Faculty

Institution

Unit

Venue

James R. Groome

Associate Professor

Idaho State University

Affiliations

College of Science and Engineering

Biological Sciences

Biological Sciences/idaho Museum of Natural History

James R. Groome is currently serving as a Biological Sciences Associate Professor at Idaho State University.

Honors

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Experiences

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Education

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James R. Groome

Idaho State University

Associate Professor

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neuroscience pharmacology electrophysiology physiology membrane biology skeletal muscle molecular biology neurophysiology cellular physiology molecular physiology protein science biophysical modeling signal transduction muscle function sodium channels physiological research voltage sensor module neuroanatomy neurogenetics molecular neuroscience gene expression redox biology cellular neurobiology molecular neurobiology cellular biochemistry brain science translational physiology experimental pharmacology neurotransmission neurochemistry differential effects closed-state fast inactivation movement disorders applied physiology physiological measurements enzyme inhibition applied pharmacology analytical toxicology pesticide science regulatory toxicology forensic toxicology marine chemistry toxins brain function human physiology hyperpolarization (biology) experimental toxicology insecticides selective toxicity clinical toxicology endocrine disruptors nicotine membrane transport pharmacokinetics cellular biology toxinology induced resistance intrinsic impurity neuromodulation (medicine) mutagenesis mammalian physiology inhibitory activity mechanisms of action charge transport omega pore hypokalaemic periodic paralysis normokalaemic periodic paralysis transient compartment-like syndrome inactivated states voltage sensor domain ion channels clinical symptoms fast‐inactivation onset muscle nerve 30 channel gating pyrethroid insecticides pathology electrical signaling developmental biology ion channel function

Notable Scholarly Works

Notable Federal Grants

Collaborators

Gating Defects in K1126I, a Putative Hypokalemic Periodic Paralysis Mutation in Hnav1.4. Biophysical Journal (2023)

James R. Groome

biophysicsgene expressionbiophysical modelingneurosciencemolecular biologybiophysical review

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels. Marine Drugs (2023)

James R. Groome

induced resistancepharmacologyhistorical perspectivemedicinal chemistryelectrophysiologytoxinologyneuromodulation (medicine)neuropharmacologyredox biologybiochemistrymedicinal researchvoltage-gated sodium channelstoxicologymarine drugneurochemistryintrinsic impuritymarine biologymolecular biologytoxinsmarine chemistry

Characterizing Gating Defects of Scn2A Countercharge Mutations in Epilepsy Syndromes. Biophysical Journal (2022)

James R. GroomeSarah N. Brockway

biophysicsgeneticsepilepsy syndromesmolecular biophysicsmolecular biology

EDITORIAL: Emerging Perspectives in Sodium Channelopathies. Frontiers in Pharmacology (2022)

J. R. GroomeH. J. RayM. Chahine

medicineneuropharmacologysodium channelopathiespharmacologyneurology

Charge Substitutions at the Voltage-Sensing Module of Domain III Enhance Actions of Site-3 and Site-4 Toxins on an Insect Sodium Channel. Insect Biochemistry and Molecular Biology (2021)

Qing ZhuYuzhe DuYoshiko NomuraRong GaoZixuan CangGuo-Wei WeiDalia GordonMichael GurevitzJames GroomeKe Dong

avian biologyinsect sodium channelinsect biochemistryinsect sciencephysiologyvoltage-sensing moduleentomologycharge substitutions

Markov and Eyring Modeling Predict Differential Contributions of Homologous Mutations in Hypokalemic Periodic Paralysis to Skeletal Muscle Fiber Excitability. Biophysical Journal (2021)

James R. GroomeLandon Bayless-EdwardsLance PortFrank Lehmann-HornKarin Jurkat-Rott

skeletal muscleprotein sciencehypokalemic periodic paralysismuscle functionneurosciencepharmacologybiomechanicsmolecular physiologybiophysical modelingmathematical bioscienceelectrophysiologymolecular biophysicsbioenergeticsmembrane biologymedical biophysicsmathematical biologyhomologous mutationsbiophysicsmolecular scienceexperimental biophysics

Cysteine Mutagenesis to Probe Site-Specific Interactions in the Voltage Sensor Module of Hnav1.4. Biophysical Journal (2020)

James R. GroomeRyann CampLandon Bayless-Edwards

biophysicscell biologyprotein sciencemolecular biophysicsneurosciencesite-specific interactionscysteine mutagenesisvoltage sensor moduleexperimental biophysicsstructural biology

Roles for Countercharge in the Voltage Sensor Domain of Ion Channels. Frontiers in Pharmacology (2020)

James R. GroomeLandon Bayless-Edwards

ion channelsvoltage sensor domainmedicinebioelectronicsneuropharmacologyelectrophysiologyneurosciencepharmacology

Domain I Countercharges Limit Slow Inactivation in Hnav1.4 Sodium Channels. Biophysical Journal (2019)

James R. GroomeAndromeda WheelerRyann Camp

biophysicsslow inactivationphysiology

Ribbon α-Conotoxin Ktm Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors. Marine Drugs (2019)

Leanna A. MarquartMatthew W. TurnerLisa R. WarnerMatthew D. KingJames R. GroomeOwen M. McDougal

receptorsmedicinenicotinic acetylcholine receptorsimmunologypharmacologyinhibitory activity

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James R. Groome

Associate Professor

Idaho State University

Affiliations

College of Science and Engineering

Biological Sciences

Biological Sciences/idaho Museum of Natural History

James R. Groome is currently serving as a Biological Sciences Associate Professor at Idaho State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

James R. Groome

Idaho State University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Gating Defects in K1126I, a Putative Hypokalemic Periodic Paralysis Mutation in Hnav1.4. Biophysical Journal (2023)

James R. Groome

biophysicsgene expressionbiophysical modelingneurosciencemolecular biologybiophysical review

Historical Perspective of the Characterization of Conotoxins Targeting Voltage-Gated Sodium Channels. Marine Drugs (2023)

James R. Groome

Characterizing Gating Defects of Scn2A Countercharge Mutations in Epilepsy Syndromes. Biophysical Journal (2022)

James R. GroomeSarah N. Brockway

biophysicsgeneticsepilepsy syndromesmolecular biophysicsmolecular biology

EDITORIAL: Emerging Perspectives in Sodium Channelopathies. Frontiers in Pharmacology (2022)

J. R. GroomeH. J. RayM. Chahine

medicineneuropharmacologysodium channelopathiespharmacologyneurology

Charge Substitutions at the Voltage-Sensing Module of Domain III Enhance Actions of Site-3 and Site-4 Toxins on an Insect Sodium Channel. Insect Biochemistry and Molecular Biology (2021)

Qing ZhuYuzhe DuYoshiko NomuraRong GaoZixuan CangGuo-Wei WeiDalia GordonMichael GurevitzJames GroomeKe Dong

avian biologyinsect sodium channelinsect biochemistryinsect sciencephysiologyvoltage-sensing moduleentomologycharge substitutions

Markov and Eyring Modeling Predict Differential Contributions of Homologous Mutations in Hypokalemic Periodic Paralysis to Skeletal Muscle Fiber Excitability. Biophysical Journal (2021)

James R. GroomeLandon Bayless-EdwardsLance PortFrank Lehmann-HornKarin Jurkat-Rott

Cysteine Mutagenesis to Probe Site-Specific Interactions in the Voltage Sensor Module of Hnav1.4. Biophysical Journal (2020)

James R. GroomeRyann CampLandon Bayless-Edwards

biophysicscell biologyprotein sciencemolecular biophysicsneurosciencesite-specific interactionscysteine mutagenesisvoltage sensor moduleexperimental biophysicsstructural biology

Roles for Countercharge in the Voltage Sensor Domain of Ion Channels. Frontiers in Pharmacology (2020)

James R. GroomeLandon Bayless-Edwards

ion channelsvoltage sensor domainmedicinebioelectronicsneuropharmacologyelectrophysiologyneurosciencepharmacology

Domain I Countercharges Limit Slow Inactivation in Hnav1.4 Sodium Channels. Biophysical Journal (2019)

James R. GroomeAndromeda WheelerRyann Camp

biophysicsslow inactivationphysiology

Ribbon α-Conotoxin Ktm Exhibits Potent Inhibition of Nicotinic Acetylcholine Receptors. Marine Drugs (2019)

Leanna A. MarquartMatthew W. TurnerLisa R. WarnerMatthew D. KingJames R. GroomeOwen M. McDougal

receptorsmedicinenicotinic acetylcholine receptorsimmunologypharmacologyinhibitory activity

1
2
3
4
5
10 / page

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University of Illinois Chicago

membrane protein

membrane transport

Riccardo Olcese

Institution

University of California, Los Angeles

molecular medicine

laboratory investigation

Gyorgy. Csordas

Institution

Thomas Jefferson University

cardiomyopathy

cardiovascular research

Christopher Ahern

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University of Iowa

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neuroscience

Jingsong Zhou

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physiology

skeletal muscle

Barbara Ehrlich

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neuroscience

electrophysiological evaluation

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Institution

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neurophysiology

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aural augmentation

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