Faculty

Institution

Unit

Venue

Yelena V Grinkova

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Yelena V Grinkova is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

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Experiences

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Education

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Yelena V Grinkova

UIUC

Research Scientist

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biochemistry drug metabolism biophysical chemistry molecular metabolism biophysics molecular biology membrane proteins enzymes pharmacology membrane biology biological chemistry pharmacological research membrane science biochemical sciences nanodisc chemical biology molecular pharmacology cell metabolism biological macromolecules enzyme inhibition biochemical interaction membranes protein science redox biology proteinlipid interaction biomolecules nanoparticle research structural molecular biology heme degradation drug targets cytochrome p450 3a4 dna nanotechnology redox chemistry biochemical genetics nucleic acids biomolecular structure free radical biology dna computing steroid metabolism structure-function enzyme kinetics biomolecular interactions membrane systems cytochrome p450 active site membrane formation protein nanoparticles bioelectrochemistry biological inorganic chemistry toxicological mechanism heme transport hormonal receptor membrane structure scaffold protein membrane scaffold proteins synthetic nanopore cytochrome p450s p450 cyp17a1 monomeric cyp3a4 lipid movement amphiphilic system micelles dna analysis separation techniques separation technology separation science cellular enzymology molecular self-assembly nanobiotechnology lipid chemistry membrane scaffold protein controlled size msp1 fusion several different msps nanometer-diameter pore diameter separation relative quantum yield

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Effective Vaccine Against Influenza a Virus Based on the Matrix Protein 2 (M2). Veterinary Microbiology (2024)

Federico A ZuckermannYelena V GrinkovaRobert J HusmannMelissa Pires-AlvesSuzanna StormsWei-Yu ChenStephen G Sligar

vaccine designinfectious diseasesvirologyvaccineseffective vaccinevaccine developmentvaccinationimmunologyinfluenza vaccineinfluenza a virusmatrix protein 2antiviral researchmedical virologyinfluenzavirus research

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

chemical engineeringoptical annealingperovskite modulematerial chemistryoptical materialsphotochemistrytransition metal chemistrylead-free perovskiteschemistrycrystal growth

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

new drug candidatesmolecular pharmacologypharmaceutical sciencesapplied pharmacologymd simulationsdrug targetsbiochemistrypharmacokineticspharmacologytherapeutic targetsdrug metabolismdrug discoverypharmacotherapypharmacological researchlipid nanodiscs

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

pharmacologysteroid metabolismhormonal receptorcytochrome p450 cyp17a1cytochrome p450sendocrine researchdrug metabolismbiochemistrycell metabolismbiological chemistryendocrinologybiochemical geneticsmetabolismmolecular metabolismactive sitemetabolic pathwaysendocrine mechanismsbiochemical sciencesmolecular pharmacologyenzyme inhibition

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

membrane surfacemolecular pharmacologydrug targetsbiochemistryfirst mdz moleculepharmacologyproductive sitedrug metabolismdrug discoverypharmacological researchenzyme inhibitionmechanisms of action

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for Membrane Protein Investigations. Analytical Biochemistry (2020)

Mark A. McLeanIlia G. DenisovYelena V. GrinkovaStephen G. Sligar

biophysicsnanodiscprotein sciencemembrane proteinsmembrane protein investigationsmembrane biology

P450 Cyp17A1 Variant With a Disordered Proton Shuttle Assembly Retains Peroxo‐Mediated Lyase Efficiency. Chemistry - A European Journal (2020)

Yilin LiuIlia G. DenisovYelena V. GrinkovaStephen G. SligarJames R. Kincaid

resonance raman spectroscopyenzymesp450 cyp17a1 variantmolecular metabolismenzyme catalysisredox biologybiochemistrycell metabolismchemical biologymolecular biologybiological chemistrydrug metabolismstructure-function enzyme kineticsp450 cyp17a1enzyme inhibition

Biotransformation of the Mycotoxin Enniatin B1 by Cyp P450 3A4 and Potential for Drug-Drug Interactions. Metabolites (2019)

Lada IvanovaIlia G. DenisovYelena V. GrinkovaStephen G. SligarChristiane K. Fæste

toxicologytoxicological mechanismmycotoxin researchmycotoxin enniatin b1molecular metabolismnatural toxinssecondary metabolitesbiochemistrytoxinscell metabolismhepatotoxicitybioactive compoundspharmacologydrug metabolismcytochrome p450 3apharmacological researchmycotoxin formationin vitro toxicology

Correction to “Allosteric Interactions in Human Cytochrome P450 Cyp3A4: The Role of Phenylalanine 213”. Biochemistry (2019)

Ilia G. DenisovYelena V. GrinkovaPrithviraj NandigramiMrinal ShekharEmad TajkhorshidStephen G. Sligar

biochemical geneticsphenylalanine 213enzymesmolecular metabolismbiochemistrychemical biologybiochemical sciencespharmacologybiological chemistrydrug metabolismaltmetric attention scorebiochemical interactionenzyme inhibitionallosteric interactions

Drug–Drug Interactions Between Atorvastatin and Dronedarone Mediated by Monomeric Cyp3a4. Biochemistry (2017)

Ilia G. DenisovJavier L. BaylonYelena V. GrinkovaEmad TajkhorshidStephen G. Sligar

drug–drug interactionseffector bindingmonomeric cyp3a4molecular pharmacologydrug targetsmedicinal researchmedicinal chemistrybiochemistrypharmacologydrug metabolismbiochemical interactionpharmacological researchenzyme inhibition

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Yelena V Grinkova

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Yelena V Grinkova is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Yelena V Grinkova

UIUC

Research Scientist

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Effective Vaccine Against Influenza a Virus Based on the Matrix Protein 2 (M2). Veterinary Microbiology (2024)

Federico A ZuckermannYelena V GrinkovaRobert J HusmannMelissa Pires-AlvesSuzanna StormsWei-Yu ChenStephen G Sligar

Optical Annealing of Peroxo-Ferric Intermediates in Cyp17A1 and Product Formation.. Journal of Inorganic Biochemistry (2024)

Ilia G DenisovYelena V GrinkovaStephen G Sligar

chemical engineeringoptical annealingperovskite modulematerial chemistryoptical materialsphotochemistrytransition metal chemistrylead-free perovskiteschemistrycrystal growth

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

Mechanism of the Clinically Relevant E305G Mutation in Human P450 Cyp17a1. Biochemistry (2021)

Yilin LiuYelena GrinkovaMichael C. GregoryIlia G. DenisovJames R. KincaidStephen G. Sligar

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

membrane surfacemolecular pharmacologydrug targetsbiochemistryfirst mdz moleculepharmacologyproductive sitedrug metabolismdrug discoverypharmacological researchenzyme inhibitionmechanisms of action

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for Membrane Protein Investigations. Analytical Biochemistry (2020)

Mark A. McLeanIlia G. DenisovYelena V. GrinkovaStephen G. Sligar

biophysicsnanodiscprotein sciencemembrane proteinsmembrane protein investigationsmembrane biology

P450 Cyp17A1 Variant With a Disordered Proton Shuttle Assembly Retains Peroxo‐Mediated Lyase Efficiency. Chemistry - A European Journal (2020)

Yilin LiuIlia G. DenisovYelena V. GrinkovaStephen G. SligarJames R. Kincaid

Biotransformation of the Mycotoxin Enniatin B1 by Cyp P450 3A4 and Potential for Drug-Drug Interactions. Metabolites (2019)

Lada IvanovaIlia G. DenisovYelena V. GrinkovaStephen G. SligarChristiane K. Fæste

Correction to “Allosteric Interactions in Human Cytochrome P450 Cyp3A4: The Role of Phenylalanine 213”. Biochemistry (2019)

Ilia G. DenisovYelena V. GrinkovaPrithviraj NandigramiMrinal ShekharEmad TajkhorshidStephen G. Sligar

Drug–Drug Interactions Between Atorvastatin and Dronedarone Mediated by Monomeric Cyp3a4. Biochemistry (2017)

Ilia G. DenisovJavier L. BaylonYelena V. GrinkovaEmad TajkhorshidStephen G. Sligar

1
2
3
4
5
10 / page