Jason A. Willis

Jason A. Willis is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on colorectal and gastrointestinal oncology, specifically investigating tumor biology, oncogenes, and molecular cancer mechanisms. His recent work includes leading a phase 1b/2 trial of the Nous-209 neoantigen vaccine for cancer prevention in Lynch syndrome carriers, published in Nature Medicine, and examining racial and ethnic disparities in KRAS mutations and survival outcomes in pancreatic adenocarcinoma. He also investigates immunotherapy response in microsatellite instability-high gastrointestinal cancers and ctDNA-defined minimal residual disease in colorectal cancer. His clinical research encompasses phase I and II trials for metastatic pancreatic cancer and anal cancer outcomes by HIV status.