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James Stivers

Professor of Pharmacology and Molecular Sciences Professor of Oncology

Johns Hopkins University

Affiliations

School of Medicine

Pharmacology & Molecular Sciences

James Stivers is currently serving as a Pharmacology & Molecular Sciences Professor of Pharmacology and Molecular Sciences Professor of Oncology at Johns Hopkins University.

Honors

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Experiences

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Education

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James Stivers

Johns Hopkins University

Professor of Pharmacology and Molecular Sciences Professor of Oncology

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biochemistry molecular biology enzymes protein science genetics structural biology enzyme inhibition pharmacology dna repair uracil dna glycosylase biological chemistry enzyme catalysis structural molecular biology catalysis epigenetics nucleic acids drug discovery virology medicinal chemistry rna biology virus research genome biology redox biology protein chemistry biochemical sciences biocatalysis molecular catalysis general virology viral genetics molecular science biomolecular structure clinical chemistry fragmentation effect structure-function enzyme kinetics molecular virology genome instability antiviral research dna analysis microbial genetics molecular substrates molecular biotechnology virus-host interactions viral evolution epigenomics molecular research active site residues arylstibonic acids dna glycosylase enzymes peptide science molecular structure catalyst activation yeast antiviral therapy viral pathogenesis molecular microbiology pharmaceutical chemistry epigenetic changes protein genetics biological inorganic chemistry gene editing antiviral drug development inhibitory activity colorectal cancer abasic sites ph dependence dna repair glycosylases dna damage dna translocation n-terminal domain dna binding dna sequencing dna demethylation base sequence effects enzymatic capture extrahelical thymine uracil flipping

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transition Metal Activation Reframes Samhd1 Regulation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

metalloproteinsmolecular biologyredox biologygene expression

Ablating Ung Activity in a Mouse Model Inhibits Colorectal Cancer Growth by Increasing Tumor Immunogenicity. JCI Insight (2025)

immunologycancer growthcancer cellstumor microenvironmentcolorectal cancertumor biologycell biology

Inhibitors of Samhd1 Obtained From Chemical Tethering to the Guanine Antiviral Acyclovir. Biochemistry (2025)

antiviral researchenzyme inhibitionantiviral compoundsantiviral drugschemical biologydrug discoveryantiviral therapyantiviral drug developmentbiochemistry

Ssdna and Ssrna Promote Phase Condensation of Samhd1. Biochemistry (2025)

molecular researchmolecular biologystructural biologyprotein sciencebiochemistry

Archive of Biochemical Data Sets Contained in: Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Samhd1 in Cryo-Em and Binding Studies. Zenodo (CERN European Organization for Nuclear Research) (2023)

Ben OrrisMin Woo SungShridhar BhatKevin HuynhYingrong XuSeungil HanDarren C. JohnsonBosbach BendiktDavid ShieldsJames T. Stivers

genomicsbinding studiesgene expressionbiochemical data setsgeneticsnuclear scienceguanine-containing ssdnamolecular biologyrna biologybiochemistry

Deoxyguanosine-Linked Bifunctional Inhibitor of Samhd1 Dntpase Activity and Nucleic Acid Binding. ACS Chemical Biology (2023)

Matthew EglestonLinghao DongA. Hasan HowladerShridhar BhatBenjamin OrrisMario A. BianchetMarc M. GreenbergJames T. Stivers

medicinal chemistrygene expressionpharmacologyenzyme inhibitionprotein chemistrydeoxyguanosine-linked bifunctional inhibitorclinical chemistrygeneticsmolecular pharmacologyenzymesnucleic acid bindingdrug discoverymolecular biologybiological chemistryrna biology

Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Samhd1 in Cryo-Em and Binding Studies. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Benjamin OrrisMin Woo SungShridhar BhatYingrong XuKevin W. HuynhSeungil HanDarren C. JohnsonBenedikt BosbachDavid J. ShieldsJames T. Stivers

genomicsbinding studiesgene expressiongeneticsguanine-containing ssdnaenzymesmolecular biologyrna biologyprotein sciencebiochemistrymolecular evidence

Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Structural Forms of Samhd1. Nucleic Acids Research (2023)

Benjamin OrrisMin Woo SungShridhar BhatYingrong XuKevin W HuynhSeungil HanDarren C JohnsonBenedikt BosbachDavid J ShieldsJames T Stivers

genomicsgene expressionrna biologynucleic acid chemistrygeneticsguanine-containing ssdnamolecular biologystructural biologytetrameric structural formsnanotechnologybiochemistrynucleic acids

Isolde Model and Validation Statistics to Support: Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Samhd1 in Cryo-Em and Binding Studies. Zenodo (CERN European Organization for Nuclear Research) (2023)

Benjamin OrrisShridhar BhatMin Woo SungKevin HuynhYingrong XuSeungil HanDarren C. JohnsonBenedikt BosbachDavid ShieldsJames T Stivers

genomicsbinding studiespharmacologygeneticsnuclear scienceisolde modelguanine-containing ssdnamolecular biologyrna biologyprotein sciencevalidation statistics

Phosphorylation of Samhd1 Thr592 Increases C-Terminal Domain Dynamics, Tetramer Dissociation and Ssdna Binding Kinetics. Nucleic Acids Research (2022)

Benjamin OrrisKevin W HuynhMark AmmiratiSeungil HanBen BolañosJason CarmodyMatthew D PetroskiBenedikt BosbachDavid J ShieldsJames T Stivers

protein phosphorylationc-terminal domain dynamicsmolecular biologydna repairtetramer dissociationsignal transductionssdna binding kineticsnucleic acids

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James Stivers

Professor of Pharmacology and Molecular Sciences Professor of Oncology

Johns Hopkins University

Affiliations

School of Medicine

Pharmacology & Molecular Sciences

James Stivers is currently serving as a Pharmacology & Molecular Sciences Professor of Pharmacology and Molecular Sciences Professor of Oncology at Johns Hopkins University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

James Stivers

Johns Hopkins University

Professor of Pharmacology and Molecular Sciences Professor of Oncology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transition Metal Activation Reframes Samhd1 Regulation. bioRxiv (Cold Spring Harbor Laboratory) (2026)

metalloproteinsmolecular biologyredox biologygene expression

Ablating Ung Activity in a Mouse Model Inhibits Colorectal Cancer Growth by Increasing Tumor Immunogenicity. JCI Insight (2025)

immunologycancer growthcancer cellstumor microenvironmentcolorectal cancertumor biologycell biology

Inhibitors of Samhd1 Obtained From Chemical Tethering to the Guanine Antiviral Acyclovir. Biochemistry (2025)

antiviral researchenzyme inhibitionantiviral compoundsantiviral drugschemical biologydrug discoveryantiviral therapyantiviral drug developmentbiochemistry

Ssdna and Ssrna Promote Phase Condensation of Samhd1. Biochemistry (2025)

molecular researchmolecular biologystructural biologyprotein sciencebiochemistry

Ben OrrisMin Woo SungShridhar BhatKevin HuynhYingrong XuSeungil HanDarren C. JohnsonBosbach BendiktDavid ShieldsJames T. Stivers

genomicsbinding studiesgene expressionbiochemical data setsgeneticsnuclear scienceguanine-containing ssdnamolecular biologyrna biologybiochemistry

Deoxyguanosine-Linked Bifunctional Inhibitor of Samhd1 Dntpase Activity and Nucleic Acid Binding. ACS Chemical Biology (2023)

Matthew EglestonLinghao DongA. Hasan HowladerShridhar BhatBenjamin OrrisMario A. BianchetMarc M. GreenbergJames T. Stivers

Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Samhd1 in Cryo-Em and Binding Studies. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Benjamin OrrisMin Woo SungShridhar BhatYingrong XuKevin W. HuynhSeungil HanDarren C. JohnsonBenedikt BosbachDavid J. ShieldsJames T. Stivers

genomicsbinding studiesgene expressiongeneticsguanine-containing ssdnaenzymesmolecular biologyrna biologyprotein sciencebiochemistrymolecular evidence

Guanine-Containing Ssdna and Rna Induce Dimeric and Tetrameric Structural Forms of Samhd1. Nucleic Acids Research (2023)

Benjamin OrrisMin Woo SungShridhar BhatYingrong XuKevin W HuynhSeungil HanDarren C JohnsonBenedikt BosbachDavid J ShieldsJames T Stivers

genomicsgene expressionrna biologynucleic acid chemistrygeneticsguanine-containing ssdnamolecular biologystructural biologytetrameric structural formsnanotechnologybiochemistrynucleic acids

Benjamin OrrisShridhar BhatMin Woo SungKevin HuynhYingrong XuSeungil HanDarren C. JohnsonBenedikt BosbachDavid ShieldsJames T Stivers

genomicsbinding studiespharmacologygeneticsnuclear scienceisolde modelguanine-containing ssdnamolecular biologyrna biologyprotein sciencevalidation statistics

Phosphorylation of Samhd1 Thr592 Increases C-Terminal Domain Dynamics, Tetramer Dissociation and Ssdna Binding Kinetics. Nucleic Acids Research (2022)

Benjamin OrrisKevin W HuynhMark AmmiratiSeungil HanBen BolañosJason CarmodyMatthew D PetroskiBenedikt BosbachDavid J ShieldsJames T Stivers

protein phosphorylationc-terminal domain dynamicsmolecular biologydna repairtetramer dissociationsignal transductionssdna binding kineticsnucleic acids

1
2
3
4
5
15
10 / page