Jack Wiedrick

Oregon Health & Science University

Affiliations

OHSU-PSU School of Public Health

Department Of Biostatistics

Jack Wiedrick is a Senior Professor at Oregon Health & Science University, where his research bridges neuroscience, dermatology, and cardiovascular medicine. His recent work focuses on proteomic and extracellular vesicle miRNA signatures in neurological and systemic disease, including a 2026 eLife study on GPCR-specific vesicle signatures. He has also published extensively on transthyretin amyloid cardiomyopathy and atrial fibrillation outcomes, with multiple 2026 papers in the Journal of the American College of Cardiology and Journal of Cardiac Failure. His interests span Alzheimer’s disease biomarkers, orthopedic surgery, and mammalian biology, reflecting a translational approach to clinical diagnostics.

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Jack Wiedrick

Oregon Health & Science University

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health sciences neuroscience neurology alzheimer's disease dermatology orthopedic surgery proteomics mammalian biology biomarkers microrna detection cerebrospinal fluid neuroimaging regenerative medicine orthopaedic research musculoskeletal disorders molecular neurodegeneration obstetrics and gynaecology experimental medicine respiratory medicine biogerontology microbiome immune responses protein science clinical evidence obstetrics older men human cerebrospinal fluid osteoporotic fractures sport medicine knee surgery bone research human-computer interaction biomarker (medicine) joint replacement musculoskeletal research musculoskeletal surgery bone health human nutrition caesarean section musculoskeletal science neonatology gut microbiome pattern united states neuroradiology clinical proteomics arthritis reproductive immunology healthy aging clinical neuroscience brain imaging arthroscopic techniques orthopedic biomechanics immunogenetics sex differences masculinity fetal medicine rna biology science studies later adulthood prospective cohort studies retrospective cohort studies cohort studies bone density graft rejection bone repair male ms subjects microrna biomarkers concurrent pathology focal cartilage lesions mechanical chondroplasty meta-analytic review testosterone therapy transgender patients fracture risk markers hip bmd loss population-based serum proteomics

Notable Scholarly Works

Notable Federal Grants

Collaborators

26-A-11765-Acc Association Between Atrial Fibrillation or Flutter and Outcomes in Transthyretin Amyloid Cardiomyopathy. Journal of the American College of Cardiology (2026)

cardiologyneurologyheart failurecardiovascular interventionselectrophysiologycardiovascular researchcardiovascular imagingnuclear cardiologyechocardiographymolecular psychiatryalzheimer's diseaseneuroscience of agingneurodegenerative diseasescardiovascular disease

26-A-14018-Acc Characteristics of Patients With Atrial Fibrillation and Transthyretin Amyloid Cardiomyopathy. Journal of the American College of Cardiology (2026)

cardiologyneurologyheart failuremedicinecardiovascular interventionselectrophysiologythrombosiscardiovascular researchcardiovascular imagingchronic diseasesnuclear cardiologyechocardiographycritical carealzheimer's diseaseneuroscience of agingneurodegenerative diseasescardiovascular disease

Author Response: Specific Gpcrs Elicit Unique Extracellular Vesicle Mirna Array Signatures. (2026)

small rnaextracellular microvesiclesmicrorna detectioncell signalingmolecular cell biologymolecular biologysignal transductioncell biology

Author Response: Specific Gpcrs Elicit Unique Extracellular Vesicle Mirna Array Signatures: An Exploratory Study. (2026)

Incidence and Outcomes of Atrial Fibrillation and Systolic Dysfunction in Patients Receiving Mavacamten for Obstructive Hypertrophic Cardiomyopathy: A Multicenter Study. Journal of Cardiac Failure (2026)

cardiologyheart failuremedicinecardiovascular researchcritical carecardiomyopathy

Reviewer #1 (Public Review): Specific Gpcrs Elicit Unique Extracellular Vesicle Mirna Array Signatures: An Exploratory Study. (2026)

Specific Gpcrs Elicit Unique Extracellular Vesicle Mirna Array Signatures. eLife (2026)

small rnaextracellular microvesiclesmicrorna detectioncell signalingmolecular cell biologymolecular biologysignal transductioncell biology

Assessment of a Combined Z-Score of Peak Vo2 and Ve/Vco2Slope in Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology (2025)

Comparison of Multi-Mirna Models From Donor-Matched Plasma and Cerebrospinal Fluid as Candidate Biomarkers for Alzheimer’s Disease Prediction. Scientific Reports (2025)

neurologybiomedical informaticsbiomarkersneuroimaging biomarkerscandidate biomarkersneuroimagingmolecular neurodegenerationneuroscience of agingmulti-mirna modelsdonor-matched plasmaalzheimer's diseaseneuroscienceneurochemical biomarkers

Relationship Between Percent-Predicted Peak Oxygen Consumption and Nyha Class in Men vs Women With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology (2025)