, One (or Rather Three) Mutations at a Time. Neuro-Oncology (2025)

surgeryanatomical pathologydiagnosisintraoperative diagnosticshuman pathologymedical diagnosismolecular diagnosticsoncologysurgical pathologypathologymolecular pathologymutation-based testing

A Network-Based Discovery of Prognostic Markers in Recurrent Idh Wild-Type Gliomas. Frontiers in Genetics (2025)

network-based discoverybiomarkersgliomassystems biologybrain tumor researchcancer discoverycancer genomicsmolecular diagnosticsprognostic biomarkersneuro-oncologyprognostic markerspathology

Atrx Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to Tead Inhibition in Soft Tissue Sarcomas. bioRxiv (Cold Spring Harbor Laboratory) (2025)

cancer researchsoft tissue sarcomasnovel therapiestherapeutic targetssarcomatead inhibitioncancer cellscancer biologypathologytumor biologyexperimental medicinetherapeutic vulnerabilitycell biology

Brd7 Loss Reawakens Dormant Metastasis Initiating Cells in Lung by Forging an Immunosuppressive Niche. Nature Communications (2025)

Jayanta MondalJunfeng ZhangFeng QingShunping LiDhiraj KumarJason T. HuseFilippo G. Giancotti

immunologymetastasisimmunosuppressive niche

Cesium-131 Collagen Tile Brachytherapy for Salvage of Recurrent Intracranial Metastases. Journal of Neuro-Oncology (2025)

surgeryneurosurgerymetastasisrecurrent intracranial metastasesradiation oncologybrain tumor researchsurgical oncologyoncologyneuro-oncologyradiation therapyspinal oncology

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Jason T Huse, M.D., Ph.D.

Professor with Tenure

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Breast Pathology

Department Of Pathology And Genomic Medicine

Department Of Pathology And Translational Molecular Pathology

Department Of Surgical Pathology

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jason T Huse, M.D., Ph.D.

The University of Texas MD Anderson Cancer Center

Professor with Tenure

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

omicsomics integrationgliomasbrain tumor researchsingle-cell analysiscancer genomicsabstract 1296neuro-oncologycancer cellstumor heterogeneitypathologytumor biologyglioma plasticitycell biology

Exploring Csf Microrna Signatures as Diagnostic Biomarkers in Adult-Type Diffuse Gliomas. Non-coding RNA Research (2026)

HYPATIA: Comparative Isoform Profiling Across Cell Populations From Long-Read Single-Cell Transcriptomes. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Ionizing Radiation Enhances Prognostically Significant Cellular Immunity Programs in the Brain Metastasis Microenvironment. Clinical Cancer Research (2026)

Single-Cell Atlas of Renal Cell Carcinoma Brain Metastasis Uncovers Mechanisms of Immune Dysfunction and Resistance. bioRxiv (Cold Spring Harbor Laboratory) (2026)

immunologymetastasisbrain tumor researchcancer immunosurveillancesingle-cell analysiskidney cancercell biology

Advancing Intraoperative Diagnostics, One (or Rather Three) Mutations at a Time. Neuro-Oncology (2025)

surgeryanatomical pathologydiagnosisintraoperative diagnosticshuman pathologymedical diagnosismolecular diagnosticsoncologysurgical pathologypathologymolecular pathologymutation-based testing

A Network-Based Discovery of Prognostic Markers in Recurrent Idh Wild-Type Gliomas. Frontiers in Genetics (2025)

network-based discoverybiomarkersgliomassystems biologybrain tumor researchcancer discoverycancer genomicsmolecular diagnosticsprognostic biomarkersneuro-oncologyprognostic markerspathology

Atrx Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to Tead Inhibition in Soft Tissue Sarcomas. bioRxiv (Cold Spring Harbor Laboratory) (2025)

cancer researchsoft tissue sarcomasnovel therapiestherapeutic targetssarcomatead inhibitioncancer cellscancer biologypathologytumor biologyexperimental medicinetherapeutic vulnerabilitycell biology

Brd7 Loss Reawakens Dormant Metastasis Initiating Cells in Lung by Forging an Immunosuppressive Niche. Nature Communications (2025)

Jayanta MondalJunfeng ZhangFeng QingShunping LiDhiraj KumarJason T. HuseFilippo G. Giancotti

immunologymetastasisimmunosuppressive niche

Cesium-131 Collagen Tile Brachytherapy for Salvage of Recurrent Intracranial Metastases. Journal of Neuro-Oncology (2025)

surgeryneurosurgerymetastasisrecurrent intracranial metastasesradiation oncologybrain tumor researchsurgical oncologyoncologyneuro-oncologyradiation therapyspinal oncology

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10 / page