Faculty

Institution

Unit

Venue

Gary Cline

Professor Emeritus of Medicine Endocrinology

Yale University

Affiliations

Internal Medicine

Gary Cline is currently serving as an Internal Medicine Professor Emeritus of Medicine Endocrinology at Yale University.

Honors

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Experiences

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Education

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Gary Cline

Yale University

Professor Emeritus of Medicine Endocrinology

You can click a keyword to filter the displayed items

physiology endocrinology liver physiology membrane biology pharmacology biochemistry diabetes metabolism health sciences hepatology molecular physiology metabolic regulation mammalian biology mitochondrial function cell metabolism cellular physiology hematology redox biology energy metabolism endocrine research animal physiology gene expression medicinal research insulin signaling clinical physiology clinical research clinical investigation clinical biochemistry biological chemistry molecular metabolism protein science clinical medicine clinical lipidology experimental medicine enzyme inhibition mammalian physiology muscle function skeletal muscle comparative endocrinology secondary metabolism insulin resistance lipoprotein metabolism hyperlipidemia hepatic insulin resistance developmental endocrinology lipid science molecular regulation tissue physiology clinical evidence diabetes mellitus renal function hepatic steatosis insulin secretion liver disease lipid chemistry insulin sensitivity pet imaging human sciences metabolic disorders neurochemistry energy homeostasis nuclear magnetic resonance spectroscopy inhibitory activity pancreatic b-cell mass cell physiology protein transport nutritional neuroscience glucose homeostasis glucose-stimulated insulin secretion glucose transport hepatic glycogen synthesis mitochondrial dysfunction fatty acids differential effects brain energy metabolism fat mass

Notable Scholarly Works

Notable Federal Grants

Collaborators

High-Fat-Diet-Induced Hepatic Insulin Resistance Per Se Attenuates Murine De Novo Lipogenesis. iScience (2024)

Leigh GoedekeJordan W StroberRebecca SuhLauren M PaolellaXiruo LiJillian C RogersMax C PetersenAli R NasiriGregori CasalsMario KahnGary W ClineVarman T SamuelGerald I ShulmanDaniel F Vatner

lipidsmetabolic disordershepatic insulin resistanceliver physiologyhigh fat dietbiochemistry

Sglt2 Inhibition Alters Substrate Utilization and Mitochondrial Redox in Healthy and Failing Rat Hearts. Journal of Clinical Investigation (2024)

Leigh GoedekeYina MaRafael C GasparAli NasiriJieun LeeDongyan ZhangKatrine Douglas GalsgaardXiaoyue HuJiasheng ZhangNicole GuerreraXiruo LiTraci LaMoiaBrandon T HubbardSofie HaedersdalXiaohong WuJohn StackSylvie DufourGina Marie ButricoMario KahnRachel J PerryGary W ClineLawrence H YoungGerald I Shulman

lipid peroxidationsecondary metabolismfailing rat heartsbiochemistryheart failureantioxidantsinflammationredox signalingreactive oxygen speciesgene expressionpharmacologyenzyme inhibitionfree radical biologyredox biologymitochondrial functionbiomolecular engineeringmitochondrial redoxclinical investigationoxidative stresscardiovascular disease

Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Network Open (2023)

Brittany GaluppoGiuseppina Rosaria UmanoZhongyao LiMichelle Van NameStephanie L. SamuelsC. Lawrence KienGary W. ClineDavid A. WagnerEmiliano BarbieriDomenico TricòNicola Santoro

public healthphysiologyadolescent healthcolonic fermentationobesitygastroenterologymetabolic healthmetabolismhealth sciencesmetabolic response

Cells Adapt to Resist Fluoride Through Metabolic Deactivation and Intracellular Acidification. Chemical Research in Toxicology (2022)

Nichole R. JohnstonGary ClineScott A. Strobel

immunologyphysiologytoxicologymetabolic deactivationintracellular acidificationmembrane biologycell biology

Distinct Subcellular Localisation of Intramyocellular Lipids and Reduced Pkcε/Pkcθ Activity Preserve Muscle Insulin Sensitivity in Exercise-Trained Mice. Diabetologia (2022)

Rafael C. GasparKun LyuBrandon T. HubbardBrooks P. LeitnerPanu K. LuukkonenSandro M. HirabaraIkki SakumaAli NasiriDongyan ZhangMario KahnGary W. ClineJosé Rodrigo PauliRachel J. PerryKitt F. PetersenGerald I. Shulman

diabetesmuscle functioninhibitory activityliver physiologydiabetes researchmedicineendocrinologyskeletal muscleexercise physiologydistinct subcellular localisationathletic trainingmembrane biologyinsulin signalingmammalian biologymolecular physiologyexercise-trained micephysiologypharmacologyintramyocellular lipidsexercise sciencemuscle insulin sensitivitydiabetic medicine

Metformin, Phenformin, and Galegine Inhibit Complex IV Activity and Reduce Glycerol-Derived Gluconeogenesis. Proceedings of the National Academy of Sciences (2022)

Traci E. LaMoiaGina M. ButricoHasini A. KalpageLeigh GoedekeBrandon T. HubbardDaniel F. VatnerRafael C. GasparXian-Man ZhangGary W. ClineKeita NakaharaSeungwan WooAtsuhiro ShimadaMaik HüttemannGerald I. Shulman

physiologymedicinal chemistryenzyme inhibitionpharmacologydrug metabolismmetabolic regulationenzymesdrug discoveryglycerol-derived gluconeogenesisactive ingredienthost-guest chemistryherb-drug interactionsprotein sciencemembrane biologybiochemistry

Noninvasive Quantitative Pet Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers Vmat2 and Dopamine D2/D3 Receptors in Vivo. Methods in molecular biology (2022)

Jason BiniRichard E. CarsonGary W. Cline

receptorsbiomarkersneuroimaging biomarkersneuroimagingbrain imagingmedical imagingin vivo systemsdopaminemolecular biologystructural biologyneurosciencecell biology

Sex‐ and Strain‐Specific Effects of Mitochondrial Uncoupling on Age‐Related Metabolic Diseases in High‐Fat Diet‐Fed Mice. Aging Cell (2022)

Leigh GoedekeKelsey N. MurtAndrea Di FrancescoJoão Paulo CamporezAli R. NasiriYongliang WangXian‐Man ZhangGary W. ClineRafael de CaboGerald I. Shulman

experimental gerontologylongevityresidual stresshigh-fat diet-fed micemetabolismliver physiologyneuroscience of agingageingbiogerontologymetabolic regulationage-related metabolic diseasesaging processstrain-specific effectsmembrane biologyaging cellmammalian biologyphysiologysystems biologymitochondrial functionneuroscience

281-or: Endothelial Cell Cd36 Regulates Systemic Glucose and Lipid Metabolism. Diabetes (2021)

LEIGH GOEDEKENI-HUIPING SONTRACI E. LAMOIAALI NASIRIMARIO KAHNXIAN-MAN ZHANGGARY CLINEIRA J. GOLDBERGGERALD I. SHULMAN

physiologylipid metabolismdiabetescellular physiologymetabolic regulationsystems biologyendocrinologycell signalingvascular biologymolecular regulationsystemic glucosesignal transductioncellular regulatory mechanismmembrane biologycell biology

323-or: Sglt2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart. Diabetes (2021)

LEIGH GOEDEKEJI EUN LEEYINA MAXIAOYUE HUJIASHENG ZHANGJIANYING DONGKATRINE D. GALSGAARDNICOLE GUERRERASOFIE HAEDERSDALXIAN-MAN ZHANGRACHEL J. PERRYGARY CLINELAWRENCE H. YOUNGGERALD I. SHULMAN

cardiologyheart failuremedicinepharmacologydiabetesmyocardial ketone utilizationhypertensionfailing hearthealth sciences

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Gary Cline

Professor Emeritus of Medicine Endocrinology

Yale University

Affiliations

Internal Medicine

Gary Cline is currently serving as an Internal Medicine Professor Emeritus of Medicine Endocrinology at Yale University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Gary Cline

Yale University

Professor Emeritus of Medicine Endocrinology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

High-Fat-Diet-Induced Hepatic Insulin Resistance Per Se Attenuates Murine De Novo Lipogenesis. iScience (2024)

Leigh GoedekeJordan W StroberRebecca SuhLauren M PaolellaXiruo LiJillian C RogersMax C PetersenAli R NasiriGregori CasalsMario KahnGary W ClineVarman T SamuelGerald I ShulmanDaniel F Vatner

lipidsmetabolic disordershepatic insulin resistanceliver physiologyhigh fat dietbiochemistry

Sglt2 Inhibition Alters Substrate Utilization and Mitochondrial Redox in Healthy and Failing Rat Hearts. Journal of Clinical Investigation (2024)

Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Network Open (2023)

Brittany GaluppoGiuseppina Rosaria UmanoZhongyao LiMichelle Van NameStephanie L. SamuelsC. Lawrence KienGary W. ClineDavid A. WagnerEmiliano BarbieriDomenico TricòNicola Santoro

public healthphysiologyadolescent healthcolonic fermentationobesitygastroenterologymetabolic healthmetabolismhealth sciencesmetabolic response

Cells Adapt to Resist Fluoride Through Metabolic Deactivation and Intracellular Acidification. Chemical Research in Toxicology (2022)

Nichole R. JohnstonGary ClineScott A. Strobel

immunologyphysiologytoxicologymetabolic deactivationintracellular acidificationmembrane biologycell biology

Distinct Subcellular Localisation of Intramyocellular Lipids and Reduced Pkcε/Pkcθ Activity Preserve Muscle Insulin Sensitivity in Exercise-Trained Mice. Diabetologia (2022)

Metformin, Phenformin, and Galegine Inhibit Complex IV Activity and Reduce Glycerol-Derived Gluconeogenesis. Proceedings of the National Academy of Sciences (2022)

Noninvasive Quantitative Pet Imaging in Humans of the Pancreatic Beta-Cell Mass Biomarkers Vmat2 and Dopamine D2/D3 Receptors in Vivo. Methods in molecular biology (2022)

Jason BiniRichard E. CarsonGary W. Cline

receptorsbiomarkersneuroimaging biomarkersneuroimagingbrain imagingmedical imagingin vivo systemsdopaminemolecular biologystructural biologyneurosciencecell biology

Sex‐ and Strain‐Specific Effects of Mitochondrial Uncoupling on Age‐Related Metabolic Diseases in High‐Fat Diet‐Fed Mice. Aging Cell (2022)

Leigh GoedekeKelsey N. MurtAndrea Di FrancescoJoão Paulo CamporezAli R. NasiriYongliang WangXian‐Man ZhangGary W. ClineRafael de CaboGerald I. Shulman

281-or: Endothelial Cell Cd36 Regulates Systemic Glucose and Lipid Metabolism. Diabetes (2021)

LEIGH GOEDEKENI-HUIPING SONTRACI E. LAMOIAALI NASIRIMARIO KAHNXIAN-MAN ZHANGGARY CLINEIRA J. GOLDBERGGERALD I. SHULMAN

323-or: Sglt2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart. Diabetes (2021)

LEIGH GOEDEKEJI EUN LEEYINA MAXIAOYUE HUJIASHENG ZHANGJIANYING DONGKATRINE D. GALSGAARDNICOLE GUERRERASOFIE HAEDERSDALXIAN-MAN ZHANGRACHEL J. PERRYGARY CLINELAWRENCE H. YOUNGGERALD I. SHULMAN

cardiologyheart failuremedicinepharmacologydiabetesmyocardial ketone utilizationhypertensionfailing hearthealth sciences

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