Faculty

Institution

Unit

Venue

George Dubyak

Professor

Case Western Reserve University

Affiliations

School of Medicine

Pharmacology

Physiology and Biophysics

George Dubyak is currently serving as a Pharmacology Professor at Case Western Reserve University.

Honors

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Experiences

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Education

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George Dubyak

Case Western Reserve University

Professor

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pharmacology immunology cell biology cell signaling membrane biology receptors physiology signal transduction cellular physiology gene expression immune responses inflammation molecular physiology cell physiology medicinal research hematology receptor (biochemistry) biological chemistry vascular biology redox biology protein science enzyme inhibition mammalian biology cell death liver physiology cell regulation apoptosis cellular immune responses innate immune system biochemical sciences cancer biology molecular immunology host factors murine macrophages animal physiology signaling pathways cytokines molecular regulation extracellular atp cellular biochemistry adaptive immune system protein secretion atp release protein transport tissue physiology clinical physiology cytosolic free calcium clinical investigation catalyst activation skeletal muscle protein function g protein-coupled receptor protein expression receptor tyrosine kinases clinical immunology host specificity inflammasome activation pharmacological research cell trafficking translational physiology phagocytes cellular biology biomolecular interactions anti-inflammatory myeloid leukocytes disease pathophysiology apoptotic induction xenopus oocytes ehrlich ascites human phagocytic leukocytes calcium mobilization extracellular adenosine triphosphate human amnion cells cell-free system inositol phosphates inflammatory cell death regulated cell death autophagy autoinflammatory disease

Notable Scholarly Works

Notable Federal Grants

Collaborators

A T H 17-Intrinsic Il-1β–Stat5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation. Science Immunology (2024)

William A. Miller-LittleXing ChenVanessa SalazarCaini LiuKatarzyna BulekJulie Y. ZhouXiao LiOlaf StüveThaddeus StappenbeckGeorge DubyakJunjie ZhaoXiaoxia Li

autoimmunityimmunologyautoimmune neuroinflammation

How Ninj1 Mediates Plasma Membrane Rupture and Why Ninj2 Cannot. Cell (2024)

Bibekananda SahooZongjun MouWei LiuGeorge DubyakXinghong Dai

molecular biologybiologymembrane biologybiophysics

Neutrophil Extracellular Traps Induced by Chemotherapy Inhibit Tumor Growth in Murine Models of Colorectal Cancer. Journal of Clinical Investigation (2024)

Yamu LiSulin WuYiqing ZhaoTrang DinhDongxu JiangJ. Eva SelfridgeGeorge MyersYuxiang WangXuan ZhaoSuzanne TomchuckGeorge DubyakRichard T. LeeBassam EstfanMarc ShapiroSuneel KamathAmr MohamedStanley Ching-Cheng HuangAlex Y. HuangRonald ConlonSmitha KrishnamurthiJennifer EadsJoseph E. WillisAlok A. KhoranaDavid BajorZhenghe Wang

biochemistrylateral spreadearly detectionlung cancergliomasvascular biologyneurologykidney cancermulti-omics studiesbreast cancerextracellular trapsmeso levelbrain tumor researchpharmacotherapycellular therapyprostate cancerurologypath dependencemurine modelsmedicinal research

Perturbation of Azurophilic Granule Integrity Drives Nlrp3-Independent Il-1B Processing and Release in Neutrophils. The Journal of Immunology (2024)

Brandon MillerGeorge Dubyak

immune responsesimmunologic mechanismsazurophilic granule integrityimmunology

Post-Translational Control of Nlrp3 Inflammasome Signaling. Journal of Biological Chemistry (2024)

Meghan E O'KeefeGeorge R DubyakDerek W Abbott

pharmacologysignal transductionbiochemistrycell regulationpost-translational controlcell signalingimmunology

The Structual Basis of Ninj1-Mediated Plasma Membrane Rupture. Biophysical Journal (2024)

Bibekananda SahooZongjun MouWei LiuGeorge R. DubyakXinghong Dai

structural biologystructual basisphysiologybiophysics

Double Damps – Nlrp3 Priming of Murine Bone Marrow Derived Mast Cells With Il-33 Leads to Robust Il-1β Secretion in a Gasdermin-D Independent Manner. The Journal of Immunology (2023)

Cheyanne FosterElizabeth LeeGeorge R Dubyak

mast cellsadaptive immune systemimmune responsesmurine bone marrowinnate immune systemcell signalingimmunologydermatologybone marrow transplantationcell biologygasdermin-d independent mannerlaboratory immunologymolecular immunologyclinical immunology

Lyososome Membrane Permeabilization Induces Plasma Membrane Macropores to Activate K +-Efflux-Dependent Nlrp3 Inflammasomes in Murine Dendritic Cells. The Journal of Immunology (2023)

George R DubyakKatherine HoranBrandon A Miller

immune responseshost factorsmurine dendritic cellshost responsecell signalingimmunologydermatologycell biology

Murine Eosinophils Release Il-1β via a Non-Lytic Mechanism Dependent on Gasdermin D (Gsdmd) Expression but Independent of Gsdmd Proteolytic Processing. The Journal of Immunology (2023)

Thu R NguyenJose R Diaz-AponteGeorge R Dubyak

gsdmd proteolytic processingpharmacologygene expressionimmunologydermatology

Neutrophils Use a Novel Nlrp3 Inflammasome-Independent Mechanism to Release Bioactive Il-1β in Response to Lysosomal Disruption. The Journal of Immunology (2023)

Brandon A MillerEric PearlmanGeorge R Dubyak

gene expressionimmunomodulationhost factorsinnate immune systemhost responseimmunologyimmune responseslysosomal disruptiongranulocyte

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George Dubyak

Professor

Case Western Reserve University

Affiliations

School of Medicine

Pharmacology

Physiology and Biophysics

George Dubyak is currently serving as a Pharmacology Professor at Case Western Reserve University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

George Dubyak

Case Western Reserve University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A T H 17-Intrinsic Il-1β–Stat5 Axis Drives Steroid Resistance in Autoimmune Neuroinflammation. Science Immunology (2024)

William A. Miller-LittleXing ChenVanessa SalazarCaini LiuKatarzyna BulekJulie Y. ZhouXiao LiOlaf StüveThaddeus StappenbeckGeorge DubyakJunjie ZhaoXiaoxia Li

autoimmunityimmunologyautoimmune neuroinflammation

How Ninj1 Mediates Plasma Membrane Rupture and Why Ninj2 Cannot. Cell (2024)

Bibekananda SahooZongjun MouWei LiuGeorge DubyakXinghong Dai

molecular biologybiologymembrane biologybiophysics

Neutrophil Extracellular Traps Induced by Chemotherapy Inhibit Tumor Growth in Murine Models of Colorectal Cancer. Journal of Clinical Investigation (2024)

Perturbation of Azurophilic Granule Integrity Drives Nlrp3-Independent Il-1B Processing and Release in Neutrophils. The Journal of Immunology (2024)

Brandon MillerGeorge Dubyak

immune responsesimmunologic mechanismsazurophilic granule integrityimmunology

Post-Translational Control of Nlrp3 Inflammasome Signaling. Journal of Biological Chemistry (2024)

Meghan E O'KeefeGeorge R DubyakDerek W Abbott

pharmacologysignal transductionbiochemistrycell regulationpost-translational controlcell signalingimmunology

The Structual Basis of Ninj1-Mediated Plasma Membrane Rupture. Biophysical Journal (2024)

Bibekananda SahooZongjun MouWei LiuGeorge R. DubyakXinghong Dai

structural biologystructual basisphysiologybiophysics

Double Damps – Nlrp3 Priming of Murine Bone Marrow Derived Mast Cells With Il-33 Leads to Robust Il-1β Secretion in a Gasdermin-D Independent Manner. The Journal of Immunology (2023)

Cheyanne FosterElizabeth LeeGeorge R Dubyak

Lyososome Membrane Permeabilization Induces Plasma Membrane Macropores to Activate K +-Efflux-Dependent Nlrp3 Inflammasomes in Murine Dendritic Cells. The Journal of Immunology (2023)

George R DubyakKatherine HoranBrandon A Miller

immune responseshost factorsmurine dendritic cellshost responsecell signalingimmunologydermatologycell biology

Murine Eosinophils Release Il-1β via a Non-Lytic Mechanism Dependent on Gasdermin D (Gsdmd) Expression but Independent of Gsdmd Proteolytic Processing. The Journal of Immunology (2023)

Thu R NguyenJose R Diaz-AponteGeorge R Dubyak

gsdmd proteolytic processingpharmacologygene expressionimmunologydermatology

Neutrophils Use a Novel Nlrp3 Inflammasome-Independent Mechanism to Release Bioactive Il-1β in Response to Lysosomal Disruption. The Journal of Immunology (2023)

Brandon A MillerEric PearlmanGeorge R Dubyak

gene expressionimmunomodulationhost factorsinnate immune systemhost responseimmunologyimmune responseslysosomal disruptiongranulocyte

1
2
3
4
5
22
10 / page

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Salvatore Vincent Pizzo

Institution

Duke University

pharmacology

biochemistry

Mark Donowitz

Institution

Johns Hopkins University

pharmacology

gastroenterology

Suresh C. Tyagi

Institution

University of Louisville

health science

cardiovascular translational research

Richard Minshall

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apoptosis

Paul Insel

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University of California, San Diego

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gastroenterology

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