Faculty

Institution

Unit

Venue

Han Xu

Assistant Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Han Xu is an Associate Professor at The University of Texas MD Anderson Cancer Center, where his research integrates molecular biology, CRISPR-based functional genomics, and bioinformatics to dissect cancer mechanisms. His recent work employs base editing and tiling mutagenesis screens to map DNA repair variant phenotypes, revealing how Pol θ-mediated end-joining tolerates mismatched microhomologies. He has also identified SART3 as a reader of methylarginine motifs and uncovered DARS1-AS1/YBX1-controlled posttranscriptional circuits driving glioblastoma radioresistance. His studies on MTA-cooperative PRMT5 inhibitors highlight immunotherapeutic strategies for MTAP-loss tumors. Xu’s multiomics and in vivo CRISPR approaches address metabolic vulnerabilities in melanoma brain metastasis, advancing precision oncology through systems-level genome biology.

Honors

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Experiences

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Education

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Han Xu

The University of Texas MD Anderson Cancer Center

Assistant Professor Associate Professor

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molecular biology genetics genome biology crispr bioinformatics genomics gene expression systems biology cell biology nucleic acids functional genomics cancer cells tumor biology oncogenes molecular cell biology oncology genome editing molecular cancer molecular informatics cancer biology biomedical informatics gene editing tumor suppressors chromatin cancer genetics cancer genomics heredity protein science cancer discovery medicinal research molecular diagnostics genotype-phenotype association genome-wide association studies cell regulation computational genomics transcriptomics technology cell research cellular biochemistry sequence analysis high-throughput screening chromatin remodeling epigenomics signaling pathways cancer treatment immune checkpoint inhibitors molecular regulation sequence determinants histone modification crispr knockout screens integrative analysis stem cell research genetic analysis prostatic disease epigenetic changes chromosome biology cytogenetics complex diseases variant interpretation allelic variant genome sequencing genome analysis small rna rna processing early detection functional annotation essential genes robust identification computational correction copy number effect ezh2 oncogenic activity androgen receptor critical cell types chromatin marks cell-type-specific variants common diseases gene-independent cell response personalized medicine cancer letter molecular genetics computer science genetic programming informatics bio-inspired computation biostatistics plo biology biosystems theoretical biology computational science developmental biology mutagenesis (molecular biology technique) scientific computing biotechnology advance forensic genetics mathematical bioscience quantitative biology data science transcriptome genetic engineering transcription (biology) transcription factors biochemistry computational biology omics epigenetics natural computing developmental system synthetic biology nature method

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Base Editing Resource for Functional Annotation of Dna Repair Variants in Breast-Derived Cell Models. Frontiers in Cell and Developmental Biology (2026)

geneticsfunctional genomicsgenome surgerygenome biologydna repairgenome editing

Mechanistic Insights Into Proteomic Mutation-Phenotype Linkages From Tiling Mutagenesis Screens. bioRxiv (Cold Spring Harbor Laboratory) (2025)

geneticsproteome researchmutation-based testinggenomicsmutagenesisgenome biologymolecular biology

Pol θ-Mediated End-Joining Uses Microhomologies Containing Mismatches. Nature Communications (2025)

molecular biologystructural biologycross-linkstructural molecular biology

Dddr-07. Functional Genomics in Vivo Using Crispr/Cas9 Identifies Potential Metabolic Vulnerabilities Within Melanoma Brain Metastasis. Neuro-Oncology (2024)

Yanxia MaNhat NguyenWei HeSanjay SinghRongjie FuLiang ZhangSheri HolmenPhil JonesMichael DaviesHan XuChibawanye Ene

melanomacrisprmelanoma brain metastasisfunctional genomicsneuro-oncologygenomicsmolecular biology

Mta-Cooperative Prmt5 Inhibitors Enhance T Cell-Mediated Antitumor Activity in Mtap-Loss Tumors. Journal for ImmunoTherapy of Cancer (2024)

Si ChenJiakai HouRoshni JafferyAshley GuerreroRongjie FuLeilei ShiNingbo ZhengRitu BohatNicholas A EganChengtai YuSana SharifYue LuWei HeShuyue WangDonjeta GjukaEverett M StonePooja Anil ShahJordi Rodon AhnertTaiping ChenXinli LiuMark T BedfordHan XuWeiyi Peng

cancer immunotherapycellular therapyoncologycancer researchtumor suppressorsmtap-loss tumorscancer cellsimmune checkpoint inhibitorsimmunotherapyclinical immunologyimmunologycancer treatmenttumor targetingtumor microenvironment

Sart3 Reads Methylarginine-Marked Glycine- and Arginine-Rich Motifs. Cell Reports (2024)

Yalong WangJujun ZhouWei HeRongjie FuLeilei ShiNgoc Khoi DangBin LiuHan XuXiaodong ChengMark T. Bedford

geneticsgene expressionmolecular geneticshuman geneticscellular biologysingle-cell analysisarginine-rich motifscell biologyprotein sciencesequence motifgenomicsprotein geneticscell researchmammalian biologymolecular biology

Crispr–Cas9-Based Functional Interrogation of Unconventional Translatome Reveals Human Cancer Dependency on Cryptic Non-Canonical Open Reading Frames. Nature Structural & Molecular Biology (2023)

Caishang ZhengYanjun WeiPeng ZhangKangyu LinDandan HeHongqi TengGaniraju ManyamZhao ZhangWen LiuHye Rin Lindsay LeeXiming TangWei HeNelufa IslamAntrix JainYulun ChiuShaolong CaoYarui DiaoSherita Meyer-GauenMagnus HöökAnna MalovannayaWenbo LiMing HuWenyi WangHan XuScott KopetzYiwen Chen

cancer genomicsgeneticsstructural genomicsoncologycancer researchmolecular cancermolecular sciencemolecular structurecrisprcancer biologyfunctional genomicsneurosciencestructural molecular biologygenomicsstructural bioinformaticsgenome biologymolecular biologystructural biology

Crispr/Cas9 Screen Uncovers Functional Translation of Cryptic Lncrna-Encoded Open Reading Frames in Human Cancer. Journal of Clinical Investigation (2023)

Caishang ZhengYanjun WeiPeng ZhangLongyong XuZhenzhen ZhangKangyu LinJiakai HouXiangdong LvYao DingYulun ChiuAntrix JainNelufa IslamAnna MalovannayaYun WuFeng DingHan XuMing SunXi ChenYiwen Chen

clinical investigationgeneticsoncologycancer biologycrisprhuman cancercomputational biologyclinical researchtranslational bioinformaticslong non-coding rna

Guide-Specific Loss of Efficiency and Off-Target Reduction With Cas9 Variants. Nucleic Acids Research (2023)

Liang ZhangWei HeRongjie FuShuyue WangYiwen ChenHan Xu

off-target reductiongeneticsnucleic acidsbioinformaticsmolecular biologyguide-specific loss

Multiomics Analyses Reveal Dars1-As1 /Ybx1–Controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/Radioresistance. Science Advances (2023)

Caishang ZhengYanjun WeiQiang ZhangMing SunYunfei WangJiakai HouPeng ZhangXiangdong LvDan SuYujie JiangJoy GuminNidhi SahniBaoli HuWenyi WangXi ChenDaniel J. McGrailChaolin ZhangSuyun HuangHan XuJunjie ChenFrederick F. LangJian HuYiwen Chen

cancer biologytumor suppressorsneurosciencegene expressiontumor biologyoncologybrain tumor researchmultiomicscancer genomicsgeneticsneuropharmacologyradiation oncologymolecular cancerneuro-oncologygenome biologymedicinal researchscience advancecancer geneticsmultiomics analyses

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Han Xu

Assistant Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Metabolomics Core Facility

Department Of Bioinformatics And Computational Biology

Department Of Epigenetics And Molecular Carcinogenesis

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Han Xu

The University of Texas MD Anderson Cancer Center

Assistant Professor Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Base Editing Resource for Functional Annotation of Dna Repair Variants in Breast-Derived Cell Models. Frontiers in Cell and Developmental Biology (2026)

geneticsfunctional genomicsgenome surgerygenome biologydna repairgenome editing

Mechanistic Insights Into Proteomic Mutation-Phenotype Linkages From Tiling Mutagenesis Screens. bioRxiv (Cold Spring Harbor Laboratory) (2025)

geneticsproteome researchmutation-based testinggenomicsmutagenesisgenome biologymolecular biology

Pol θ-Mediated End-Joining Uses Microhomologies Containing Mismatches. Nature Communications (2025)

molecular biologystructural biologycross-linkstructural molecular biology

Dddr-07. Functional Genomics in Vivo Using Crispr/Cas9 Identifies Potential Metabolic Vulnerabilities Within Melanoma Brain Metastasis. Neuro-Oncology (2024)

Yanxia MaNhat NguyenWei HeSanjay SinghRongjie FuLiang ZhangSheri HolmenPhil JonesMichael DaviesHan XuChibawanye Ene

melanomacrisprmelanoma brain metastasisfunctional genomicsneuro-oncologygenomicsmolecular biology

Mta-Cooperative Prmt5 Inhibitors Enhance T Cell-Mediated Antitumor Activity in Mtap-Loss Tumors. Journal for ImmunoTherapy of Cancer (2024)

Sart3 Reads Methylarginine-Marked Glycine- and Arginine-Rich Motifs. Cell Reports (2024)

Yalong WangJujun ZhouWei HeRongjie FuLeilei ShiNgoc Khoi DangBin LiuHan XuXiaodong ChengMark T. Bedford

Crispr–Cas9-Based Functional Interrogation of Unconventional Translatome Reveals Human Cancer Dependency on Cryptic Non-Canonical Open Reading Frames. Nature Structural & Molecular Biology (2023)

Crispr/Cas9 Screen Uncovers Functional Translation of Cryptic Lncrna-Encoded Open Reading Frames in Human Cancer. Journal of Clinical Investigation (2023)

Caishang ZhengYanjun WeiPeng ZhangLongyong XuZhenzhen ZhangKangyu LinJiakai HouXiangdong LvYao DingYulun ChiuAntrix JainNelufa IslamAnna MalovannayaYun WuFeng DingHan XuMing SunXi ChenYiwen Chen

clinical investigationgeneticsoncologycancer biologycrisprhuman cancercomputational biologyclinical researchtranslational bioinformaticslong non-coding rna

Guide-Specific Loss of Efficiency and Off-Target Reduction With Cas9 Variants. Nucleic Acids Research (2023)

Liang ZhangWei HeRongjie FuShuyue WangYiwen ChenHan Xu

off-target reductiongeneticsnucleic acidsbioinformaticsmolecular biologyguide-specific loss

Multiomics Analyses Reveal Dars1-As1 /Ybx1–Controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/Radioresistance. Science Advances (2023)

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