Faculty

Institution

Unit

Venue

Hyemin Lee

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Experimental Radiation Oncology

Hyemin Lee is a Senior Professor at The University of Texas MD Anderson Cancer Center. Her research integrates cell biology, tumor biology, and redox biology to investigate cancer metabolism and cell death regulation. Her recent work has focused on ferroptosis and cuproptosis, revealing mechanisms of therapy resistance, including cell cycle arrest-induced lipid droplet formation, IRE1α-mediated glutathione synthesis, and BRCA1-dependent ferroptosis regulation. Her 2025 study in *Cancer Cell* demonstrated that radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome radioresistance. Her findings have identified novel therapeutic vulnerabilities, including GPX4 and PARP co-inhibition in BRCA1-deficient cancers, with implications for improving cancer treatment outcomes.

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Hyemin Lee

The University of Texas MD Anderson Cancer Center

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cell biology tumor biology molecular biology cancer cells biochemistry cancer biology cell metabolism cell signaling cancer research redox biology cell death pharmacology signal transduction oncogenes molecular cancer oxidative stress membrane biology tumor suppressors free radical biology metabolic regulation redox signaling cell regulation metabolism liver physiology cellular physiology molecular metabolism molecular physiology biological chemistry molecular cell biology cancer genetics molecular medicine cancer discovery cellular biochemistry medicinal research cellular biology rna biology long non-coding rna metabolic remodeling signaling pathways dhodh-mediated ferroptosis defence parp co-inhibition reactive oxygen species cell physiology metabolic control non-coding rna cancer prevention cancer risk tumor targeting molecular regulation transcription regulation cancer genomics host factors host specificity energy metabolism lipid peroxidation lipid movement functional regulation stress biomarkers radiation biology radiation therapy radiation effects cellular senescence breast cancer metastasis mtorc1 couples cyst gpx4 protein synthesis targetable metabolic vulnerability disulfide stress cystine transporter regulation energy stress metabolic checkpoint c-myc-mediated energy metabolism metabolic stress response tumor radioresistance cuproptosis inducers calcium-induced ampk activation ferroptosis exposes

Notable Scholarly Works

Notable Federal Grants

Collaborators

Radiotherapy Promotes Cuproptosis and Synergizes With Cuproptosis Inducers to Overcome Tumor Radioresistance. Cancer Cell (2025)

radiation therapyradiation oncologytumor biologyradiation biologycuproptosis inducerscell biologybrain tumor researchcancer researchtumor radioresistanceradiation effectscancer cellsoncology

Brca1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to Gpx4 and Parp Co-Inhibition in Brca1 -Deficient Cancers. Cancer Discovery (2024)

cancer cellstumor biologyparp co-inhibitioncell deathcell signalingcell biologymolecular cancersignaling pathwaysbrca1-mediated dual regulationcancer researchmolecular cell biologytumor suppressorsmolecular biologycancer geneticsferroptosis exposessignal transductioncell regulationcancer biology

Cell Cycle Arrest Induces Lipid Droplet Formation and Confers Ferroptosis Resistance. Nature Communications (2024)

lipidsphysiologycell deathcell signalinglipid peroxidationcell biologycellular physiologybiochemistrycell divisioncell metabolismmembrane biologyoxidative stressfree radical biologylipid movementredox biology

Data From Myc Induces Oncogenic Stress Through Rna Decay and Ribonucleotide Catabolism in Breast Cancer. (2024)

Jitendra K. MeenaJarey H. WangNicholas J. NeillDianne KeoughNagireddy PutluriPanagiotis KatsonisAmanda M. KoireHyemin LeeElizabeth A. BowlingSiddhartha TyagiMayra OrellanaRocio Dominguez-VidañaHeyuan LiKenneth EagleCharles DananHsiang-Ching ChungAndrew D. YangWilliam WuSarah J. KurleyBrian M. HoJoseph R. ZoellerCalla M. OlsonKristen L. MeerbreyOlivier LichtargeArun SreekumarClifford C. DacsoLuke W. GuddatDominik RejmanDana HockováZlatko JanebaLukas M. SimonCharles Y. LinMonica C. PillonThomas F. Westbrook

rna decaymolecular biologybreast cancer

Ire1α Determines Ferroptosis Sensitivity Through Regulation of Glutathione Synthesis. Nature Communications (2024)

enzymesmolecular metabolismferroptosis sensitivityredox signalingbiochemistrybiochemical sciencesmolecular biologybiological chemistrysignal transductionredox biology

Proteomic Analysis of Ferroptosis Pathways Reveals a Role of Cept1 in Suppressing Ferroptosis. Protein & Cell (2024)

Xiaoguang LiuZhen ChenYuelong YanFereshteh ZandkarimiLitong NieQidong LiAmber HorbathKellen OlszewskiLavanya KondiparthiChao MaoHyemin LeeLi ZhuangMasha PoyurovskyBrent R StockwellJunjie ChenBoyi Gan

proteomic analysisproteomicsprotein sciencecell biologyferroptosis pathways

Rewiring Cancer Cell Death: Lpcat1 Shapes Lipid Composition and Ferroptosis Resistance. Cell Death and Differentiation (2024)

lipidscancer cell deathapoptosistumor biologycell deathcell biologyferroptosis resistancebiochemistrycell metabolismcancer researchmetabolic remodelinglipid compositioncancer cellscancer biology

Supplementary Table S1 From Brca1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to Gpx4 and Parp Co-Inhibition in I Brca1 /I -Deficient Cancers. (2024)

supplementary table s1tumor biologyparp co-inhibitioncell deathcell signalingcell biologymolecular cancersignaling pathwaysbrca1-mediated dual regulationmolecular cell biologytumor suppressorscancer geneticsmolecular biologycancer cellscell regulationcancer biology

Data From Ablation of Mir-10B Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. (2023)

breast oncologyoncogenesmetastasispathologytumor biologycancer biologysmall rnareactivates tumor-suppressive pathwayscell biologymolecular cancercarcinogenesistumor suppressorscancer cellsbreast cancer

Data From H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death. (2023)

Yilei ZhangJiejun ShiXiaoguang LiuZhenna XiaoGuang LeiHyemin LeePranavi KoppulaWeijie ChengChao MaoLi ZhuangLi MaWei LiBoyi Gan

epigenetic regulationcancer cellscancer cell deathcancer biologyphysiologycell deathepigeneticscell biologycell metabolismendocrinologygenetics

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Hyemin Lee

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Experimental Radiation Oncology

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Hyemin Lee

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Radiotherapy Promotes Cuproptosis and Synergizes With Cuproptosis Inducers to Overcome Tumor Radioresistance. Cancer Cell (2025)

radiation therapyradiation oncologytumor biologyradiation biologycuproptosis inducerscell biologybrain tumor researchcancer researchtumor radioresistanceradiation effectscancer cellsoncology

Brca1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to Gpx4 and Parp Co-Inhibition in Brca1 -Deficient Cancers. Cancer Discovery (2024)

Cell Cycle Arrest Induces Lipid Droplet Formation and Confers Ferroptosis Resistance. Nature Communications (2024)

Data From Myc Induces Oncogenic Stress Through Rna Decay and Ribonucleotide Catabolism in Breast Cancer. (2024)

rna decaymolecular biologybreast cancer

Ire1α Determines Ferroptosis Sensitivity Through Regulation of Glutathione Synthesis. Nature Communications (2024)

enzymesmolecular metabolismferroptosis sensitivityredox signalingbiochemistrybiochemical sciencesmolecular biologybiological chemistrysignal transductionredox biology

Proteomic Analysis of Ferroptosis Pathways Reveals a Role of Cept1 in Suppressing Ferroptosis. Protein & Cell (2024)

Xiaoguang LiuZhen ChenYuelong YanFereshteh ZandkarimiLitong NieQidong LiAmber HorbathKellen OlszewskiLavanya KondiparthiChao MaoHyemin LeeLi ZhuangMasha PoyurovskyBrent R StockwellJunjie ChenBoyi Gan

proteomic analysisproteomicsprotein sciencecell biologyferroptosis pathways

Rewiring Cancer Cell Death: Lpcat1 Shapes Lipid Composition and Ferroptosis Resistance. Cell Death and Differentiation (2024)

lipidscancer cell deathapoptosistumor biologycell deathcell biologyferroptosis resistancebiochemistrycell metabolismcancer researchmetabolic remodelinglipid compositioncancer cellscancer biology

Supplementary Table S1 From Brca1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to Gpx4 and Parp Co-Inhibition in I Brca1 /I -Deficient Cancers. (2024)

Data From Ablation of Mir-10B Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. (2023)

Data From H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death. (2023)

Yilei ZhangJiejun ShiXiaoguang LiuZhenna XiaoGuang LeiHyemin LeePranavi KoppulaWeijie ChengChao MaoLi ZhuangLi MaWei LiBoyi Gan

epigenetic regulationcancer cellscancer cell deathcancer biologyphysiologycell deathepigeneticscell biologycell metabolismendocrinologygenetics

1
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3
10 / page