Faculty

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James J Mahoney

Associate Professor of Psychiatry and Neurobehavioral Sciences

University of Virginia

Affiliations

School of Medicine

Department of Psychiatry and Neurobehavioral Sciences

James J. Mahoney is an Associate Professor of Psychiatry and Neurobehavioral Sciences at the University of Virginia, where he directs the Center for Psychiatric Neuromodulation Research. He earned his PhD from the University of Houston (2014) and a Master's from Pepperdine University (2007). His research focuses on neuromodulation techniques—particularly focused ultrasound—for treating substance use disorders, including opioid and methamphetamine addiction. He has published over 85 peer-reviewed manuscripts and leads clinical trials investigating novel interventions targeting the nucleus accumbens. His recent work explores closed-loop overdose reversal mechanisms and fentanyl-related health outcomes. He serves as principal investigator on NIDA- and NIGMS-funded projects and presents internationally.

Honors

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James J Mahoney

University of Virginia

Associate Professor of Psychiatry and Neurobehavioral Sciences

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pharmacology neuroscience addiction psychiatry neurology neuropharmacology neuropsychology neuropsychopharmacology psychopharmacology depression substance use disorders substance abuse neuropsychiatry addiction medicine mental health biological psychiatry addiction treatment drug treatment clinical neuroscience opioid use disorder ultrasound pharmacotherapy substance use clinical psychiatry cocaine use disorder subjective effects cannabis use substance addiction alcohol dependence addictive behaviors translational psychiatry pharmacokinetics opioid overdose drug assessment methamphetamine-dependent volunteers psychological medicine respiratory medicine experimental medicine addiction biology impulsivity working memory brain stimulation drug safety opioid epidemic deep brain stimulation positive subjective effects tobacco control applied cognitive psychology psychiatric research molecular psychiatry medical ultrasound short-term variability dopamine experimental psychopathology covid-19 pandemic experimental pharmacology psychoactive drugs animal models psychotic symptoms methamphetamine use disorders lifetime stress potential treatment feasibility clinical trial west virginia mental health practitioners methamphetamine-dependent individuals nicotine-dependent volunteers cue-induced craving biomedical imaging neurochemistry brain science clinical pharmacology biomedical research abdominal imaging relapse prevention brain function

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Case Report of Focused Ultrasound Neuromodulation of the Bilateral Nucleus Accumbens for Methamphetamine Use Disorder.. Experimental and Clinical Psychopharmacology (2025)

psychiatryneuropharmacologyneuropsychopharmacologyneurosciencepsychopharmacologyultrasoundpsychopathologypsychiatric researchpsychoactive drugscentral nervous system

Brain Injury During Focused Ultrasound Neuromodulation for Substance Use Disorder. Brain stimulation (2025)

substance use disordersneurologyaddiction biologyneuroscienceultrasoundbrain injuryneuroimaginghead trauma rehabilitation

Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder. Biological Psychiatry (2025)

Ali RezaiDaisy G Y Thompson-LakePierre-François D'HaeseNathalie MeyerManish RanjanDaniel FarmerVictor FinomoreJennifer L MartonSally HodderJeffrey CarpenterAniruddha BhagwatJames BerryPadma TirumalaiGeoffrey AdamsTasneem ArsiwalaOlaf BlankeJames J Mahoney

psychiatrybiological psychiatryultrasound neuromodulationultrasoundopioid use disordernovel treatment

Morbidity, Mortality, and Health Outcomes Following Emergency Department Visits for Fentanyl-Related Overdoses: A Retrospective Cohort Study. Drug and Alcohol Dependence Reports (2025)

substance use disordersforensic toxicologyopioid epidemicemergency department visitsopioid use disorderfentanyl-related overdosesaddiction medicineanesthesiologyretrospective cohort studyaddictionemergency nursingemergency caresubstance abuseopioid overdosedrug overdoseemergency medicinemortality

Neuromodulation as a Therapeutic Approach for Opioid Use Disorder: Mechanisms, Efficacy, and Future Directions. Current Addiction Reports (2025)

substance use disorderspsychiatryneuropharmacologyaddiction medicineaddiction biologyneuropsychopharmacologyneurosciencetherapeutic approachaddictionfuture directionspsychopharmacologyopioid use disorderpain management

Preliminary Findings in the Development of a Closed-Loop, Automated Mechanism for Opioid Overdose Reversal. Drug and Alcohol Dependence (2025)

substance use disordersapplied pharmacologyaddiction medicineanesthesiologysubstance usemedicinesubstance abuseopioid overdosedrug overdoseopioid use disordera closed-loop

Changes in the Clinical Practice of Mental Health Service Providers Throughout the Covid-19 Pandemic: Longitudinal Questionnaire Study. JMIR Formative Research (2024)

Milena GotraKatharine LindbergNicholas JasinskiDavid ScarisbrickShannon ReillyJonathan PerleLiv MillerJames Mahoney Iii

mental healthpublic healthlongitudinal questionnaire studylongitudinal studiescovid-19covid-19 pandemic

Cognitive Outcomes Following Unilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy for Essential Tremor: Findings From Two Cohorts. Brain Communications (2024)

Julie PetersenJosh McGoughGeorgia GopinathNadia ScantleburyRicha TripathiCheryl BrandmeirSilina Z BoshmafNicholas J BrandmeirIsabella J SewellPeter E KonradAgessandro AbrahaoAnn MurrayBenjamin LamManish RanjanClement HamaniJessica FreyCamryn RohringerMelissa McSweeneyJames J MahoneyMichael L SchwartzAli RezaiNir LipsmanDavid M ScarisbrickJennifer S Rabin

cognitive sciencecohort studiesneuroscienceessential tremorcognitive outcomesunilateral magnetic resonance-guidedultrasoundneuroimagingultrasound thalamotomy

First in the World Trial of Low Intensity Focused Ultrasound for Substance Use Disorder. Drug and Alcohol Dependence (2024)

Daisy Thompson-LakeJames MahoneyMarc HautJeffery CarpenterJennifer MartonWanhong ZhengJames BerryManish RanjanPadma TirumalaiAshley MearsPierre D'HaeseVictor FinomoreAli Rezai

substance use disorderslow intensityclinical trialspharmacologyultrasoundworld trialhealth sciences

Neurosurgical Neuromodulation Therapy for Psychiatric Disorders. Neurotherapeutics (2024)

Manish RanjanJames J MahoneyAli R Rezai

neurologyneurosurgical neuromodulation therapy

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James J Mahoney

Associate Professor of Psychiatry and Neurobehavioral Sciences

University of Virginia

Affiliations

School of Medicine

Department of Psychiatry and Neurobehavioral Sciences

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

James J Mahoney

University of Virginia

Associate Professor of Psychiatry and Neurobehavioral Sciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Case Report of Focused Ultrasound Neuromodulation of the Bilateral Nucleus Accumbens for Methamphetamine Use Disorder.. Experimental and Clinical Psychopharmacology (2025)

psychiatryneuropharmacologyneuropsychopharmacologyneurosciencepsychopharmacologyultrasoundpsychopathologypsychiatric researchpsychoactive drugscentral nervous system

Brain Injury During Focused Ultrasound Neuromodulation for Substance Use Disorder. Brain stimulation (2025)

substance use disordersneurologyaddiction biologyneuroscienceultrasoundbrain injuryneuroimaginghead trauma rehabilitation

Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder. Biological Psychiatry (2025)

psychiatrybiological psychiatryultrasound neuromodulationultrasoundopioid use disordernovel treatment

Morbidity, Mortality, and Health Outcomes Following Emergency Department Visits for Fentanyl-Related Overdoses: A Retrospective Cohort Study. Drug and Alcohol Dependence Reports (2025)

Neuromodulation as a Therapeutic Approach for Opioid Use Disorder: Mechanisms, Efficacy, and Future Directions. Current Addiction Reports (2025)

Preliminary Findings in the Development of a Closed-Loop, Automated Mechanism for Opioid Overdose Reversal. Drug and Alcohol Dependence (2025)

substance use disordersapplied pharmacologyaddiction medicineanesthesiologysubstance usemedicinesubstance abuseopioid overdosedrug overdoseopioid use disordera closed-loop

Changes in the Clinical Practice of Mental Health Service Providers Throughout the Covid-19 Pandemic: Longitudinal Questionnaire Study. JMIR Formative Research (2024)

Milena GotraKatharine LindbergNicholas JasinskiDavid ScarisbrickShannon ReillyJonathan PerleLiv MillerJames Mahoney Iii

mental healthpublic healthlongitudinal questionnaire studylongitudinal studiescovid-19covid-19 pandemic

Cognitive Outcomes Following Unilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy for Essential Tremor: Findings From Two Cohorts. Brain Communications (2024)

cognitive sciencecohort studiesneuroscienceessential tremorcognitive outcomesunilateral magnetic resonance-guidedultrasoundneuroimagingultrasound thalamotomy

First in the World Trial of Low Intensity Focused Ultrasound for Substance Use Disorder. Drug and Alcohol Dependence (2024)

Daisy Thompson-LakeJames MahoneyMarc HautJeffery CarpenterJennifer MartonWanhong ZhengJames BerryManish RanjanPadma TirumalaiAshley MearsPierre D'HaeseVictor FinomoreAli Rezai

substance use disorderslow intensityclinical trialspharmacologyultrasoundworld trialhealth sciences

Neurosurgical Neuromodulation Therapy for Psychiatric Disorders. Neurotherapeutics (2024)

Manish RanjanJames J MahoneyAli R Rezai

neurologyneurosurgical neuromodulation therapy

1
2
3
4
5
11
10 / page