Faculty

Institution

Unit

Venue

Gorazd Rosoklija

Associate Professor at the Columbia University Medical Center

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

PSY Molec Imaging & Neuropath

Gorazd Rosoklija is an Associate Professor at Columbia University Medical Center, where his research bridges neuroscience, molecular psychiatry, and neurogenetics. His work focuses on the neurobiology of major depression and suicide, employing multi-omics profiling of the human hippocampus neurogenic niche and mitochondrial respiratory capacity mapping. Recent breakthroughs include a human brain map of mitochondrial diversity (Nature, 2025) and identifying a rare GPR156 variant linked to depression that induces habenula hyperactivity in mice (PNAS, 2025). His investigations integrate transcriptomic and genetic analyses to elucidate mitochondrial dysregulation in schizophrenia, alongside developing scalable light-sheet microscopy for cleared tissue imaging.

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Gorazd Rosoklija

Columbia University

Associate Professor at the Columbia University Medical Center

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neuroscience neurology psychiatry biological psychiatry molecular psychiatry schizophrenia cognitive neuroscience neuropsychology psychiatric research clinical neuroscience genetics systems neuroscience translational psychiatry neuropathology neuropsychopharmacology suicide neurogenetics molecular neuroscience neuroimaging molecular neurodegeneration genome biology neuropsychiatry mammalian biology neuroradiology brain science psychiatric genetics neuroinflammation major depression major depressive disorder developmental cognitive neuroscience experimental neuropathology world psychiatry epigenomics cellular neurobiology diabetic neuropathy psychological medicine affective disorders psychoneuroendocrinology amyotrophic lateral sclerosis psychopharmacology respiratory neurobiology hippocampal neurogenesis human hippocampus diabetic medicine neurorehabilitation adult development neural science molecular neurobiology brain mapping genetic factors genome-wide association studies brain function mammalian tissues mood disorders human hippocampal neurogenesis biogerontology lifespan development aging process primate behavior apoptosis mitochondrial function clinical psychiatry brain-immune interaction brain structure cytokines muscle function neurological disorders neural progenitor cells adult nonhuman primates antidepressant-induced neurogenesis spatial epigenome-transcriptome co-profiling hippocampal granule dentate gyrus volume spatial profiling chromatin accessibility structural abnormalities

Notable Scholarly Works

Notable Federal Grants

Collaborators

Human Hippocampus Niche and Circuit Neurotypical and Major Depression Profiles. Research Square (2026)

psychiatryneurosciencedepressionpsychiatric disorderspsychologybiological psychiatry

A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Nature (2025)

Eugene V. MosharovAyelet M. RosenbergAnna S. MonzelCorey A. OstoLinsey StilesGorazd B. RosoklijaAndrew J. DworkSnehal BindraAlex JunkerYa ZhangMasashi FujitaMadeline B. MarianiMihran BakalianDavid SulzerPhilip L. De JagerVilas MenonOrian S. ShirihaiJ. John MannMark D. UnderwoodMaura BoldriniMichel Thiebaut de SchottenMartin Picard

brain mappingsystems neurosciencehuman brain mapneurosciencephysiologymitochondrial respiratory capacityrespiratory neurobiologyhuman brain

A Rare Variant in Gpr156 Associated With Depression in a Mennonite Pedigree Causes Habenula Hyperactivity and Stress Sensitivity in Mice. Proceedings of the National Academy of Sciences (2025)

Bradley R. MillerClaudia Gonzaga-JaureguiKarlla W. BrigattiJob de JongRobert S. BreeseSeung Yeon KoErik G. PuffenbergerCristopher Van HoutMillie YoungVictor M. LunaJeffrey StaplesMichael B. FirstHilledna J. GregoireAndrew J. DworkEvangelos PefanisShane McCarthySusannah BrydgesJose RojasBin YeEli StahlSilvio Alessandro Di GioiaRené HenKevin ElwoodGorazd RosoklijaDadong LiScott MellisDavid CareySusan D. CrollJohn D. OvertonLynn E. MacdonaldAris N. EconomidesAlan R. ShuldinerNao ChuhmaStephen RayportNajaf AminSteven A. KushnerNicole Alessandri-HaberSander MarkxKevin A. Strauss

geneticsstress sensitivitypsychiatric geneticsrare variantmental healthmolecular psychiatrybiologydepressionmennonite pedigree causesmolecular biologybiological psychiatrystress (biology)

Author Correction: A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Nature (2025)

Eugene V MosharovAyelet M RosenbergAnna S MonzelCorey A OstoLinsey StilesGorazd B RosoklijaAndrew J DworkSnehal BindraAlex JunkerYa ZhangMasashi FujitaMadeline B MarianiMihran BakalianDavid SulzerPhilip L De JagerVilas MenonOrian S ShirihaiJ John MannMark D UnderwoodMaura BoldriniMichel Thiebaut de SchottenMartin Picard

human brain mapneurosciencenaturemitochondrial respiratory capacityrespiratory neurobiologyhuman brain

Multi-Omics Profiling of Human Hippocampus Neurogenic Niche to Decipher the Neurobiology of Major Depression. The International Journal of Neuropsychopharmacology (2025)

depressionpsychiatric diseasesneuropsychopharmacologyneuroscience

Transcriptomic and Genetic Analysis Suggests a Role for Mitochondrial Dysregulation in Schizophrenia. medRxiv (2025)

Lisa BastShuyang YaoJose A. Martinez-LopezFatima MemicHayley FrenchMilda ValiukonyteRobert KarlssonJia WenJie SongRuyue ZhangAnthony AbrantesFrank KoopmansAnne-May OesterholmGorazd RosoklijaJ. John MannAleksandar StankovIskra TrencevskaAndrew DworkCraig A. StockmeierMichael I LovePaola Giusti-RodriguezAugust B. SmitPatrick F SullivanJens Hjerling-Leffler

genomic mechanismsneurogeneticsgene expressionmitochondrial dysregulationsystems biologymolecular neurodegenerationgeneticspsychiatric geneticsgenomicsgenetic disordersgenome biologypersonal genomicsfunctional genomicspsychiatric researchmolecular psychiatrygenetic factorsschizophreniamolecular biologybiological psychiatry

46. Transcriptional Signatures of Blood Brain Barrier Compromise in Suicide. Biological Psychiatry (2024)

Shengnan SunZhaoyu WangQingkun LiuGorazd RosoklijaYongchao GeHanga GalfalvyJ. John MannAndrew DworkFatemeh Haghighi

geneticssuicideneurosciencetranscriptional signaturesgenomicsmolecular biologybiological psychiatry

476. Claudin-5 and Blood-Brain Barrier Integrity in Prefrontal Cortex in Suicide. Biological Psychiatry (2024)

cerebral blood flowpsychiatryneuropharmacologyneurosciencepsychopharmacologybiological psychiatry

Brain and Blood Transcriptome Profiles Delineate Common Genetic Pathways Across Suicidal Ideation and Suicide. Molecular Psychiatry (2024)

Shengnan SunQingkun LiuZhaoyu WangYung-yu HuangM. Elizabeth SubletteAndrew J. DworkGorazd RosoklijaYongchao GeHanga GalfalvyJ. John MannFatemeh Haghighi

geneticsmolecular neurosciencesuicidesuicidal ideationneurosciencemolecular psychiatryneurogeneticsneurology

Late-Stage Borreliosis and Substance Abuse. Heliyon (2024)

Robert C. BransfieldShiva Kumar Goud GadilaLaura J. KursaweAndrew J. DworkGorazd RosoklijaElizabeth J. HornMichael J. CookMonica E. Embers

substance abuselate-stage borreliosisinfectious diseasespublic healthhealth sciences

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Gorazd Rosoklija

Associate Professor at the Columbia University Medical Center

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

PSY Molec Imaging & Neuropath

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gorazd Rosoklija

Columbia University

Associate Professor at the Columbia University Medical Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Human Hippocampus Niche and Circuit Neurotypical and Major Depression Profiles. Research Square (2026)

psychiatryneurosciencedepressionpsychiatric disorderspsychologybiological psychiatry

A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Nature (2025)

brain mappingsystems neurosciencehuman brain mapneurosciencephysiologymitochondrial respiratory capacityrespiratory neurobiologyhuman brain

A Rare Variant in Gpr156 Associated With Depression in a Mennonite Pedigree Causes Habenula Hyperactivity and Stress Sensitivity in Mice. Proceedings of the National Academy of Sciences (2025)

geneticsstress sensitivitypsychiatric geneticsrare variantmental healthmolecular psychiatrybiologydepressionmennonite pedigree causesmolecular biologybiological psychiatrystress (biology)

Author Correction: A Human Brain Map of Mitochondrial Respiratory Capacity and Diversity. Nature (2025)

human brain mapneurosciencenaturemitochondrial respiratory capacityrespiratory neurobiologyhuman brain

Multi-Omics Profiling of Human Hippocampus Neurogenic Niche to Decipher the Neurobiology of Major Depression. The International Journal of Neuropsychopharmacology (2025)

depressionpsychiatric diseasesneuropsychopharmacologyneuroscience

Transcriptomic and Genetic Analysis Suggests a Role for Mitochondrial Dysregulation in Schizophrenia. medRxiv (2025)

46. Transcriptional Signatures of Blood Brain Barrier Compromise in Suicide. Biological Psychiatry (2024)

Shengnan SunZhaoyu WangQingkun LiuGorazd RosoklijaYongchao GeHanga GalfalvyJ. John MannAndrew DworkFatemeh Haghighi

geneticssuicideneurosciencetranscriptional signaturesgenomicsmolecular biologybiological psychiatry

476. Claudin-5 and Blood-Brain Barrier Integrity in Prefrontal Cortex in Suicide. Biological Psychiatry (2024)

cerebral blood flowpsychiatryneuropharmacologyneurosciencepsychopharmacologybiological psychiatry

Brain and Blood Transcriptome Profiles Delineate Common Genetic Pathways Across Suicidal Ideation and Suicide. Molecular Psychiatry (2024)

Shengnan SunQingkun LiuZhaoyu WangYung-yu HuangM. Elizabeth SubletteAndrew J. DworkGorazd RosoklijaYongchao GeHanga GalfalvyJ. John MannFatemeh Haghighi

geneticsmolecular neurosciencesuicidesuicidal ideationneurosciencemolecular psychiatryneurogeneticsneurology

Late-Stage Borreliosis and Substance Abuse. Heliyon (2024)

Robert C. BransfieldShiva Kumar Goud GadilaLaura J. KursaweAndrew J. DworkGorazd RosoklijaElizabeth J. HornMichael J. CookMonica E. Embers

substance abuselate-stage borreliosisinfectious diseasespublic healthhealth sciences

1
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4
5
11
10 / page