Faculty

Institution

Unit

Venue

Jamie Towle-Weicksel

Associate Professor

Rhode Island College

Affiliations

Faculty of Arts and Sciences

Department of Physical Sciences

Physical Sciences

Jamie Towle-weicksel is currently serving as a Physical Sciences Associate Professor at Rhode Island College.

Honors

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Experiences

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Education

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Jamie Towle-Weicksel

Rhode Island College

Associate Professor

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molecular biology genetics biochemistry cancer genetics nucleic acids biomolecular structure structural molecular biology oncogenes protein structure biological chemistry mutagenesis cancer research biophysical chemistry molecular biophysics breast cancer molecular cancer molecular cell biology cancer cells cancer biology tumor biology genetic variation epigenetics protein science mammalian biology cancer genomics protein expression single molecule biophysics phage biology bacteriophages melanoma somatic variant biomolecular analysis nucleotide selection active site residues single-molecule fret chimeric proteins bacteriophage t7 gp4 arabidopsis thaliana genomic instability biophysics cell research developmental system zoology molecular diagnostics cancer imaging chemical sciences dna sequencing nucleic acid chemistry neuroecology variant interpretation macromolecular machines molecular biological method breast oncology epigenetic changes structure elucidation biochemical genetics dna analysis mismatch conformational pathway low fidelity defective nucleotide release functional changes remote mutations nucleotide-dependent conformational landscape polymerase β-dna complexes dna polymerase activity zebrafish pol-theta dna polymerase protein dynamics protein purification chemistry dna repair

Notable Scholarly Works

Notable Federal Grants

Collaborators

Zebrafish Polymerase Theta and Human Polymerase Theta: Orthologues With Homologous Function. PLoS ONE (2025)

neurogeneticsgeneticsbiologymammalian biologyhuman polymerase thetamolecular geneticszebrafish polymerase thetahomologous functiondevelopmental biology

Melanoma-Derived Dna Polymerase Theta Variants Exhibit Altered Dna Polymerase Activity. Biochemistry (2024)

Corey ThomasLisbeth Avalos-IrvingJorge VictorinoSydney GreenMorgan AndrewsNaisha RodriguesSarah EbirimAyden MuddJamie B. Towle-Weicksel

melanomacancer geneticscancer researchmolecular cancergeneticsgenetic variationenzymesdna polymerase activitymolecular biologytumor biologybiochemistry

Zebrafish Pol-Theta and Human Pol-Theta, Orthologues With Homologous Function. bioRxiv (Cold Spring Harbor Laboratory) (2024)

developmental systemneurogeneticszoologyneuroecologybiologymammalian biologymorphology (biology)zebrafish pol-theta

Figure S3 From Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer–Associated R438W Dna Polymerase Lambda Protein. (2023)

Antonia A. NemecKorie B. BushJamie B. Towle-WeickselB. Frazier TaylorVincent SchulzJoanne B. WeidhaasDavid P. TuckJoann B. Sweasy

gene expressioncancer geneticsmolecular cancermutagenesisgeneticsepigenetic changesmolecular cell biologynucleic acidscancer imagingbreast cancermolecular biologymolecular geneticsoncogenesepigeneticsprotein expressioncancer biologymutagenesis (molecular biology technique)cell biology

Characterizing the Role of Polq Variants in Genomic Instability and Cancer. The FASEB Journal (2020)

genomicscarcinogenesisvariant interpretationcancer geneticssystems biologygeneticspolq variantsmolecular diagnosticssomatic variantoncogenesgenomic instability

Using Single-Molecule Fret to Probe the Nucleotide-Dependent Conformational Landscape of Polymerase β-Dna Complexes. Journal of Biological Chemistry (2020)

biophysical chemistrymolecular biophysicsnucleotide-dependent conformational landscapesingle molecule biophysicsnucleic acid chemistrystructural biologyprotein structurebiomolecular structuremolecular biologystructural molecular biologypolymerase β-dna complexessingle-molecule fretdna replicationprotein sciencebiochemistrynucleic acids

Cancer‐Associated Variants of Polq Induce Genomic Instability. The FASEB Journal (2019)

carcinogenesiscancer geneticsgeneticscancer genomicssomatic variantoncogenesgenomic instability

Dna Polymerase β Fingers Movement Revealed by Single-Molecule Fret Suggests a Partially Closed Conformation as a Fidelity Checkpoint. bioRxiv (Cold Spring Harbor Laboratory) (2018)

molecular biophysicsmacromolecular machinessingle molecule biophysicsclosed conformationtranscription (biology)biomolecular engineeringmolecular biologystructural molecular biologysingle-molecule fretfidelity checkpointbiomolecular structureprotein sciencemolecular biological methodnucleic acids

I260Q Dna Polymerase β Highlights Precatalytic Conformational Rearrangements Critical for Fidelity. Nucleic Acids Research (2018)

Cary LiptakMariam M MahmoudBrian E EckenrothMarcus V MorenoKyle EastKhadijeh S AlnajjarJi HuangJamie B Towle-WeickselSylvie DoubliéJ Patrick LoriaJoann B Sweasy

genomicsgeneticsbiomolecular engineeringnucleic acidsdna sequencingmolecular biologydna repairgenetic engineeringbioinformatics

Defective Nucleotide Release by Dna Polymerase β Mutator Variant E288K is the Basis of Its Low Fidelity. Biochemistry (2017)

Mariam M. MahmoudAllison SchechterKhadijeh S. AlnajjarJi HuangJamie Towle-WeickselBrian E. EckenrothSylvie DoubliéJoann B. Sweasy

low fidelitygeneticsgenetic variationmolecular biologydefective nucleotide releasebiochemistry

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Jamie Towle-Weicksel

Associate Professor

Rhode Island College

Affiliations

Faculty of Arts and Sciences

Department of Physical Sciences

Physical Sciences

Jamie Towle-weicksel is currently serving as a Physical Sciences Associate Professor at Rhode Island College.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Jamie Towle-Weicksel

Rhode Island College

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Zebrafish Polymerase Theta and Human Polymerase Theta: Orthologues With Homologous Function. PLoS ONE (2025)

neurogeneticsgeneticsbiologymammalian biologyhuman polymerase thetamolecular geneticszebrafish polymerase thetahomologous functiondevelopmental biology

Melanoma-Derived Dna Polymerase Theta Variants Exhibit Altered Dna Polymerase Activity. Biochemistry (2024)

Corey ThomasLisbeth Avalos-IrvingJorge VictorinoSydney GreenMorgan AndrewsNaisha RodriguesSarah EbirimAyden MuddJamie B. Towle-Weicksel

melanomacancer geneticscancer researchmolecular cancergeneticsgenetic variationenzymesdna polymerase activitymolecular biologytumor biologybiochemistry

Zebrafish Pol-Theta and Human Pol-Theta, Orthologues With Homologous Function. bioRxiv (Cold Spring Harbor Laboratory) (2024)

developmental systemneurogeneticszoologyneuroecologybiologymammalian biologymorphology (biology)zebrafish pol-theta

Figure S3 From Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer–Associated R438W Dna Polymerase Lambda Protein. (2023)

Antonia A. NemecKorie B. BushJamie B. Towle-WeickselB. Frazier TaylorVincent SchulzJoanne B. WeidhaasDavid P. TuckJoann B. Sweasy

Characterizing the Role of Polq Variants in Genomic Instability and Cancer. The FASEB Journal (2020)

genomicscarcinogenesisvariant interpretationcancer geneticssystems biologygeneticspolq variantsmolecular diagnosticssomatic variantoncogenesgenomic instability

Using Single-Molecule Fret to Probe the Nucleotide-Dependent Conformational Landscape of Polymerase β-Dna Complexes. Journal of Biological Chemistry (2020)

Cancer‐Associated Variants of Polq Induce Genomic Instability. The FASEB Journal (2019)

carcinogenesiscancer geneticsgeneticscancer genomicssomatic variantoncogenesgenomic instability

Dna Polymerase β Fingers Movement Revealed by Single-Molecule Fret Suggests a Partially Closed Conformation as a Fidelity Checkpoint. bioRxiv (Cold Spring Harbor Laboratory) (2018)

I260Q Dna Polymerase β Highlights Precatalytic Conformational Rearrangements Critical for Fidelity. Nucleic Acids Research (2018)

Cary LiptakMariam M MahmoudBrian E EckenrothMarcus V MorenoKyle EastKhadijeh S AlnajjarJi HuangJamie B Towle-WeickselSylvie DoubliéJ Patrick LoriaJoann B Sweasy

genomicsgeneticsbiomolecular engineeringnucleic acidsdna sequencingmolecular biologydna repairgenetic engineeringbioinformatics

Defective Nucleotide Release by Dna Polymerase β Mutator Variant E288K is the Basis of Its Low Fidelity. Biochemistry (2017)

Mariam M. MahmoudAllison SchechterKhadijeh S. AlnajjarJi HuangJamie Towle-WeickselBrian E. EckenrothSylvie DoubliéJoann B. Sweasy

low fidelitygeneticsgenetic variationmolecular biologydefective nucleotide releasebiochemistry

1
2
3
10 / page