Hu, Jian

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Epigenetics And Molecular Carcinogenesis

Dr. Jian Hu is a Senior Professor at The University of Texas MD Anderson Cancer Center, where his research focuses on the tumor microenvironment, immunology, and cell biology of gliomas. His recent work has elucidated the role of the RNA-binding protein QKI in lipid homeostasis and gliomagenesis, and he has demonstrated that STING agonists can reprogram the immune microenvironment to improve survival in preclinical glioblastoma models. He has also investigated novel combinatorial immunotherapies, including Fc-enhanced anti-CTLA-4 and anti-PD-1 agents with ultrasound-mediated blood-brain barrier opening. His awards include a 2025 grant for establishing the tissue distribution of a novel PPAR agonist and a 2017 grant on QKI's role in glioma stem cell self-renewal.

Honors

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Hu, Jian

The University of Texas MD Anderson Cancer Center

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brain tumor research cell biology tumor biology gliomas cancer biology neurology oncology immunology neuro-oncology cancer research cancer cells medicinal research tumor microenvironment oncogenes genetics stem cells molecular cancer stem cell research cancer genetics cancer genomics immunotherapy cellular therapy cancer treatment neuroinflammation vascular biology molecular cell biology tumor heterogeneity tumor suppressors experimental medicine tumor targeting cell regulation glioma stem cells genome biology clinical investigation cell research mammalian biology molecular diagnostics cancer care cellular senescence cell proliferation therapeutic efficacy novel therapies small rna microrna detection genome instability metabolic regulation clinical medicine pancreatic cancer tumor innervation brain-immune interaction tumor evolution terminal differentiation narrative review biological microenvironments genome sequencing genome studies sequence analysis stem cell mobilization myelopoiesis gene function rna biology epigenetic changes treatment development oncogenic agent immunological changes somatic alterations systematic analysis cancer types telomere length multisector exome sequencing metabolic homeostasis passenger deletions therapeutic vulnerabilities epigenetic activation invasive growth stem cell differentiation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6659: Defective Lipid Homeostasis Induced by Qki Loss is a Mutator on Gliomagenesis. Cancer Research (2025)

molecular pathwaysqki losssignal transductiondefective lipid homeostasismolecular medicinebrain tumor researchmolecular neurodegenerationcell metabolismlipid synthesislipidscellular physiologyabstract 6659cell signalinggliomascell biologycellular biochemistryphysiology

DROSHA: A New Tumor Suppressor in Pineoblastoma. Genes & Development (2025)

pathologycancer biologynew tumor suppressorcancer cellsoncogenescancer researchtumor biologycarcinogenesiscell biology

Peroxisomal Integrity in Demyelination-Associated Microglia Enables Cellular Debris Clearance and Myelin Renewal in Mice. Journal of Clinical Investigation (2025)

neurologyinflammationautophagymyelin renewalneuroscienceperoxisomal integritymolecular neurodegenerationbrain-immune interactioncell biologycell deathneurodegenerative diseasesneuroinflammationneuroimmunology

233 Evolutionary Analysis Identifies Early Responsive Macrophage Representing as Anti-Tumor Myeloid Cell in Glioblastoma. Neurosurgery (2024)

Ailiang ZengKristin HuntoonBetty Y.S. KimJian Hu

cancer biologybiologyneurosurgeryresponsive macrophagetumor microenvironmentneuro-oncologybrain tumor researchevolutionary analysis identifiesanti-tumor myeloid celltumor biologyimmunologygliomasmyeloid neoplasia

872 Quaking Modulates Anti-Tumor Immunity by Regulating Antigen Processing and Presentation in Dendritic Cells. Regular and Young Investigator Award Abstracts (2024)

Yating LiJian HuCassian Yee

immunity (medicine)cancer immunotherapycellular immune responsesimmune responsesinflammationimmunomodulationmodulates anti-tumor immunityimmunologyimmunotherapycancer immunosurveillancecell biologyantigen processingmolecular immunologydendritic cells

Fc-Enhanced Anti-Ctla-4, Anti-Pd-1, Doxorubicin, and Ultrasound-Mediated Blood–Brain Barrier Opening: A Novel Combinatorial Immunotherapy Regimen for Gliomas. Neuro-Oncology (2024)

Kwang-Soo KimKarl HabashyAndrew GouldJunfei ZhaoHinda NajemChristina AmideiRuth SagantyVíctor A ArrietaCrismita DmelloLi ChenDaniel Y ZhangBrandyn CastroLeah BillinghamDaniel LeveyOlivia HuberMarilyn MarquesDavid A SavitskyBenjamin M MorinMiguel MuzzioMichael CanneyCraig HorbinskiPeng ZhangJason MiskaSurya PadneyBin ZhangRaul RabadanJoanna J PhillipsNicholas ButowskiAmy B HeimbergerJian HuRoger StuppDhan ChandCatalina Lee-ChangAdam M Sonabend

pharmacologyurologytumor innervationcancer imagingcancer cellsbrain lesiontumor targetingtumor microenvironmentneuro-oncologybrain tumor researchcellular therapyimmunologygliomasimmunotherapyvascular biologyneuroinflammationclinical neurologytherapeutic targets

Hormonal Basis of Brain Fog in Cancer Treatment. The Journal of Experimental Medicine (2024)

brain fogbrain scienceneurosciencebrain tumor researchneuro-oncologyneurophysiology

Mature Microrna-Binding Protein Qki Suppresses Extracellular Microrna Let-7B Release. Journal of Cell Science (2024)

KW MinKM ChoiH MunS KoJW LeeCA SagumMT BedfordYK Kim...

cell biologymolecular and cellular biologycellular biology

Sting Agonist 8803 Reprograms the Immune Microenvironment and Increases Survival in Preclinical Models of Glioblastoma. Journal of Clinical Investigation (2024)

Hinda NajemSpencer T. LeaShashwat TripathiLisa HurleyChao-Hsien ChenIvana WilliamMoloud SooreshjaniMichelle BowieGenevieve HartleyCorey DussoldSebastian PachecoCrismita DmelloCatalina Lee-ChangKathleen McCortneyAlicia SteffensJordain WalshonMartina OttJun WeiAnantha MarisettyIrina BalyasnikovaRoger StuppRimas V. LukasJian HuCharles David JamesCraig M. HorbinskiMaciej S. LesniakDavid M. AshleyWaldemar PriebeLeonidas C. PlataniasMichael A. CurranAmy B. Heimberger

tumor targetingmedicineanti-cancer agentsclinical researchcytokinesneuro-oncologyneurologytumor suppressorsoncologyimmune microenvironmentbrain tumor researchimmunologycancer careclinical investigationcancer immunotherapytumor microenvironmentpreclinical modelsclinical medicinemedicinal researchexperimental medicine

Supplementary Figure 1 From Opening of the Blood–Brain Barrier Using Low-Intensity Pulsed Ultrasound Enhances Responses to Immunotherapy in Preclinical Glioma Models. (2024)

neurologycancer immunotherapycancer imagingpreclinical glioma modelspower ultrasoundtumor microenvironmentultrasound enhances responsesneuro-oncologybrain tumor researchmedical ultrasoundradiation oncologysupplementary figure 1gliomastherapeutic imagingultrasound