Faculty

Institution

Unit

Venue

Paul Hergenrother

Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Paul Hergenrother is currently serving as a College Of Liberal Arts & Sciences Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry at Uiuc.

Honors

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Experiences

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Education

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Paul Hergenrother

UIUC

Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry

You can click a keyword to filter the displayed items

pharmacology therapeutic targets biochemistry anti-cancer agents molecular cancer cancer cells drug discovery tumor biology medicinal research enzyme inhibition medicinal chemistry radiation oncology cancer research oncogenes microbiology cancer discovery cell death antimicrobial agents cancer biology cancer treatment antimicrobial resistance biological chemistry antibiotics natural product research small molecules biomolecules pharmaceutical chemistry apoptosis tumor targeting antibacterial agents natural product synthesis antimicrobial compounds drug targeting structural molecular biology pharmacological research antimicrobial susceptibility chemoprevention strategies nucleic acids clinical microbiology antimicrobial chemotherapy antibiotic resistance drug development synthetic chemistry enzyme catalysis cell culture toxins escherichia coli glycosylation antimicrobial resistance genes rna biology structure-function enzyme kinetics nucleic acid chemistry enzymatic modification enantioselective synthesis rna structure prediction protein synthesis analytical biotechnology cellular enzymology enzyme specificity total synthesis small rna carbohydrate-protein interactions active site diverse compounds procaspase-activating compound 1 rna hairpin loops kinetic parameters phosphatidylcholine-preferring phospholipase c ring distortion lactate dehydrogenase warburg effect melanoma cells substrate specificity pet dogs unfolded protein response fusidic acid organic chemistry synthetic organic chemistry future medicinal chemistry enzyme inhibitors biomolecular engineering chemical synthesis antibacterial compounds

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4326: Krb-456: A Novel Kras G12D Switch-I/II Allosteric Pocket Binder That Thwarts Pancreatic Cancer Patient-Derived Tumors. Cancer Research (2025)

Aslamuzzaman KaziAlok RanjanVasanth M. KumarBogos AgianianMartin Garcia ChavezVignesh VudathaRui WangRajani Kanth VangipurapuLiwei ChenPerry KennedyKarthikeyan SubramanianQuirke Jonathan Charles KennethFrancisca BeatoPatrick W. UnderwoodJason B. FlemingPaul HergenrotherJose TrevinoEvripidis GavathiotisSaid M. Sebti

kras g12dtumor targetingcancer researchmolecular cancercancer discoverytherapeutic targetsbiomolecular engineeringdrug discoveryoncogenescancer cellstumor microenvironmentmedicinal researchcancer biologytumor biologyabstract 4326kras boundcell biology

Abstract 5626: Exploring a New Therapeutic Strategy Through Hyperactivation of the Unfolded Protein Response Pathway in Bone Cancer Treatment. Cancer Research (2025)

Yoongyeong LeeMichael MulliganBrooke BouwensJenny DrnevichKeith BaileyMichael SpinellaDavid ShapiroPaul HergenrotherTimothy Fan

metastasisradiation oncologytrpm4 expressiontherapeutic targetsoncologybreast canceroncogenescancer cellscancer treatmentestrogen receptor alphacancer biologytumor biologybone researchbone cancer cellscell biology

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

immunologycell deathendocrine-related cancersnecrosis inducergynecologic oncologyovarian hormonespatient ascites organoidsapoptosismouse xenograftscancer cellsgynecologytumor biologyovarian cancerinflammation

Comparative Oncology in Action: Vignettes on Small Molecule Development. Veterinary oncology. (2025)

Amy LeBlancChristina MazckoCheryl LondonPaul J. HergenrotherTimothy M. Fan

small molecule developmentsmall moleculesradiation oncologycancer researchmalignant diseasecancer discoverycancer growthoncologymolecular baseoncogenescancer cellstumor biology

Fluorescent Substrates for Poly(Adp-Ribosyl) Hydrolases. U.S. Patent No. 12235275 (2025)

Paul Hergenrother

enzymesbiocatalysisfluorescenceenzyme catalysisenzymatic modificationbiomoleculesfluorescent substratesbiopolymersbiochemistry

Identification of a Selective Anticancer Agent From a Collection of Complex-And-Diverse Compounds Synthesized From Stevioside. Journal of the American Chemical Society (2025)

Rachel E. SchaafJonathan C. K. QuirkeMaryam GhavamiEmily J. TonogaiHyang Yeon LeeSamantha L. BarlockThomas R. TrzupekKyle R. AboMatthew G. ReesMelissa M. RonanJennifer A. RothPaul J. Hergenrother

medicinal chemistrypharmaceutical chemistrychemoprevention strategiesbiochemistrytumor targetingmolecular cancerchemical biologyanti-cancer agentsgpx4 inhibitionstevix4 actsbioactive compoundsdrug targetingpharmacologycancer discoverybiomolecular engineeringdrug discoverymedicinal researchcancer cellsnatural product research

Pac-1 Synergizes With Sunitinib to Enhance Cell Death in Pancreatic Neuroendocrine Tumors. ACS Pharmacology & Translational Science (2025)

Hyang Yeon LeeMyung Ryul LeeTimothy M. FanPaul J. Hergenrother

cell deathcell culturecell autophagyradiation oncologytherapeutic targetspnet cell deathpac-1 synergizesoncogenescancer cellsautophagycancer biologytumor biologycell biology

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

estrogen receptor αendocrine-related cancerspharmacologyradiation oncologytherapeutic targetsanti-cancer agentsoncologybreast canceroncogenescancer cellscancer treatmentsingle dosetumor biologybreast oncology

Substituted Imidazo[5,1-D][1,2,3,5]Tetrazines for the Treatment of Cancer. U.S. Patent No. 12234240 (2025)

Paul Hergenrother

medicinal chemistrypharmacologypharmacotherapytherapeutic targetsanti-cancer agentsdrug discovery

Understanding Compound Efflux From Gram-Negative Bacteria, a Final Frontier for Antibiotic Discovery. Microbial Drug Resistance (2025)

Rebecca J. UlrichPaul J. Hergenrother

antimicrobial agentsantimicrobial resistanceantibiotic resistanceantimicrobial compoundsclinical microbiologyantimicrobial susceptibilitydrug resistanceantibioticsantibacterial agentsdrug discoveryinfectious diseasesmachine learningmicrobiologygram-negative bacteriacompound efflux

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Paul Hergenrother

Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Chemistry

School of Chemical Sciences

Department of Chemistry

Paul Hergenrother is currently serving as a College Of Liberal Arts & Sciences Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Paul Hergenrother

UIUC

Kenneth L Rinehart Jr Endowed Chair in Natural Products Chemistry and Professor of Chemistry

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4326: Krb-456: A Novel Kras G12D Switch-I/II Allosteric Pocket Binder That Thwarts Pancreatic Cancer Patient-Derived Tumors. Cancer Research (2025)

Abstract 5626: Exploring a New Therapeutic Strategy Through Hyperactivation of the Unfolded Protein Response Pathway in Bone Cancer Treatment. Cancer Research (2025)

Yoongyeong LeeMichael MulliganBrooke BouwensJenny DrnevichKeith BaileyMichael SpinellaDavid ShapiroPaul HergenrotherTimothy Fan

A Necrosis Inducer Promotes an Immunogenic Response and Destroys Ovarian Cancers in Mouse Xenografts and Patient Ascites Organoids. Cancer Letters (2025)

Darjan DurakiMusarrat JabeenChengjian MaoLawrence WangSantanu GhoshXinyi DaiJunyao ZhuMatthew W BoudreauErik R NelsonPaul J HergenrotherGeorgina ChengDavid J Shapiro

Comparative Oncology in Action: Vignettes on Small Molecule Development. Veterinary oncology. (2025)

Amy LeBlancChristina MazckoCheryl LondonPaul J. HergenrotherTimothy M. Fan

small molecule developmentsmall moleculesradiation oncologycancer researchmalignant diseasecancer discoverycancer growthoncologymolecular baseoncogenescancer cellstumor biology

Fluorescent Substrates for Poly(Adp-Ribosyl) Hydrolases. U.S. Patent No. 12235275 (2025)

Paul Hergenrother

enzymesbiocatalysisfluorescenceenzyme catalysisenzymatic modificationbiomoleculesfluorescent substratesbiopolymersbiochemistry

Identification of a Selective Anticancer Agent From a Collection of Complex-And-Diverse Compounds Synthesized From Stevioside. Journal of the American Chemical Society (2025)

Rachel E. SchaafJonathan C. K. QuirkeMaryam GhavamiEmily J. TonogaiHyang Yeon LeeSamantha L. BarlockThomas R. TrzupekKyle R. AboMatthew G. ReesMelissa M. RonanJennifer A. RothPaul J. Hergenrother

Pac-1 Synergizes With Sunitinib to Enhance Cell Death in Pancreatic Neuroendocrine Tumors. ACS Pharmacology & Translational Science (2025)

Hyang Yeon LeeMyung Ryul LeeTimothy M. FanPaul J. Hergenrother

cell deathcell culturecell autophagyradiation oncologytherapeutic targetspnet cell deathpac-1 synergizesoncogenescancer cellsautophagycancer biologytumor biologycell biology

Single Dose of a Small Molecule Leads to Complete Regressions of Large Breast Tumors in Mice. ACS Central Science (2025)

Michael P. MulliganMatthew W. BoudreauBrooke A. BouwensYoongyeong LeeHunter W. CarrellJunyao ZhuSpyro MoussesDavid J. ShapiroErik R. NelsonTimothy M. FanPaul J. Hergenrother

Substituted Imidazo[5,1-D][1,2,3,5]Tetrazines for the Treatment of Cancer. U.S. Patent No. 12234240 (2025)

Paul Hergenrother

medicinal chemistrypharmacologypharmacotherapytherapeutic targetsanti-cancer agentsdrug discovery

Understanding Compound Efflux From Gram-Negative Bacteria, a Final Frontier for Antibiotic Discovery. Microbial Drug Resistance (2025)

Rebecca J. UlrichPaul J. Hergenrother

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10 / page