Faculty

Institution

Unit

Venue

Hong-Gang Wang, PhD

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Pharmacology

NoneHong-gang Wang, Phd is currently serving as a Pharmacology faculty at Pennsylvania State University.

Honors

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Experiences

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Education

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Hong-Gang Wang, PhD

Pennsylvania State University

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pharmacology cell biology tumor biology molecular biology oncology cancer research cell death cancer biology immunology medicinal research apoptosis membrane biology autophagy cell signaling gene expression cancer cells oncogenes cancer treatment molecular cancer enzyme inhibition cell regulation leukemia hematological malignancies hematology anti-cancer agents signal transduction molecular cell biology protein science cancer genetics tumor targeting acute myeloid leukemia brain tumor research cancer genomics myeloid neoplasia biological chemistry cellular therapy mitochondrial function pharmacotherapy cellular biochemistry cellular biology biomolecular interactions molecular regulation tumor suppressors cellular physiology protein expression drug targeting cell migration cell autophagy signaling pathways protein function mitophagy breast oncology neuroinflammation gene regulation protein phosphorylation immunohistochemical analysis experimental biology disease progression catalyst activation therapeutic efficacy conformational studies protein transport chronic lymphocytic leukemia bax conformational change phagophore closure pivotal role phagophore expansion acid ceramidase cell death machinery virus infection autophagosomal membranes extracellular vesicles bax gene expression hierarchical activation calcineurin dephosphorylation human carcinoma cells

Notable Scholarly Works

Notable Federal Grants

Collaborators

Involvement of P38 Mapk and Mapkapk2 in Promoting Cell Death and the Inflammatory Response to Ischemic Stress Associated With Necrotic Glioblastoma. Cell Death and Disease (2025)

Soo Yeon KimMiaolu TangStephen Y. ChihJessica SallavantiYan GaoZhiqiang QiuHong-Gang WangWei Li

degenerative pathologygliomascell deathimmunologycancer discoverycellular immune responsesvascular biologytumor biologypathogenesischronic inflammationcell biologycellular senescencecancer researchmolecular biologyoxidative stresscancer cellsinflammatory diseasesinflammatory responsenecrotic glioblastomabrain tumor research

Physiological Insights Into Escrt-Mediated Phagophore Closure: Potential Cytoprotective Roles for Atg8Ylated Membranes. Autophagy (2025)

Kouta HamamotoXinwen LiangDavid M. OpozdaHong-Gang WangYoshinori Takahashi

potential cytoprotective rolesautophagyg protein-coupled receptorextracellular microvesiclesescrt-mediated phagophore closurevascular biologyphysiologycell signalingcell biologyphagocytescellular biochemistryendocytic pathwaymembrane proteinscellular physiologyextracellular matrixmembrane systemsprotein sciencephysiological insightsmembrane biologymembranesbiomolecular engineering

Abstract 393: Ras and Pi3K Activation Promote Glioblastoma Progression and Ischemia-Associated Tumor Cell Death. Cancer Research (2024)

Soo Yeon KimMiaolu TangStephen ChihJessica ThorpeTong LuHong-Gang WangWei Li

cancer researchcancer biology

Abstract 5994: Neutrophils Internalized Through Lc3-Associated Phagocytosis Trigger Tumor Ferroptotic Cell Death in Glioblastoma. Cancer Research (2024)

Tong Y. LuPatricia P. YeeStephen Y. ChihDawit G. AregawiMichael J. GlantzBrad E. ZachariaHong-Gang WangWei Li

neurologyradiation oncologytumor targetingtumor biologycancer biologycell deathimmunologymedicinal researchhematological malignanciesbrain tumor researchmolecular cancercancer researchcancer genomicsclinical researchcancer treatmentcancer careoncologyneuro-oncology

Blocking Autophagosome Closure Manifests the Roles of Mammalian Atg8-Family Proteins in Phagophore Formation and Expansion During Nutrient Starvation. Autophagy (2024)

Van BuiXinwen LiangYansheng YeWilliam GiangFang TianYoshinori TakahashiHong-Gang Wang

phagophore formationmammalian biologyautophagymolecular biologyautophagosome closurenutrient starvation

Drp1 Splice Variants Regulate Ovarian Cancer Mitochondrial Dynamics and Tumor Progression. EMBO Reports (2024)

Zaineb JavedDong Hui ShinWeihua PanSierra R WhiteAmal Taher ElhawYeon Soo KimShriya KamlapurkarYa-Yun ChengJ Cory BensonAhmed Emam AbdelnabyRébécca PhaëtonHong-Gang WangShengyu YangMara L G SullivanClaudette M St CroixSimon C WatkinsSteven J MullettStacy L GelhausNam LeeLan G CoffmanKatherine M AirdMohamed TrebakKarthikeyan MythreyeVonn WalterNadine Hempel

tumor biologycancer biologycancer researchtumor progressionmolecular biologyovarian cancergene expressioncancer geneticsgenetics

Identification of Contactin-1 as a Potential Biomarker and Therapeutic Target in Neuroblastoma. Biomedicines (2024)

Christa N. GrantCarson A. WillsXiaoming LiuLonggui ChenZhenqiu LiuHong-Gang Wang

neurosciencecancer discoverytherapeutic targetstumor biologybiomedical researchmolecular biologycancer cellsbiomolecular engineeringoncogenesgene therapymolecular neurodegenerationbiomarker targetpotential biomarkertumor targetingbrain tumor researchneurochemical biomarkerscancer genomicsoncologyneuro-oncology

Identification of Membrane Curvature Sensing Motifs Essential for Vps37A Phagophore Recruitment and Autophagosome Closure. Communications Biology (2024)

Yansheng YeXinwen LiangGuifang WangMaria C. BewleyKouta HamamotoXiaoming LiuJohn M. FlanaganHong-Gang WangYoshinori TakahashiFang Tian

communicationmembrane biologyautophagymembrane curvatureautophagosome closure

Lc3-Associated Phagocytosis of Neutrophils Triggers Tumor Ferroptotic Cell Death in Glioblastoma. The EMBO Journal (2024)

Tong LuPatricia P YeeStephen Y ChihMiaolu TangHan ChenDawit G AregawiMichael J GlantzBrad E ZachariaHong-Gang WangWei Li

ferroptotic cell deathcell deathneutrophils triggersimmunologyneurosciencecellular immune responsestumor biologyhematologyneuroinflammationcancer researchphagocytescancer cellsmedicinal researchcancer biologyneurologyoncologybrain tumor researchhost factorsvenereologyneuro-oncology

Unveiling the Physiological Impact of Escrt-Dependent Autophagosome Closure by Targeting the Vps37A Ubiquitin E2 Variant-Like Domain. Cell Reports (2024)

Kouta HamamotoXinwen LiangAyako ItoMatthew LanzaVan BuiJiawen ZhangDavid M OpozdaTatsuya HattoriLonggui ChenDavid HaddockFumiaki ImamuraHong-Gang WangYoshinori Takahashi

molecular and cellular biologyescrt-dependent autophagosome closurephysiologycell biologycell autophagyautophagymolecular biologyphysiological impact

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Hong-Gang Wang, PhD

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Pharmacology

NoneHong-gang Wang, Phd is currently serving as a Pharmacology faculty at Pennsylvania State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Hong-Gang Wang, PhD

Pennsylvania State University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Involvement of P38 Mapk and Mapkapk2 in Promoting Cell Death and the Inflammatory Response to Ischemic Stress Associated With Necrotic Glioblastoma. Cell Death and Disease (2025)

Soo Yeon KimMiaolu TangStephen Y. ChihJessica SallavantiYan GaoZhiqiang QiuHong-Gang WangWei Li

Physiological Insights Into Escrt-Mediated Phagophore Closure: Potential Cytoprotective Roles for Atg8Ylated Membranes. Autophagy (2025)

Kouta HamamotoXinwen LiangDavid M. OpozdaHong-Gang WangYoshinori Takahashi

Abstract 393: Ras and Pi3K Activation Promote Glioblastoma Progression and Ischemia-Associated Tumor Cell Death. Cancer Research (2024)

Soo Yeon KimMiaolu TangStephen ChihJessica ThorpeTong LuHong-Gang WangWei Li

cancer researchcancer biology

Abstract 5994: Neutrophils Internalized Through Lc3-Associated Phagocytosis Trigger Tumor Ferroptotic Cell Death in Glioblastoma. Cancer Research (2024)

Tong Y. LuPatricia P. YeeStephen Y. ChihDawit G. AregawiMichael J. GlantzBrad E. ZachariaHong-Gang WangWei Li

Blocking Autophagosome Closure Manifests the Roles of Mammalian Atg8-Family Proteins in Phagophore Formation and Expansion During Nutrient Starvation. Autophagy (2024)

Van BuiXinwen LiangYansheng YeWilliam GiangFang TianYoshinori TakahashiHong-Gang Wang

phagophore formationmammalian biologyautophagymolecular biologyautophagosome closurenutrient starvation

Drp1 Splice Variants Regulate Ovarian Cancer Mitochondrial Dynamics and Tumor Progression. EMBO Reports (2024)

tumor biologycancer biologycancer researchtumor progressionmolecular biologyovarian cancergene expressioncancer geneticsgenetics

Identification of Contactin-1 as a Potential Biomarker and Therapeutic Target in Neuroblastoma. Biomedicines (2024)

Christa N. GrantCarson A. WillsXiaoming LiuLonggui ChenZhenqiu LiuHong-Gang Wang

Identification of Membrane Curvature Sensing Motifs Essential for Vps37A Phagophore Recruitment and Autophagosome Closure. Communications Biology (2024)

Yansheng YeXinwen LiangGuifang WangMaria C. BewleyKouta HamamotoXiaoming LiuJohn M. FlanaganHong-Gang WangYoshinori TakahashiFang Tian

communicationmembrane biologyautophagymembrane curvatureautophagosome closure

Lc3-Associated Phagocytosis of Neutrophils Triggers Tumor Ferroptotic Cell Death in Glioblastoma. The EMBO Journal (2024)

Tong LuPatricia P YeeStephen Y ChihMiaolu TangHan ChenDawit G AregawiMichael J GlantzBrad E ZachariaHong-Gang WangWei Li

Unveiling the Physiological Impact of Escrt-Dependent Autophagosome Closure by Targeting the Vps37A Ubiquitin E2 Variant-Like Domain. Cell Reports (2024)

Kouta HamamotoXinwen LiangAyako ItoMatthew LanzaVan BuiJiawen ZhangDavid M OpozdaTatsuya HattoriLonggui ChenDavid HaddockFumiaki ImamuraHong-Gang WangYoshinori Takahashi

molecular and cellular biologyescrt-dependent autophagosome closurephysiologycell biologycell autophagyautophagymolecular biologyphysiological impact

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10 / page

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