Faculty

Institution

Unit

Venue

Gary P. Schools

Research Associate Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Gary P. Schools is currently serving as a College Of Pharmacy Research Associate Professor at University of South Carolina.

Honors

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Experiences

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Education

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Gary P. Schools

University of South Carolina

Research Associate Professor

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pharmacology cancer treatment oncology cancer research medicinal research cancer biology tumor targeting molecular biology tumor biology drug targeting medicine clinical research cancer care cellular therapy immunology cancer immunotherapy enzyme inhibition molecular cancer cancer genomics anti-cancer agents gene expression prostate cancer pharmacotherapy leukemia oncogenes cell regulation cancer genetics breast cancer mammalian biology cancer cells transcription regulation triple-negative breast cancer cell line surgical oncology clinical investigation experimental medicine cancer imaging cell death reproductive biology molecular regulation gene regulation cellular senescence cell cycle cancer management clinical medicine hematological malignancies mutagenesis cancer growth cancer screening reproductive physiology potentiate induction cellular model cell cycle progression conditional depletion topoisomerase ii mammalian cells bypasses resistance castration resistance advanced prostate cancer mediator kinase inhibition dna-damaging agents cell cycle effects parp inhibitor anti-metastatic activities free radical biology oncogenic agent oxidative stress cell biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichZachary T. MackGary P. SchoolsChang-uk LimLeigh EllisXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

prostate cancerneurologytumor targetingcancer managementcastration resistancecancer biologycancer researchsurgical oncologyurologycancer immunotherapycancer treatmentadvanced prostate cancerpharmacologypharmacotherapyclinical researchoncologymedicinal researchclinical investigationclinical medicinemediator kinase inhibitionexperimental medicine

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Jing LiThomas HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikitzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall KerrCharles DowlingGary SchoolsChang-Uk LimEugenia BroudeGeorge WildingMichael LillyIgor RoninsonMengqian Chen

cancer geneticsprostate cancermedicinemolecular cancercancer genomicscancer researchurologycastration-resistant prostate cancerdrug targetingcancer treatmenttumor biologydruggable drivergene expressionpharmacologytranscription regulationpharmacotherapyoncologyoncogenesmedicinal researchcellular therapy

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

neurologycarcinogenesispharmacologycancer geneticscell regulationcancer researchtumor biologyurologycancer growthcastration-resistant prostate canceroncologyoncogenesmedicinal researchcancer cellscancer treatmentcancer biologyprostate cancer

Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Alexandra V. BruterEkaterina A. VarlamovaNina I. StavskayaZoia G. AntyshevaVasily N. ManskikhAnna V. TvorogovaDiana. S. KorshunovaAlvina I. KhamidullinaMarina V. UtkinaViktor P. BogdanovIuliia P. BaikovaAlyona I. NikiforovaEugene A. AlbertDenis O. MaksimovJing LiMengqian ChenGary. P SchoolsAlexey V. FeoktistovAlexander A. ShtilIgor B. RoninsonVladislav A. MogilaYulia Y. SilaevaVictor V. Tatarskiy

male fertilityfertilityreproductive physiologyreproductive biologymolecular biology

Inhibition of Cdk8/19 Mediator Kinase Potentiates Her2-Targeting Drugs and Bypasses Resistance to These Agents in Vitro and in Vivo. Proceedings of the National Academy of Sciences (2022)

Xiaokai DingAmanda C. SharkoMartina S. J. McDermottGary P. SchoolsAlexander ChumanevichHao JiJing LiLi ZhangZachary T. MackVitali SikirzhytskiMichael ShtutmanLaura IversNorma O’DonovanJohn CrownBalázs GyőrffyMengqian ChenIgor B. RoninsonEugenia V. Broude

immunologymedicinegene expressionpharmacologyreceptorsenzyme inhibitioncell signalingdrug resistancedrug discoverydrug targetingmedicinal researchcancer treatmentbypasses resistancecell regulation

Abstract Lb132: Cdk8/19 Inhibition Overcomes in Vitro and in Vivo Resistance to Lapatinib in Her2+ Breast Cancer via Stat1 and Stat3. Cancer Research (2021)

Xiaokai DingAmanda C. SharkoMartina S-J McDermottHao JiAlexander ChumanevichGary P. SchoolsZachary T. MackElena PugachevaVictor TatarskiyAnastasia KhrustalevaAlexander TyakhtMichael ShtutmanMengqian ChenIgor RoninsonEugenia V. Broude

vivo resistancecancer screeningtumor targetingcancer carecancer genomicsanti-cancer agentsleukemiacancer immunotherapycancer treatmentimmunotherapyenzyme inhibitionpharmacologyradiation oncologydrug resistancestatisticsoncologyclinical researchmedicinal researchoncogenes

Cdk8/19 Mediator Kinases Potentiate Induction of Transcription by Nfκb. Proceedings of the National Academy of Sciences (2017)

Mengqian ChenJiaxin LiangHao JiZhengguan YangSerena AltiliaBing HuAdam SchronceMartina S. J. McDermottGary P. SchoolsChang-uk LimDavid OliverMichael S. ShtutmanTao LuGeorge R. StarkDonald C. PorterEugenia V. BroudeIgor B. Roninson

immunologygene expressiontranscription regulationgeneticsmolecular regulationmolecular biologypotentiate inductionsignal transductioncell regulationgene regulation

Thiopurine‐Induced Mitotic Catastrophe in Rad51D ‐Deficient Mammalian Cells. Environmental and Molecular Mutagenesis (2017)

Michael D. WyattNicole M. ReillyShikha PatelPreeti RajeshGary P. SchoolsPhillip G. SmiraldoDouglas L. Pittman

immunologythiopurine-induced mitotic catastrophecell deathmutagenesisgeneticsmammalian biologydna repairmutagenesis (molecular biology technique)cell biology

Cellular Model of P21-Induced Senescence. Methods in molecular biology (2016)

Michael ShtutmanBey-Dih ChangGary P. SchoolsEugenia V. Broude

cellular senescencelongevitycellular modelgeneticsmolecular biologyneuroscience

Abstract Pr08: Targeting Tumor Microenvironment With Selective Small-Molecule Inhibitors of Cdk8/19. Cancer Research (2015)

Donald C. PorterMengqian ChenJiaxin LiangVimala KazaAlexander ChumanevichSerena AltiliaElena FarmakiMarj PenaGary P. SchoolsIoulia ChatzistamouLawrence T. FriedhoffMark P. WentlandEugenia V. BroudeHippokratis KiarisIgor B. Roninson

tumor targetingmedicineenzyme inhibitionpharmacologyselective small-molecule inhibitorsradiation oncologycancer researchtherapeutic targetscellular therapyanti-cancer agentsoncologytargeting tumor microenvironmentdrug targetingmedicinal researchtumor microenvironmentcancer treatmentcancer biologytumor biology

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Gary P. Schools

Research Associate Professor

University of South Carolina

Affiliations

College of Pharmacy

Department of Drug Discovery and Biomedical Sciences (ddbs)

Gary P. Schools is currently serving as a College Of Pharmacy Research Associate Professor at University of South Carolina.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary P. Schools

University of South Carolina

Research Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Mediator Kinase Inhibition Reverses Castration Resistance of Advanced Prostate Cancer. Journal of Clinical Investigation (2024)

Abstract A043: Cdk8/19-Regulated Transcriptional Reprogramming: A Druggable Driver of Castration-Resistant Prostate Cancer. Molecular Cancer Therapeutics (2023)

Cdk19 and Cdk8 Mediator Kinases Drive Androgen-Independent in Vivo Growth of Castration-Resistant Prostate Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Jing LiThomas A. HilimireYueying LiuLili WangJiaxin LiangBalazs GyorffyVitali SikirzhytskiHao JiLi ZhangChen ChengXiaokai DingKendall R. KerrCharles E. DowlingAlexander A. ChumanevichGary P. SchoolsChang-uk LimXiaolin ZiDonald C. PorterEugenia V. BroudeCampbell McInnesGeorge WildingMichael B. LillyIgor B. RoninsonMengqian Chen

Knockout of Cyclin Dependent Kinases 8 and 19 Leads to Depletion of Cyclin C and Suppresses Spermatogenesis and Male Fertility in Mice. bioRxiv (Cold Spring Harbor Laboratory) (2023)

male fertilityfertilityreproductive physiologyreproductive biologymolecular biology

Inhibition of Cdk8/19 Mediator Kinase Potentiates Her2-Targeting Drugs and Bypasses Resistance to These Agents in Vitro and in Vivo. Proceedings of the National Academy of Sciences (2022)

immunologymedicinegene expressionpharmacologyreceptorsenzyme inhibitioncell signalingdrug resistancedrug discoverydrug targetingmedicinal researchcancer treatmentbypasses resistancecell regulation

Abstract Lb132: Cdk8/19 Inhibition Overcomes in Vitro and in Vivo Resistance to Lapatinib in Her2+ Breast Cancer via Stat1 and Stat3. Cancer Research (2021)

Cdk8/19 Mediator Kinases Potentiate Induction of Transcription by Nfκb. Proceedings of the National Academy of Sciences (2017)

immunologygene expressiontranscription regulationgeneticsmolecular regulationmolecular biologypotentiate inductionsignal transductioncell regulationgene regulation

Thiopurine‐Induced Mitotic Catastrophe in Rad51D ‐Deficient Mammalian Cells. Environmental and Molecular Mutagenesis (2017)

Michael D. WyattNicole M. ReillyShikha PatelPreeti RajeshGary P. SchoolsPhillip G. SmiraldoDouglas L. Pittman

immunologythiopurine-induced mitotic catastrophecell deathmutagenesisgeneticsmammalian biologydna repairmutagenesis (molecular biology technique)cell biology

Cellular Model of P21-Induced Senescence. Methods in molecular biology (2016)

Michael ShtutmanBey-Dih ChangGary P. SchoolsEugenia V. Broude

cellular senescencelongevitycellular modelgeneticsmolecular biologyneuroscience

Abstract Pr08: Targeting Tumor Microenvironment With Selective Small-Molecule Inhibitors of Cdk8/19. Cancer Research (2015)

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