Faculty

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George Holz

Professor of Pharmacology Professor of Medicine

Upstate Medical University

George Holz is currently serving as a Center Of Heart And Vascular Professor of Pharmacology Professor of Medicine at Upstate Medical University.

Honors

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Experiences

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Education

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George Holz

Upstate Medical University

Professor of Pharmacology Professor of Medicine

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biochemistry physiology pharmacology cell biology signal transduction cell signaling receptors molecular physiology cellular physiology diabetes endocrinology diabetes research insulin signaling cellular biochemistry gastrointestinal peptide hormone g protein-coupled receptor cell physiology lipids molecular and cellular biology metabolism cell metabolism peptides diabetes therapies molecular cell biology receptor (biochemistry) visceral leishmaniasis natural product research neurotransmission diabetes mellitus parasitic protozoa biological chemistry peptide science pharmacological research enzyme inhibition lipid analysis natural product communication signaling pathways biochemical sciences leishmania promastigotes glucagon-like peptide-1 molecular metabolism phycology marine biota cell interactions pancreatic β-cells marine biotechnology lipid chemistry natural product biosynthesis antiparasitic agent pharmaceutical chemistry secondary metabolites insulin management molecular pathways metabolic regulation sterol biosynthesis camp sensor epac clinical physiology neurochemistry pancreas transplantation parasite genomics phytochemistry african trypanosomiasis omega-3 fatty acids neurotransmitters insulin secretion cestode spirometra mansonoides endocrine oncology pancreatic b-cells leptin suppression camp signaling glucose-stimulated insulin secretion dual agonist glucose competence glycemic control weight loss new insights pharmacognosy chronic diseases bioactive compounds therapeutic targets metabolic syndrome drug delivery individualized medicine translational research pediatric diabetes drug metabolism drug discovery pharmacotherapy integrative medicine health sciences gene therapy translational medicine medicinal research diabetes technology medicinal chemistry drug resistance diabetic medicine implementation research phytotherapy research clinical trials personalized medicine obesity medicine diabetes care future medicinal chemistry drug analysis alternative medicine preventive healthcare applied pharmacology molecular medicine pharmaceutics metabolic pathways medicine experimental medicine molecular pharmacology clinical research biomolecular engineering

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Melanocortin 4- and Glucagon-Like Peptide 1 Receptor Multiple Agonist for the Treatment of Diabetes and Obesity. Metabolism (2025)

receptorsobesity medicinediabetesgastrointestinal peptide hormoneendocrinologydiabetes mellitusglucagon-like peptide 1pharmacologydiabetes carephysiologydiabetes therapieshealth sciencesreceptor multiple agonistmetabolic syndromeobesity

Glp-1 Receptor Agonist Properties of a Chimeric Peptide Derived by Hybridization of Latrodectus αLatrotoxin and Heloderma Exendin-4. General and Comparative Endocrinology (2025)

receptorschimeric peptidepeptide engineeringnon-peptide ligandg protein-coupled receptorpeptide therapeuticsbiochemistrypharmacologyheloderma exendin-4molecular pharmacologypeptide sciencepeptideslatrodectus αlatrotoxin

Two Gnrh-Mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells. Current Molecular Pharmacology (2025)

gynecologygnrh-mitoxantrone conjugatesgynecologic cancerscancer researchcancer biologycancer cellsendocrine-related cancerspharmacologytherapeutic targetsendocrine oncologygynecologic oncology

Cytotoxic Activity of Novel Gnrh Analogs Conjugated With Mitoxantrone in Ovarian Cancer Cells. Molecules (2024)

gynecologyanti-cancer agentsgynecologic cancerspharmacological researchovarian cancer cellsovarian cancerendocrine-related cancerspharmacologycytotoxic activitygynecologic oncology

Reductions of Food Intake and Body Weight in Diet-Induced Obese Rats Following Chronic Treatment With a Monomeric Peptide Multiagonist. Clinical Nutrition (2024)

obesity medicinemonomeric peptide multiagonistobesity managementmetabolismchronic treatmentappetite controlendocrinologyfood intakeenergy homeostasisnutritionpharmacologyphysiologynutritional biochemistryhealth sciencesmetabolic syndromeobesity

[55Co]Co-Dota-Sp4: Towards Nk1R-Targeted Theranostics of Glioblastoma. Nuclear Medicine and Biology (2023)

cancer immunotherapymolecular cancercell biologycancer cellsneuro-oncologyoncogenesimmune checkpoint inhibitorsnk1r-targeted theranosticscancer treatmentbrain tumor researchtherapeutic targetsgliomastumor targeting

A Peptide Triple Agonist of Glp-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic. Scientific Reports (2023)

receptorsneuropeptide receptorsdiabetesgastrointestinal peptide hormoneendocrinologyg protein-coupled receptorneuropeptidespharmacologypsychoneuroendocrinologyphysiologydiabetes therapiesdiabetes researchpeptidesneuropsychopharmacology

A Peptide Triple Agonist of Glp-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss. Scientific Reports (2023)

Kylie S. ChichuraClinton T. ElfersTherese S. SalamehVarun KamatOleg G. ChepurnyAelish McGivneyBrandon T. MillikenGeorge G. HolzSarah V. ApplebeyMatthew R. HayesIan R. SweetChristian L. RothRobert P. Doyle

diabetesneuropharmacologyglycemic controlneuroscienceweight losspharmacologyphysiologypeptide triple agonistobesity

Corrination Mitigates Peptide Aggregation as Exemplified for Glucagon. Peptides (2023)

corrination mitigatespeptide therapeuticsbiochemistryglycobiologypeptide sciencepeptides

Excess Pancreatic Elastase Alters Acinar-β Cell Communication by Impairing the Mechano-Signaling and the Par2 Pathways. Cell Metabolism (2023)

Giorgio BasileAmedeo VetereJiang HuOluwaseun IjaduolaYi ZhangKa-Cheuk LiuAmira M. EltonyDario F. De JesusKazuki FukudaGrace DohertyColin A. LeechOleg G. ChepurnyGeorge G. HolzSeok-Hyun YunOlov AnderssonAmit ChoudharyBridget K. WagnerRohit N. Kulkarni

cell communicationcell biologycell signalingpharmacologygene expressionpathway analysisenzymesliver physiologymembrane biologycell metabolismintercellular communicationmolecular cell biologymolecular communicationprotein expressioncell interactionssignal transductionmolecular biologycellular physiologycellular biochemistry

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George Holz

Professor of Pharmacology Professor of Medicine

Upstate Medical University

George Holz is currently serving as a Center Of Heart And Vascular Professor of Pharmacology Professor of Medicine at Upstate Medical University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

George Holz

Upstate Medical University

Professor of Pharmacology Professor of Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Melanocortin 4- and Glucagon-Like Peptide 1 Receptor Multiple Agonist for the Treatment of Diabetes and Obesity. Metabolism (2025)

Glp-1 Receptor Agonist Properties of a Chimeric Peptide Derived by Hybridization of Latrodectus αLatrotoxin and Heloderma Exendin-4. General and Comparative Endocrinology (2025)

Two Gnrh-Mitoxantrone Conjugates, Con-3 and Con-7, Target Endometrial Cancer Cells. Current Molecular Pharmacology (2025)

gynecologygnrh-mitoxantrone conjugatesgynecologic cancerscancer researchcancer biologycancer cellsendocrine-related cancerspharmacologytherapeutic targetsendocrine oncologygynecologic oncology

Cytotoxic Activity of Novel Gnrh Analogs Conjugated With Mitoxantrone in Ovarian Cancer Cells. Molecules (2024)

gynecologyanti-cancer agentsgynecologic cancerspharmacological researchovarian cancer cellsovarian cancerendocrine-related cancerspharmacologycytotoxic activitygynecologic oncology

Reductions of Food Intake and Body Weight in Diet-Induced Obese Rats Following Chronic Treatment With a Monomeric Peptide Multiagonist. Clinical Nutrition (2024)

[55Co]Co-Dota-Sp4: Towards Nk1R-Targeted Theranostics of Glioblastoma. Nuclear Medicine and Biology (2023)

A Peptide Triple Agonist of Glp-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic. Scientific Reports (2023)

A Peptide Triple Agonist of Glp-1, Neuropeptide Y1, and Neuropeptide Y2 Receptors Promotes Glycemic Control and Weight Loss. Scientific Reports (2023)

diabetesneuropharmacologyglycemic controlneuroscienceweight losspharmacologyphysiologypeptide triple agonistobesity

Corrination Mitigates Peptide Aggregation as Exemplified for Glucagon. Peptides (2023)

corrination mitigatespeptide therapeuticsbiochemistryglycobiologypeptide sciencepeptides

Excess Pancreatic Elastase Alters Acinar-β Cell Communication by Impairing the Mechano-Signaling and the Par2 Pathways. Cell Metabolism (2023)

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5
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10 / page