Faculty

Institution

Unit

Venue

Irina Minko

Oregon Health & Science University

Affiliations

Science Education Opportunities

NoneIrina Minko is currently serving as a Science Education Opportunities faculty at Oregon Health & Science University.

Honors

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Experiences

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Education

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Irina Minko

Oregon Health & Science University

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molecular biology biochemistry genetics dna repair enzymes nucleic acids chemical biology mutagenesis (molecular biology technique) biological chemistry enzyme inhibition cell biology mutagenesis toxicology molecular cell biology nucleic acid chemistry gene expression dna replication oligonucleotides genome biology replication protein science in vitro toxicology toxins genome instability cell death experimental toxicology toxicological mechanism replication bypass redox biology biochemical sciences biochemical genetics cellular enzymology enzymatic modification dna analysis sequential action molecular metabolism cell metabolism chemical sciences peptides biomolecular structure biological inorganic chemistry molecular biotechnology molecular basis cancer genetics nucleic acid amplification environmental biotechnology error-free replication uvrabc nuclease mutagenic spectra translesion dna synthesis mutagenic potential dna strand cleavage nucleotide excision repair energy metabolism lipid peroxidation lipid chemistry rna biology yeast cellular biology cancer risk hepatocellular carcinoma cancer biology cancer prevention liver cancer aldehyde dehydrogenase protein expression molecular research host response toxinology neil1 dna glycosylase environmental sources interstrand dna cross-links minor-groove dna adduct dna-protein crosslinks translesion synthesis acrolein-derived dna adduct

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Metal Ion-Dependent Mechanism Promoting Gain of Function in Neil1 Variants. International Journal of Radiation Biology (2026)

receptorsgene expressionmetal ion-dependent mechanismchemical biologymolecular cell biologycell signalingbiological chemistrybiochemistrysignal transductionmolecular biologyneil1 variantsmolecular physiology

Small Molecule Agonists of 8-Oxoguanine Dna Glycosylase, Ogg1. bioRxiv (Cold Spring Harbor Laboratory) (2026)

enzymesnucleic acidschemical biologysmall molecule agonistsbiological chemistrybiochemistryglycobiologyoligonucleotidesmolecular biology

Aflatoxin B1-Induced Dna Adduct Formation in Murine Kidney and Liver. Environmental Toxicology and Pharmacology (2025)

toxicological mechanismmurine kidneyin vitro toxicologycell biologybiochemistrymycotoxin formationtoxinsmolecular medicinemycotoxin researchtoxicology

Aflatoxin B 1 ‐Induced Hepatic Mutagenesis in Mice Expressing Gene‐Edited Neil1. Environmental and Molecular Mutagenesis (2025)

toxicological mechanismmutagenesis (molecular biology technique)drug metabolismliver physiologydrug-induced liver injuryoxidative stressin vitro toxicologycell biologyfree radical biologyhepatotoxicitytoxinsmolecular medicinemycotoxin researchtoxicologyhepatic mutagenesis

Corrigendum to “Role of Neil1 in Genome Maintenance” [Dna Repair 148 (2025) 103820]. DNA repair (2025)

genomic mechanismsgeneticsnucleic acidsgenome instabilitygenomicsdna repairmolecular biologygenome editinggenome biology

Figure S1 From the Distinct Roles of Neil1 and Xpa in Limiting Aflatoxin B Sub 1 /Sub –Induced Mutagenesis in Mice. (2025)

molecular geneticscell biologygene expressionmycotoxin researchtoxicological mechanismmutagenesis (molecular biology technique)limiting aflatoxin bmolecular and cellular biologyknockout miceexperimental toxicologymutagenesismycotoxin formationgeneticsin vitro toxicologymolecular cell biologyfigure s1cell deathtoxicologydistinct rolesmolecular biologytoxins

Role of Neil1 in Genome Maintenance. DNA repair (2025)

genome maintenancegenomic mechanismsgeneticsmolecular geneticsgene expressiondna repairmolecular biologygenome biology

Table S10 From the Distinct Roles of Neil1 and Xpa in Limiting Aflatoxin B 1 –Induced Mutagenesis in Mice. (2025)

toxicological mechanismmutagenesis (molecular biology technique)molecular and cellular biologyin vitro toxicologymolecular cell biologyexperimental toxicologymutagenesismolecular biologymycotoxin formationtoxinscell deathmycotoxin researchtoxicology

Frequencies and Spectra of Aflatoxin B1-Induced Mutations in Liver Genomes of Neil1-Deficient Mice as Revealed by Duplex Sequencing. NAR Molecular Medicine (2024)

Irina G MinkoMichael M LuzadderVladimir L VartanianSean P M RiceMegan M NguyenMonica Sanchez-ContrerasPhu VanScott R KennedyAmanda K McCulloughR Stephen Lloyd

cancer genomicsmutagenesis (molecular biology technique)geneticsduplex sequencinggene expressionhuman geneticsbioinformaticscell biologycomputational genomicsgenomicsmammalian biologymutagenesisgenome biologymolecular biologygenome analysiscancer geneticsliver genomes

Functional Characterization of Single Nucleotide Polymorphic Variants of Dna Repair Enzyme Neil1 in South Asian Populations. DNA repair (2024)

Jamie T. ZuckermanAsia Sage JacksonIrina G. MinkoMelis KantPawel JarugaMichael P. StoneMiral DizdarogluAmanda K. McCulloughR. Stephen Lloyd

geneticsfunctional characterizationmolecular geneticsbiomolecular engineeringpopulation geneticsfunctional genomicspopulation genomicsfunctional modificationdna repairmolecular biologygenetic engineeringgenome biologysouth asian populations

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Irina Minko

Oregon Health & Science University

Affiliations

Science Education Opportunities

NoneIrina Minko is currently serving as a Science Education Opportunities faculty at Oregon Health & Science University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Irina Minko

Oregon Health & Science University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Metal Ion-Dependent Mechanism Promoting Gain of Function in Neil1 Variants. International Journal of Radiation Biology (2026)

Small Molecule Agonists of 8-Oxoguanine Dna Glycosylase, Ogg1. bioRxiv (Cold Spring Harbor Laboratory) (2026)

enzymesnucleic acidschemical biologysmall molecule agonistsbiological chemistrybiochemistryglycobiologyoligonucleotidesmolecular biology

Aflatoxin B1-Induced Dna Adduct Formation in Murine Kidney and Liver. Environmental Toxicology and Pharmacology (2025)

toxicological mechanismmurine kidneyin vitro toxicologycell biologybiochemistrymycotoxin formationtoxinsmolecular medicinemycotoxin researchtoxicology

Aflatoxin B 1 ‐Induced Hepatic Mutagenesis in Mice Expressing Gene‐Edited Neil1. Environmental and Molecular Mutagenesis (2025)

Corrigendum to “Role of Neil1 in Genome Maintenance” [Dna Repair 148 (2025) 103820]. DNA repair (2025)

genomic mechanismsgeneticsnucleic acidsgenome instabilitygenomicsdna repairmolecular biologygenome editinggenome biology

Figure S1 From the Distinct Roles of Neil1 and Xpa in Limiting Aflatoxin B Sub 1 /Sub –Induced Mutagenesis in Mice. (2025)

Role of Neil1 in Genome Maintenance. DNA repair (2025)

genome maintenancegenomic mechanismsgeneticsmolecular geneticsgene expressiondna repairmolecular biologygenome biology

Table S10 From the Distinct Roles of Neil1 and Xpa in Limiting Aflatoxin B 1 –Induced Mutagenesis in Mice. (2025)

Frequencies and Spectra of Aflatoxin B1-Induced Mutations in Liver Genomes of Neil1-Deficient Mice as Revealed by Duplex Sequencing. NAR Molecular Medicine (2024)

Irina G MinkoMichael M LuzadderVladimir L VartanianSean P M RiceMegan M NguyenMonica Sanchez-ContrerasPhu VanScott R KennedyAmanda K McCulloughR Stephen Lloyd

Functional Characterization of Single Nucleotide Polymorphic Variants of Dna Repair Enzyme Neil1 in South Asian Populations. DNA repair (2024)

Jamie T. ZuckermanAsia Sage JacksonIrina G. MinkoMelis KantPawel JarugaMichael P. StoneMiral DizdarogluAmanda K. McCulloughR. Stephen Lloyd

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