Faculty

Institution

Unit

Venue

Guy Lenk

University of Michigan

Affiliations

Michigan Medical School

Human Genetics

NoneGuy Lenk is currently serving as a Human Genetics faculty at University of Michigan.

Honors

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Experiences

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Education

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Guy Lenk

University of Michigan

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genetics human genetics molecular biology neurology genomics genetic disorders molecular genetics neuroscience gene expression neurogenetics medical genetics genome biology neurodegenerative diseases genetic variation membrane biology molecular neurodegeneration mammalian biology genome analysis mouse models abdominal aortic aneurysms autophagy neuroscience of aging neurodevelopmental disorders cellular physiology vascular biology cell autophagy genetic basis neurological disorders neuroregeneration disease gene identification intracranial aneurysm phosphoinositide phosphatase dravet syndrome neuronal expression respiratory medicine developmental cell cellular biochemistry protein science peptide science free radical biology redox biology brain tumor research myocardial infarction amyotrophic lateral sclerosis phagocytes lipid science protein function signaling pathways functional modification lipid synthesis host response neuroinflammation neurochemistry cardiac muscle neuroprotection oligonucleotides genetic factors brain science cellular neurobiology neurological function peripheral nervous system crispr gene function cell physiology cellular biology physiological research abdominal aortic aneurysm same sequence variant deleterious variants trp channel focal exocytosis large particle phagocytosis major precursor signaling lipid mice deficient defective autophagy

Notable Scholarly Works

Notable Federal Grants

Collaborators

110Vp Fig4 Loss of Function: Unraveling the Phenotypic Spectrum for Clinical Trial Readiness. Neuromuscular Disorders (2024)

G. BoyekR. OrbachK. GottliebJ. DuffG. LenkC. Bönnemann

clinical trialsphenotypic spectrumneuroscienceclinical trial readinessneuromuscular medicine

A Model Organism Pipeline Provides Insight Into the Clinical Heterogeneity of Tars1 Loss-Of-Function Variants. Human Genetics and Genomics Advances (2024)

Rebecca Meyer-SchumanAllison R. CaleJennifer A. PierluissiKira E. JonatzkeYoung N. ParkGuy M. LenkStephanie N. OprescuMarina A. GrachtchoukAndrzej A. DlugoszAsim A. BegMiriam H. MeislerAnthony Antonellis

geneticshuman geneticsgenomicsmodel organism pipelinegenetic variationclinical heterogeneity

Biallelic Loss-Of-Function Variants of Slc12A9 Cause Lysosome Dysfunction and a Syndromic Neurodevelopmental Disorder. Genetics in Medicine (2024)

Andrea AccogliYoung N. ParkGuy M. LenkMariasavina SeverinoMarcello ScalaJonas DeneckeMaja HempelDavor LesselFanny KortümVincenzo SalpietroPatrizia de MarcoSara GuerrisiAnnalaura TorellaVincenzo NigroMyriam SrourErnest TurroVeerle LabarqueKathleen FresonGianluca PiatelliValeria CapraJacob O. KitzmanMiriam H. Meisler

geneticsmedicinebiallelic loss-of-function variantsneurogeneticsgenetic disordersneurodevelopmental disordersmedical geneticssyndromic neurodevelopmental disorder

Predictive Modeling Provides Insight Into the Clinical Heterogeneity Associated With Tars1 Loss-Of-Function Mutations. bioRxiv (Cold Spring Harbor Laboratory) (2024)

geneticsgenomic medicinemolecular cancerhealth sciencesgenomicscancer genomicsmedical geneticscancer geneticstumor biologyimmunologymedicinal researchclinical heterogeneity

Protein Family Fam241 in Human and Mouse. Mammalian Genome (2024)

Quinlan DoctroveYoung ParkDaniel G. CalameJacob KitzmanGuy M. LenkMiriam H. Meisler

genomicsmolecular biologygenome biologygenome structuremammalian biologygenome analysis

Altered Phenotypes Due to Genetic Interaction Between the Mouse Phosphoinositide Biosynthesis Genes Fig4 and Pip4k2c. G3 Genes Genomes Genetics (2023)

Xu CaoGuy M LenkMiriam H Meisler

geneticsbiosynthesisgenotype-phenotype associationgenetic interactionaltered phenotypesgenomicsgenome biologygenetic variation

Lysosome Enlargement During Inhibition of the Lipid Kinase Pikfyve Proceeds Through Lysosome Coalescence. (2023)

Christopher H ChoyGolam SaffiMatthew A GrayCallen WallaceRoya Monica DayamZhen-Yi A OuGuy M. LenkRosa PuertollanoSimon C. WatkinsRoberto Botelho

pharmacologymembrane biologylysosome coalescenceenzyme inhibitionmolecular biologycell biologylysosome enlargement

The Chloride Antiporter Clcn7 is a Modifier of Lysosome Dysfunction in Fig4 and Vac14 Mutants. PLoS Genetics (2023)

Xu CaoGuy M. LenkVedrana MikusevicJoseph A. MindellMiriam H. Meisler

geneticsmolecular biologyhuman geneticslysosome dysfunction

Chloroquine Corrects Enlarged Lysosomes in Fig4 Null Cells and Reduces Neurodegeneration in Fig4 Null Mice. Molecular Genetics and Metabolism (2022)

Guy M. LenkMiriam H. Meisler

geneticsmolecular geneticsgenetic disordersreduces neurodegenerationmolecular neurodegenerationbiochemistrymolecular biologyneurodegenerative diseasesmetabolism

Aav9-Mediated Fig4 Delivery Prolongs Life Span in Charcot-Marie-Tooth Disease Type 4J Mouse Model. Journal of Clinical Investigation (2021)

Maximiliano PresaRachel M. BaileyCrystal DavisTara MurphyJenn CookRandy WallsHannah WilpanLaurent BogdanikGuy M. LenkRobert W. BurgessSteven J. GrayCathleen Lutz

geneticsneurologygenetic basismouse modelavian biologygene expressionneuroscienceclinical researchtranslational medicinemammalian biologyclinical investigation

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Guy Lenk

University of Michigan

Affiliations

Michigan Medical School

Human Genetics

NoneGuy Lenk is currently serving as a Human Genetics faculty at University of Michigan.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Guy Lenk

University of Michigan

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

110Vp Fig4 Loss of Function: Unraveling the Phenotypic Spectrum for Clinical Trial Readiness. Neuromuscular Disorders (2024)

G. BoyekR. OrbachK. GottliebJ. DuffG. LenkC. Bönnemann

clinical trialsphenotypic spectrumneuroscienceclinical trial readinessneuromuscular medicine

A Model Organism Pipeline Provides Insight Into the Clinical Heterogeneity of Tars1 Loss-Of-Function Variants. Human Genetics and Genomics Advances (2024)

geneticshuman geneticsgenomicsmodel organism pipelinegenetic variationclinical heterogeneity

Biallelic Loss-Of-Function Variants of Slc12A9 Cause Lysosome Dysfunction and a Syndromic Neurodevelopmental Disorder. Genetics in Medicine (2024)

geneticsmedicinebiallelic loss-of-function variantsneurogeneticsgenetic disordersneurodevelopmental disordersmedical geneticssyndromic neurodevelopmental disorder

Predictive Modeling Provides Insight Into the Clinical Heterogeneity Associated With Tars1 Loss-Of-Function Mutations. bioRxiv (Cold Spring Harbor Laboratory) (2024)

geneticsgenomic medicinemolecular cancerhealth sciencesgenomicscancer genomicsmedical geneticscancer geneticstumor biologyimmunologymedicinal researchclinical heterogeneity

Protein Family Fam241 in Human and Mouse. Mammalian Genome (2024)

Quinlan DoctroveYoung ParkDaniel G. CalameJacob KitzmanGuy M. LenkMiriam H. Meisler

genomicsmolecular biologygenome biologygenome structuremammalian biologygenome analysis

Altered Phenotypes Due to Genetic Interaction Between the Mouse Phosphoinositide Biosynthesis Genes Fig4 and Pip4k2c. G3 Genes Genomes Genetics (2023)

Xu CaoGuy M LenkMiriam H Meisler

geneticsbiosynthesisgenotype-phenotype associationgenetic interactionaltered phenotypesgenomicsgenome biologygenetic variation

Lysosome Enlargement During Inhibition of the Lipid Kinase Pikfyve Proceeds Through Lysosome Coalescence. (2023)

Christopher H ChoyGolam SaffiMatthew A GrayCallen WallaceRoya Monica DayamZhen-Yi A OuGuy M. LenkRosa PuertollanoSimon C. WatkinsRoberto Botelho

pharmacologymembrane biologylysosome coalescenceenzyme inhibitionmolecular biologycell biologylysosome enlargement

The Chloride Antiporter Clcn7 is a Modifier of Lysosome Dysfunction in Fig4 and Vac14 Mutants. PLoS Genetics (2023)

Xu CaoGuy M. LenkVedrana MikusevicJoseph A. MindellMiriam H. Meisler

geneticsmolecular biologyhuman geneticslysosome dysfunction

Chloroquine Corrects Enlarged Lysosomes in Fig4 Null Cells and Reduces Neurodegeneration in Fig4 Null Mice. Molecular Genetics and Metabolism (2022)

Guy M. LenkMiriam H. Meisler

geneticsmolecular geneticsgenetic disordersreduces neurodegenerationmolecular neurodegenerationbiochemistrymolecular biologyneurodegenerative diseasesmetabolism

Aav9-Mediated Fig4 Delivery Prolongs Life Span in Charcot-Marie-Tooth Disease Type 4J Mouse Model. Journal of Clinical Investigation (2021)

Maximiliano PresaRachel M. BaileyCrystal DavisTara MurphyJenn CookRandy WallsHannah WilpanLaurent BogdanikGuy M. LenkRobert W. BurgessSteven J. GrayCathleen Lutz

geneticsneurologygenetic basismouse modelavian biologygene expressionneuroscienceclinical researchtranslational medicinemammalian biologyclinical investigation

1
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4
5
10 / page

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