Faculty

Institution

Unit

Venue

James McCormick

Professor of Medicine Renal Research Director

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Pediatrics

Department of Medicine

Division of Nephrology & Hypertension

Department Of Pediatrics

Division Of Nephrology

Oregon Health & Science University

James McCormick is a Professor of Medicine and Renal Research Director at Oregon Health & Science University. His research integrates molecular physiology, cell signaling, and pharmacology to elucidate renal pathophysiology, with a focus on hypertension and signal transduction. Recent breakthroughs include identifying renal PIEZO2 as an essential regulator of renin (Cell, 2025) and demonstrating that SGLT2 inhibitors blunt kidney magnesium wasting in cisplatin-induced hypomagnesemia (JASN, 2025). His current work examines NKCC2 phosphorylation via the PKA–DARPP-32–PP1 pathway in hypokalemia, macula densa-specific NOS1 in ischemic acute kidney injury, and ENaC complex assembly across epithelial tissues. He also investigates ovarian hormone modulation of systolic hypertension in elastin haploinsufficient mice.

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James McCormick

Oregon Health & Science University

Professor of Medicine Renal Research Director

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physiology pharmacology nephrology molecular physiology cell biology cell signaling cellular physiology hypertension renal pathophysiology signal transduction renal function endocrinology receptors molecular cell biology vascular biology circulatory physiology membrane biology gene expression endocrine hypertension neuroscience kidney research medicinal research cardiovascular research blood pressure signaling pathways familial hyperkalemic hypertension mammalian biology cell metabolism protein science glucocorticoids protein phosphorylation applied physiology mineral metabolism cell physiology pharmacological research liver physiology hyperpolarization (biology) biological chemistry antihypertensive therapy gene function acute kidney injury osmoregulation molecular pathways cullin 3 distal convoluted tubule thrombosis genetic disorders receptor (biochemistry) enzyme inhibition metabolic regulation energy metabolism veterinary physiology human physiology receptor tyrosine kinases insulin signaling therapeutic efficacy medical genetics protein function osmotic stress cellular pharmacology wnk kinases salt-sensitive hypertension nacl cotransporter activity direct observation multi-omics studies intrinsic impurity distal cell voltage calcineurin inhibitor tacrolimus atypical protein pleiotropic actions variant transcripts early-life events differential regulation calcineurin inhibitor-induced hypertension renal salt transport spak isoform switch

Notable Scholarly Works

Notable Federal Grants

Collaborators

Differential Assembly of Native Enac Complexes Across Mouse Epithelial Tissues. bioRxiv (Cold Spring Harbor Laboratory) (2026)

cytoskeletonmolecular and cellular biologybiological macromoleculescell biologymolecular cell biologycell interactionsmolecular basiscell and molecular biologysignal transductiontissue (biology)molecular biologydifferential assemblymulti-protein assemblycellular physiologycellular biochemistry

Macula Densa-Specific Nos1 Knockout Determines Susceptibility to Ischemic Acute Kidney Injury. Clinical Science (2026)

translational medicineinflammationoxidative stressacute kidney injuryfree radical biologyphysiologycritical carenephrologydisease pathophysiologyrenal pathophysiologymolecular medicine

Ovarian Hormones Moderate Systolic Hypertension in Female Eln Haploinsufficient Mice. American Journal of Physiology-Renal Physiology (2026)

gynecologyfertilitycirculatory physiologyendocrinologyhypertensionblood pressurereproductive medicineovarian hormonesreproductive endocrinologyphysiologypregnancy hypertensionreproductive health

Wcn26-5639 Regulation of Nkcc2 Phosphorylation by Hypokalemia Through the Pka–Darpp-32–Pp1 Pathway in the Renal Medulla. Kidney International Reports (2026)

protein phosphorylationsignaling pathwaysrenal medullacell biologycell signalingwcn26-5639 regulationpka–darpp-32–pp1 pathwayphysiologynephrologysignal transductionrenal pathophysiologycell deathmolecular medicinecellular physiologymolecular physiology

Authors' Reply: Acute Cisplatin Nephrotoxicity, Sodium-Glucose Cotransporter 2 Inhibitors, and Benefits Beyond Magnesium. Journal of the American Society of Nephrology (2025)

urologydrug metabolismmedicinetranslational medicinepharmacological researchacute cisplatin nephrotoxicitypharmacologyapplied pharmacologytherapeutic targetsnephrologymolecular pharmacologytranslational pharmacologyclinical pharmacologybenefits beyond magnesiumpharmacotherapysodium-glucose cotransporter 2medicinal researchrenal function

Dietary Potassium Restriction Reprograms the Distal Convoluted Tubule (Dct) and Induces Proliferative Dct Populations. Physiology (2025)

receptorscell biologycell signalingrenal pathophysiologynutritional biochemistrymolecular physiologydevelopmental biologychronic kidney diseasemetabolismclinical nutritionmineral metabolismdietary potassium restrictionkidney researchphysiologynephrologynutritiondct populationssignal transductioncellular physiology

Effects of Ovariectomy and Elastin Haploinsufficiency on Vasopressin Receptor-Mediated Water Handling by the Kidney. Physiology (2025)

receptorsendocrinologyphysiologynephrologyosmoregulationendocrine hypertensionelastin haploinsufficiency

Empagliflozin Counters Metolazone-Induced Hypomagnesemia and Modifies Renal Ion Transporters and Channels. Journal of the American Society of Nephrology (2025)

chronic kidney diseasemedicinecirculatory physiologyelectrolyte disturbancepharmacologyphysiologynephrologyelectrolyte disordersrenal pathophysiologyclinical biochemistryrenal function

Empagliflozin Modulates the Expression of Renal Ion Transporters and Channels and Partially Reverses Metolazone-Induced Hypomagnesemia. Physiology (2025)

renal functionelectrolyte disturbancepharmacologyphysiologynephrologymolecular pharmacologyelectrolyte disordersrenal ion transportersclinical biochemistrymolecular physiologymetolazone-induced hypomagnesemia

Enhanced Tubuloglomerular Feedback by Specific Deletion of Macula Densa Nos1 Enhances Aki by Activating Inflammatory and Fibrogenic Factors. Journal of the American Society of Nephrology (2025)

enhanced tubuloglomerular feedbacktranslational medicinespecific deletioninflammationcell biologycell signalingimmunologyactivating inflammatorysignal transductionmolecular medicinecellular physiologymolecular physiology

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James McCormick

Professor of Medicine Renal Research Director

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Pediatrics

Department of Medicine

Division of Nephrology & Hypertension

Department Of Pediatrics

Division Of Nephrology

Oregon Health & Science University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

James McCormick

Oregon Health & Science University

Professor of Medicine Renal Research Director

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Differential Assembly of Native Enac Complexes Across Mouse Epithelial Tissues. bioRxiv (Cold Spring Harbor Laboratory) (2026)

Macula Densa-Specific Nos1 Knockout Determines Susceptibility to Ischemic Acute Kidney Injury. Clinical Science (2026)

translational medicineinflammationoxidative stressacute kidney injuryfree radical biologyphysiologycritical carenephrologydisease pathophysiologyrenal pathophysiologymolecular medicine

Ovarian Hormones Moderate Systolic Hypertension in Female Eln Haploinsufficient Mice. American Journal of Physiology-Renal Physiology (2026)

gynecologyfertilitycirculatory physiologyendocrinologyhypertensionblood pressurereproductive medicineovarian hormonesreproductive endocrinologyphysiologypregnancy hypertensionreproductive health

Wcn26-5639 Regulation of Nkcc2 Phosphorylation by Hypokalemia Through the Pka–Darpp-32–Pp1 Pathway in the Renal Medulla. Kidney International Reports (2026)

Authors' Reply: Acute Cisplatin Nephrotoxicity, Sodium-Glucose Cotransporter 2 Inhibitors, and Benefits Beyond Magnesium. Journal of the American Society of Nephrology (2025)

Dietary Potassium Restriction Reprograms the Distal Convoluted Tubule (Dct) and Induces Proliferative Dct Populations. Physiology (2025)

Effects of Ovariectomy and Elastin Haploinsufficiency on Vasopressin Receptor-Mediated Water Handling by the Kidney. Physiology (2025)

receptorsendocrinologyphysiologynephrologyosmoregulationendocrine hypertensionelastin haploinsufficiency

Empagliflozin Counters Metolazone-Induced Hypomagnesemia and Modifies Renal Ion Transporters and Channels. Journal of the American Society of Nephrology (2025)

chronic kidney diseasemedicinecirculatory physiologyelectrolyte disturbancepharmacologyphysiologynephrologyelectrolyte disordersrenal pathophysiologyclinical biochemistryrenal function

Empagliflozin Modulates the Expression of Renal Ion Transporters and Channels and Partially Reverses Metolazone-Induced Hypomagnesemia. Physiology (2025)

Enhanced Tubuloglomerular Feedback by Specific Deletion of Macula Densa Nos1 Enhances Aki by Activating Inflammatory and Fibrogenic Factors. Journal of the American Society of Nephrology (2025)

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10 / page